Abstracts Archive - Page 1490 of 2425 - ACR Meeting Abstracts

Abstract Number: 1085 • 2016 ACR/ARHP Annual Meeting
The Anti-CD38 Monoclonal Antibody TAK-079 Depletes Antibody Secreting Cells from Normal and SLE Patients
Xiaoqian Wang¹, Martin Dahl², Doan Nguyen³, Scott Jenks¹, Kevin Cashman¹, F. Eun-Hyung Lee⁴, Lachy McLean⁵ and Ignacio Sanz⁶, ¹Division of Rheumatology and Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA, ²Tekada Pharmaceuticals, San Diego, CA, ³Emory University School of Medicine, Atlanta, GA, ⁴Medicine, Emory University School of Medicine, Atlanta, GA, ⁵Takeda Global Research & Development Center, Inc, San Diego, CA, ⁶Rheumatology and Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by expanded antibody secreting cells (ASCs) and the production of a variety of autoantibodies. Depletion of B cells…
Abstract Number: 1086 • 2016 ACR/ARHP Annual Meeting
Analysis of the Naive B Cell Repertoire in Belimumab Treated SLE Patients
Weiqing Huang¹, Cynthia Aranow², Cosmin Dascalu¹, Richard Furie³ and Anne Davidson⁴, ¹Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ²The Feinstein Institute for Medical Research, Manhasset, NY, ³Division of Rheumatology, North Shore LIJ Health System, Great Neck, NY, ⁴Autoimmunity and Musculoskeletal Diseases, Feinstein Inst for Med Rsch, Manhasset, NY
Background/Purpose: BAFF is a TNF-like cytokine that supports the survival and differentiation of B cells. The anti-BAFF antibody belimumab is the only new drug that…
Abstract Number: 1087 • 2016 ACR/ARHP Annual Meeting
Nonmemory B Cell Signature Alterations in Belimumab Patients
Karina Marianne D. Torralba¹, Vaneet Sandhu², Abigail Benitez¹ and Sheila Lezcano³, ¹Rheumatology, Loma Linda University, Loma Linda, CA, ²Division of Rheumatology, Loma Linda University, Loma Linda, CA, ³Rheumatology, Loma Linda University Medical Center, Loma Linda, CA
Background/Purpose: Insight into B cell subset dynamics and homeostasis can provide a biological rationale for use of B cell targeted therapies in SLE patients. Using…
Abstract Number: 1088 • 2016 ACR/ARHP Annual Meeting
Expansion of Transitional B Cells in SLE Patients Correlates with Increased Toll-like Receptor 7 Expression
Ting Wang^1,2, John Marken¹, Karen Cerosaletti³ and Natalia V. Giltiay¹, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, USA, Seattle, WA, ²Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China, Beijing, China, ³Translational Research Program Benaroya Research Institute at Virginia Mason, Seattle, WA, USA, Seattle, WA
Background/Purpose: B cell hyperactivation and autoantibody (auto-Ab) production are hallmarks of SLE. Auto-Abs, reactive to RNA-containing antigens are found in a fraction of SLE patients,…
Abstract Number: 1089 • 2016 ACR/ARHP Annual Meeting
Decreased B Cell Activation-Induced Apoptosis in Cells Overexpressing Interferon Regulatory Factor 5 (IRF5), a Gene Associated with Risk for Systemic Lupus Erythematosus and Other Autoimmune Diseases
Brian Poole¹, Caleb Cornaby², Kalare Eberting², Wesley Cheney², Grant Walker², Craig Smith², Tosh Dowling² and Emily Mello², ¹Brigham Young University, Provo, UT, ²Microbiology and Molecular Biology, Brigham Young University, Provo, UT
Background/Purpose: The transcription factor Interferon Regulatory Factor 5 (IRF5) plays a crucial role in the functioning of several cell types such as macrophages, dendritic, and…
Abstract Number: 1090 • 2016 ACR/ARHP Annual Meeting
CpG-Stimulated B Cells Require Glutaminolysis for Glycolysis, Mitochondrial Respiration, and Cytokine Production
Matthew Cheung¹, Dongyue Huang¹, Doujiao Wu², Edward Pearce³ and Alfred Kim¹, ¹Rheumatology, Washington University School of Medicine, Saint Louis, MO, ²Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO, ³Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany
Background/Purpose: B cells contribute to disease pathophysiology through several mechanisms, including cytokine secretion. A wide variety of stimuli can activate B cells to produce cytokines…
Abstract Number: 1091 • 2016 ACR/ARHP Annual Meeting
Synergistic Immunoregulatory Effects of IL-10 and TGF-β on Humoral Immunity
Toshihiko Komai¹, Tomohisa Okamura^1,2, Mariko Inoue¹, Yukiko Iwasaki¹, Kaoru Morita¹, Kazuhiko Yamamoto¹ and Keishi Fujio¹, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Max Planck-The University of Tokyo Center for Integrative Inflammology, The University of Tokyo, Tokyo, Japan
Background/Purpose: We have previously identified CD4+CD25-Foxp3- regulatory T cells (Treg) that characteristically express lymphocyte-activation gene 3 (LAG3) produce IL-10. Recently we reported that these Treg…
Abstract Number: 1092 • 2016 ACR/ARHP Annual Meeting
Expansion of Age Associated B Cells in Murine Lupus Is Regulated By DEF6 and Its Homologue Swap-70
Michela Manni¹, Sanjay Gupta², Edd Ricker³, Yurii Chinenov⁴, Rolf Jessberger⁵ and Alessandra B. Pernis^2,6,7,8, ¹Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, ²Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ³Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, NY, ⁴Arthritis & Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, ⁵Dresden University of Technology, Dresden, Dresden, Germany, ⁶Autoimmunity & Inflammation, Hospital for Special Surgery, New York, NY, ⁷David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁸Department of Medicine, Weill Cornell Medical College, New York, NY
Background/Purpose: Age-associated B cells (ABCs) are a novel B cell subset, which expresses CD11c and preferentially accumulates with age in female mice. Increased expansion of…
Abstract Number: 1093 • 2016 ACR/ARHP Annual Meeting
DNA Methylation Defines Joint Specific Differences in Synovial Fibroblasts from OA and RA Patients
Emmanuel Karouzakis¹, Mojca Frank Bertoncelj², Kerstin Klein¹, Christoph Kolling³, Renate E. Gay¹, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Schulthess Clinic, Zurich, Switzerland
Background/Purpose: Recent studies revealed epigenetic changes in DNA methylation associated with rheumatoid arthritis (RA) synovial fibroblasts (SF). In addition, we have shown that SF exhibit…
Abstract Number: 1094 • 2016 ACR/ARHP Annual Meeting
A Dual Role of Bromodomain Containing 1 Protein in Rheumatoid Arthritis Synovial Fibroblasts
Kerstin Klein¹, Renate E. Gay¹, Christoph Kolling², Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Schulthess Clinic, Zurich, Switzerland
Background/Purpose: Methods: Results: Conclusion: Acknowledgements: IMI-BT Cure (Pfizer), IAR Epalinges, euroTEAM, EMDO Stiftung, Novartis Stiftung, Jubiläumsstiftung
Abstract Number: 1095 • 2016 ACR/ARHP Annual Meeting
Periarticular Bone Loss in Arthritis Is Induced By Autoantibodies Against Citrullinated Vimentin
Cecilia Engdahl¹, Holger Bang², Katharina Dietel¹, Stefanie C Lang¹, Ulrike Harre¹ and Georg Schett³, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ²Orgentec Diagnostics, Mainz, Germany, ³Department of Internal Medicine III, Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany
Background/Purpose: Periarticular bone loss is a long known and early but yet insufficiently understood phenomenon in patients with rheumatoid arthritis. This study investigated whether autoimmunity…
Abstract Number: 1096 • 2016 ACR/ARHP Annual Meeting
Augmentation of Wnt Signaling By IL-1β in Fibroblast-like Synoviocytes
Satoshi Yamasaki¹, Yusuke Yoshida² and Eiji Sugiyama², ¹Hiroshima University Hospital, Hiroshima, Japan, ²Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan
Background/Purpose: Wnt family proteins canonically stabilize β-catenin to activate T-cell factor (TCF) for the transcription of several genes, including Runx2, which is important for osteoblastogenesis.…
Abstract Number: 1097 • 2016 ACR/ARHP Annual Meeting
Tankyrase Regulates Osteoclastogenesis Via SH3BP2
Shunichi Fujita, Tomoyuki Mukai, Takafumi Mito, Shoko Kodama, Akiko Nagasu, Hiroyasu Hirano and Yoshitaka Morita, Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan
Background/Purpose: Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Axin, a regulatory protein of Wnt/β-catenin signaling, is one…
Abstract Number: 1098 • 2016 ACR/ARHP Annual Meeting
ZCCHC6/TUT7 Negatively Regulates Osterix Activity and Influences Osteoblast-Mediated Regulation of Osteoclastogenesis
Gregory Sondag¹, Mohammad Khan¹, Mohammad Ansari², Nazar Hussein^1,3, Sara Haynie¹, Fayez Safadi¹ and Tariq M. Haqqi¹, ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, ³School of Biomedical Sciences, Kent State University, Kent, OH
Background/Purpose: Mechanisms associated with intrinsic mRNA regulation are important players in development and disease processes. The terminal uridylyl transferases (TUT) are a family of enzymes…
Abstract Number: 1099 • 2016 ACR/ARHP Annual Meeting
Synovial Exosomes Induce Osteoclast Differentiation in Rheumatoid arthritis
Ji Eun Song¹, Ji Hye Shin¹, Ki Won Moon², Se Hui Shon¹, Ji Soo Park³, Eun Bong Lee³, Yeong Wook Song^1,3 and Eun Young Lee³, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea, Seoul, Korea, The Republic of, ²Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Republic of Korea, Chuncheon, Korea, The Republic of, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Seoul, Korea, The Republic of
Background/Purpose: Exosomes are small membrane vesicles (40-150 nm) of endocytic origin secreted by many types of cells and engage in cell-to-cell communication by transferring proteins,…

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