Abstracts Archive - Page 1485 of 2425 - ACR Meeting Abstracts

Abstract Number: 1009 • 2016 ACR/ARHP Annual Meeting
Plasmacytoid Dendritic Cells Are Activated in Systemic Sclerosis and Contribute to the Disease By Inducing Ifnα and CXCL4
Marie-Dominique Ah Kioon¹, Eliza Pelrine², Robert F. Spiera³, Jessica K. Gordon⁴ and Franck J. Barrat¹, ¹Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery, Cornell, New York, NY, ⁴Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Plasmacytoid Dendritic Cells (PDCs) are key immune cells involved with anti-viral responses due to their ability to produce large amount of type I IFN…
Abstract Number: 1010 • 2016 ACR/ARHP Annual Meeting
Elucidating the Activation Profile of Systemic Sclerosis Macrophages
Michael S. Ball¹, Emilie P. Shipman¹, Mohamed A. Eltanbouly¹, Viktor Martyanov², Kimberly A. Archambault³, Mary A. Carns⁴, Esperanza Arroyo⁴, Kathleen Aren⁴, Monique Hinchcliff⁵, Michael L. Whitfield^2,3 and Patricia A. Pioli¹, ¹Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁵Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL
Background/Purpose: Genome-wide gene expression studies implicate macrophages (MØs) as mediators of fibrosis in systemic sclerosis (SSc) and our data indicate that MØs constitute the dominant…
Abstract Number: 1011 • 2016 ACR/ARHP Annual Meeting
Correlations Between B Cell Epitope Specificity and Clinical Features in Patients with Jo-1 Antibodies and the Anti-Synthetase Syndrome
Joseph LaConti¹, Fanny Kippelen², Rohit Aggarwal³ and Dana P. Ascherman⁴, ¹Division of Rheumatology, University of Miami Miller School of Medicine, Miami, FL, ²Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, ³Department of Medicine / Rheumtology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL
Correlations Between B Cell Epitope Specificity and Clinical Features in Patients with Jo-1 Antibodies and the Anti-Synthetase Syndrome Background/Purpose: Idiopathic inflammatory myopathy (IIM) is an…
Abstract Number: 1013 • 2016 ACR/ARHP Annual Meeting
The Risk of Colchicine Associated Myopathy in Gout: Influence of Concomitant Use of Statin
Oh Chan Kwon¹, Byeongzu Ghang², Seokchan Hong³, Yong-Gil Kim⁴, Chang-Keun Lee³ and Bin Yoo⁴, ¹Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Univerisy of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, University of Ulsan Collage of Medicine, Asan Medical Center, Seoul, South Korea
Background/Purpose: To investigate the risk of concomitant use of statin on the development of myopathy in gout patients who received colchicine. Methods: We included patients…
Abstract Number: 1014 • 2016 ACR/ARHP Annual Meeting
Juvenile Dermatomyositis: What Comes Next?
Christina A. Boros¹, Liza J. McCann², Nicola Ambrose³, Mario Cortina-Borja⁴, Stephanie Simou⁵, Clarissa Pilkington⁶ and Lucy R Wedderburn⁷, ¹UCL INstiute of Chuld Health, London, United Kingdom, ²Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, ³Department of Vascular Sciences, National Heart and Lung Institute, Imperial College, London, United Kingdom, ⁴Population, PLociy and Practice, UCL Institute of Child Health, London, United Kingdom, ⁵Infection, Inflammation and Rheumatology, UCL Institute of Child Health, London, United Kingdom, ⁶Infection, Inflammation and Rheumatology Section, UCL Institute of Child Health, London, United Kingdom, ⁷Paediatric Rheumatology Department, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
Background/Purpose: Few studies describe the natural course and long term outcomes of myositis in childhood in large, prospectively-followed patient cohorts, treated in the modern era.…
Abstract Number: 1015 • 2016 ACR/ARHP Annual Meeting
Pro-Inflammatory Cytokines Produced By Different Subsets of Peripheral Blood Mononuclear Cells Are Associated with Ro52/TRIM21 Deficiency in Patients with Inflammatory Myopathies
Ana Barrera-Vargas¹, Angeles Shunashy Galindo-Feria², Diana Gómez-Martín¹, Javier Merayo-Chalico¹ and Jorge Alcocer-Varela¹, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a group of rare, heterogeneous autoimmune diseases of unknown etiology. Different physiopathogenic mechanisms have been proposed, including the production…
Abstract Number: 1016 • 2016 ACR/ARHP Annual Meeting
Soluble BAT-3: A New Biomarker for Antisynthetase Syndrome
Baptiste Hervier^1,2, Samra Ouaras², Laurent Gilardin³, Hanane Ouakrim⁴, Damien Amelin⁵, Fleur Cohen⁶, Yurdagul Uzunhan⁷, Yves Allenbach¹, Anne Bourgarit-Durand⁸, Olivier Benveniste⁹ and Vincent Vieillard¹⁰, ¹Internal Medicine, Pitié-Salpêtrière University Hospital, Paris, France, ²CIMI Paris, UMR-S 1135, INSERM & UPMC, Paris, France, ³Internal Medicine, APHP, Hôpital Pitié Salpêtrière, Paris, France, ⁴INSERM UMR-S 1138, Centre des cordeliers & APHP, Cochin Hospital, Laboratory of Pathology, Paris, France, ⁵Sorbonne Universités UPMC Univ Paris 06, Myology research center, INSERM UMRS974, CNRS FRE3617, Pitié-Salpêtrière University Hospital, Paris, France, Paris, France, ⁶Department of Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France, ⁷Pulmonary diseases department, Avicenne Hospital (AP-HP), Bobigny, France, ⁸CHU Bondy, Bondy, France, ⁹Pitié-Salpêtrière University Hospital, Paris, France, ¹⁰P&M Curie university, INSERM 543, Paris, France
Background/Purpose: Antisynthetase syndrome (ARS) is an inflammatory myopathy (IM) commonly associated to interstitial lung disease (ILD) and different anti-tRNA-synthetase autoantibodies. The immune mechanisms leading to…
Abstract Number: 1017 • 2016 ACR/ARHP Annual Meeting
Statistical Simulation Using Data from the Foundation for the National Institute of Health/Osteoarthritis Initiative Biomarkers Consortium to Evaluate the Clinical Utility of Prognostic Knee Osteoarthritis Biomarkers in Designing a Knee Osteoarthritis Clinical Trial
Sheng Feng¹, Zheng (Roger) Liu², Feng Hong¹, Jeroen Medema¹, Rajesh Kamath¹ and Marc C. Levesque¹, ¹AbbVie Bioresearch Center, Worcester, MA, ²AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA
Background/Purpose: Development of disease-modifying osteoarthritis drugs (DMOADs) for knee osteoarthritis (OA) has been challenging, partially owing to lack of prognostic biomarkers. Our objective was to…
Abstract Number: 1018 • 2016 ACR/ARHP Annual Meeting
Dietary Intake of Fiber and Risk of Knee Osteoarthritis
Zhaoli (Joy) Dai¹, Jingbo Niu¹, Yuqing Zhang², Paul Jacques³ and David T. Felson⁴, ¹Clinical epidemiology research and training unit, Boston University School of Medicine, Boston, MA, ²Clinical Epidemiology and Training Unit, Boston University School of Medicine, Boston, MA, ³Jean Mayer USDA Human Nutrition Research Center on Aging and Friedman School of Nutrition Science and Policy, Tufts University, Boston, Boston, MA, ⁴Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Dietary fiber reduced risks of metabolic diseases in part by reducing systemic inflammation and body weight. These factors are both likely to contribute to…
Abstract Number: 1019 • 2016 ACR/ARHP Annual Meeting
The Impact of Hip and Knee Osteoarthritis on the Subsequent Risk of Incident Diabetes: A Population-Based Cohort Study
Tetyana Kendzerska^1,2,3, Lauren King¹, Ruth Croxford², Ian Stanaitis³, Angela Wall³ and Gillian Hawker^1,2,3, ¹University of Toronto, Toronto, ON, Canada, ²Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, ³Women's College Research Institute/Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Osteoarthritis (OA) and diabetes commonly co-occur. Potential explanations include common risk factors (aging, obesity) and the effects of OA-related functional limitations on diabetes risk…
Abstract Number: 1020 • 2016 ACR/ARHP Annual Meeting
Risk Factors Can Classify Individuals Who Develop Accelerated Knee Osteoarthritis
Jeffrey Driban¹, Timothy E. McAlindon², Mamta Amin³, Lori Lyn Price⁴, Charles B. Eaton⁵, Julie Davis⁶, Bing Lu⁷, Grace H. Lo⁸, Jeffrey Duryea⁹ and Mary Barbe¹⁰, ¹Tufts Medical Center, Boston, MA, ²Division of Rheumatology, Tufts Medical Center, Boston, MA, ³Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, ⁴Clinical Care Research, Tufts Medical Center, Boston, MA, ⁵Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁶Rheumatology, Tufts Medical Center, Boston, MA, ⁷Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁸Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ⁹Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ¹⁰Temple University School of Medicine, Philadelphia, PA
Background/Purpose: Accelerated knee osteoarthritis (KOA) is a painful disorder and associated with several risk factors: greater age, greater body mass index (BMI), static knee alignment,…
Abstract Number: 1021 • 2016 ACR/ARHP Annual Meeting
Maintaining Sufficient Serum Vitamin D Levels over 2 Years Is Associated with Reduced Knee Structural and Symptomatic Changes in Patients with Knee Osteoarthritis
Shuang Zheng¹, Xingzhong Jin¹, Flavia M Cicuttini², Xia Wang¹, Zhaohua Zhu¹, Anita E Wluka³, Weiyu Han¹, Tania Winzenberg¹, Leigh Blizzard¹, Graeme Jones⁴ and Changhai Ding⁴, ¹Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ²Monash University, Department of Epidemiology and Preventive Medicine, Melbourne, Australia, ³Australia, Armadale, Australia, ⁴Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
Background/Purpose: To examine whether those maintaining sufficient serum vitamin D levels have reduced knee structural changes and symptomatic improvement compared with those not maintaining sufficient…
Abstract Number: 1022 • 2016 ACR/ARHP Annual Meeting
The Risk of Symptomatic Knee Osteoarthritis after Arthroscopic Meniscus Repair Vs Partial Meniscectomy Vs the General Population
Martin Englund¹, Aleksandra Turkiewicz², Dan Bergkvist³, Paul Neuman⁴ and Fredrik Persson⁴, ¹Clinical Epidemiology Unit, Lund University, Skåne University Hospital, Department of Clinical Sciences Lund, Orthopedics, Lund, Sweden, ²Clinical Epidemiology Unit, Lund University, Department of Clinical Sciences Lund, Orthopedics, Lund, Sweden, ³Clinical Epidemiology Unit, Orthopedics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden, ⁴Lund University, Skåne University Hospital, Orthopedics, Malmoe, Sweden
Background/Purpose: Traumatic meniscus injury is associated with increased risk of developing knee osteoarthritis (OA). The purpose of meniscus repair, beyond short time symptom relief and…
Abstract Number: 1023 • 2016 ACR/ARHP Annual Meeting
Fracture Risk Reduction with Romosozumab: Results of a Phase 3 Study in Postmenopausal Women with Osteoporosis
F Cosman¹, DB Crittenden², JD Adachi³, N Binkley⁴, E Czerwinski⁵, S Ferrari⁶, LC Hofbauer⁷, E Lau⁸, EM Lewiecki⁹, A Miyauchi¹⁰, CAF Zerbini¹¹, CE Milmont², L Chen², J Maddox², PD Meisner¹², C Libanati¹² and A Grauer², ¹Helen Hayes Hospital, West Haverstraw, and Columbia University, New York, NY, ²Amgen Inc., Thousand Oaks, CA, ³McMaster University, Hamilton, ON, Canada, ⁴University of Wisconsin–Madison Osteoporosis Clinical Center and Research Program, Madison, WI, ⁵Krakow Medical Center, Krakow, Poland, ⁶Geneva University Hospital, Geneva, Switzerland, ⁷Division of Endocrinology, Diabetes, and Bone Diseases, TU Dresden Medical Center, Dresden, Germany, ⁸Center for Clinical and Basic Research, Hong Kong, China, ⁹New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, ¹⁰Miyauchi Medical Center, Osaka, Japan, ¹¹Centro Paulista de Investigação Clinica, São Paulo, Brazil, ¹²UCB Pharma, Brussels, Belgium
Background/Purpose: Romosozumab (Romo) is an investigational bone-forming monoclonal antibody that binds sclerostin and has a dual effect, increasing bone formation and decreasing bone resorption. Here,…
Abstract Number: 1024 • 2016 ACR/ARHP Annual Meeting
Superior Gains in Bone Mineral Density and Estimated Strength at the Hip for Romosozumab Compared with Teriparatide in Women with Postmenopausal Osteoporosis Transitioning from Bisphosphonate Therapy: Results of a Phase 3, Open-Label Clinical Trial
B Langdahl¹, C Libanati², DB Crittenden³, MA Bolognese⁴, JP Brown⁵, NS Daizadeh³, K Engelke⁶, HK Genant⁷, S Goemaere⁸, Lars Hyldstrup⁹, E Jodar-Gimeno¹⁰, TM Keaveny¹¹, D Kendler¹², P Lakatos¹³, J Maddox³, J Malouf¹⁴, FE Massari¹⁵, JF Molina¹⁶, MR Ulla¹⁷ and A Grauer³, ¹Aarhus University Hospital, Aarhus, Denmark, ²UCB Pharma, Brussels, Belgium, ³Amgen Inc., Thousand Oaks, CA, ⁴Bethesda Health Research Center, Bethesda, MD, ⁵Laval University and CHU de Québec (CHUL) Research Centre, Quebec City, QC, Canada, ⁶BioClinica Inc., Hamburg, Germany, ⁷Department of Radiology, University of California San Francisco, San Francisco, CA, ⁸Ghent University Hospital, Gent, Belgium, ⁹Hvidovre University Hospital, Hvidovre, Denmark, ¹⁰Servicio de Endocrinología, Hospital Universitario Quirón, Madrid, Spain, ¹¹University of California at Berkeley, Berkeley, CA, ¹²University of British Columbia, Vancouver, BC, Canada, ¹³Department of Medicine, Semmelweis University, Budapest, Hungary, ¹⁴Universitat Autònoma de Barcelona, Barcelona, Spain, ¹⁵Instituto de Investigaciones Metabólicas, Buenos Aires, Argentina, ¹⁶Reumalab Centro Integral de Reumatologia, Medellin, Colombia, ¹⁷Instituto Latinoamericano de Investigaciones Médicas, Córdoba, Argentina
Background/Purpose: STRUCTURE was a phase 3, open-label study evaluating the effect of romosozumab or teriparatide for 12 months in women with postmenopausal osteoporosis transitioning from…

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