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  • Abstract Number: 994 • 2016 ACR/ARHP Annual Meeting

    Validation Studies of the American College of Rheumatology (ACR) 2010 Fibromyalgia Diagnostic Criteria and the 2011 Self-Report Modification for Survey and Clinical Research

    Frederick Wolfe1, Daniel J. Clauw2, MaryAnn FitzCharles3, Don Goldenerberg4, Winfried Häuser5, Robert S. Katz6, Philip J. Mease7, Anthony Russell8, I Jon Russell9 and Brian Walitt10, 1National Data Bank, Wichita, KS, 2Chronic Pain & Fatigue Research Center, University of Michigan, Ann Arbor, MI, 3Rheumatology, McGill University, Montreal, QC, Canada, 4Newton-Wellesley Hospital and Tufts University School of Medicine, Newton, MA., Newton, MA, 5Department of Psychosomatic Medicine and Psychotherapy, Technische Universität München, Munich, Germany, 6Rush University Medical Center, Chicago, IL, 7Swedish Medical Center and University of Washington, Seattle, WA, 8Medicine, University of Alberta, Edmonton, AB, Canada, 9Arthritis & Osteoporosis Ctr of South Texas, San Antonio, TX, 10National Institutes of Health, National Institute of Nursing Research, Bethesda, DC

    Background/Purpose: The provisional criteria of the American College of Rheumatology (ACR) 2010 and the 2011 self-report modification for survey and clinical research are widely used…
  • Abstract Number: 995 • 2016 ACR/ARHP Annual Meeting

    Use of Opiate Diminished the Treatment Benefits of Motivational Interviewing for Fibromyalgia

    Dennis Ang1 and James Slaven2, 1Wake Forest University, Winston-Salem, NC, 2Biostatistics, Indiana University, Indianapolis, IN

    Background/Purpose: Opiate is not indicated in the treatment of fibromyalgia (FM). In fact, chronic use of opiate may even worsen the symptoms of fibromyalgia. There…
  • Abstract Number: 996 • 2016 ACR/ARHP Annual Meeting

    Use of a Shared Medical Appointment for Patients with Fibromyalgia in a Rural, Academic Medical Center: A Process Improvement Initiative for the Development of a New Care Model

    Nicole M. Orzechowski1, Debra Lloyd2, Katherine Tuthill1, Julie Puttgen3 and Rachael Bergeron1, 1Rheumatology, Dartmouth Hitchcock Medical Center, Lebanon, NH, 2Rheumatology, Dartmouth-Hitchcock Med Ctr, Lebanon, NH, 3Dartmouth Hitchcock Medical Center, Lebanon, NH

    Background/Purpose:  Fibromyalgia is a complex chronic pain condition with patients often presenting with multiple somatic complaints that are difficult to address in standard new patient…
  • Abstract Number: 997 • 2016 ACR/ARHP Annual Meeting

    2016 Revisions to the 2010/2011 Fibromyalgia Diagnostic Criteria

    Frederick Wolfe1, Daniel J. Clauw2, MaryAnn FitzCharles3, Don Goldenerberg4, Winfried Häuser5, Robert S. Katz6, I Jon Russell7, Philip J. Mease8, Anthony Russell9 and Brian Walitt10, 1National Data Bank, Wichita, KS, 2Chronic Pain & Fatigue Research Center, University of Michigan, Ann Arbor, MI, 3Rheumatology, McGill University, Montreal, QC, Canada, 4Newton-Wellesley Hospital and Tufts University School of Medicine, Newton, MA., Newton, MA, 5Department of Psychosomatic Medicine and Psychotherapy, Technische Universität München, Munich, Germany, 6Rush University Medical Center, Chicago, IL, 7Arthritis & Osteoporosis Ctr of South Texas, San Antonio, TX, 8Swedish Medical Center and University of Washington, Seattle, WA, 9Medicine, University of Alberta, Edmonton, AB, Canada, 10National Institutes of Health, National Institute of Nursing Research, Bethesda, DC

    Background/Purpose: The provisional criteria of the ACR 2010 and the 2011 self-report modification for survey and clinical research are valid, reliable and widely used for…
  • Abstract Number: 998 • 2016 ACR/ARHP Annual Meeting

    Brain Responses to Other’s Pain in Fibromyalgia – a Magnetoencephalography (MEG)  Study

    Abraham Goldstein1, Maor Wolf2 and Jacob N. Ablin3, 1Gonda Brain Research Center, Department of Psychology, Bar-Ilan University, Ramat Gan, Israel, 2Gonda Brain Research Center, Department of Psychology, Bar-Ilan University, Ramat - Gan, Israel, 3Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

    Background/Purpose: Fibromyalgia Syndrome (FMS) is a disorder characterized by the presence of widespread pain and tenderness, which is now believed to be, at least in…
  • Abstract Number: 999 • 2016 ACR/ARHP Annual Meeting

    Utility of Neutrophil CD64 Expression & sTREM-1 in Distinguishing Bacterial Infection from Disease Flare in SLE and ANCA Associated Vasculitis

    Sajal Ajmani, Harshit Singh, Saurabh Chaturvedi, Mohit kumar Rai and Vikas Agrawal, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Background/Purpose: Fever is a common presenting manifestation of systemic lupus erythematosus (SLE) and ANCA associated vasculitis (AAV). Treating physician is challenged to differentiate between disease…
  • Abstract Number: 1000 • 2016 ACR/ARHP Annual Meeting

    Subclinical Cytomegalovirus Viremia Is Associated with Increased Nosocomial Infections and Prolonged Hospitalization in Patients with Systemic Autoimmune Diseases

    John McKinnon1, Junying Zhou2, Jenna Hudy1, Sara Hegab1 and Kathleen Maksimowicz-McKinnon3, 1Henry Ford Hospital, Detroit, MI, 2Infectious Diseases, Henry Ford Hospital, Detroit, MI, 3Rheumatology, Henry Ford Hospital, Detroit, MI

    Background/Purpose: Both subclinical cytomegalovirus (CMV) viremia and CMV disease have been associated with adverse outcomes in select immunosuppressed populations, including an increased incidence of other…
  • Abstract Number: 1001 • 2016 ACR/ARHP Annual Meeting

    Cytomegalovirus Reactivation in Connective Tissue Disease By Immunosuppressive Therapy Predicts Severe Infection and High Mortality

    Yuichiro Ota1, Yuko Kaneko2 and Tsutomu Takeuchi3, 1Division of Rheumatology, Department of Internal Medicine., Keio University School of Medicine, Tokyo, Japan, 2Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 3Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose:  Intensive immunosuppressive treatment for remission induction in connective tissue diseases (CTDs) sometimes causes serious infection. Cytomegalovirus (CMV) is a herpesvirus remaining latent after primary…
  • Abstract Number: 1002 • 2016 ACR/ARHP Annual Meeting

    Pneumocystis Jiroveci in Rheumatic Disease: A 20 Year Single-Center Experience

    Christopher A. Mecoli1, Deanna Saylor1, Allan C. Gelber1 and Lisa Christopher-Stine2, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Ste 4100 Rm 409, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Pneumocystis jiroveci (PJP) is an opportunistic infection associated with high mortality in patients with rheumatologic conditions. Given the paucity of data, clinical guidelines to…
  • Abstract Number: 1003 • 2016 ACR/ARHP Annual Meeting

    Ultrasonography Changes during the Course of Septic Arthritis ARE Associated with Functional Outcome

    Emeline Gaigneux1, Grégoire Cormier2, Oriane Merot3, Yves Maugars4 and Benoit Le Goff4, 1rheumatology unit, Nantes University Hospital, Nantes, France, 2rheumatology unit, Hospital, La roche sur Yon, France, 3rheumatology unit, Hospital, Saint Nazaire, France, 4Rheumatology, Nantes University Hospital, Nantes, France

    Background/Purpose:   The main goal of this study was to describe the US changes observed during the course of septic arthritis and their association with…
  • Abstract Number: 1004 • 2016 ACR/ARHP Annual Meeting

    Herpes Zoster Virus Infection in Patients Treated with Biological Therapies (BIOBADASAR)

    Juan Pablo Pirola1, Soledad Retamozo2, Diego Baenas3, Alejandro Alvarellos4, Francisco Caeiro5, María Celina De La Vega6, Gustavo Casado7, Gimena Gomez8, Javier Roberti6, Osvaldo Luis Cerda9, Maria de los Angeles Gallardo10, Ana Quinteros11, Ida Exeni12, Juan Manuel Bande13, Pablo Astesana14, Analia Alvarez15, Amelia Granel16, Alejandra Peluzzon17, Ana Capuccio18, Romina Nieto19, Rossana Quintana20, Eduardo Mussano21, Santiago Scarafia22, Carolina Costi23, Mercedes De La Sota24, Monica Patricia Diaz25, Edson Javier Velozo26, Santiago Aguero27, Cristina Battagliotti28, Sidney Soares de Souza29, Emilia Cavillon30, Analia Bohr31, Andrea Smichowski32, Alejandro Benitez33, Daniela Vidal34, Dora Pereira35, Liliana Martinez36, Luis Somma37, Marta Zalazar38, Pablo Finucci Curi39, Leandro Carlevaris40, Guillermo Berbotto41 and Veronica Saurit1, 1Rheumatology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, 2Rheumatology Unit, Hospital Privado Centro Médico de Córdoba, Argentina, Córdoba, Argentina, 3Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, 4Rheumatology, Hospital Privado Centro Médico de Córdoba, Cordoba, Argentina, 5Reumatología, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, 6SAR, CABA, Argentina, 7Sociedad Argentina de Reumatologia, CABA, Argentina, 8Section of Rheumatology an, SAR, CABA, Argentina, 9IREP, CABA, Argentina, 10Hospital Italiano de Buenos Aires, CABA, Argentina, 11Centro Integral Reumatológico, Tucuman, Argentina, 12Sanatorio Parque, Córdoba, Argentina, 13Hospital Tornú, CABA, Argentina, 14Sanatorio Allende, Cordoba, Argentina, 15Hospital Penna, Bahía Blanca, Argentina, 16Centro Platense de Reumatología, La Plata, Argentina, 17Hospital Clínica José de San Martín, CABA, Argentina, 18Hospital Cesar Milstein, CABA, Argentina, 19Hospital Provincial, Rosario, Argentina, 20Sanatorio Parque, Rosario, Argentina, 21Córdoba, Hospital Nacional de Clínicas, Córdoba, Argentina, 22Hospital Bernardino Rivadavia, CABA, Argentina, 23Hospital San Martín, LaPlata, Argentina, 24Consultorios, Bahia Blanca, Argentina, 25Hospital Zonal Bariloche, Bariloche, Argentina, 26Rheumatology, Sanatorio Adventista del Plata, Entre Rios, Argentina, 27Sanatorio Pasteur, Catamarca, Argentina, 28Hospital de Niños Dr Orlando Alasia, Santa Fé, Argentina, 29Ramallo 1851, REUMAR, CABA, Argentina, 30Consultorio, Cordoba, Argentina, 31Hospital de Rehabilitación Rocca, CABA, Argentina, 32Atención Integral de Reumatología, CABA, Argentina, 33CEIM, CABA, Argentina, 34Hospital de Niños de Córdoba, Córdoba, Argentina, 35Centro Raquis, Buenos Aires, Argentina, 36Hospital Fernandez, CABA, Argentina, 37SOMMA, Buenos Aires, Argentina, 38Hospital Pirovano, CABA, Argentina, 39Centro Médico Mitre, Entre Rios, Argentina, 40IARI, CABA, Argentina, 41Sanatorio Británico, Rosario, Argentina

    Background/Purpose: Biologic therapies (bDMARDs) have improved the treatment of rheumatic diseases; however, the risk of herpes zoster (HZ) virus infection or reactivation in patients treated…
  • Abstract Number: 1005 • 2016 ACR/ARHP Annual Meeting

    Biallelic Hypomorphic Mutations in a Linear Deubiquitinase Define Otulipenia, an Early-Onset Systemic Autoinflammatory Disease

    Qing Zhou1, Xiaomin Yu2, Erkan Demirkaya3, Natalie Deuitch4, Deborah L. Stone5, Wanxia L. Tsai6, Hongying Wang7, Yong Hwan Park7, Amanda K. Ombrello8, Tina Romeo4, Elaine F. Remmers4, JaeJin Chae9, Massimo G. Gadina10, Steven B. Welch11, Seza Ozen12, Rezan Topaloglu13, Mario Abinun14, Daniel L. Kastner7 and Ivona Aksentijevich8, 1Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, 2National Institute of Allergy and Infectious Diseases, Bethesda, MD, 3Gulhane Military Medical Academy, FMF Arthritis Vasculitis and Orphan disease Research Center (FAVOR), Ankara, Turkey, 4National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 5Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 6National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 7National Human Genome Research Institute, Bethesda, MD, 8Inflammatory Disease Section, NHGRI, National Institutes of Health, Bethesda, MD, 9Inflammatory disease section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 10[email protected], Bethesda, MD, 11Heart of England NHS Foundation Trust, Birmingham, United Kingdom, 12Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 13Hacettepe University Faculty of Medicine, Ankara, Turkey, 14Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom

    Background/Purpose: Autoinflammatory diseases are caused by mutations in genes regulating innate immune responses. More than 20 genes have been associated with various monogenic autoinflammatory disorders.…
  • Abstract Number: 1006 • 2016 ACR/ARHP Annual Meeting

    Immune Complex-Mediated TLR8 Activation Shifts Neutrophils from Phagocytosis to Netosis through Furin-Dependent Shedding of Fcgriia

    Christian Lood1, Sabine Arve2, Laura Durcan2, Jeffrey Ledbetter2 and Keith B. Elkon1, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2University of Washington, Seattle, WA

    Background/Purpose:  Neutrophils, isolated from healthy individuals, were incubated with RNA-ICs and analyzed for phagocytosis and NETosis by flow cytometry and fluorimetry, respectively, in the presence…
  • Abstract Number: 1007 • 2016 ACR/ARHP Annual Meeting

    Interferon Regulatory Factor 1 Is the Key Driver of Inflammasome Activity in Systemic Lupus Erythematosus

    Jianhua Liu1 and J. Michelle Kahlenberg2, 1Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI

    Background/Purpose: The inflammasome complex has recently emerged as a driver of organ damage in systemic lupus erythematosus (SLE). This complex, via its enzymatic subunit caspase-1,…
  • Abstract Number: 1008 • 2016 ACR/ARHP Annual Meeting

    Advantageous Effect of an Endogenous Retroviral Envelope Protein in Systemic Lupus Erythematosus with Ex Vivo and In Vivo Anti-Inflammatory Potential

    Anne Troldborg1,2, Magdalena Janina Laska3, Ellen-Margrethe Hauge4,5, Shervin Bahrami6 and Kristian Stengaard-Pedersen7,8, 1clinical medicine, Aarhus University, Aarhus, Denmark, 2Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 3Biomedicine, Aarhus University, Aarhus, Denmark, 4Dept. of Anatomy, Aarhus University, Aarhus, Denmark, 5Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 6Clinical Medicine, Aarhus University, Aarhus, Denmark, 7Clinical medicine, Aarhus University, Aarhus, Denmark, 8Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: Human Endogenous Retroviruses (HERVs) are remnants of retroviral infections in the human germline. Most, but not all, HERV genes have become inactive by accumulation…
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