Abstract Number: 1433 • 2016 ACR/ARHP Annual Meeting
Self-Perception Reporting to Healthcare Professionals: Do Individuals with Systemic Sclerosis Report Quality of Life Changes Accurately?
Background/Purpose: Systemic Sclerosis (SS) involves multiple systems that affect the ability to move and function. When ability is lost the individuals living with this autoimmune…Abstract Number: 1434 • 2016 ACR/ARHP Annual Meeting
Effect of Systemic and Local Inflammation on the Insulin Resistance and Glucose/Lipid Metabolism in Rheumatoid Arthritis: Humans and CIA Mouse Model
Background/Purpose: Rheumatoid arthritis (RA) patients are at higher risk for insulin resistance (IR). The association between RA and IR, and its role on the different…Abstract Number: 1435 • 2016 ACR/ARHP Annual Meeting
KCa1.1 Potassium Channels Are a Novel Therapeutic Target on Fibroblast-like Synoviocytes in Rheumatoid Arthritis
Background/Purpose: Fibroblast-like synoviocytes (FLS) develop a high degree of invasiveness during rheumatoid arthritis (RA), leading to joint degradation. There are currently no therapeutics that specifically…Abstract Number: 1436 • 2016 ACR/ARHP Annual Meeting
TAS8274, a Highly Selective Janus Kinase 3 Inhibitor, Demonstrates Potent Efficacy in an Animal Model of Rheumatoid Arthritis
Background/Purpose: The family of Janus kinases (JAKs) plays important roles in signaling pathway mediated by various cytokine receptors. An aberrant activation of JAK-STAT signaling…Abstract Number: 1437 • 2016 ACR/ARHP Annual Meeting
Netrin-1 and Its Receptor Unc5b Are Novel Targets for the Treatment of Inflammatory Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation and destruction of joints. Netrin-1, a laminin-like matrix protein that acts as a…Abstract Number: 1438 • 2016 ACR/ARHP Annual Meeting
Tofacitinib Restores Reverse Cholesterol Transport Inhibition Induced By Inflammation. Understanding the Lipid Paradox
Background/Purpose: Patients with active rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality, paradoxically in association with reduced circulating levels of total cholesterol…Abstract Number: 1439 • 2016 ACR/ARHP Annual Meeting
The EP4 Receptor Antagonist CR6086 Is More Effective Than Classical NSAID and DMARD Treatment in a Murine Model of Arthritis and in Human RA Synovial Explants
Background/Purpose: CR6086 is a novel small molecule acting as a potent and selective antagonist of the prostaglandin E2 (PGE2) receptor EP4 subtype (EP4 receptor). Recent…Abstract Number: 1440 • 2016 ACR/ARHP Annual Meeting
Anti-TNF Vaccination Protects from Experimental Arthritis without Affecting Resistance to Mycobacterium Tuberculosis or Listeria Monocytogenes infection
Background/Purpose: Anti-TNF-alpha therapy has been a successful treatment strategy for rheumatoid arthritis (RA), but is associated with reduced resistance to infection. In mice, TNF is…Abstract Number: 1441 • 2016 ACR/ARHP Annual Meeting
Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Knockout Attenuates Arthritis Progression and Systemic Inflammation in TNF-Tg Arthritis Mouse Models
Background/Purpose: Tumor necrosis factor-transgenic (TNF-Tg) mice develop systemic inflammatory polyarthritis. DC-STAMP, a multi-pass transmembrane protein, was originally identified from a dendritic cell library and required…Abstract Number: 1442 • 2016 ACR/ARHP Annual Meeting
Suppression of Acute Arthritis By N-Methyl-3,4-Dichloropropionaniline (N-MeDCPA), a Reversible Orai Calcium Channel Inhibitor
Background/Purpose: Bone maintenance is a balance between the removal of old bone by osteoclasts (OCL) and the production of new bone by osteoblasts. In the…Abstract Number: 1443 • 2016 ACR/ARHP Annual Meeting
A Therapeutic Peptide Vaccine Reduces Pro-Inflammatory Responses and Suppresses Arthritis in the Cartilage Proteoglycan G1 Domain-Induced Mouse Model of Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease leading to inflammatory destruction of the peripheral joints. Although pro-inflammatory T helper 1 (Th1) and/or Th17 cell…Abstract Number: 1444 • 2016 ACR/ARHP Annual Meeting
Differential Expression of Wnt Inhibitors before and after Joint Inflammation Onset in Rat Arthritis Could Partly Explain Paradoxical Effect of Sclerostin Inhibition
Background/Purpose: Periarticular bone loss in rheumatoid arthritis is considered to be mainly related to synovial inflammation, leading to uncoupling between decreased bone formation and increased…Abstract Number: 1445 • 2016 ACR/ARHP Annual Meeting
Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Ameliorate Rheumatoid Arthritis Via Regulation of Macrophage Activation and Polarization
Background/Purpose: Immunomodulatory properties enable mesenchymal stem cells (MSCs) to be a promising alternative for the treatment of a wide range of immune-related diseases including rheumatoid…Abstract Number: 1446 • 2016 ACR/ARHP Annual Meeting
High Fat Diet Alleviates Antigen-Induced Arthritis Severity in Male Mice By Enhancing Both Treg and B10 Cells
Background/Purpose: Obesity is associated with many chronic diseases. However, evidence regarding obesity’s impact on rheumatoid arthritis (RA) initiation and development remains controversial. Recent studies indicate…Abstract Number: 1447 • 2016 ACR/ARHP Annual Meeting
Therapeutic Blockade of Interleukin-6 Trans-Signalling Restores Vascular Function in Murine Collagen Induced Arthritis
Background/Purpose: Mortality is increased in rheumatoid arthritis (RA), mainly due to cardiovascular disease (CVD). While molecular mechanisms underlining this clinical observation are unknown, systemic elevations…
ACR Meeting Abstracts