Abstracts Archive - Page 1481 of 2607 - ACR Meeting Abstracts

Abstract Number: 1406 • 2017 ACR/ARHP Annual Meeting
Methods for Generating Multiple High-Dimensional Analyses of Cryopreserved Synovial Tissue Developed By the Accelerating Medicines Partnership RA/SLE Network
Deepak Rao¹, Laura T. Donlin², Kevin Wei³, Nida Meednu⁴, Jason Turner⁵, Mandy J. McGeachy⁶, Fumitaka Mizoguchi⁷, Joshua Keegan⁸, James Lederer⁹, Maria Gutierrez-Arcelus¹⁰, Kamil Slowikowski¹¹, Kaylin Muskat¹², Joshua Hillman¹², Cristina Rozo¹³, Edd Ricker¹⁴, Thomas Eisenhaure¹⁵, David Lieb¹⁵, Shuqiang Li¹⁵, Edward Browne¹⁵, Chad Nusbaum¹⁵, William H. Robinson¹⁶, Stephen Kelly¹⁷, Alessandra B. Pernis¹⁸, Lionel Ivashkiv¹⁹, Susan M. Goodman²⁰, Ellen M. Gravallese²¹, Michael Holers²², Nir Hacohen²³, Costantino Pitzalis¹⁷, Peter Gregersen²⁴, Vivian P. Bykerk²⁵, Larry W. Moreland²⁶, Gary Firestein²⁷, Soumya Raychaudhuri²⁸, Andrew Filer²⁹, David L. Boyle³⁰, Michael Brenner¹⁰ and Jennifer H. Anolik⁴, ¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁵Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁶Medicine, University of Pittsburgh, Pittsburgh, PA, ⁷Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, ⁸Brigham and Women's Hospital, Boston, MA, ⁹Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹⁰Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹¹Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical Schoo, Boston, MA, ¹²University of California, San Diego, San Diego, CA, ¹³Hospital for Special Surgery, New York, NY, ¹⁴Weill Cornell Graduate School of Medical Sciences, New York, NY, ¹⁵Broad Institute, Cambridge, MA, ¹⁶Stanford University School of Medicine, Stanford, CA, ¹⁷Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ¹⁸David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ¹⁹Medicine, Hospital for Special Surgery, New York, NY, ²⁰Medicine, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ²¹Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA, ²²Medicine, Division of Rheumatology, University of Colorado Denver, Aurora, CO, ²³Harvard Medical School, Boston, MA, ²⁴The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, ²⁵2-005, Mt Sinai Hospital, Toronto, ON, Canada, ²⁶Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²⁷EGG, St Cloud, France, ²⁸Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²⁹Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, ³⁰University of California San Diego, La Jolla, CA
Background/Purpose: Detailed analyses of cells from rheumatoid arthritis (RA) synovium may identify cell phenotypes and functions that drive tissue pathology and joint damage. The AMP…
Abstract Number: 1407 • 2017 ACR/ARHP Annual Meeting
Huntingtin Interactin Protein 1 (HIP1) Regulates Invasiveness, Actin Filament and Lamellipodia Formation in Rheumatoid Arthritis Fibroblast-like Synoviocytes (FLS)
Teresina Laragione, Carolyn Harris, Erjing Gao and Percio S. Gulko, Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Huntingtin-interacting protein 1 (Hip1) is an arthritis severity and joint damage gene recently discovered in rodent models of arthritis. Hip1 regulates fibroblast-like synoviocytes (FLS)…
Abstract Number: 1408 • 2017 ACR/ARHP Annual Meeting
The Cation Channel TRPV2 Decreases Rheumatoid Arthritis Fibroblast-like Synoviocyte Invasiveness By Inhibiting RhoA Activation, Cell Adhesion and Actin Cytoskeleton Changes
Teresina Laragione, Carolyn Harris, Erjing Gao and Percio S. Gulko, Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: We have recently identified the non-selective cation channel TRPV2 (transient receptor potential vanilloid subfamily, type 2 channel) as a new central mediator of arthritis…
Abstract Number: 1409 • 2017 ACR/ARHP Annual Meeting
Ursolic Acid Promotes Apoptosis of Rheumatoid Athritis Synovial Fibroblasts By Upregulating Noxa Expression and Recruiting E3 Ligase Mule to Degrade Mcl-1
Eugene Kim¹, Solomon Agere¹, Sadik Khuder² and Salahuddin Ahmed¹, ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ²Department of Medicine, University of Toledo, Toledo, OH
Background/Purpose: In our previous study, we discovered that ursolic acid (UA), a pentacyclic triterpenoid with anti-inflammatory properties, induces apoptosis in synovial fibroblasts from rheumatoid arthritis…
Abstract Number: 1410 • 2017 ACR/ARHP Annual Meeting
Tyrosine Kinase Receptor Axl Is Down Regulated in Highly Inflamed Rheumatoid Synovium and Negatively Correlates with Markers of Disease Activity
Alessandra Nerviani¹, Sara Pagani¹, Daniele Mauro¹, Frances Humby¹, Stephen Kelly¹, Felice Rivellese¹, Gloria Lliso Ribera¹, Myles J. Lewis², Michele Bombardieri³ and Costantino Pitzalis¹, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ²Rheumatology, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ³Willian Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Background/Purpose: Emerging evidence highlighted the role of Tyro3, Axl and Mer Tyrosine Kinase receptors (TAMs) and their ligands Gas6 and ProteinS in the pathogenesis of…
Abstract Number: 1411 • 2017 ACR/ARHP Annual Meeting
Protein Tyrosine Phosphatase Non-Receptor 22 / C-Src Tyrosine Kinase Complex Down-Regulated in Patients with Rheumatoid Arthritis
Sara Remuzgo-Martínez¹, Fernanda Genre¹, Raquel López-Mejías¹, Santos Castañeda², Alfonso Corrales¹, Pablo Moreno Fresneda^2,3, Begoña Ubilla¹, Verónica Mijares¹, Virginia Portilla¹, Jesús González-Vela¹, Trinitario Pina¹, J. Gonzalo Ocejo-Vinyals⁴, Juan Irure-Ventura⁴, Ricardo Blanco¹, Javier Martin⁵, Javier Llorca⁶ and Miguel Angel González-Gay⁷, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ²Rheumatology Division, Hospital Universitario La Princesa, IIS-IP, Madrid, Spain, ³Rheumatology, Rheumatology Division, Hospital Universitario La Princesa, IIS-IP, Madrid, Spain, ⁴Immunology Division, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁵Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Granada, Spain, ⁶Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁷Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL and School of Medicine, University of Cantabria, Santander, Spain
Background/Purpose: Protein tyrosine phosphatase non-receptor 22 (PTPN22) binds to C-Src tyrosine kinase (CSK) forming a key regulator complex in autoimmunity1. In this regard, PTPN22 is…
Abstract Number: 1412 • 2017 ACR/ARHP Annual Meeting
Yra-1909 suppresses Production of Pro-Inflammatory Mediators and MMPs through Downregulating Akt, p38, JNK and NF-κb Activation in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Hyun Jung Yoo^1,2, Jeong Yeon Kim¹, Shin Eui Kang¹, Ji Seok Yoo³, Yong Nam Lee³, Dong Goo Lee³, Ji Soo Park¹, Eun Bong Lee⁴, Eun Young Lee⁴ and Yeong Wook Song^2,5, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Korea, Republic of (South), ³Central R&D Institute, Yungjin Pharm Co., Ltd., Suwon, Korea, Suwon, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁵Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South)
Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocyte (FLS) are a key component…
Abstract Number: 1413 • 2017 ACR/ARHP Annual Meeting
Cytokine-Induced Aire Activity in Rheumatoid Arthritis Fibroblast-like Synoviocytes Regulates Expression of Interferon-γ Response Genes
Beatrice Bergström¹, Christina Lundqvist¹, Hans Carlsten¹, Olov Ekwall² and Anna-Karin Hultgård Ekwall¹, ¹Rheumatology and Inflammation Research, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden, ²Dept. of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy University of Gothenburg, Göteborg, Sweden
Background/Purpose: AIRE is a transcriptional regulator of tissue specific antigens in medullary thymic epithelial cells (mTEC). AIRE orchestrates the negative selection of self-reactive T cells…
Abstract Number: 1414 • 2017 ACR/ARHP Annual Meeting
Stimulation with Resistin Upregulates Chemokine Production By Fibroblast-like Synoviocytes from Patients with Rheumtoid Arthritis
Hiroshi Sato¹, Sei Muraoka¹, Natsuko Kusunoki¹, Shotaro Masuoka¹, Soichi Yamada¹, Toshio Imai², Shinichi Kawai³ and Toshihiro Nanki¹, ¹Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan, ²KAN Research Institute, Inc., Kobe, Japan, ³Department of Inflammation and Pain Control Research, Toho University School of Medicine, Tokyo, Japan
Background/Purpose: Adipose tissue synthesizes and releases physiologically active molecules that are known as adipokines. Resistin, an adipokine, has been widely studied the regulation of glucose…
Abstract Number: 1415 • 2017 ACR/ARHP Annual Meeting
TNF-Induced IRF1 Is Critical for the Inflammatory Gene Expression in Fibroblast-like Synoviocytes
Michael Bonelli¹, Karolina von Dalwigk², Birgit Niederreiter¹, Thomas Pap³, Josef S. Smolen⁴, Hans Peter Kiener¹ and Thomas Karonitsch¹, ¹Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ⁴Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria
Background/Purpose: Fibroblast-like synoviocytes (FLS) are increasingly recognised as major pathogenic cells in synovial inflammation of patients with Rheumatoid Arthritis (RA). In response to pro-inflammatory stimuli,…
Abstract Number: 1416 • 2017 ACR/ARHP Annual Meeting
Higher Expression of Type 1 Interferon in Synovitis of Patient with Undifferentiated Arthritis before They Met Rheumatoid Arthritis Criteria Compared to Established Rheumatoid Arthritis. a Retrospective Study with 14 Years of Follow-up
Andrea Cuervo¹, Raquel Celis², Julio Ramírez³, Alicia Usategui⁴, Regina Faré⁵, M. Victoria Hernández⁶, Virginia Ruiz-Esquide³, Jose Inciarte-Mundo⁷, Raimon Sanmarti⁸, Jose L. Pablos⁹ and Juan D. Cañete⁷, ¹Arthritis Unit. Rheumatology Dpt, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, ²Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, ³Rheumatology Service, Hospital Clínic de Barcelona, Barcelona, Spain, ⁴Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ⁵Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ⁶Hospital Clinic. Barcelona. Spain, Barcelona, Spain, ⁷Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona, Barcelona, Spain, ⁸Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona, Barcelona, Spain, ⁹Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain
Background/Purpose: Undifferentiated Arthritis (UA) is defined as an inflammatory oligo/poly arthritis that does not fulfil criteria for a definitive diagnosis.Delay in diagnosis and treatment leads…
Abstract Number: 1417 • 2017 ACR/ARHP Annual Meeting
Mitophagy Defect in Fibroblast-like Synoviocytes of Rheumatoid Arthritis Is Improved By Pyruvate Treatment
Jeong Yeon Kim^1,2, ShinEui Kang^3,4, Hyun Jung Yoo^1,5, Ji Soo Park^1,2, Sehui Shon^1,2, Eun Young Lee², Eun Bong Lee⁵ and Yeong Wook Song^1,6, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea., Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., Seoul, Korea, Republic of (South), ³Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea., seoul, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., seoul, Korea, Republic of (South), ⁵Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), ⁶Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South)
Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining produce pro-inflammatory cytokines resulting in increase of joint inflammation. Recent studies about the cellular metabolism in…
Abstract Number: 1418 • 2017 ACR/ARHP Annual Meeting
The Value of Adalimumab Trough Levels and Clinical Assessments in Predicting Clinical Response in Patients with Established Rheumatoid Arthritis and an Inadequate Response to Methotrexate
Josef S. Smolen¹, Nael Mostafa², Xin Huang², Peter Noertersheuser³, Ben Klünder³, Kun Chen², Jasmina Kalabic³, Iain Sainsbury², Ruud Oerlemans⁴, Stefan Florentinus⁴ and Gerd R. Burmester⁵, ¹Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, ²AbbVie Inc., North Chicago, IL, ³AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, ⁴AbbVie, Nederland, Hoofddorp, Netherlands, ⁵Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany
Background/Purpose: Low trough levels of the tumor necrosis factor inhibitor, adalimumab (ADL), and anti-ADL antibodies (AAA) were reported to be correlated with lack of response…
Abstract Number: 1419 • 2017 ACR/ARHP Annual Meeting
Characteristics of Patients with Early Rheumatoid Arthritis Who Have a Delayed Response to Treatment with Methotrexate in Monotherapy or in Combination with Adalimumab
Josef S. Smolen¹, Xianwei Bu², Xin Wang², Jessica L. Suboticki³ and Arthur Kavanaugh⁴, ¹Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, ²AbbVie Inc., North Chicago, IL, ³AbbVie Inc., Mettawa, IL, ⁴Medicine, University of California, San Diego, La Jolla, CA
Background/Purpose: In patients (pts) with rheumatoid arthritis (RA), treat-to-target recommendations call for adjustment of treatment if a target is not met within 3-6 months (mths)…
Abstract Number: 1420 • 2017 ACR/ARHP Annual Meeting
The Ability of Patients with Early Rheumatoid Arthritis to Taper Low-Dose Glucocorticoids on Methotrexate Monotherapy and in Combination with Adalimumab
Josef S. Smolen¹, Prashanth Sunkureddi², Jaclyn K. Anderson³, Jenny Griffith³, Dingfeng Jiang³, Kun Chen³, Jessica L. Suboticki⁴ and Arthur Kavanaugh⁵, ¹Division of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ²Clear Lake Rheumatology, Nassau Bay, TX, ³AbbVie Inc., North Chicago, IL, ⁴AbbVie Inc., Mettawa, IL, ⁵Medicine, University of California, San Diego, La Jolla, CA
Background/Purpose: Low dose glucocorticoids (GCs) are recommended in combination with ≥1 synthetic DMARDs as part of the initial treatment strategy in rheumatoid arthritis (RA), with…

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