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  • Abstract Number: 558 • 2016 ACR/ARHP Annual Meeting

    Clinical,  Sonographic and Immunological Biomarkers of Ramris Progression in RA Patients in Clinical Remission: A Prospective Study with 12 Months of Follow-up

    Julio Ramírez1, Andrea Cuervo2, Jose Antonio Narváez3, Virginia Ruiz-Esquide2, Javier Hernández-Gañán3, Raquel Celis4, Jose Inciarte-Mundo2, M. Victoria Hernández2, Jose L. Pablos5, Raimon Sanmarti2 and Juan D. Cañete2, 1Rheumatology, Hospital Clínic, Barcelona, Spain, 2Rheumatology Department, Hospital Clínic de Barcelona, Barcelona, Spain, 3Radiology, Hospital Bellvitge, Barcelona, Spain, 4Rheumatology, Arthritis Unit, Barcelona, Spain, 5Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain

    Background/Purpose: To determine clinical, sonographic and immunological biomarkers predicting structural damage progression at 12 months of follow-up as measured by Magnetic Resonance Imaging (MRI) in a…
  • Abstract Number: 559 • 2016 ACR/ARHP Annual Meeting

    Comparison of Multi-Dimensional Health Assessment Questionnaire (MD-HAQ)-Based and Patient-Reported Outcomes Measurement Information System (PROMIS) 29-Based Routine Assessment of Patient Index 3 (RAPID3) for Assessing Rheumatoid Arthritis Disease Activity

    Yong Gil Hwang1, Juan (June) Feng2, Heather Eng2, Jason Lyons2, Anthony Fabio2 and Larry W. Moreland1, 1Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 2Epidemiology, University of Pittsburgh, School of Public Health, Pittsburgh, PA

    Background/Purpose:   Patient-reported outcomes measurement information system (PROMIS) 29 is recommended by the National Institute of Health (NIH) consensus panel as the preferred battery of…
  • Abstract Number: 560 • 2016 ACR/ARHP Annual Meeting

    There Is No Further Gain from Calculating Disease Activity Score in 28 Joints with High Sensitivity Assays of C-Reactive Protein Because of High Intraindividual Variability of CRP: A Cross Sectional Study and Theoretical Consideration

    Inger Marie J. Hansen1,2,3, Rikke Asmussen4, Steen Antonsen5 and Amir Emamifar6, 1Department of Reumatology, OUH, Svendborg Hospital, Svendborg, Denmark, 2University of Southern Denmark, 5000 Odense, Denmark, 3DANBIO, Glostrup, Denmark, 4Dep. of Rheumatology, OUH, Svendborg Hospital, Svendborg, Denmark, 5Biochemestry, OUH, Svendborg Hospital, 5700 Svendborg, Denmark, 6Rheumatology, OUH, Svendborg Hospital, 5700 Svendborg, Denmark

    Background/Purpose: The threshold for reporting of C-reactive protein (CRP) differs from laboratory to laboratory. Moreover, CRP values are affected by the intra individual biological variability.[1]…
  • Abstract Number: 561 • 2016 ACR/ARHP Annual Meeting

    Sodium Intake Is Increased in Patients with Early Rheumatoid Arthritis and Is Associated with Radiographic Erosions

    sarah marouen1, Guilhem du Cailar2, Rachel Audo3, Cédric Lukas4, Gaelle Vial5, Anne Tournadre6, Emmanuel Barrat7, Jean Ribstein2, Bernard Combe8, Jacques Morel9 and Claire I. Daien10, 1Rhumatology Department, Lapeyronie Hospital and Montpellier University, Montpellier, France, 2Internal Medicine and Hypertension, Hopital Lapeyronie, Montpellier, France, 3Rheumatology, Teaching Hospital of Lapeyronie, Montpellier, France, 4Rheumatology, CHU Lapeyronie and EA2415, Montpellier University, University of Montpellier, France, 5Rheumatology, Gabriel Montpied Hospital and Clermont Ferrand University, Clermont Ferrand, France, 6Rheumatology, UNH-UMR 1019 INRA University of Auvergne and Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, 7Recherche et Développement, Laboratoire Lescuyer, AYTRE, France, 8Département Rhumatologie, Hôpital Lapeyronie, Montpellier, France, 9Rheumatology, Department of Rheumatology, Montpellier University Hospital, Montpellier, France, 10Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease resulting from an interaction between genetic and environmental factors. Recently, sodium intake was suggested as a risk…
  • Abstract Number: 562 • 2016 ACR/ARHP Annual Meeting

    Does Surgical Intervention to the Upper Extremity Make the Patients with Rheumatoid Arthritis Happy?

    Asami Abe1, Hajime Ishikawa2 and Akira Murasawa3, 1Rheumatplogy, Niigata Rheumatic Center, Shibata, Japan, 2Niigata Rheumatic Center, Shibata, Japan, 3Department of Rheumatology, Niigata Rheumatic Center, Shibata, Japan

    Background/Purpose: Disease activity dramatically ameliorated with the use of bDMARD or a recently appeared tsDMARD and more than one-half of the patients with RA were…
  • Abstract Number: 563 • 2016 ACR/ARHP Annual Meeting

    Factors Associated with Cognitive Impairment in Korean Adults with Rheumatoid Arthritis

    So Young Shin1, Joo Hyun Lee2 and Bo Young Yoon3, 1Department of Nursing, Inje University, College of Medicine, Department of Nursing, Busan, Korea, The Republic of, 2Rheumatology/Internal medicine, Inje University Ilsan Paik Hospital, Goyang, Korea, The Republic of, 3Rheumatology/Internal medicine, Inje Iniversity Ilsan Paik Hospital, Goyang, Korea, The Republic of

    Background/Purpose:  For persons with chronic diseases such as rheumatoid arthritis (RA), intact cognitive function is crucial for performing main daily activities and adhering to self-management…
  • Abstract Number: 564 • 2016 ACR/ARHP Annual Meeting

    Serum Adiponectin and Body Composition in a Group of Patients with Rheumatoid Arthritis: Relationship Between Disease Parameters

    PINAR BORMAN1,2, Seçil Vural3, Seher Kocaoglu4, Damla Dedebayraktar5, Sümeyra Öteleş5, Pelin Bilgiç5 and Hatice Sürer6, 1Dept of PMR, University of Hacettepe Faculty of Medicine, Ankara, Turkey, 2Dept of PMR, University of Hacettepe, Ankara, Turkey, 3Ankara Education and Research Hospital, Ankara, Turkey, 4Department of 1st Physical Medicine and Rehabilitation, Ministry of Health Ankara Education and Research Hospital, Ankara, Turkey, 5Dept of Nutrition and Dietetics, University of Hacettepe, Ankara, Turkey, 6Dept of Biochemistry, Ankara Education and Research Hospital, Ankara, Turkey

    Background/Purpose: Patients with rheumatoid arthritis (RA) tend to have impaired distribution of adipose tissue and may have the risks of metabolic complications (1,2). The aim…
  • Abstract Number: 565 • 2016 ACR/ARHP Annual Meeting

    Factors Associated with Gastrointestinal Tolerance in Patients with Rheumatoid Arthritis and Methotrexate Daily Doses

    Adriana Nallely Rangel-Botello1, Marco Ulises Martinez-Martinez2, Carlos Abud Mendoza1, Alexa Bazua Gerez3, Ángel Cárdenas Hernández3, Luis Domínguez Salgado3, José Espinoza Martínez3, Héctor García González3, Oswaldo González Rivera3, Gustavo Hernández de la Cruz3, Germán Magaña Ávila3, Miguel Martínez Rojas3 and Mariana Moctezuma Dávila3, 1Unidad de Investigaciones Reumatológicas y Osteoporosis, Faculty of Medicine, Universidad Autónoma de San Luis Potosí and Hospital Central, San Luis Potosí, Mexico, 2Unidad de Investigaciones Reumatológicas, Faculty of Medicine, Universidad Autónoma de San Luis Potosí and Hospital Central, San Luis Potosí, Mexico, 3Faculty of Medicine, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico

    Background/Purpose: Methotrexate (MTX) is the cornerstone of rheumatoid arthritis (RA) treatment. We reported the liver safety with daily dose of MTX1. Weekly doses of MTX…
  • Abstract Number: 566 • 2016 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Patients’ Ability to Accurately Recall DMARD Information Immediately Following an Office Visit with Their Rheumatologist

    Delesha Carpenter1, Lorie Geryk2, Courtney Roberts2, Beth L. Jonas3 and Susan J. Blalock4, 1Division of Pharmaceutical Outcomes and Policy, University of North Carolina Eshelman School of Pharmacy, Asheville, NC, 2Division of Pharmaceutical Outcomes and Policy, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC, 3Thurston Arthritis Research Ct, University of North Carolina Thruston Arthritis Research Center, Chapel Hill, NC, 4Eshelman School of Pharmacy, UNC at Chapel Hill, Chapel Hill, NC

    Background/Purpose: Patient misunderstandings about DMARDs may contribute to nonadherence. We present longitudinal observational data regarding whether patients can accurately recall medication information about a newly-prescribed…
  • Abstract Number: 567 • 2016 ACR/ARHP Annual Meeting

    Understanding Contextual Factors That Influence Decisions Related to Health and Work Among People with Recently Diagnosed Rheumatoid Arthritis

    Graham Macdonald1, Catherine Backman2, Anne F. Townsend3 and Linda Li4, 1Occupational Science and Occupational Therapy, University of British Columbia, Vancouver, BC, Canada, 2Occup Science & OccupTherapy, University of British Columbia, Vancouver, BC, Canada, 3Qualitative Research, Arthritis Research Centre of Canada, Richmond, BC, Canada, 4Department of Physical Therapy, The University of British Columbia, Vancouver, BC, Canada

    Background/Purpose:  In rheumatoid arthritis (RA), early diagnosis and treatment are essential to better outcomes. Many people defer seeking help or treatment for reasons that are…
  • Abstract Number: 568 • 2016 ACR/ARHP Annual Meeting

    Triggering Receptor Expressed on Myeloid Cells (TREM) As a Novel Indicator of Disease Progression in ‘at-Risk’ Individuals

    Laura Hunt1, Sahar Musaad1,2, John Stephenson3, Becki Burn2, Isao Matsuura1, Kulveer Mankia1, Jackie L. Nam1 and Paul Emery1, 1NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2Microbiology, Calderdale & Huddersfield NHS Foundation Trust, Huddersfield, United Kingdom, 3Department Health Sciences, University of Huddersfield, Huddersfield, United Kingdom

    Background/Purpose: Whilst the exact aetiology of rheumatoid arthritis (RA) remains unclear, current concepts suggest an environmental link with possible microbial triggers.  Studying individuals at-risk of…
  • Abstract Number: 570 • 2016 ACR/ARHP Annual Meeting

    A Molecular Timeline for Preclinical RA Pathogenesis Defined By Dysregulated PTPN22, Hypercitrullination, and Aberrant Cytokine/Metabolic Profiles in PBMC of at-Risk Individuals

    Hui-Hsin Chang1, Nishant Dwivedi2, Bo Sun2, Deepak A. Rao3, Jeffrey A. Sparks3, Jennifer Kinslow4, Yuko Okamoto4, Kevin D. Deane5, M. Kristen Demoruelle6, Jill M. Norris7, Elizabeth Karlson2, V. Michael Holers8 and I-Cheng Ho1, 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 3Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 4University of Colorado School of Medicine, Aurora, CO, 5Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 6Rheumatology, University of Colorado School of Medicine, Aurora, CO, 7Epidemiology, Colorado School of Public Health, Aurora, CO, 8Rheumatology Division, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: One unique feature of RA is the presence of ACPA. PTPN22 is a phosphatase that also acts to suppress citrullination independently of its phosphatase…
  • Abstract Number: 571 • 2016 ACR/ARHP Annual Meeting

    High Titer Rheumatoid Arthritis Antibodies Distinguish Between PAD2 and PAD4 Citrullinated Fibrinogen

    Nathalie Blachere1,2, Salina Parveen1, Mayu Frank1, Brian D. Dill1, Henrik Molina1 and Dana E. Orange1,3,4, 1The Rockefeller University, New York, NY, 2Howard Hughes Medical Institute, Chevy Chase, MD, 3Rheumatology, Hospital for Special Surgery, New York, NY, 4The New York Genome Center, New York, NY

    Background/Purpose: Most patients with rheumatoid arthritis (RA) harbor antibodies to citrullinated autoantigens, such as citrullinated fibrinogen. Two isoforms of peptidylarginine deiminase (PAD), PAD2 and PAD4,…
  • Abstract Number: 572 • 2016 ACR/ARHP Annual Meeting

    Anti-Periodontal Bacteria Antibody Titers Are Inversely Correlated with ACPA in RA-Free Individuals with Periodontal Disease Compared to Community Controls

    Emma Weeding1, Londyn Robinson2, Jeremy Sokolove3, Julie Marchesan4, Steven Offenbacher4, William H. Robinson3, Ryan Demmer5, Bryan Michalowicz6 and Jerry A. Molitor7, 1Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 2University of Minnesota, Minneapolis, MN, 3Stanford University School of Medicine, Stanford, CA, 4Department of Periodontology, Dental School, University of North Carolina at Chapel Hill, Chapel Hill, NC, 5Epidemiology, Columbia University Mailman School of Public Health, New York, NY, 6Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, 7Rheumatic/Autoimmune Diseases, University of Minnesota, Minneapolis, MN

    Background/Purpose: Rheumatoid arthritis (RA) and periodontal disease (PD) are comorbid conditions that share multiple underlying risk factors and pathophysiological features. A dysbiotic periodontal microbiome might…
  • Abstract Number: 573 • 2016 ACR/ARHP Annual Meeting

    Synovial Fibroblast-Neutrophil Interactions Promote Pathogenic Adaptive Immunity in Rheumatoid Arthritis

    Carmelo Carmona-Rivera1, Erica Moore2, Nithya Lingampalli3, Hannes Uchtenhagen4, Eddie James5, Kevin L. Bicker6, Heidi Wähämaa7, Victoria Hoffmann8, Anca I Catrina7, Paul Thompson9, Jane H. Buckner5, William Robinson10, David Fox11 and Mariana Kaplan2, 1Systemic Autoimmunity Branch/ NIAMS, National Institutes of Health, Bethesda, MD, 2Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 4Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, 5Benaroya Research Institute at Virginia Mason, Seattle, WA, 6Middle Tennessee State University, Murfreesboro, TN, 7Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 8Division of Veterinary Resources, National Institutes of Health, Bethesda, MD, 9University of Massachusetts, Worcester, MA, 10Stanford University School of Medicine, Stanford, CA, 11Department of Medicine [Division of Rheumatology], University of Michigan, Ann Arbor, MI

    Background/Purpose:   Methods:   Results:   Conclusion:  
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