Abstracts Archive - Page 1478 of 2607 - ACR Meeting Abstracts

Abstract Number: 1361 • 2017 ACR/ARHP Annual Meeting
How Often Do Rheumatologists Use Valid Prognostic Factors of Rheumatoid Arthritis? the Progresar Project
Teresa Oton-Sanchez¹, Loreto Carmona², Sara Luján³, Ana Royo³, Jose Luis Baquero⁴ and Santiago Muñoz-Fernandez⁵, ¹InMusc. Instituto de Salud Músculo-Esquelética, Madrid, Spain, ²Instituto de Salud Musculoesquelética (InMusc), Madrid, Spain, ³Medical Department Bristol-Myers Squibb, Madrid, Spain, ⁴Scientific Department Scientia Salus, Madrid, Spain, ⁵Rheumatology, Hospital Universitario Infanta Sofia. Universidad Europea, Madrid, Spain
Background/Purpose: Prognostic factors facilitate decisions on treatment and follow-up of patients with rheumatoid arthritis (RA). Rheumatologists might use factors with poor link to evidence in…
Abstract Number: 1362 • 2017 ACR/ARHP Annual Meeting
Assessing the Quality, Reliability and Readability of Online Health Information Regarding Rheumatoid Arthritis
Mathew Reynolds¹, David Ta¹ and Russell Buchanan², ¹Department of Rheumatology, Austin Health, Heidelberg, Australia, ²Department of Rheumatology, Austin Health, Melbourne, Australia
Background/Purpose: Rheumatoid arthritis is a common autoimmune disease with complex pathophysiology and varied treatment options, which accounts for many visits to health care professionals. With…
Abstract Number: 1363 • 2017 ACR/ARHP Annual Meeting
Disease Duration and Shared Epitope, but Not Smoking History, Are Associated with Peptidylarginine Deiminase 4-Antibody Development in Rheumatoid Arthritis
Laura Cappelli¹, Maximilian Konig¹, Pooja Naik², Arvin Saleh³, Allan C. Gelber³, Clifton O. Bingham III⁴ and Erika Darrah⁵, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Rheumatology, Johns Hopkins University, Baltimore, MD, ⁵Department of Medicine/Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Clinical characteristics and biomarkers help clinicians predict disease features in rheumatoid arthritis (RA). Both peptidylarginine deiminase 4 (PAD4) antibodies and smoking have been associated…
Abstract Number: 1364 • 2017 ACR/ARHP Annual Meeting
Incidence of Rheumatoid Arthritis in a Cohort of First Degree Relatives from the Studies of the Etiology of Rheumatoid Arthritis
Diraj R. Karnani¹, Lindsy J. Forbess², Michael Weisman³, Kevin D. Deane⁴, V. Michael Holers⁵ and Jill M. Norris⁶, ¹Department of Rheumatology, Cedars Sinai Medical Center, Los Angeles, CA, ²Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ³Cedars-Sinai Medical Center Division of Rheumatology, Los Angeles, CA, ⁴Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁵Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁶Department of Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: First-degree relatives (FDRs) of patients with rheumatoid arthritis (RA) are at increased risk for developing RA compared to the general population. The purpose of…
Abstract Number: 1365 • 2017 ACR/ARHP Annual Meeting
Correlation of the Multi-Biomarker Disease Activity Score with Composite Rheumatoid Arthritis Disease Activity Measures: A Systematic Review and Meta-Analysis
Tate Johnson¹, Kyle A. Register², Cynthia Schmidt³, James R. O'Dell⁴, Ted R. Mikuls⁵, Kaleb Michaud¹ and Bryant R. England⁶, ¹University of Nebraska Medical Center, Omaha, NE, ²Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, ³McGoogan Library of Medicine, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁵Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁶Division of Rheumatology & Immunology, Department of Internal Medicine, Nebraska-Western IA VA Health Care System & University of Nebraska Medical Center, Omaha, NE
Background/Purpose: The regular assessment of disease activity is necessary to implement a treat-to-target management approach in RA. The Multi-Biomarker Disease Activity (MBDA) Score is a…
Abstract Number: 1366 • 2017 ACR/ARHP Annual Meeting
Evaluation of Synovial Fluid 14-3-3η Protein As a Marker of Joint Damage in Rheumatoid Arthritis Patients
Nevin Hammam^1,2, Shaimaa Salah³, Anthony Marotta⁴ and Emad F. Kholef⁵, ¹Rheumatology and Rehabilitation Department, University of Assiut, Assiut, Egypt, ²University of Alberta, Edmonton, AB, Canada, ³Rheumatology, Rehabilitation and Physical Medicine department, Faculty of Medicine, Assiut, Assiut, Egypt, ⁴Augurex Life Sciences Corp., Vancouver, BC, Canada, ⁵Clinical Pathology Department, Aswan University Hospital, Aswan, Egypt
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease that results in severe joint damage and physical disability, therefore, the discovery of new marker(s) for…
Abstract Number: 1367 • 2017 ACR/ARHP Annual Meeting
Circulating Microbial Small RNAs Are Altered in Patients with Rheumatoid Arthritis
Michelle J. Ormseth¹, Shilin Zhao², Ryan Allen², Joseph F. Solus², Quanhu Sheng², Yan Guo², Fei Ye², Marisol Ramirez², Kasey Vickers² and C Michael Stein², ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Small RNAs (sRNAs), such as microRNAs, are important regulators of biological processes and serve as important biomarkers of disease. We found that approximately half…
Abstract Number: 1368 • 2017 ACR/ARHP Annual Meeting
Small RNA Sequencing Identifies Plasma microRNA Panel for Rheumatoid Arthritis Diagnosis
Michelle J. Ormseth¹, Joseph F. Solus², Quanhu Sheng², Yan Guo², Fei Ye², Ryan Allen², Kasey Vickers² and C Michael Stein², ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Small noncoding RNAs (sRNAs), such as microRNAs (miRNAs), are regulators of biological processes and serve as important biomarkers of disease. Most previous plasma sRNA…
Abstract Number: 1369 • 2017 ACR/ARHP Annual Meeting
Interferon Gamma Signature Genes and CXCL10 As New Biomarkers in Early Stage of Rheumatoid Arthritis
Kijun Lee¹, Jennifer Lee², Hong-Ki Min¹, Hae-Rim Kim³, Sang-Heon Lee⁴, Sung-Hwan Park⁵, Ji Hyeon Ju⁶ and Hoyoun Kim¹, ¹The Catholic University of Korea, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ³Konkuk University Medical Center, Seoul, Korea, Republic of (South), ⁴Konkuk University School of Medicine, Seoul, Korea, Republic of (South), ⁵Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁶Division of Rheumatology, Department of Internal Medicine,, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
Background/Purpose: The purpose of this study is to explore new biomarkers for early diagnosis of rheumatoid arthritis (RA). For better discrimination power, we especially investigated…
Abstract Number: 1370 • 2017 ACR/ARHP Annual Meeting
Higher Disease Activity in Current Smokers with Established RA: Is It Disease, Damage or Disability?
Emily Keeler¹, Danielle Feger², Nancy J. Olsen¹ and Rayford R. June³, ¹Medicine/Rheumatology, Penn State Hershey Medical Center, Hershey, PA, ²Medicine/Rheumatology, Penn State College of Medicine, Hershey, PA, ³Rheumatology, Penn State Hershey Medical Center, Hershey, PA
Background/Purpose: Smoking is an important environmental risk factor for development of rheumatoid arthritis (RA). Smoking has been linked to lower rates of disease remission, incomplete…
Abstract Number: 1371 • 2017 ACR/ARHP Annual Meeting
Development of an Adjusted Multi-Biomarker Disease Activity (MBDA) Score for Rheumatoid Arthritis (RA) That Accounts for Age, Sex and Adiposity, with Subsequent Evaluation of Ability to Predict Risk for Radiographic Damage
Jeffrey R. Curtis¹, Darl D. Flake II², Michael Weinblatt³, Nancy A. Shadick⁴, Mikkel Østergaard⁵, Merete Lund Hetland⁶, Cecilie Heegaard Brahe⁶, Yong Gil Hwang⁷, Daniel E. Furst⁸, Vibeke Strand⁹, Carol J. Etzel¹⁰, Dimitrios A. Pappas¹¹, Xingbin Wang¹², Ching Chang Hwang¹³, Eric H. Sasso¹², Alexander Gutin², Elena Hitraya¹² and Jerry S. Lanchbury², ¹Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Myriad Genetics Inc., Salt Lake City, UT, ³Brigham and Women’s Hospital, Boston, MA, ⁴Rheumatology Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, ⁶Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ⁷Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁸David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁹Stanford University, Palo Alto, CA, ¹⁰Departments of Epidemiology and Biostatistics, University of Texas School of Public Health, Houston, TX, ¹¹Columbia University, New York, NY, ¹²Crescendo Bioscience Inc., South San Francisco, CA, ¹³Biostatistics, Crescendo Bioscience Inc., South San Francisco, CA
Background/Purpose: The MBDA score, based on 12 serum proteins, is a validated tool for assessing disease activity in RA patients. MBDA biomarkers may be influenced…
Abstract Number: 1372 • 2017 ACR/ARHP Annual Meeting
A Single Immunosignature Test Accurately Discriminates RA from Related Autoimmune and Inflammatory Disorders
Theodore M. Tarasow¹, Robert Gerwien¹, Jonathan Melnick¹, Scott A. Melville¹ and Chaim Putterman², ¹HealthTell, Inc., San Ramon, CA, ²Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory autoimmune disease primarily targeting the synovium. RA is B-cell driven, and is associated with autoantibody production. The…
Abstract Number: 1373 • 2017 ACR/ARHP Annual Meeting
Ultrasound of Subtalar Joint Synovitis in Patients with Rheumatoid Arthritis: Results of an Omeract Reliability Exercise Using Consensual Definitions
George A. W. Bruyn¹, Heidi Siddle², Petra Hanova³, Felicie Costantino⁴, Annamaria Iagnocco⁵, Andrea Delle Sedie⁶, Marwin Gutierrez⁷, Hilde B. Hammer⁸, Elizabeth Jernberg⁹, Damien Loeuille¹⁰, Carlos Pineda¹¹, Mihaela Cosmina Micu¹², Ingrid Moller¹³, bethan richards¹⁴, Maria S. Stoenoiu¹⁵, Takeshi Suzuki¹⁶, Lene Terslev¹⁷, Violeta Vlad¹⁸, Robert Wonink¹⁹, MA D'Agostino²⁰ and Richard J. Wakefield²¹, ¹Dept of Rheumatology, MC Groep hospitals, Lelystad, Netherlands, ²University of Leeds, Leeds, United Kingdom, ³Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ⁴Hôpital Universitaire Ambroise Pare, Paris, France, ⁵Academic Rheumatology Unit, Università degli Studi di Torino, Torino, Italy, ⁶Department Rheumatology, University of Pisa, Pisa, Italy, ⁷Rheumatology, Instituto Nacional de Rehabilitación, Mexico City, Mexico, ⁸Dept. of Rheumtology, Diakonhjemmet Hospital, Oslo, Norway, ⁹University of Washington, Seattle, WA, ¹⁰Rheumatology, CHRU Vandoeuvre les Nancy, Nancy, France, ¹¹Instituto Nacional de Rehabilitation, Mexico, Mexico, ¹²Division of Rheumatology, Department of Rehabilitation II, Clinical Rehabilitation Hospital, Cluj Napoca, Romania, ¹³Instituto de Poal, Barcelona, Spain, ¹⁴University of New South Wales, Sydney, Australia, ¹⁵Service de Rhumatologie, Cliniques Universitaires Saint-Luc,Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain,, Brussels, Belgium, ¹⁶Division of Allergy and Rheumatology, Japanese Red Cross Medical Center, Tokyo, Japan, ¹⁷Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, ¹⁸RCRD Research Center, Bucharest, Romania, ¹⁹Bergman Clinics, Naarden, Netherlands, ²⁰Rheumatology, Versailles-Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ²¹University of Leeds, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom
Background/Purpose: To evaluate the intra- and interobserver reliability of the ultrasonographic (US) assessment of subtalar joint (STJ) synovitis in patients with rheumatoid arthritis (RA). Methods:…
Abstract Number: 1374 • 2017 ACR/ARHP Annual Meeting
Flares in Patients with Rheumatoid Arthritis Are Strongly Associated with Worse Clinical Outcomes but Are Difficult to Predict
Katie Bechman¹, L. Tweehuysen², James Galloway³, Andrew P. Cope⁴ and Margaret Ma¹, ¹Academic Rheumatology Department, Kings College London, London, United Kingdom, ²Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ³King's College Hospital, Department of Rheumatology, London, London, United Kingdom, ⁴Academic Department of Rheumatology in the Division of Immunology, Infection and Inflammatory Diseases (DIIID), King's College London, London, Great Britain
Background/Purpose: Disease flares in RA are associated with radiographic progression1 and functional deterioration2. Predicting flare is of direct relevance to clinical practice, particularly in patients…
Abstract Number: 1375 • 2017 ACR/ARHP Annual Meeting
Foot Arthritis : Poor Prognosis Factor in RA
Sung-Hae Chang¹, Sung Won Lee², Mi-Il Kang³ and Seong Yong Kim⁴, ¹Soonchunhyang University Cheonan Hospital, Cheonan, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Department of Rheumatology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea, Republic of (South), ³Dankuk University Hospital, Cheonan, Korea, Republic of (South), ⁴Application Statistics, Hoseo University, Cheonan, Korea, Republic of (South)
Background/Purpose: The objective of the current study is to evaluate the clinical importance of foot and ankle joint arthritis.Methods: Data from Korean Biologic Registry (KoBio)…

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