Abstracts Archive - Page 1454 of 2607 - ACR Meeting Abstracts

Abstract Number: 1001 • 2017 ACR/ARHP Annual Meeting
Persistence, Discontinuation, and Switching Patterns Among Ankylosing Spondylitis Patients Newly Initiating Biologic Therapy
Theresa Hunter¹, Krista Schroeder², Sarah Al Sawah² and David Sandoval Calderon², ¹Global Patient Outcomes and Real World Evidence, Eli Lilly and Company, Indianapolis, IN, ²Eli Lilly and Company, Indianapolis, IN
Background/Purpose: The primary goals of treating Ankylosing Spondylitis (AS) patients are to maximize long-term health-related quality of life through control of symptoms and inflammation, prevention…
Abstract Number: 1002 • 2017 ACR/ARHP Annual Meeting
Survival and Years of Potential Life Lost in Connective Tissue Disease and Vasculitis; Data from the Norwegian Connective Tissue Diseases and Vasculitis Registry (NOSVAR)
Torhild Garen¹, Karoline Lerang¹, Anna Maria Hoffmann-Vold², Helena Andersson¹, Øyvind Midtvedt¹, Karin Kilian¹, Ragnar Gunnarsson¹, Birgir Gudbrandsson¹, Gudrun Norby¹, Oyvind Molberg² and Øyvind Palm¹, ¹Department of Rheumatology, Oslo University Hospital, Oslo, Norway, OSLO, Norway, ²Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway
Background/Purpose: Survival is decreased in patients with connective tissue diseases (CTDs) and vasculitis, however few studies have compared the mortality between the specific diseases prospectively…
Abstract Number: 1003 • 2017 ACR/ARHP Annual Meeting
Hair Treatments and the Risk of Systemic Lupus Erythematosus: the Michigan Lupus Epidemiology & Surveillance (MILES) Program
Emily C. Somers¹, Christina Mrukowicz², Wendy Marder¹, W. Joseph McCune³, Afton L. Hassett⁴, Suzanna Zick⁵, Siobán Harlow⁶ and Caroline Gordon⁷, ¹Internal Medicine-Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan, Ann Arbor, MI, ³Int Med/ Rheum, University of Michigan, Ann Arbor, MI, ⁴Rheumatology, Emory University, Atlanta, GA, ⁵Department of Family Medicine, University of Michigan, Ann Arbor, MI, ⁶Epidemiology Department- School of Public Health, Obstetrics and Gynecology- Medical School, University of Michigan, Ann Arbor, MI, ⁷School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Hair dye exposure has been reported as a risk factor for systemic lupus erythematosus (SLE) and connective tissue diseases, though conflicting results exist. We…
Abstract Number: 1004 • 2017 ACR/ARHP Annual Meeting
Arthritis Impact at the State and County Level — United States, 2015
Kamil E. Barbour¹, Suson Moss², Janet Croft², Jennifer M. Hootman³, Louise Murphy⁴, Kristina Theis², Yan Wang², Hua Lu², Teresa J. Brady¹ and Charles G. Helmick², ¹Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ²Centers for Disease Control and Prevention, Atlanta, GA, ³Centers for Disease Control and Prevention, Kennesaw, GA, ⁴Division of Population Health, Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Arthritis, a leading cause of disability, affects 54.4 million US adults. By knowing the state and county level arthritis impact, state-level public health professionals…
Abstract Number: 1005 • 2017 ACR/ARHP Annual Meeting
The Prevalence of Patellofemoral Osteoarthritis in China: A Multi-Center Population-Based Cross-Sectional Study
Zhanglai Li¹, Qiang Liu¹, Changsheng Zhao², Yuqing Zhang³, Xiaowei Li¹ and Jianhao Lin¹, ¹Arthritis Clinic and Research Center, Peking University People's Hospital,Peking University, Beijing, China, ²Peking University International Hospital, Peking University International Hospital, Beijing, China, ³School Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: To describe the prevalence and risk factors of patellofemoral osteoarthritis (OA) in a Chinese population.Methods: A multi-center population-based cross-sectional survey was conducted in 2015…
Abstract Number: 1006 • 2017 ACR/ARHP Annual Meeting
Sex Differences in Depressive Symptom Subtypes in Knee Osteoarthritis
Alan Rathbun¹, Megan Schuler², Elizabeth Stuart³, Michelle Shardell⁴, Michelle S. Yau⁵ and Marc Hochberg⁶, ¹Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, ²Rand Coportation, Boston, MA, ³Mental Health, Biostatistics, and Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁴Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, ⁵Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, ⁶Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Knee osteoarthritis (OA) is characterized by structural changes in subchondral bone and degradation of articular cartilage, but the pathology does not necessarily lead to…
Abstract Number: 1007 • 2017 ACR/ARHP Annual Meeting
Smoking Signicantly Reduces Effectiveness and Long-Term Survival of Biologic Treatment in Patients with Rheumatoid Arthritis
Roger Rolon Campuzano¹, Andrea Lujan Coronel Ale¹, Osvaldo Luis Cerda¹, Fernando Dal Pra¹, Emilce E Schneeberger¹, María de los Angeles Correa², Marcos Rosemffet¹, Emilio Buschiazzo³, Rodrigo Garcia Salinas⁴, Silvia Papasidero⁵, Belén Barrios⁵, Hernán Maldonado Ficco⁶ and Gustavo Citera⁷, ¹Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Buenos Aires, Argentina, ²Section Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Buenos Aires, Argentina, ³Section of Rheumatology, Hospital Señor del Milagro, Salta, Argentina, Salta, Argentina, ⁴Section of Rheumatology, Hospital Italiano de La Plata, Buenos Aires, Argentina, La Plata, Argentina, ⁵Section of Rheumatology, Hospital General de Agudos “Dr. E. Tornú”, Buenos Aires, Argentina, Buenos Aires, Argentina, ⁶section of Rheumatology, Clinica Regional del Sud, Córdoba, Argentina, Córdoba, Argentina, ⁷Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Buenos Aires, Argentina
Background/Purpose: The introduction of biological agents has been an important advance in the treatment of RA. However, they are not exempt from adverse events and…
Abstract Number: 1008 • 2017 ACR/ARHP Annual Meeting
mtDNA Cybrids from OA Patients Are Less Efficient Using Glycolysis and Are More Susceptible to Apoptosis Under Stress Conditions
Mercedes Fernandez Moreno^1,2, Tamara Hermida-Gómez³, Andrea Dalamao-Fernandez⁴, M. Eugenia Vazquez Mosquera⁴, Estefanía Cortés-Pereira¹, Morena Scotece⁴, Sara Relaño-Fernandez⁵, Ignacio Rego-Pérez¹ and Francisco J Blanco⁶, ¹Servicio de Reumatología. Area Genomica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²CIBER-BBM, Madrid, Spain, ³Rheumatology, INIBIC. Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. CIBER-BBN., A Coruña, Spain, ⁴Servicio de Reumatología. Area Genomica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A CORUÑA, Spain, ⁵Plataforma de Genómica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ⁶Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruña, Spain
Background/Purpose: Previous studies have showed that chondrocytes from OA patients had mitochondrial alteration in comparison with healthy. However the role of mitochondria in the biological…
Abstract Number: 1009 • 2017 ACR/ARHP Annual Meeting
Novel Non-Coding RNAs Associated with Rheumatoid Arthritis in Asians By Gene-Based Testing
Aleksander Lenert¹ and David W. Fardo², ¹Internal Medicine, Div. of Rheumatology, University of Kentucky, Lexington, KY, ²Biostatistics, College of Public Health, University of Kentucky, Lexington, KY
Background/Purpose: Rheumatoid arthritis (RA) is a complex genetics disease driven by multiple genetic contributors as evidenced by association with over 100 risk SNPs by GWAS.…
Abstract Number: 1010 • 2017 ACR/ARHP Annual Meeting
Identification of Circulating Biomarkers of Disease Activity and Organ Involvement in ANCA-Associated Vasculitis By Targeted Proteomics
Jun Ishizaki¹, Ayako Takemori², Koichiro Suemori¹, Takuya Matsumoto¹, Yoko Akita¹, Masaki Yasukawa¹, Nobuaki Takemori² and Hitoshi Hasegawa¹, ¹Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Ehime, Japan, ²Division of Proteomics Research, Proteo-Science Center, Ehime University, Ehime, Japan
Background/Purpose: Targeted proteomics, which involves quantitative analysis of targeted proteins using selected reaction monitoring (SRM) mass spectrometry, has emerged as a new methodology for discovery…
Abstract Number: 1011 • 2017 ACR/ARHP Annual Meeting
Mitochondrial Haplogroups-Mediated Methylation Regulates Apoptosis in Osteoathritis Cartilage
Ignacio Rego-Pérez¹, Estefanía Cortés-Pereira¹, Juan Fernández-Tajes Sr.², Mercedes Fernandez Moreno¹, Maria Eugenia Vazquez Mosquera¹, Sara Relaño-Fernandez³, Natividad Oreiro⁴, Carlos Fernandez-Lopez¹ and Francisco J Blanco¹, ¹Servicio de Reumatología. Area Genomica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²The Wellcome Trust Center for Human Genetics. McCarthy´s Group. University of Oxford, Oxford, United Kingdom, ³Plataforma de Genómica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ⁴1) Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruna, Spain
Background/Purpose: Recent studies revealed that haplogroup J associates with a decreased rate of incident knee Osteoarthritis. Among the functional characteristics of this haplogroup, lower rates…
Abstract Number: 1012 • 2017 ACR/ARHP Annual Meeting
Analysis of microRNAs in Familial Mediterranean Fever
Gil Amarilyo¹, Nir Pillar², Ilan Ben-Zvi³, Daphna Weissglas-Volkov², Jonatan Zalcman², Liora Harel⁴, Avi Livneh³ and Noam Shomron², ¹Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel Aviv University, Petach Tikva, Israel, ²Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, ³Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁴Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Background/Purpose: Familial Mediterranean fever (FMF) is thought to be inherited as an autosomal recessive trait. However, there are frequent deviations from this model. The aim…
Abstract Number: 1013 • 2017 ACR/ARHP Annual Meeting
HLA-Class II Associations with ANCA-Associated Vasculitis in the Japanese Population: Different Features from European Populations
Aya Kawasaki¹, Fumio Hirano², Ken-ei Sada³, Shigeto Kobayashi⁴, Hidehiro Yamada⁵, Hiroshi Furukawa¹, Kenji Nagasaka⁶, Takahiko Sugihara⁷, Kunihiro Yamagata⁸, Takayuki Sumida⁹, Shigeto Tohma¹⁰, Shoichi Ozaki⁵, Seiichi Matsuo¹¹, Hiroshi Hashimoto¹², Hirofumi Makino¹³, Yoshihiro Arimura¹⁴, Masayoshi Harigai¹⁵ and Naoyuki Tsuchiya¹, ¹Molecular and Genetic Epidemiology Laboratory, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ²Departments of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ³Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ⁴Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, ⁵Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁶Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan, ⁷Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, ⁸Department of Nephrology, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ⁹Department of Internal Medicine, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ¹⁰Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ¹¹Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ¹²Juntendo University School of Medicine, Tokyo, Japan, ¹³Okayama University Hospital, Okayama, Japan, ¹⁴First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan, ¹⁵Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: HLA-class II region harbors the strongest genetic factors for ANCA-associated vasculitis (AAV), and differences in the genetic background of HLA-class II may partly explain…
Abstract Number: 1014 • 2017 ACR/ARHP Annual Meeting
The Rheumatic Disease Data Refinery: A Case Study in Integrative Genomics Reveals Complex IFN Signatures in Therapeutic Studies in SLE
Jaclyn N Taroni and Casey S. Greene, Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Over the past 15 years, more than 10,000 whole tissue biopsies from patients with rheumatic diseases have been deposited into publicly available gene expression…
Abstract Number: 1015 • 2017 ACR/ARHP Annual Meeting
Key Genes and Pathways between Rheumatoid Arthritis and Osteoarthritis By Integrative Genome-Wide Gene Expression Profiling Analysis
Rongqiang Zhang^1,2, Aimin Yang³, Xiaomei Ren², Jie Zhang³, Xiaoli Yang⁴, Qiling Liu², Na Sun², Puwei Yuan⁵ and Yongmin Xiong⁴, ¹School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of the National Health and Family Planning Commission, Xi'an 710061, China, Xi'an, China, ²Shaanxi University of Chinese Medicine, Xianyang 712046, China, Xianyang, China, ³School of Public Health, Brown University, Providence, RI 02906, US, Providence, RI, ⁴School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of the National Health and Family Planning Commission, Xi'an 710061, China, Xian, China, ⁵Shaanxi University of Chinese Medicine, Xianyang 712046, China, XianYang, China
Background/Purpose: Rheumatoid arthritis (RA) and Osteoarthritis (OA) are two most common types of joint diseases with lots of similar symptoms, and their pathological mechanisms remain…

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