ACR Meeting Abstracts

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  • Abstract Number: 709 • 2016 ACR/ARHP Annual Meeting

    Development of a Novel Medication Adherence Prediction Model for Patients with Ankylosing Spondylitis Based on Results from a Global Clinical Study

    Philip J Mease1, Josef S. Smolen2, Dafna D Gladman3, Joachim Sieper4, John Weinman5, Julia Sommer6, Pascal Nurwakagari7 and Maja Hojnik8, 1Swedish Medical Center and University of Washington, Seattle, WA, 2Medical University of Vienna, Vienna, Austria, 3University of Toronto, Toronto, ON, Canada, 4Charité Universitätsmedizin Berlin, Berlin, Germany, 5King's College, London, United Kingdom, 6GKM Gesellschaft für Therapieforschung mbH, Munich, Germany, 7AbbVie Deutschland GmbH & Co. KG, Wiesbaden, Germany, 8AbbVie, Ljubljana, Slovenia

    Background/Purpose: Adherence to systemic therapies, such as tumor necrosis factor inhibitors (TNFi’s), is affected by various factors and may be critical for optimal disease outcomes…
  • Abstract Number: 710 • 2016 ACR/ARHP Annual Meeting

    Patient-Reported Quality of Life in Patients with Baseline Objective Signs of Inflammation and Active Nonradiographic Axial Spondyloarthritis Treated with Golimumab: Results of the Open-Label Extension of a Randomized, Double-Blind Study

    Walter Maksymowych1, Maxime Dougados2, Joachim Sieper3, Jürgen Braun4, G Bergman5, Sean P. Curtis6, Anjela Tzontcheva6, George Philip6, Susan Huyck6 and Désirée van der Heijde7, 1Medicine, University of Alberta,, Edmonton, AB, Canada, 2Paris-Descartes University, Paris, France, 3Rheumatology Department, Charité – University Medicine Berlin, Berlin, Germany, 4Rheumazentrum Ruhrgebiet, Herne, Germany, 5Merck & Co., Inc., Whitehouse Station, NJ, 6Merck & Co., Inc., Kenilworth, NJ, 7Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: In an open-label extension (OLE) of a 16-week, randomized, double blind (DB), placebo (PBO)-controlled, phase 3 study (GO-AHEAD; NCT1453725) in patients with nonradiographic axial…
  • Abstract Number: 711 • 2016 ACR/ARHP Annual Meeting

    The Diagnostic Value of the Symptom of Inflammatory Back Pain in the Rheumatology Setting

    Denis Poddubnyy1, Inge Spiller1, Joachim Listing2, Jürgen Braun3, Joachim Sieper1 and Martin Rudwaleit4, 1Charité Medical University, Berlin, Germany, 2German Rheumatism Research Center, Berlin, Germany, 3Rheumazentrum Ruhrgebiet, Herne, Germany, 4Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany

    Background/Purpose: Inflammatory back pain (IBP) as a symptom has been shown to perform effectively for selecting patients in primary care / orthopaedic settings for referral…
  • Abstract Number: 712 • 2016 ACR/ARHP Annual Meeting

    Efficacy of Golimumab for Nonradiographic Axial Spondyloarthritis (nr-axSpA): Subgroup Analysis By Baseline MRI and C-Reactive Protein Status

    Joachim Sieper1, Désirée van der Heijde2, Walter Maksymowych3, Jürgen Braun4, G Bergman5, Sean P. Curtis6, Anjela Tzontcheva6, George Philip6, Susan Huyck6 and Maxime Dougados7, 1Rheumatology Department, Charité – University Medicine Berlin, Berlin, Germany, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Medicine, University of Alberta,, Edmonton, AB, Canada, 4Rheumazentrum Ruhrgebiet, Herne, Germany, 5Merck & Co., Inc., Whitehouse Station, NJ, 6Merck & Co., Inc., Kenilworth, NJ, 7Paris-Descartes University, Paris, France

    Background/Purpose: Efficacy of golimumab (GLM) for nr-axSpA was demonstrated in a randomized, double-blind (DB), placebo (PBO)-controlled, phase 3 study (GO-AHEAD; NCT01453725).1 In a subgroup analysis,…
  • Abstract Number: 713 • 2016 ACR/ARHP Annual Meeting

    Predictors of Treatment Retention Among Patients with Rheumatoid Arthritis or Ankylosing Spondylitis Treated with Remicade® (Infliximab) for Long-Term in Canadian Real-World

    Michael Starr1, Edward Keystone2, Rafat Faraawi3, Louis Bessette4, Boulos Haraoui5, Wojciech Olszynski6, John Kelsall7, Raman Joshi8, Andrew Chow9, Algis Jovaisas10, J Carter Thorne11, Emmanouil Rampakakis12, Eliofotisti Psaradellis13, Marilise Marrache14, Brendan Osborne15, Karina Maslova16, Francois Nantel17, Allen J Lehman16 and Cathy Tkaczyk15, 1Rheumatology, Mcgill University, Pointe-Claire,, QC, Canada, 2Mt. Sinai Hospital, University of Toronto, Toronto, ON, Canada, 3McMaster University, Hamilton, ON, Canada, 4Rheumatology, CHUL de Quebec, Quebec, QC, Canada, 5Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada, 6103 Midtown Professional Center, Rheumatology Associates of Saskatoon, Saskatoon, SK, Canada, 7Mary Pack Arthritis Centre, Vancouver, Vancouver, BC, Canada, 8William Osler Health Centre-Brampton Civic Hospital, Brampton, ON, Canada, 9Credit Valley Rheumatology, Mississauga, ON, Canada, 10Capital North Therapeutics & Research, Ottawa, ON, Canada, 11Southlake Regional Health Centre, Newmarket, ON, Canada, 12JSS Medical Research, St-Laurent, QC, Canada, 13JSS Medical Research, Montreal, QC, Canada, 14Medical Affairs, Janssen Inc, Toronto, ON, Canada, 15Medical Affairs, Janssen Inc., Toronto, ON, Canada, 16Janssen Inc., Toronto, ON, Canada, 1719 Green belt Dr, Janssen Inc., Toronto, ON, Canada

    Background/Purpose: Remission has become a target to achieve in rheumatic diseases and it also could be linked to treatment retention. The aim of this analysis…
  • Abstract Number: 714 • 2016 ACR/ARHP Annual Meeting

    Functional Relevance of Structural Damage in the Sacroiliac Joints in Patients with Axial Spondyloarthritis – Results from the German Spondyloarthritis Inception Cohort

    Mikhail Protopopov1, Hildrun Haibel1, Jürgen Braun2, Martin Rudwaleit3, Joachim Sieper1 and Denis Poddubnyy1, 1Charité Medical University, Berlin, Germany, 2Rheumazentrum Ruhrgebiet, Herne, Germany, 3Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany

    Background/Purpose: To analyze the association between the presence of structural damage in the sacroiliac joints and physical function / spinal mobility in patients with axial…
  • Abstract Number: 715 • 2016 ACR/ARHP Annual Meeting

    Are Patients with Ankylosing Spondylitis Willing to Pay for Treatment with Infliximab?

    Casper Webers1,2, Ivette Essers1,2, Astrid van Tubergen1,2, Jürgen Braun3, Frank Heldmann4, Xenofon Baraliakos5 and Annelies Boonen2,6, 1Department of Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 2School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, Netherlands, 3Rheumazentrum Ruhrgebiet, Herne, Germany, 4Zeisigwaldkliniken Bethanien, Chemnitz, Germany, 5Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 6Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands

    Background/Purpose: In view of the continuous pressure of biologicals on healthcare budgets, it is essential to assess the value of biologicals for patients from different…
  • Abstract Number: 716 • 2016 ACR/ARHP Annual Meeting

    Radiographic Progression and Changes in Inflammation and Structural Damage on Serial MRI Examinations over 5 Years in Patients with Ankylosing Spondylitis Treated with TNF-Alpha Inhibitors

    Susanne Juhl Pedersen1, Ulrich Weber2, Roula Said Nahal3, Inge Juul Sorensen1, Anne Gitte Loft4, Niels Tvede1, Gina Kollerup1, Lars Juul1, Gorm Thamsborg1, Ole Rintek Madsen1, Jakob M. Møller5, Lone Balding6, Anne Grethe Jurik7 and Mikkel Østergaard8, 1Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, 2Department of Research, King Christian 10th Hospital for Rheumatic Diseases, Graasten, Denmark, 3Ambroise Paré Hospital, Boulogne-Billancourt, France, 4Departments of Rheumatology at Vejle and Aarhus Hospitals, Vejle and Aarhus, Denmark, 5Department of Radiology, Copenhagen University Hospital Herlev and Gentofte, Herlev, Denmark, 6Department of Radiology, Copenhagen University Hospital Herlev and Gentofte, Copenhagen, Denmark, 7Dept. of Radiology, Aarhus University Hospital, Aarhus, Denmark, 8Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark

    Background/Purpose: Only few studies have investigated long-term radiographic progression in the spine of patients with ankylosing spondylitis (AS). Moreover, no studies have reported changes in…
  • Abstract Number: 717 • 2016 ACR/ARHP Annual Meeting

    NSAID Use and Functional Impairment in Ankylosing Spondylitis

    Mark Hwang1, Seth Eisen1, MinJae Lee2, Michael Ward3, Lianne S. Gensler4, Prabha Ranganathan5, Johnathan Jia6, Amirali Tahanan2, Matthew A. Brown7, Mohammad H. Rahbar2, Michael Weisman8 and John D. Reveille9, 1Internal Medicine-Rheumatology, Washington University in Saint Louis, School of Medicine, Saint Louis, MO, 2Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, 3NIH/NIAMS, Bethesda, MD, 4Medicine/Rheumatology, UCSF, San Francisco, CA, 5Washington University in Saint Louis, School of Medicine, Saint Louis, MO, 6University of Texas-McGovern Medical School, Houston, TX, 7The University of Queensland Diamantina Institute, Brisbane, Australia, 8Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 9Rheumatology, University of Texas-McGovern Medical School, Houston, TX

    Background/Purpose:   Ankylosing spondylitis (AS) is a chronic inflammatory disease with significant burden to patients and society.  NSAIDs are the first line pharmacologic therapy in…
  • Abstract Number: 718 • 2016 ACR/ARHP Annual Meeting

    Radiographic Progression of Hip Arthritis in Patients with Ankylosing Spondylitis Treated with TNF Inhibitors

    Maria Konsta1, Michael Nurmohamed2, J.C. van Denderen3, Ingrid Visman4 and I.E. Van der Horst - Bruinsma5, 1Amsterdam Rheumatology and Immunology Center,VUmc and Reade, Amsterdam, Netherlands, 2Rheumatology, Amsterdam Rheumatology and immunology Center | Reade, Amsterdam, Netherlands, 3Center for Rheumatology and Rehabilitation, Jan van Breemen Institute, Amsterdam, Netherlands, 4Amsterdam Rheumatology and Immunology Center, VUmc and Reade, Amsterdam, Netherlands, 5GENRA Consortium, Amsterdam, Netherlands

    Background/Purpose: Although current evidence suggests that anti-TNF treatment may not inhibit spinal radiographic progression, its effect on hip involvement in AS is not known. The…
  • Abstract Number: 719 • 2016 ACR/ARHP Annual Meeting

    Prevalence and Incidence of Comorbidities in Patients with Ankylosing Spondylitis Versus General Population

    Jessica Walsh1, Xue Song2, Gilwan Kim2 and Jina Park3, 1University of Utah School of Medicine, Salt Lake City, UT, 2Truven Health Analytics, Cambridge, MA, 3Novartis Pharmaceuticals Corporation, East Hanover, NJ

      Background/Purpose: Comorbidities associated with ankylosing spondylitis (AS) have been inadequately studied in American populations. This study used a large US national claims database to…
  • Abstract Number: 720 • 2016 ACR/ARHP Annual Meeting

    Impact of HLA-B27 on Patient Profile and Treatment Response in As Patients Treated with Anti-TNF in Canadian Real-World

    Isabelle Fortin1, Maqbool Sheriff2, Proton Rahman3, Michael Starr4, Wojciech Olszynski5, Sanjay Dixit6, Viktoria Pavlova7, Derek Haaland8, Emmanouil Rampakakis9, Eliofotisti Psaradellis10, Brendan Osborne11, Karina Maslova12, Allen J Lehman12, Francois Nantel13 and Cathy Tkaczyk11, 1Centre de Rhumatologie De l’Est du Quebec, Rimouski, QC, Canada, 2Nanaimo Regional General Hospital, Nanaimo, BC, Canada, 3Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada, 4Rheumatology, Mcgill University, Pointe-Claire,, QC, Canada, 5103 Midtown Professional Center, Rheumatology Associates of Saskatoon, Saskatoon, SK, Canada, 6Rheumatology, McMaster University Hamilton, Burlington, ON, Canada, 7Ancaster Medical Centre, Ancaster, ON, Canada, 8Rheumatology, Clinical Immunology & Allergy, McMaster University, Barrie, ON, Canada, 9JSS Medical Research, St-Laurent, QC, Canada, 10JSS Medical Research, Montreal, QC, Canada, 11Medical Affairs, Janssen Inc., Toronto, ON, Canada, 12Janssen Inc., Toronto, ON, Canada, 1319 Green belt Dr, Janssen Inc., Toronto, ON, Canada

    Background/Purpose:  The human leukocyte antigen (HLA)-B27 allele is one of the strongest known genetic factors associated with the development of ankylosing spondylitis, however, previous studies…
  • Abstract Number: 721 • 2016 ACR/ARHP Annual Meeting

    Safety and Efficacy of Switching from Originator to CT-P13 Infliximab Biosimilar in Patients Affected By Spondyloarthritis. a 6-Month Observational Study

    Alberto Batticciotto1,2, Marco Antivalle2, Francesca Li Gobbi3, Simone Parisi4, Rossella Talotta2, Valentina Varisco2, Maurizio Benucci3, Enrico Fusaro4 and Piercarlo Sarzi-Puttini1, 1Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milano, Italy, 2Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milan, Italy, 3Rheumatology Unit, Ospedale S. Giovanni di Dio, Florence, Florence, Italy, 4Department of Rheumatology, University Hospital Città Della Salute e della Scienza di Torino, Turin, Italy

    Background/Purpose: Biosimilar infliximab (INX) was recently approved by the European Medicine Agency based on comparable pharmacokinetics, safety and efficacy profile to innovator INX for the…
  • Abstract Number: 722 • 2016 ACR/ARHP Annual Meeting

    Impact of Aerobic Fitness on Axial Spondyloarthritis Activity: Systematic Review and Meta-Analysis of Controlled Studies

    Frank Verhoeven1, Xavier Guillot2, Clément Prati3, Nicolas Tordi4, Céline Demougeot1 and Daniel Wendling5, 1EA 4267 FDE, FHU INCREASE, Université de Bourgogne Franche-Comté, Besançon, France, 2EA 4267 FDE, FHU INCREASE, Université de Bourgogne FrancheComté, Besançon, France, 3FDE EA4267, FHU INCREASE, Bourgogne Franche-Comté University, Besançon, France, 4EA 4267 FDE, FHU INCREASE,, Bourgogne Franche-Comté University, Besançon, France, 5Service de Rhumatologie, CHU Jean Minjoz, Besancon, France

    Background/Purpose: The current ASAS recommendations for the management of the ankylosing spondylitis suggest, beside pharmacological therapy, a significant part of physical therapy with supervised exercises.…
  • Abstract Number: 723 • 2016 ACR/ARHP Annual Meeting

    Hip Disease Treatment and Progression in Ankylosing Spondylitis

    Daphne Scaramangas-Plumley1, MinJae Lee2, Mohammad H. Rahbar2, Lianne S. Gensler3, John D. Reveille4 and Michael Weisman1, 1Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 2Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, 3Medicine/Rheumatology, UCSF, San Francisco, CA, 4Rheumatology, University of Texas-McGovern Medical School, Houston, TX

    Methods: We included 613 AS patients meeting the modified New York criteria and had at least 2 sets of hip radiographs. Using the Bath Ankylosing…
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