ACR Meeting Abstracts

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  • Abstract Number: 694 • 2016 ACR/ARHP Annual Meeting

    Diagnostic Delay Leads to Worse Response to Treatment

    Marijn Vis1, Kim Wervers2, Ilja Tchetverikov3, Mark R. Kok4, Lindy-Anne Korswagen5, Andreas H. Gerards6, Hans van Groenendaal7, Jozien Veris8, Wiebo L. van der Graaff9, Cathelijne W. Y. Appels10, Johanna M.W. Hazes11 and Jolanda J. Luime1, 1Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands, 2Erasmus Medical Centre, Rotterdam, Netherlands, 3Albert Schweitzer Hospital, Dordrecht, Netherlands, 4Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, 5Sint Franciscus Gasthuis, Rotterdam, Netherlands, 6Rheumatology, Vlietland Hospital, Schiedam, Netherlands, 7Rheumatology, ReumaZorg ZuidWest nederland, Roosendaal, Netherlands, 8Rheumatology, Reumazorg Zuid West Nederland, Goes, Netherlands, 9Rheumatology, Rivas hospital, Gorinchem, Netherlands, 10Rheumatology, Amphia Hospital, Breda, Netherlands, 11Department of Rheumatology, Erasmus University Medical Centre, Rotterdam, Netherlands

    Is there a clinical patient profile for PsA Patients with a diagnostic delay? Background/Purpose: Psoriatic arthritis (PsA) is a progressive inflammatory musculoskeletal disease. Several recent…
  • Abstract Number: 695 • 2016 ACR/ARHP Annual Meeting

    Secukinumab Sustains Individual Clinical Responses over Time in Patients with Active Ankylosing Spondylitis: 2-Year Results from a Phase 3 Randomized Placebo-Controlled Trial

    Xenofon Baraliakos1, Michael Schiff2, Karel Pavelka3, Ruvie Martin4, Brian Porter4 and Corine Gaillez5, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 2University of Colorado, School of Medicine, Denver, CO, 3Institute and Cliníc of Rheumatology, Charles University, Prague, Czech Republic, 4Novartis Pharmaceuticals Corporation, East Hanover, NJ, 5Novartis Pharma AG, Basel, Switzerland

    Background/Purpose: The assessment of achieving, maintaining, and improving clinical response to biologics in Ankylosing Spondylitis (AS) is part of treat-to-target recommendations aimed at optimizing treatment…
  • Abstract Number: 696 • 2016 ACR/ARHP Annual Meeting

    Significantly Reduced Recurrence Rate of Acute Anterior Uveitis in Ankylosing Spondylitis during Treatment with Golimumab

    S.C. Heslinga1,2, M. T. Nurmohamed1,3, A. H. Gerards4, E. Griep5, C. Koehorst6, M. R. Kok7, A. Schilder8, M. Verhoef9 and I.E. Van der Horst - Bruinsma1,2, 1Rheumatology, Reade, Amsterdam Rheumatology and immunology Center, Reade, Amsterdam, Netherlands, 2Rheumatology, Amsterdam Rheumatology and immunology Center, VU University medical center, Amsterdam, Netherlands, 3Amsterdam Rheumatology and immunology Center, VU University medical center, Amsterdam, Netherlands, 4Rheumatology, Vlietland Hospital, Schiedam, Netherlands, 5Rheumatology, Antonius Hospital, Sneek, Netherlands, 6Rheumatology, Gelre Hospital, Apeldoorn, Netherlands, 7Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, 8Rheumatology, Medical Centre Leeuwarden, Leeuwarden, Netherlands, 9Immunology, MSD the Netherlands, Haarlem, Netherlands

    Background/Purpose:  Acute anterior uveitis (AAU) is common in ankylosing spondylitis (AS) (1). Golimumab, a tumor necrosis factor alpha (TNF-α) blocker, has proven to be effective…
  • Abstract Number: 697 • 2016 ACR/ARHP Annual Meeting

    Does Axial Spondyloarthritis Phenotype Correlate with Imaging Morphotype?

    Xenofon Baraliakos1, Annette Szumski2, Heather Jones3 and Lianne S. Gensler4, 1Rheumazentrum, Ruhr University, Bochum, Germany, 2inVentiv Health, Princeton, NJ, 3Inflammation & Immunology, Pfizer, Collegeville, PA, 4Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA

    Background/Purpose: Traditionally, radiographic imaging was used to describe morphological differences between various types of axial SpA (axSpA). MRI has advanced understanding of disease, enabled earlier…
  • Abstract Number: 698 • 2016 ACR/ARHP Annual Meeting

    Performance of Modified Minimal Disease Activity (MDA) in Patients with Peripheral Spondyloarthritis

    Laura C. Coates1, Sonya Abraham2, William Tillett3, Philip J Mease4, Sofia Ramiro5, Yinglin Xia6, Xin Wang7, Aileen L. Pangan7 and In-Ho Song7, 1University of Leeds, Leeds, United Kingdom, 2NIHR/Wellcome CRF, Imperial College Healthcare NHS Trust, London, United Kingdom, 3Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 4Swedish Medical Center and University of Washington, Seattle, WA, 5Leiden University Medical Center, Leiden, Netherlands, 6University of Illinois at Chicago, Chicago, IL, 7AbbVie Inc., North Chicago, IL

    Background/Purpose: Due to lack of validated outcome measures in non-psoriatic peripheral spondyloarthritis (pSpA), recent studies in this patient (pt) population have used varying endpoints [1].…
  • Abstract Number: 699 • 2016 ACR/ARHP Annual Meeting

    In Contrast to Men, Women with Nonradiographic Axial Spondyloarthritis Have Lower Response Rates to TNF Inhibitors Than Women with Ankylosing Spondylitis

    Adrian Ciurea1, Monika Hebeisen2, Ulrich Weber3,4, Giorgio Tamborrini5, Raphael Micheroli1, Lukas Wildi1, Pascal Zufferey6, Michael J. Nissen7, Peter M. Villiger8, Juerg Bernhard9, Désirée van der Heijde10, RBM Landewé11,12, Almut Scherer2 and Pascale Exer13, 1Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2SCQM Foundation, Zurich, Switzerland, 3Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark, 4Department of Research, King Christian 10th Hospital for Rheumatic Diseases, Graasten, Denmark, 5Department of Rheumatology and Musculoskeletal Ultrasound, Bethesda Hospital Basel, Basel, Switzerland, 6Rheumatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, 7Rheumatology, Geneva University Hospital, Geneva, Switzerland, 8Rheumatology, Clinical immunology & Alllergology, University Hospital Bern, Bern, Switzerland, 9Rheumatology Center, Buergerspital, Solothurn, Switzerland, 10Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 11Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 12Zuyderland Medical Center, Heerlen, Netherlands, Heerlen, Netherlands, 13Private rheumatology practice, Basel, Switzerland

    Background/Purpose: Response to tumor necrosis factor inhibition (TNFi) has been shown to be similar in nonradiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) in patients…
  • Abstract Number: 700 • 2016 ACR/ARHP Annual Meeting

    Incidence of Inflammatory Bowel Disease Events in Adalimumab (HUMIRA) Clinical Trials Across Indications

    Jeffrey R. Curtis1, Dirk Elewaut2, Su Chen3, Maja Hojnik4, Navit Naveh5 and Jaclyn K. Anderson3, 1Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2VIB Inflammation Research Center, University of Ghent, Ghent, Belgium, 3AbbVie Inc., North Chicago, IL, 4AbbVie, Ljubljana, Slovenia, 5AbbVie, Hod HaSharon, Israel

    Background/Purpose:  Adalimumab (ADA) is approved for treatment of Crohn’s disease (CD) and ulcerative colitis (UC); therefore, it is postulated that new onset or flare of…
  • Abstract Number: 701 • 2016 ACR/ARHP Annual Meeting

    In Patients with Ankylosing Spondylitis Treated with Adalimumab, Combination Therapy with DMARD, Increase the Serum Level of Adalimumab and Decrease Immunogenicity

    José Rosas1, Francisca Llinares-Tello2, José Miguel Senabre-Gallego1, Mariana Marco-Mingot3, Ana Pons1, Xavier Barber4, Gregorio Santos-Soler1, Esteban Salas-Heredia1, Catalina Cano1, Juan Molina3, Marina Sanchís4, Mario García-Carrasco5 and AIRE-MB Group, 1Rheumatology, Hospital Marina Baixa, Villajoyosa (Alicante), Spain, 2Laboratory, Hospital Marina Baixa, Villajoyosa, Spain, 3Laboratory, Hospital Marina Baixa, Villajoyosa (Alicante), Spain, 4CIO, Universidad Miguel Hernández, Elche, Spain, 5Systemic Autoimmune Diseases Research Unit, HGR 36-CIBIOR Instituto Mexicano del Seguro Social, Puebla, Mexico

    Background/Purpose: In patients with rheumatoid arthritis, methotrexate (MTX), improves the clinical efficacy of anti-TNF (TNFi), among other reasons, for reducing the immunogenicity. However, there are…
  • Abstract Number: 702 • 2016 ACR/ARHP Annual Meeting

    Treatment with Golimumab or Infliximab Reduces Health Resource Utilization and Increases Work Productivity in Patients with Ankylosing Spondylitis in a Large, Prospective Real-Life Cohort

    Pascal Claudepierre1, Filip van Den Bosch2, Piercarlo Sarzi-Puttini3, Shiva Sajjan4, N Vastesaeger5, Marinella Govoni6 and Sumesh Kachroo7, 1Hôpital Henri Mondor, Créteil, France, 2Rheumatology, Ghent University Hospital, Ghent, Belgium, 3Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milano, Italy, 4Merck & Co., Inc., Kenilworth, NJ, 5Merck Sharp & Dohme, Belgium, Brussels, Belgium, 6Via Tasso 14, Merck Sharp & Dohme, Italy, Cento, Italy, 7CORE, Merck & Co., Inc., Kenilworth, NJ

    Background/Purpose: We evaluated the effect of the anti-tumor necrosis factor (TNF) agents, golimumab (GLM) and infliximab (IFX), on healthcare resource utilization (HCRU) and work productivity…
  • Abstract Number: 703 • 2016 ACR/ARHP Annual Meeting

    Performance of a New Spinal Mobility Index for Patients with Axial Spondyloarthritis

    Graciela Betancur1, Fernando Andres Sommerfleck2, Ana Lizarraga1, Natalia Zamora3, Maria Celeste Orozco3, Susana Gagliardi4, Emilce Schneeberger5 and Gustavo Citera5, 1Reumatologia, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 2Rheumatologia, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 3Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 4Rheumatology, Instituto de Rehabilitación Psicofísica, CABA, Argentina, 5Rheumatology Section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina

    Background/Purpose:  ASAS recommends using BASMI for evaluation of axial mobility in patients with Axial Spondyloarthritis (axSpA). The EDASMI (Edmonton Ankylosing Spondylitis Metrology Index) is another…
  • Abstract Number: 704 • 2016 ACR/ARHP Annual Meeting

    Does Change in Disease Activity over One Year Result in Change in Health-Related Quality of Life in Early Axial Spondyloarthritis Patients?

    Miranda van Lunteren1, Zineb Ez-Zaitouni1, Pauline Bakker1, Hanne Dagfinrud2, Robert Landewé3, Maikel van Oosterhout4, Roberta Ramonda5, Floris van Gaalen1 and Désirée van der Heijde1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Rheumatology, Academic Medical Center, Amsterdam, Netherlands, 4Rheumatology, Groene Hart Ziekenhuis, Gouda, Netherlands, 5Rheumatology Unit, University of Padova, Padova, Italy

    Background/Purpose: In axial Spondyloarthritis (axSpA), treatment is targeted at reducing disease activity  with the aim of improving the health-related quality of life (HRQoL). Therefore, it…
  • Abstract Number: 705 • 2016 ACR/ARHP Annual Meeting

    Is a Positive Family History of Spondyloarthritis of Value in Patients with Chronic Back Pain? Results from Two Large Early Back Pain Cohorts

    Zineb Ez-Zaitouni1, Laure Gossec2, Inger Jorid Berg3, Robert Landewé4, Maikel van Oosterhout5, Mariagrazia Lorenzin6, Maxime Dougados7, Désirée van der Heijde8 and Floris van Gaalen1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Paris 06 University and AP-HP, Hôpital Pitié Salpêtrière, Paris, France, 3Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Amsterdam Medical Center, Amsterdam, Netherlands, 5Rheumatology, Groene Hart Hospital, Gouda, Netherlands, 6Rheumatology Unit, Department of Medicine DIMED, Rheumatology Unit,University of Padova, Padova, Italy, 7Paris-Descartes University, Paris, France, 8Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: To assess whether presence of spondyloarthritis (SpA) manifestations in first- and second-degree relatives of patients with chronic back pain (CBP) is associated with higher…
  • Abstract Number: 706 • 2016 ACR/ARHP Annual Meeting

    Performance of the ASAS Classification Criteria for Axial and Peripheral Spondyloarthritis – a Systematic Literature Review and Meta-Analysis

    Alexandre Sepriano1, Roxana Rubio1, Sofia Ramiro1, Robert Landewé2 and Désirée van der Heijde3, 1Leiden University Medical Center, Leiden, Netherlands, 2Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands, 3Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The Assessment of SpondyloArthritis international Society (ASAS) has developed and validated classification criteria for axial spondyloarthritis (axSpA) and peripheral SpA (pSpA). Following their release,…
  • Abstract Number: 707 • 2016 ACR/ARHP Annual Meeting

    Anti-TNF Drugs Are Not Associated with Increasead Risk of Hzv Infections in Patients with Spondyloarthritis (SpA): Results from the GISEA Registry

    Fabiola Atzeni1, Marco Sebastiani2, Valentina Panetta3, Fausto Salaffi4, Florenzo Iannone5, Elisa Gremese6, Antonio Carletto7, Antonio Marchesoni8, Roberto Gorla9, Marcello Govoni10, Rosario Foti11, Ennio G. Favalli12, Roberta Ramonda13, Pier Carlo Sarzi-Puttini14, Giovanni Lapadula15 and Gianfranco Ferraccioli16, 1Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milano, Italy, 2SC Reumatologia, Dipartimento di Medicine, Medicina d’Urgenza e Specialità Mediche, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy, 3L'altrastatistica -Consultancy & Training- Biostatistics office., Rome, Italy, 4Rheumatology Department, Polytechnic University of Marche, C. Urbani Hospital, Jesi,, Ancona, Italy, 5Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, General Hospital, Bari, Italy, 6Division of Rheumatology, Institute of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy, 7Rheumatology Unit, University of Verona, Verona, Italy, 8Department of Rheumatology, Gaetano Pini Institute, Milan, Italy, 9Rheumatology and Immunology Unit, Spedali Civili di Brescia, Brescia, Italy, 10Medical Sciences, UOC of Rheumatology, University Hospital S. Anna, Cona Ferrara, Italy, 11Rheumatology Unit, Vittorio-Emanuele University Hospital of Catania, Catania, Italy, 12Department and Chair of Rheumatology, University of Milan, Gaetano Pini Institute, Milan, Italy, 13Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padova, Italy, 14Rheumatology Unit, L. Sacco University Hospital, Milan, Italy, 15Rheumatology Unit, University of Bari, Bari, Italy, 16Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy

    Background/Purpose: Herpes zoster virus (HZV) reactivation disproportionately affects patients with systemic rheumatic diseases and it is commonly described in short- and long-term use of anti-Tumor…
  • Abstract Number: 708 • 2016 ACR/ARHP Annual Meeting

    Development of Spondyloarthritis-Features in Patients with Chronic Back Pain over a One-Year Course: Data from the Spondyloarthritis Caught Early (SPACE)-Cohort

    Zineb Ez-Zaitouni1, Miranda van Lunteren1, Pauline Bakker1, Inger Jorid Berg2, Robert Landewé3, Maikel van Oosterhout4, Augusta Ortolan5, Désirée van der Heijde1 and Floris van Gaalen1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands, 4Rheumatology, Groene Hart Hospital, Gouda, Netherlands, 5Rheumatology Unit, Department of Medicine DIMED, Rheumatology Unit,University of Padova, Padova, Italy

    Background/Purpose: Little is known on the development of spondyloarthritis (SpA)-features over time in patients with recent onset chronic back pain (CBP). The aim was to…
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