Abstracts Archive - Page 1498 of 2607 - ACR Meeting Abstracts

Abstract Number: 1661 • 2017 ACR/ARHP Annual Meeting
STAT4 Regulates Pathogenic IL-21 and IFN-γ in Tfh Cells in Murine and Human Lupus
Fotios Koumpouras¹, XueMei Dong², Jason Weinstein² and Joseph E. Craft³, ¹Internal Medicine, Rheumatology, Yale University School of Medicine, New Haven, CT, ²Rheumatology, Yale University School of Medicine, New Haven, CT, ³Department of Internal Medicine/Rheumatology, Yale University School of Medicine, New Haven, CT
Background/Purpose: Follicular helper T cells (Tfh) cells regulate the germinal center (GC) response by delivery of contact-dependent interactions and cytokines including IL-4, IFN-γ and IL-21.…
Abstract Number: 1662 • 2017 ACR/ARHP Annual Meeting
High Type I Interferon Activity Is Associated with Active Class Ⅲ/Ⅳ Lupus Nephritis in European-American Lupus Patients Independent of dsDNA Antibodies
Taro Iwamoto¹, Jessica M. Dorschner², Mark A. Jensen¹, Danielle Vsetecka², Shreyasee Amin³, Ashima Makol⁴, Floranne C. Ernste⁵, Thomas Osborn³, Kevin Moder³, Vaidehi Chowdhary⁶ and Timothy B. Niewold¹, ¹Colton Center for Autoimmunity, New York University, New York, NY, ²Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁵Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ⁶Internal Medicine, Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN
Background/Purpose: Lupus nephritis (LN) is one of the most severe types of organ involvement in systemic lupus erythematosus (SLE), despite the recent advances in immunosuppressive…
Abstract Number: 1663 • 2017 ACR/ARHP Annual Meeting
De Novo Mutation in ΑCΑCΒ in Childhood Onset SLE Highlights a Novel Role As Modulator of Nucleic Acid Sensor-Driven Type I Interferon Responses
Isaac Harley¹, Hanna Schulz¹, John Cambier², Leah C. Kottyan³, John B. Harley⁴, V. Michael Holers⁵, Hermine I. Brunner⁶, Kristine Kuhn¹, Kevin D. Deane¹ and Kenneth Kaufman⁷, ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Deparment of Immunology & Microbiology, University of Colorado School of Medicine, Aurora, CO, ³Center for Autoimmune Genomics and Etiology (CAGE), Division of Allergy and Immunology, Cincinnati Children's Hospital, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Medicine, Division of Rheumatology, University of Colorado Denver, Aurora, CO, ⁶Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH
Background/Purpose: Rare variants provide important opportunity for mechanistic insight as they carry substantial effect sizes and provide deep insight into disease etiopathogenesis. To date, several…
Abstract Number: 1664 • 2017 ACR/ARHP Annual Meeting
Serum FAS, Ferritin, Igfbp2, sTNFR2 As Markers for Tracking Mucocutaneous and Musculoskeletal Flares in SLE Patients
Kamala Vanarsa¹, Samar Soliman², Aubrey Swilling³, Joan T. Merrill⁴ and Chandra Mohan², ¹Biomedical Engineering, University of Houston, houston, TX, ²Biomedical Engineering, University of Houston, Houston, TX, ³University of Houston, houston, TX, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic multi-systemic autoimmune disease, with a broad spectrum of clinical manifestations and unpredictable disease course with periods of…
Abstract Number: 1665 • 2017 ACR/ARHP Annual Meeting
Soluble Programmed Cell Death Protein 1 As a Biomarker for Systemic Lupus Erythematosus
Shinya Hirahara, Yasuhiro Katsumata, Yasushi Kawaguchi and Hisashi Yamanaka, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Programmed cell death protein 1 (PD-1/CD279) is a cell surface receptor that belongs to the extended CD28/CTLA-4 family and is expressed on T cells…
Abstract Number: 1666 • 2017 ACR/ARHP Annual Meeting
Anti-Mitochondrial Autoantibodies in Systemic Lupus Erythematosus and Their Association with Disease Manifestations
Yann Becker¹, Renee Claude Loignon¹, Genevieve Marcoux¹, Anne-Sophie Julien², Imene Melki¹, Lihi Eder³, Eric Wagner¹, Martin Pelletier¹, Marie-Josee Hebert⁴, Clemence Belleannee¹, Joyce Rauch⁵, Melanie Dieude⁴, Paul R. Fortin⁶ and Eric Boilard¹, ¹CHU de Quebec and Universite Laval, Quebec City, QC, Canada, ²CHU de Quebec - Universite Laval, Quebec City, QC, Canada, ³Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada, ⁴CHUM and Universite de Montreal, Montreal, QC, Canada, ⁵McGill University, Montreal, QC, Canada, ⁶Medicine, CHU de Quebec - Universite de Laval, Quebec, QC, Canada
- Background/Purpose: Eukaryotic cells contain organelles called mitochondria that govern energy supply and control of cell death. Whereas damaged organs or activated cells can extrude…
Abstract Number: 1667 • 2017 ACR/ARHP Annual Meeting
Increased Levels of BAFF in SLE Patients Correlates with Neutrophil Activation and Autoantibody Production
Andrew Vasconcellos¹, John Marken¹, Ting Wang^1,2, Christian Lood³ and Natalia V. Giltiay¹, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ²Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China, ³Division of Rheumatology, Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA
Background/Purpose: Neutrophil (PMN) activation and neutrophil extracellular trap (NET) formation are implicated in the pathogenesis of Systemic Lupus Erythematosus (SLE), particularly in the acceleration of…
Abstract Number: 1668 • 2017 ACR/ARHP Annual Meeting
Identification of a Serum Measure of Lupus Nephritis Activity That Detects Molecular Pathways and Mechanisms Implicated in Renal Damage
Mikhail Olferiev¹, Dina Greenman², David Fernandez¹, Kerry Merritt¹, Kyriakos A. Kirou¹ and Mary K. Crow³, ¹Hospital for Special Surgery, New York, NY, ²Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY, ³Department of Medicine, Hospital for Special Surgery, New York, NY
Background/Purpose: Up to 60% of SLE patients develop renal involvement, and renal injury is an important predictor of mortality in patients with SLE. Kidney biopsy…
Abstract Number: 1669 • 2017 ACR/ARHP Annual Meeting
Anti-Mitochondria DNA Antibody As an Improved Biomarker for Systemic Lupus Erythematosus
Yangsheng Yu¹, Kalika Mahato¹, Suyang Xu¹, Jenna Mu¹, Amanda Zhang¹, James R. O'Dell², Lynell W. Klassen², Michelene Hearth-Holmes³ and Kaihong Su¹, ¹Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, ²Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine/Rheumatology Division, Univ. of Nebraska Medical Center, Omaha, NE
Background/Purpose: Anti-dsDNA antibodies are highly specific for systemic lupus erythematosus (SLE) and often associate with lupus nephritis. Extracellular nucleosome DNA released from apoptotic or necrotic…
Abstract Number: 1670 • 2017 ACR/ARHP Annual Meeting
HMGB1-TLR4 Axis in Patients with Neuropsychiatric Systemic Lupus Erythematosus
Qin Huang¹, Chao Yuan², Hao Ren¹ and Min Yang¹, ¹Department of Rheumatology, Nanfang Hospital，Southern Medical University, Guangzhou, China, ²Department of Neurology, Nanfang Hospital，Southern Medical University, Guangzhou, China
Background/Purpose: Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) is a severe complication of SLE, including a variety of neurological and psychiatric features. Previous studies have demonstrated the…
Abstract Number: 1671 • 2017 ACR/ARHP Annual Meeting
Complement C4 Gene Copy Number Variations Bestow Large Ranges of Serum C4 Protein Levels in Chinese Patients with Systemic Lupus Erythematosus (SLE) and Contribute to Organ and Cardiovascular Damages over Time
Chi Chiu Mok¹, Emily King², Bi Zhou³, Gakit Yu⁴, Yee Ling Wu⁵ and CHACK-YUNG Yu⁶, ¹Rheumatology, Tuen Mun Hospital, Hong Kong, Hong Kong, ²Pediatrics, Nationwide Children's Hospital, Columbus, OH, ³Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁴Center for Molecular and Human Genetics, Nationwide Children's Hospital, Columbus, OH, ⁵Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, OH, ⁶Pediatrics, Ohio State Univ, Columbus, OH
Background/Purpose: Human SLE is characterized by fluctuating serum levels of complement proteins. There are frequent copy number variations (CNVs) of complement C4A and C4B genes…
Abstract Number: 1672 • 2017 ACR/ARHP Annual Meeting
Cytokines and Autoantibody Cluster-Interaction in Systemic Lupus Erythematosus. a Systems Medicine Approach
Julian Barahona-Correa, Yovana Pacheco, Diana M. Monsalve, Manuel Rojas, Yhojan Rodríguez, Juliana Saavedra, Mónica Rodríguez-Jiménez, Ruben Mantilla, Carolina Ramírez-Santana, Nicolás Molano-González and Juan-Manuel Anaya, Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia
Background/Purpose: Evidence supports the existence of different sub-phenotypes and the pivotal role of cytokines and autoantibodies in systemic lupus erythematosus (SLE). Cytokines interact in a…
Abstract Number: 1673 • 2017 ACR/ARHP Annual Meeting
Human C4 Gene Copy Number Influences Cell-Bound Complement Activation Product (CB-CAP) C4d in Systemic Lupus Erythematosus
Chau-Ching Liu¹, Joseph Ahearn², Amy Xiaoqin Tang², Yee Ling Wu³, CHACK-YUNG Yu³ and Susan Manzi², ¹Lupuc Center of Excellence, Allegheny Health Network Research Institute, Pittsburgh, PA, ²Lupus Center of Excellence, Allegheny Health Network Research Institute, Pittsburgh, PA, ³Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, OH
Background/Purpose: Human complement C4 protein is the product of two isotypic genes C4A and C4B that are located on chromosome 6 in various copy numbers.…
Abstract Number: 1674 • 2017 ACR/ARHP Annual Meeting
Combining Medications That Lower Systemic Oxidative Stress Is Associated with Less Atherosclerosis in Systemic Lupus Erythematosus
Jim C. Oates, Medical Service, Ralph H. Johnson VA Medical Center, Charleston, SC; Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: No single medication has been demonstrated as effective in reducing atherosclerosis or cardiovascular events in systemic lupus erythematosus (SLE), possibly due to the…
Abstract Number: 1675 • 2017 ACR/ARHP Annual Meeting
SLE Comprises Four Immune-Phenotypes, Which Differ Regarding HLA-DRB1 and Clinical Associations
Lina Marcela Diaz Gallo¹, Emeli Lundström¹, Vilija Oke¹, Kerstin Elvin², Yee Ling Wu³, Johanna Gustafsson¹, Andreas Jönsen⁴, Dag Leonard⁵, Agneta Zickert⁶, Gunnel Nordmark⁷, Anders A. Bengtsson⁴, Johanna K Sandling⁷, Lars Rönnblom⁸, Iva Gunnarsson¹, CHACK-YUNG Yu⁹, Leonid Padyukov¹⁰ and Elisabet Svenungsson¹⁰, ¹Department of Medicine, Rheumatology Unit, Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²Dept. of Clinical Immunology and Transfusion Medicine, Unit of Clinical Immunology, Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ³The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁴Lund University, Department of Clinical Sciences, Rheumatology, Lund, Sweden, ⁵Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, ⁶Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁷Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ⁸Medical Sciences, Rheumatology clinic, Uppsala, Sweden, ⁹Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, OH, ¹⁰Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: SLE is a remarkably heterogeneous disease including diverging clinical symptoms, autoantibodies and genetic susceptibility. Hitherto unrecognized patterns may define sub-phenotypes with different pathogenesis and…

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