Abstracts Archive - Page 1475 of 2425 - ACR Meeting Abstracts

Abstract Number: 859 • 2016 ACR/ARHP Annual Meeting
Long-Term Outcomes of Renal Artery Involvement in Takayasu Arteritis
Seokchan Hong¹, Oh Chan Kwon², Byeongzu Ghang³, Yong-Gil Kim¹, Chang-Keun Lee¹ and Bin Yoo¹, ¹Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, The Republic of, ³Division of Rheumatology, Department of Internal Medicine, Univerisy of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
Long-term Outcomes of Renal Artery Involvement in Takayasu Arteritis Background/Purpose: Takayasu arteritis (TA) involving the renal artery can result in hypertension, renal dysfunction, and premature…
Abstract Number: 860 • 2016 ACR/ARHP Annual Meeting
Assessment of the Frequency of Cardiovascular Risk Factors in Patients with Takayasu’s Arteritis
Fatma Alibaz-Oner¹, Matthew J. Koster², Ali Ugur Unal³, Hale Gulcin Yildirim⁴, Ceylan Cikikci⁴, Cynthia S. Crowson⁵, Ashima Makol⁶, Steven R. Ytterberg⁶, Eric L. Matteson⁶, Haner Direskeneli⁷ and Kenneth J. Warrington⁶, ¹Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ²Rheumatology, University of California Los Angeles, CA, USA Mayo Clinic, Rochester, MN, ³Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey, ⁴Marmara University Faculty of Medicine, Istanbul, Turkey, ⁵Health Sciences Research, Mayo Clinic, Rochester, MN, ⁶Rheumatology, Mayo Clinic, Rochester, MN, ⁷Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey
Background/Purpose: Accelerated atherosclerosis associated with chronic inflammation is one of the major complications of systemic inflammatory diseases. Takayasu arteritis (TAK) is a rare, systemic large-vessel…
Abstract Number: 861 • 2016 ACR/ARHP Annual Meeting
Efficacy of Methotrexate in Giant Cell Arteritis
Matthew J. Koster¹, Cynthia S. Crowson², Cristian Labarca³, Francesco Muratore⁴ and Kenneth J. Warrington⁵, ¹Rheumatology, University of California Los Angeles, CA, USA Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic, Rochester, MN, ³Rheumatology, Clinica Alemana Universidad del Desarrollo, Santiago, Chile, ⁴Rheumatology Unit, Internal Medicine Department, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy, ⁵Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Prospective trials evaluating methotrexate (MTX) as adjunct immunosuppression in giant cell arteritis (GCA) have provided evidence of a modest benefit for reducing risk of…
Abstract Number: 862 • 2016 ACR/ARHP Annual Meeting
Utility of 18f FDG Positron Emission Tomography (PET) As a Diagnostic Test and Marker of Disease Activity in Large Vessel Vasculitis
Sara Alehashemi¹, Mark Ahlman², Ali Cahid Civelek², Elaine Novakovich³, Ashkan Malayeri², Peter A. Merkel⁴, Thomas Cupps⁵, David Bluemke² and Peter C. Grayson³, ¹Rheumatology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Division of Rheumatology, Univ of Pennsylvania; Perelman School of Med, Philadelphia, PA, ⁵Rheumatology, Georgetown University, Bethesda, MD
Background/Purpose: FDG-PET may have a role in diagnosing and monitoring disease activity in large vessel vasculitis (LVV). Studies that assess the diagnostic accuracy of PET…
Abstract Number: 863 • 2016 ACR/ARHP Annual Meeting
Arterial Lesions in Giant Cell Arteritis
Tanaz A. Kermani¹, Sehriban Diab², Antoine Sreih³, David Cuthbertson⁴, Renee Borchin⁵, Simon Carette⁶, Lindsy J. Forbess⁷, Gary S. Hoffman⁸, Curry L. Koening⁹, Carol A. McAlear¹⁰, Paul A. Monach¹¹, Larry W. Moreland¹², Christian Pagnoux¹³, Philip Seo¹⁴, Robert F. Spiera¹⁵, Kenneth J. Warrington¹⁶, Steven R. Ytterberg¹⁷, Carol A. Langford¹⁸, Nader A. Khalidi¹⁹ and Peter A. Merkel²⁰, ¹Rheumatology, University of California Los Angeles, Santa Monica, CA, ²St. Joseph’s Healthcare, McMaster University, Hamilton, ON, Canada, ³Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁴Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁵University of South Florida, Tampa, FL, ⁶Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁷Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Rheumatic & Immunologic Dis, Cleveland Clinic Foundation, Cleveland, OH, ⁹Rheumatology, University of Utah, Salt Lake City, UT, ¹⁰University of Pennsylvania, Philadelphia, PA, ¹¹Rheumatology, Boston University School of Medicine, Boston, MA, ¹²Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹³Division of Rheumatology, Mount Sinai Hospital, University Health Network, University of Toronto, Toronto, Canada, Toronto, ON, Canada, ¹⁴Medicine, Johns Hopkins University, Baltimore, MD, ¹⁵Hospital for Special Surgery, Cornell, New York, NY, ¹⁶Rheumatology, University of California Los Angeles, CA, USA Mayo, Rochester, MN, ¹⁷Rheumatology, Mayo Clinic, Rochester, MN, ¹⁸Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ¹⁹Division of Rheumatology, St. Joseph’s Health Care, McMaster University, Hamilton, ON, Canada, ²⁰Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: This study aimed to describe large arterial lesions among patients with giant cell arteritis (GCA) and to understand what clinical characteristics are associated…
Abstract Number: 864 • 2016 ACR/ARHP Annual Meeting
Takayasu Arteritis Developed over the Age of 40 Has Lower Levels of Interferon Gamma and Interleukin 17 at Disease Onset and Fewer Subsequent Relapses
Shoichi Fukui¹, Naoki Iwamoto², Toshimasa Shimizu², Masataka Umeda², Ayako Nishino³, Yoshiro Horai², Tomohiro Koga⁴, Shin-ya Kawashiri⁵, Kunihiro Ichinose¹, Yasuko Hirai², Mami Tamai¹, Hideki Nakamura⁵, Tomoki Origuchi⁶, Kiyoshi Migita⁷, Yukitaka Ueki⁸ and Atsushi Kawakami⁹, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, ³Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki Universit, Nagasaki, Japan, ⁴Unit of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁶Department of Rehabilitation Sciences, Nagasaki University, Nagasaki, Japan, ⁷Department of Rheumatology and Clinical Research Center, Nagasaki Medical Center, Omura, Japan, ⁸Rheumatic and Collagen Disease Center, Sasebo Chuo Hospital, Sasebo, Japan, ⁹Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose: The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis (TAK) include age at disease onset ≤ 40 years. We aimed…
Abstract Number: 865 • 2016 ACR/ARHP Annual Meeting
Poor Predictive Value of Isolated Adventitial and Periadventitial Infiltrates in Temporal Artery Biopsies for Diagnosis of Giant Cell Arteritis
Claire Le Pendu¹, Véronique Meignin², Solange Gonzalez-Chiappe³, Françoise Galateau-Sallé⁴ and Alfred Mahr³, ¹Internal Medicine, Hospital Saint Louis, PARIS, France, ²Pathology, Saint Louis Hospital, PARIS, France, ³Internal Medicine, Hospital Saint-Louis, Paris, France, ⁴Pathology, Caen Hospital, Caen, France
Background/Purpose: Histological findings of intima-media or transmural inflammation in temporal artery biopsies (TABs) have undisputed high value for diagnosis of giant cell arteritis (GCA). Conversely,…
Abstract Number: 866 • 2016 ACR/ARHP Annual Meeting
Perivascular Inflammation in Temporal Artery Biopsies That Are Negative for Arteritis: Incidental or Harbinger?
Yousef Zarbalian¹, Kimberly P. Liang², Ronald L. Hamilton³, Li Wang⁴ and Dan Winger⁵, ¹Medicine, Division of Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Pathology, Division of Neuropathology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴Office of Clinical Research, University of Pittsburgh, Pittsburgh, PA, ⁵Office of Clinical Research, Health Sciences, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: The diagnosis of giant cell arteritis (GCA) by temporal artery (TA) biopsy requires pathologic identification of arterial inflammation, usually with giant cells. However, some…
Abstract Number: 867 • 2016 ACR/ARHP Annual Meeting
Termination of Tocilizumab-Treatment in Giant Cell Arteritis: Follow-up of Patients after the RCT (ClinicalTrials.gov registration number: NCT01450137)
Sabine Adler¹, Stephan Reichenbach², Stefan Kuchen³, Felix Wermelinger⁴, Diana Dan⁴, Michael Seitz⁴ and Peter M. Villiger⁴, ¹Rheumatology, Immunology, Allergology, University Hospital Bern, Bern, Switzerland, ²Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland, ³Rheumatology, Immunology, and Allergology, University of Bern, Bern, MD, Switzerland, ⁴Department of Rheumatology, Immunology and Allergology, University Hospital Bern, Bern, Switzerland
Background/Purpose:
Abstract Number: 868 • 2016 ACR/ARHP Annual Meeting
Infections and the Risk of Incident Giant Cell Arteritis: A Population-Based, Case-Control Study
Rennie L. Rhee¹, Peter C. Grayson², Peter A. Merkel³ and Gunnar Tomasson⁴, ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Division of Rheumatology, Univ of Pennsylvania; Perelman School of Med, Philadelphia, PA, ⁴Dept of Public Health Sciences, University of Iceland, Reykjavik, IS
Background/Purpose : Alterations in the immune system and infections are suspected to increase susceptibility to giant cell arteritis (GCA). Recently herpes zoster has been…
Abstract Number: 869 • 2016 ACR/ARHP Annual Meeting
Low Numbers of CD16+ Monocytes Predict Shorter Time to Relapse in Polymyalgia Rheumatica
Qi Wang¹, Kornelis S.M. van der Geest², Wayel H. Abdulahad¹, Abraham Rutgers¹, Suzanne Arends¹, Annemieke M.H. Boots¹ and Elisabeth Brouwer³, ¹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Rheumatology and Clinical Immunology, University of Groningen and University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Polymyalgia rheumatica (PMR) is the most frequent inflammatory disorder in persons older than 50 years of age. Biomarkers like ESR and CRP may be…
Abstract Number: 870 • 2016 ACR/ARHP Annual Meeting
Contemporary Prevalence Estimates for Giant Cell Arteritis and Polymyalgia Rheumatica, 2015
Cynthia S. Crowson¹ and Eric L. Matteson², ¹Health Sciences Research, Mayo Clinic, Rochester, MN, ²Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: There are no estimates of the prevalence of giant cell arteritis (GCA) or polymyalgia rheumatic (PMR) in a United States population in the current…
Abstract Number: 871 • 2016 ACR/ARHP Annual Meeting
Interleukin 33 Critically Regulates Angiogenesis and Inflammation in Large Vessels Vasculitis
Anne-Claire Desbois¹, Aurélie LEROYER², Marlène Garrido³, Julien Gaudric⁴, Cloé Comarmond⁵, David Klatzman⁶, Philippe Cluzel⁷, Pierre Fouret⁸, Laurent Chiche⁹, Fabien Koskas¹⁰, Gilles Kaplanski¹¹, Patrice Cacoub¹² and David Saadoun¹³, ¹Hôpital Pitié-Salpêtrière, Internal Medicine and Clinical Immunology, Paris, France, ²Faculté de Pharmacie, Marseille, France, ³I3 laboratory, Pitié-Salpétrière, Paris, France, ⁴Department of Vascular surgery GHPS, Paris, France, ⁵DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, ⁶UPMC Université Paris 06, UMR 7211, Paris, France, ⁷Cadiovascular Imaging and Interventional Radiology, Pitié-Salpétrière, Paris, France, ⁸Hôpital La Pitié Salpétrière, Paris, France, ⁹Service de Chirurgie Vasculaire, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, ¹⁰Department of Internal Medicine and 2Laboratory I3 « Immunology, Immunopathology, Immunotherapy », UMR CNRS 7211, INSERM U959, Groupe Hospitalier Pitié-Salpetrière, Université Pierre et Marie Curie, Paris 6, Paris, France, Paris, France, ¹¹Aix-Marseille Université - Internal Medicine hopital conception - F-13000 Marseilles, Marseille, France, ¹²Internal Medicine Department, University Hospital “Pitié-Salpêtrière”, “Pierre et Marie Curie Paris VI” University, Paris, France, ¹³Department of Internal Medicine and clinical Immunology. French National Reference Center for Autoimmune Diseases. DHU I2B (Inflammation, Immunotherapy and Biotherapy), UPMC, Paris VI, Hôpital Pitié Salpétrière, AP-HP, UPMC, Univ Paris 06, Paris, France
Background/Purpose: Large vessels vasculitis (LVV) include Takayasu disease (TD) and Giant Cell Arteritis (GCA). Interleukin 33 (IL-33) is a cytokine which controls immune responses and…
Abstract Number: 872 • 2016 ACR/ARHP Annual Meeting
New Insights into the Pathogenesis of Giant Cell Arteritis through a Genome-Wide Association Study
Francisco David Carmona¹, Augusto Vaglio², Sarah Mackie³, José Hernández-Rodríguez⁴, Paul A. Monach⁵, Santos Castañeda⁶, Roser Solans⁷, Inmaculada C. Morado⁸, Francisco Javier Narváez⁹, Marc Ramentol-Sintas¹⁰, Colin T. Pease¹¹, Bhaskar Dasgupta¹², Richard Watts¹³, Nader A. Khalidi¹⁴, Carol A. Langford¹⁵, Steven R. Ytterberg¹⁶, Luigi Boiardi¹⁷, Lorenzo Beretta¹⁸, Marcello Govoni¹⁹, Giacomo Emmi²⁰, Francesco Bonatti²¹, Marco A. Cimmino²², Torsten Witte²³, Thomas Neumann²⁴, Julia Holle²⁵, Verena Schönau²⁶, Laurent Sailler²⁷, Thomas Papo²⁸, Julien Haroche²⁹, Alfred Mahr³⁰, Luc Mouthon³¹, Øyvind Molberg³², Andreas P Diamantopoulos³³, Alexandre E. Voskuyl³⁴, Elisabeth Brouwer³⁵, Thomas Daikeler³⁶, Christoph Berger³⁷, Eamonn S. Molloy³⁸, Lorraine O'Neill³⁹, Daniel Blockmans⁴⁰, Benedicte A. Lie⁴¹, Paul Mclaren⁴², Timothy J. Vyse⁴³, Cisca Wijmenga⁴⁴, Yannick Allanore⁴⁵, Bobby P.C. Koeleman⁴⁶, Jennifer H. Barrett⁴⁷, Maria C. Cid⁴⁸, Carlo Salvarani⁴⁹, Peter A. Merkel⁵⁰, Ann W. Morgan⁵¹, Miguel Angel González-Gay⁵², Javier Martín¹ and Spanish GCA Group, UKGCA Consortium, and Vasculitis Clinical Research Consortium, ¹Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, ²Nephrology, University Hospital of Parma, Parma, Italy, ³NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, University of Leeds, Leeds, United Kingdom, ⁴Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ⁵Rheumatology, Boston University School of Medicine, Boston, MA, ⁶Rheumatology, Hospital de la Princesa, IIS-IP, Madrid, Spain, ⁷Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Spain, Barcelona, Spain, ⁸Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ⁹Rheumatology, Hospital Universitario de Bellvitge-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain, ¹⁰Internal Medicine, Hospital Vall d’Hebron, Autonomous University of Barcelona, Barcelona, Spain, ¹¹Rheumatology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ¹²Rheumatology, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea, United Kingdom, ¹³Rheumatology, Ipswich Hospital NHS Trust, Ipswich, United Kingdom, ¹⁴Rheumatology, McMaster University, Hamilton, ON, Canada, ¹⁵Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ¹⁶Rheumatology, Mayo Clinic, Rochester, MN, ¹⁷Rheumatology Unit, Department of Internal Medicine, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy, ¹⁸Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ¹⁹Medical Sciences, UOC of Rheumatology, University Hospital S. Anna, Cona Ferrara, Italy, ²⁰Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, ²¹Clinical and Experimental Medicine, Medical Genetics Unit, University of Parma, Parma, Italy, ²²Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ²³Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ²⁴Internal Medicine III, Jena University Hospital, Jena, Germany, ²⁵Vasculitis Clinic, Klinikum Bad Bramstedt & University Hospital of Schleswig Holstein, Bad Bramstedt, Germany, ²⁶Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany, ²⁷Internal Medicine, Internal Medicine department, Toulouse University Hospital, Toulouse, France, ²⁸Internal Medicine, Hôpital Bichat, Université Paris-Diderot, Paris, France, ²⁹Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France, ³⁰Internal Medicine, Hospital Saint-Louis, Paris, France, ³¹Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, ³²Rheumatology, Oslo University Hospital, Oslo, Norway, ³³Rheumatology, Haugesund Sanitetsforenings Revmatismesykehus, Haugesund, Norway, ³⁴Rheumatology, Amsterdam Rheumatology and immunology Center, Location VU University Medical Center, Amsterdam, Netherlands, ³⁵Rheumatology and Clinical Immunology, University of Groningen and University Medical Center Groningen, Groningen, Netherlands, ³⁶Rheumatology, University Hospital Basel, Basel, Switzerland, ³⁷Internal medicine, University hospital Basel, basel, Switzerland, ³⁸Rheumatology, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, St Vincent's University Hospital, Dublin, Ireland, ³⁹Rheumatology, St. Vincent's University Hospital, Dublin, Ireland, ⁴⁰General Internal Medicine, University Hospitals Gasthuisberg, Leuven, Belgium, ⁴¹Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway, ⁴²Swiss Institute of Bioinformatics, Lausanne, Switzerland, ⁴³Division of Immunology, Infection and Inflammatory Disease, King’s College London, London, United Kingdom, ⁴⁴Genetics, University Medical Hospital Groningen, University of Groningen, Groningen, Netherlands, ⁴⁵Rheumatology, Paris Descartes University, Paris, France, ⁴⁶Medical Genetics, University Medical Centre Utrecht, Utrecht, Netherlands, ⁴⁷NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ⁴⁸Autoimmune and Systemic Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ⁴⁹Rheumatology, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy, ⁵⁰Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁵¹Section of Musculoskeletal Disease, NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom, ⁵²Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain
Background/Purpose: Giant cell arteritis (GCA) is an immune-mediated polygenic disease characterized by inflammatory lesions in medium- and large-sized arteries. The aim of the present study…
Abstract Number: 873 • 2016 ACR/ARHP Annual Meeting
Interleukin-23 Stimulates Inflammatory and Proliferative Pathways in Giant Cell Arteritis
Richard Conway¹, Karen Creevey², Michelle Trenkmann³, Geraldine M. McCarthy⁴, Conor Murphy⁵, Douglas J. Veale⁶, Ursula Fearon⁷ and Eamonn S. Molloy⁸, ¹CARD Newman Research Fellow, University College Dublin, Dublin, Ireland, ²St. Vincent's University Hospital, Centre for Athritis and Rheuamtic Diseases, Dublin Academic Medical Centre,, Dublin, Ireland, ³St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ⁴Div of Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland, ⁵Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland, ⁶Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, ⁷Trinity College Dublin, Department of Molecular Rheumatology, Trinity College Dublin, Dublin, Ireland, ⁸Rheumatology, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, St Vincent's University Hospital, Dublin, Ireland
Background/Purpose: Giant cell arteritis (GCA) is the most common form of systemic vasculitis. The pathogenesis of GCA remains incompletely understood. Current evidence suggests that dendritic…

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