Abstracts Archive - Page 1476 of 2607 - ACR Meeting Abstracts

Abstract Number: 1331 • 2017 ACR/ARHP Annual Meeting
A Pathogenic Role of Porphyomonas Gingivalis Fimbriae (FimA) in Periodontitis-Associated Rheumatoid Arthritis
Ji-Won Kim¹, Jennifer Lee², Yeon-Sik Hong³, Sung-Hwan Park² and Ji Hyeon Ju², ¹Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
Background/Purpose: Periodontitis induced by oral pathogen Porphyromonas gingivalis (Pg) has been suggested to be associated with rheumatoid arthritis (RA). Pg peptidyl arginine deiminase -mediated citrullination…
Abstract Number: 1332 • 2017 ACR/ARHP Annual Meeting
Periostin Deficiency Exacerbates Joint Inflammation and Bone Destruction in Mouse Models of Rheumatoid Arthritis
Yun-Hong Cheon, Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, Republic of (South)
Background/Purpose: Periostin (POSTN), a matricellular protein, is involved in many fundamental biological processes such as bone metabolism, cell proliferation, cell invasion, and angiogenesis. Also, POSTN…
Abstract Number: 1333 • 2017 ACR/ARHP Annual Meeting
Mortality of Tumor Necrosis Factor Transgenic Arthritic Mice with Interstitial Lung Disease Occurs with Pulmonary Arteriole Thickening and Right Ventricular Hypertrophy but Is Not Associated with Inducible Nitric Oxide Synthase Dependent Inflammatory Cell Infiltration
Richard Bell¹, Emily Wu^1,2, Homaira Rahimi³ and Edward Schwarz^1,4,5, ¹Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ²Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, ³Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY, ⁴University of Rochester, Rochester, NY, ⁵Univ of Rochester Med Ctr, University of Rochester School of Medicine and Dentistry, Rochester, NY
Background/Purpose: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) occurs in up to 15% of RA patients, whose median survival expectancy after diagnosis is only 2.6…
Abstract Number: 1334 • 2017 ACR/ARHP Annual Meeting
Identification of Key Regulators for Resolution of Chronic Inflammatory Arthritis through a Systems Approach
Jin-Sun Kong Sr.¹, Ji-Hwan park², Seung-Ah Yoo Sr.¹, Jung Hee Koh³, Daehee Hwang⁴ and Wan-Uk Kim Sr.⁵, ¹The Catholic University of Korea, Center for Integrative Rheumatoid Transcriptomics and Dynamics, seoul, Korea, Republic of (South), ²Center for Plant Aging Research, DGIST, Daegu 42988, South Korea, Daegu, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁴Center for Plant Aging Research, DGIST, Daegu 42988, South Korea, Department of New Biology, DGIST, Daegu 42988, South Korea, Daegu, Korea, Republic of (South), ⁵The Catholic University of Korea, Department of Internal Medicine, seoul, Korea, Republic of (South)
Background/Purpose: Collagen-induced arthritis(CIA), a representative animal model of chronic inflammatory arthritis, follows phases of induction, peak of inflammation and resolution. This study aims to identify…
Abstract Number: 1335 • 2017 ACR/ARHP Annual Meeting
p62/SQSTM1 Modulates Bone Erosions in a Murine Model of Rheumatoid Arthritis
Adelheid Korb-Pap¹, Anja Römer-Hillmann¹, Marianne Heitzmann¹, Masaru Kato², Kerstin Klein², Caroline Ospelt², Steffen Gay³, Susanne Buergis⁴, Thomas Pap¹, Thomas Weide⁵, André Gessner⁴ and Hermann Pavenstädt⁵, ¹Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ²Center of Experimental Rheumatology, University Hospital Zürich, Zurich, Switzerland, ³Center of Experimental Rheumatology, University Hospital Zürich, Zürich, Switzerland, ⁴Department of Immunology, University Erlangen, Erlangen, Germany, ⁵Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany
Background/Purpose: Rheumatoid arthritis (RA) is characterised by massive bone erosions leading to irreversible joint destructions. In this context, the multi-adapter protein p62/SQSTM1 is of interest…
Abstract Number: 1336 • 2017 ACR/ARHP Annual Meeting
Unique Role for miR429 in RA and Acute Model of Arthritis
Jonatan Hervoso¹, W. Alexander Stinson¹, Yuxuan Du², Sarah Arwani¹, Ellen Cealey¹, David A. Fox¹ and M. Asif Amin¹, ¹Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ²Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, MI
Background/Purpose: Rheumatoid arthritis (RA) is characterized by inflammation and subsequent infiltration of peripheral blood monocytes (MNs) into the synovial tissue (ST). Micro (mi)RNAs are non-coding…
Abstract Number: 1337 • 2017 ACR/ARHP Annual Meeting
ASN002, a Novel Dual SYK/JAK Inhibitor, Demonstrates Strong Efficacy in a Rat Model of Collagen-Induced Arthritis
David Zammit¹, Sanjeeva Reddy¹, Roger Smith¹, Nitin Damle² and Sandeep Gupta¹, ¹Asana BioSciences LLC, Lawrenceville, NJ, ²Preclinical R&D, Sun Pharma Advanced Research Co. Ltd, Mumbai, India
Background/Purpose: Spleen tyrosine kinase (SYK) and Janus kinase (JAK) mediate signaling in immune cells and hematopoietic cells important for the initiation and progression of rheumatoid…
Abstract Number: 1338 • 2017 ACR/ARHP Annual Meeting
Important Role of CD11c+ Dendtritic Cells in Inflammatory Arthritis
Antonia Puchner¹, Victoria Saferding¹, Michael Bonelli², Harald Leiss³, Gerhard Krönke⁴, René Pfeifle⁵, Josef S. Smolen⁶, Kurt Redlich⁷ and Stephan Blüml⁶, ¹Medical University of Vienna, Austria, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Rheumatology, Medical University Vienna, Vienna, Austria, ⁴Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Austria, ⁵Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁶Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, ⁷Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Dendritic cells (DCs) are important antigen presenting cells (APCs) and therefore they play an important role in bridging the innate and the adaptive immune…
Abstract Number: 1339 • 2017 ACR/ARHP Annual Meeting
Role of Hexokinase-2 in Synovial Lining Hypertrophy in Murine Arthritis
Marta Fernandez Bustmanate¹, Jeffrey Smith², Adam Paul Croft³, Gary S. Firestein⁴, Chris Buckley⁵, Shigeki Miyamoto² and Monica Guma⁶, ¹Medicine, UCSD, San Diego, CA, ²Pharmacology, UCSD, La Jolla, CA, ³Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁴Medicine, University of California San Diego, La Jolla, CA, ⁵University of Birmingham, Birmingham, United Kingdom, ⁶Medicine, UCSD, La Jolla, CA
Background/Purpose: Recent studies indicate that fibroblast-like synoviocyte (FLS) glucose metabolism is altered in rheumatoid arthritis (RA). Hexokinases (HKs) catalyze the first step in glucose metabolism.…
Abstract Number: 1340 • 2017 ACR/ARHP Annual Meeting
Is Depression in Patients with Rheumatoid Arthritis Associated with Disease Activity? Comparative Study between Germany and Brazil
Harriet Morf¹, Olga Seifert², Geraldo Castelar-Pinheiro³, Ana Beatriz Vargas-Santos⁴ and C Baerwald⁵, ¹Department of Internal Medicine, University Hospital, Erlangen, Germany, ²University of Leipzig, Leipzig, Germany, ³Universidade do Estado do Rio de Janeiro - UERJ, Rio de Janeiro, Brazil, ⁴Internal Medicine - Rheumatology, State University of Rio de Janeiro, Rio de Janeiro, Brazil, ⁵Department of Rheumatology, University of Leipzig, Germany, Leipzig, Germany
Background/Purpose: Rheumatoid Arthritis (RA) can be associated with psychologic disorders and especially depression. About 13–20% of patients have clinical significant depression (Matcham F et al,…
Abstract Number: 1341 • 2017 ACR/ARHP Annual Meeting
The Impact of Anti-Cyclic Citrullinated Peptide Seropositivity on Erosion Prevalence Among Patients with RA of Varying Disease Duration
Leslie R Harrold¹, K Price², Heather J. Litman³, SE Connolly², E Alemao², Sabrina Rebello⁴, W Hua³ and Joel Kremer⁵, ¹University of Massachusetts Medical School, Worcester, MA, ²Bristol-Myers Squibb, Princeton, NJ, ³Corrona, Southborough, MA, ⁴Corrona, LLC, Southborough, MA, ⁵Albany Medical College and The Center for Rheumatology, Albany, NY
Background/Purpose: Little is known regarding the prevalence of erosive disease in a contemporary cohort of patients with RA and whether erosive disease prevalence differs by…
Abstract Number: 1342 • 2017 ACR/ARHP Annual Meeting
Comprehensive Provider Judgment Outweighs Disease Activity Measures in the Decision to Not Escalate Therapy in Patients with Moderate to Severe Rheumatoid Arthritis
Jacob R. Stever¹, Brian Sauer², Chia-Chen Teng, MS¹, Neil Accortt³, David Collier⁴ and Grant Cannon¹, ¹Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ²IDEAS Center and Division of Epidemiology, HSR&D SLC VA Medical Center and University of Utah, Salt Lake City, UT, ³Center for Observational Research, Amgen, Inc., Thousand Oaks, CA, ⁴Amgen, Inc., Thousand Oaks, CA
Title: Comprehensive provider judgment outweighs disease activity measures in the decision to not escalate therapy in patients with moderate to severe rheumatoid arthritis. Authors: Stever,…
Abstract Number: 1343 • 2017 ACR/ARHP Annual Meeting
Gingival Bleeding and Periodontitis in Japanese Patients with Rheumatoid Arthritis: Results from the IORRA Cohort Study
Takefumi Furuya¹, Eisuke Inoue², Shigeru Maeda³, Eiichi Tanaka¹, Katsunori Ikari¹, Ayako Nakajima¹, Atsuo Taniguchi¹ and Hisashi Yamanaka¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Division of Medical Informatics, St. Marianna University School of Medicine, Kawasaki, Japan, ³Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan
Background/Purpose: Oral health is an important issue for patients with rheumatoid arthritis (RA) because periodontitis is a potential risk factor for RA and RA patients…
Abstract Number: 1344 • 2017 ACR/ARHP Annual Meeting
Impact of Fibromyalgic RA on Composite Scores; Results from a Longitudinal Study of RA Patients Initiating Bdmard Therapy
Hilde B Hammer¹, Sella A. Provan², Brigitte Michelsen³, Till Uhlig⁴, Jon Lampa⁵ and Tore K Kvien⁶, ¹Rheumatology, Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Hospital of Southern Norway trust, Kristiansand, Norway, ⁴Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁵Karolinska Institute, Department of Medicine, Rheumatology Unit, Stockholm, Sweden, Stockholm, Sweden, ⁶On behalf of the NOR-DMARD registry, Oslo, Norway
Background/Purpose: The composite scores DAS28, CDAI and SDAI all include number of tender and swollen joints (of 28). Rheumatoid arthritis (RA) patients with tender to…
Abstract Number: 1345 • 2017 ACR/ARHP Annual Meeting
Tender Joints Have Low Associations with Patient’s Evaluation of Joint Pain and Ultrasound Findings Explored at Joint Level in Patients with Rheumatoid Arthritis
Hilde B Hammer¹, Joseph Sexton¹, Sella A. Provan², Brigitte Michelsen^3,4 and Tore Kvien⁵, ¹Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Hospital of Southern Norway trust, Kristiansand, Norway, ⁴Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁵Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: In patients with rheumatoid arthritis (RA) the pain experience in joints with different degrees of joint inflammation is highly individual and dependent upon the…

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