Abstract Number: 1736 • 2017 ACR/ARHP Annual Meeting
Deep Immunophenotyping of T-Lymphocytes with a 37-Channel Mass Cytometry (CyTOF) Panel for the Identification of Pathological Cell Functions and the Prediction of Response to Biologic Drugs in Rheumatoid Arthritis
Background/Purpose: Pathogenic immune cell types and functions have not been identified yet in rheumatoid arthritis (RA). This is explained by the impact of disease heterogeneity…Abstract Number: 1737 • 2017 ACR/ARHP Annual Meeting
An Abundance of Butyrate-Producing Bacterium in the Intestine and Increased Foxp3 Gene Expression of T Cells in Patients with Relapsing Polychondritis
Background/Purpose: Helper T cell subsets including Th17 cells and regulatory T (Treg) cells play a role in the adaptive immune response. RORC and Foxp3 are…Abstract Number: 1738 • 2017 ACR/ARHP Annual Meeting
The Pattern of Proinflamatory Cytokine Expression By CD4+ T Lymphocytes Segregates the Clinical Response to Methotrexate in Recently Diagnosed Rheumatoid Arthritis Patients
Background/Purpose: Mechanisms regulating the autoimmune response in rheumatoid arthritis (RA) are not well understood. However, it is known that T CD4+ lymphocytes play a pivotal…Abstract Number: 1739 • 2017 ACR/ARHP Annual Meeting
Vδ1, Vδ2, and Other γδT Cells in Blood and Synovium of Rheumatoid Arthritis and Other Autoimmune Arthritides
Background/Purpose: Innate-like T cells comprise on average 10-15% of peripheral T cell and have T-cell receptors (TCRs) that engage ligands other than classic HLA class…Abstract Number: 1740 • 2017 ACR/ARHP Annual Meeting
Fc-Derived Immunodominant Peptides Stimulate Natural Regulatory T Cells: A New Avenue to Overcome Defects in the Fc Antigen Processing and Restore Immune Regulation in Rheumatic Diseases
Background/Purpose: The mechanisms of action of intravenous purified immunoglobulins (IVIG) in acute Kawasaki disease (KD) have been investigated in our laboratory and have led to…Abstract Number: 1741 • 2017 ACR/ARHP Annual Meeting
Tolerance and Efficiency of Anti-Programmed Death 1 Antibodies in Patients with Cancer and Preexisting Autoimmune or Inflammatory Diseases
Background/Purpose: Patients with auto-immune or inflammatory diseases (AID) treated by immune check-points inhibitors (ICI) are intrinsically susceptible to develop immune related adverse events (irAE). We…Abstract Number: 1742 • 2017 ACR/ARHP Annual Meeting
Involvement of T Helper 17 Cells in Inflammatory Arthritis Depends on the Host Intestinal Microbiota
Background/Purpose: The intestinal microbiota has been associated with psoriatic and rheumatoid arthritis. One of the major effects of microbiota is the induction of mucosal T…Abstract Number: 1743 • 2017 ACR/ARHP Annual Meeting
Serine Arginine/Rich Splicing Factor 1 (SRSF1) Increases IL-2 Production in T Cells By Increasing the Expression of NFAT and c-Fos
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) produce insufficient amounts of the vital cytokine IL-2, and the molecular mechanisms leading to this…Abstract Number: 1744 • 2017 ACR/ARHP Annual Meeting
Transciptome Profile of Inflammation Inducted Circulating Effector and Regulatory T Cells Is Dominated By HLA-DR Pivoted Functional Networks in Active Juvenile Idiopathic Arthritis Patients
Background/Purpose: We have previously identified two dichotomous CD4 pathogenic subsets in both T effector (CPLs: Circulating pathogenic like lymphocytes) and T regulatory (iaTreg: inflammation associated…Abstract Number: 1745 • 2017 ACR/ARHP Annual Meeting
Autophagic Memory in Stress Experienced Human T Cells
Background/Purpose: Autophagy is central to many key immune related pathways, disregulation of which has been associated with rheumatoid arthritis (RA), cancer and neurodegenerative diseases. Autophagy…Abstract Number: 1746 • 2017 ACR/ARHP Annual Meeting
mTOR Pathway Activation in Takayasu Arteriti
Background/Purpose: mTORC1 drives the proinflammatory expansion of T helper (TH) type 1, TH17 cells and controls fibroblast proliferation, typical features of Takayasu arteritis (TA) pathogenesis.…Abstract Number: 1747 • 2017 ACR/ARHP Annual Meeting
Human C-C Chemokine Receptor-6 (CCR6)+ Th Memory Cells, Including Th17 and Th17.1 Cells, Change into Anti-Inflammatory Cells with Regulatory Capacity upon Exposure to Vitamin D
Background/Purpose: Autoimmune diseases such as RA are driven by an aberrantly activated immune system and an imbalance between pro- and anti-inflammatory cells, resulting in tissue…Abstract Number: 1748 • 2017 ACR/ARHP Annual Meeting
Cbl-b Associates with Bcl-6 and Is Differentially Expressed in Circulating Follicular T Helper Cells of Patients with Systemic Lupus Erythematosus
Background/Purpose: Activation of polyclonal CD4+ T cells and B cells is a hallmark of human and murine lupus, which suggests a global defect in the…Abstract Number: 1749 • 2017 ACR/ARHP Annual Meeting
The Epidemiology of ANCA Associated Vasculitis in the U.S.: A 20 Year Population Based Study
Background/Purpose: ANCA-associated vasculitis (AAV) is rare, with a worldwide reported annual incidence ranging from 1.2 to 2.0 cases per 100,000 individuals and a prevalence of…Abstract Number: 1750 • 2017 ACR/ARHP Annual Meeting
Risk of Cardiovascular and Thrombotic Disease Among Patients with Incident ANCA-Associated Vasculitis: A 20 Year Population Based Cohort Study
Background/Purpose: ANCA-associated vasculitides (AAV) are characterized by inflammation and necrosis of small-sized vessels. Because cardiovascular disease (CVD) is a leading contributor to morbidity and mortality,…
ACR Meeting Abstracts