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  • Abstract Number: 498 • 2016 ACR/ARHP Annual Meeting

    Higher Serum Heavy Metals Concentrations Are Associated with Rheumatoid Arthritis : A Study of the Korean National Health and Nutrition Examination Survey (KNHANES)

    Sang Hyun Joo1, Dong Jin Go2,3, Eun Young Ahn3, Hyun Mi Kwon3, Joongyub Lee4 and Yeong Wook Song5,6, 1Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea, The Republic of, 2Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, The Republic of, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, The Republic of, 4Division of Clinical Epidemiology Medical Research Collaborating Center Biomedical Research Institution, Seoul National University Hospital, Seoul, Korea, The Republic of, 5Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, 61Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, The Republic of

    Background/Purpose: The heavy metal Cadmium (Cd) may contribute to the high risk of developing rheumatoid arthritis (RA) through the cigarette smoking and occupational exposure including…
  • Abstract Number: 499 • 2016 ACR/ARHP Annual Meeting

    High Levels of Mir-451a Differentiate Patients at Risk of Developing RA from Healthy Controls

    Klára Prajzlerová1, Veronika Hrušková2, Petra Hánová1, Heřman F Mann1, Karel Pavelka1, Jiří Vencovský3, Ladislav Šenolt1 and Mária Filková1, 1Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 2Institute of Rheumatology and Department of Rheumatology, Faculty of Science, Charles University in Prague, Prague, Czech Republic, 3Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

    Background/Purpose:  Individuals with clinically suspect arthralgia (CSA) with positivity of antibodies to citrullinated protein antigens (ACPA) have articular symptoms without clinical signs of arthritis. CSA…
  • Abstract Number: 500 • 2016 ACR/ARHP Annual Meeting

    Can Thiol/Disulphide Is a Novel Marker in Rheumatoid Arthritis?

    Sema Haliloglu1, cemile bicer2, Murat Alisik3, Bilge Ekinci4, Mehmet Emin Budak5, Omur volkan6, Hulya Uzkeser7 and Ayse Carlioglu8, 1Physical Medicine and Rehabilitation, Maltepe Occupational Diseases Hospital, Istanbul, Turkey, 2Biochemistry, Yildirim Beyazit University Medical Faculty, Ankara, Turkey, 3Biochemistry, Ataturk Training and Research Hospital, Ankara, Turkey, 4Physical Medicine and Rehabilitation, Erzurum Region Training and Research Hospital, Erzurum, Turkey, 5Endocrinology, Erzurum Region Training and Research Hospital, erzurum, Turkey, 6Rheumatology, Erzurum Region Training and Research Hospital, Erzurum, Turkey, 7Physical Medicine and Rehabilitation, Ataturk University,Medical Faculty, Erzurum, Turkey, 8Endocrinology, Erzurum Region Training and Research Hospital, Erzurum, Turkey

    Background/Purpose:  Rheumatoid arthritis is a chronic, systemic, autoimmune disease about 5% -%1 of world population affected. Highly reactive oxygen free radicals are believed to be…
  • Abstract Number: 501 • 2016 ACR/ARHP Annual Meeting

    Use of Rheumatologic Testing By Primary Care Physicians in Patients with Inflammatory Arthritis

    Dilpreet Singh1, Jasdeep Badwal1, Ritika Vankina1, Santhi Gokaraju2, Jennifer Friderici3, Scott Halista4 and Tara Lagu1, 1Baystate Medical Center/Tufts University School of Medicine, Springfield, MA, 2Presbyterian Hospital of Dallas, Dallas, TX, 3Baystate Medical Center, Springfield, MA, 4Arthritis Treatment Center, Springfield, MA

    Background/Purpose: Anti-cyclic citrullinated peptide antibody (Anti-CCP) is a diagnostic tool that predicts the progression of undifferentiated polyarthritis and erosive disease in rheumatoid arthritis (RA). It…
  • Abstract Number: 502 • 2016 ACR/ARHP Annual Meeting

    Use, Usability and Feasibility of a Mapp for Patients with Rheumatoid Arthritis – First Results

    Christina Kampling1, Gamal Chehab2, Hasan Acar1, Arnd Becker3, Matthias Schneider4 and Jutta G. Richter5, 1Policlinic of Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, 2Policlinic of Rheumatology, Heinrich-Heine-University, 40225 Duesseldorf, Germany, 3Ortenau Klinikum Offenburg-Gengenbach, Gengenbach, Gengenbach, Germany, 4Department of Rheumatology & Hiller Research Unit, Heinrich-Heine-University, Duesseldorf, Germany, 5Policlinic of Rheumatology and Hiller Research Unit Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

    Background/Purpose: Within the MiDEAR (Mobile medically supervised patient management in rheumatoid arthritis patients using DocuMed.rh and RheumaLive App) project patients (pts) with rheumatoid arthritis (RA)…
  • Abstract Number: 503 • 2016 ACR/ARHP Annual Meeting

    Anti-CCP Titer and Prevalence Is Influenced By Age at Rheumatoid Arthritis Onset- Analysis Based on a Nationwide Database in Japan

    Eri Kato1, Tetsuji Sawada1, Koichiro Tahara2, Haeru Hayashi2, Mayu Tago2, Hiroaki Mori2, Shigeru Yoshizawa3, Jinju Nishino4, Toshihiro Matsui5 and Shigeto Tohma6, 1Rheumatology, Tokyo Medical University, Shinjuku Tokyo, Japan, 2Rheumatology, Tokyo Medical University, Tokyo, Japan, 3Department of Rheumatology, Fukuoka Hospital, National Hospital Organization, Fukuoka, Japan, 4Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan, 5Lifetime Clinical Immunology, Tokyo Medical and Dental University, Tokyo, Japan, 6Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan

    Background/Purpose: Previous studies demonstrated the lower prevalence of anti-CCP antibody and rheumatoid factor (RF) in elderly-onset rheumatoid arthritis (EORA). However, anti-CCP antibody titer in EORA…
  • Abstract Number: 504 • 2016 ACR/ARHP Annual Meeting

    Clinical Significance of Multiple Autoantibody Specificities in Rheumatoid Arthritis: The Role of Anti-Citrullinated Alpha-Enolase and Anti-Interferon Inducible Protein 16 Antibodies

    Alessia Alunno1, Onelia Bistoni1, Federico Pratesi2, Valeria Caneparo3, Fabiana Topini1, Ilaria Puxeddu2, Marco De Andrea4, Santo Landolfo4, Paola Migliorini2 and Roberto Gerli1, 1Department of Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, 2Department of Clinical and Experimental Medicine, Clinical Immunology Unit, University of Pisa, Pisa, Italy, 3Department of Translational Medicine, Virology Unit, Novara Medical School, Novara, Italy, 4Department of Public Health and Pediatric Sciences, Viral Pathogenesis Unit, Turin Medical School, Torino, Italy

    Background/Purpose: Anti-cyclic citrullinated peptide (anti-CCP) auto-antibodies (auto-Abs) represent the current gold standard for the diagnosis of rheumatoid arthritis (RA). However, growing evidence suggests that a…
  • Abstract Number: 505 • 2016 ACR/ARHP Annual Meeting

    The Longitudinal Stability of the RA Biomarkers RF and ACPA in Classifying RA Subtypes over Extended Follow up

    Carl Orr, Francis Young and Douglas J. Veale, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland

    Background/Purpose: In recent years several studies suggest that first order stratification of RA should be based on the presence or absence of rheumatoid factor (RF)…
  • Abstract Number: 506 • 2016 ACR/ARHP Annual Meeting

    The Relationship Between Elevations in CRP with Physical Function and Radiographic Progression over the Long-Term in Patients with Rheumatoid Arthritis

    Arthur Kavanaugh1, Boulos Haraoui2, Prashanth Sunkureddi3, Benjamin Wolfe4, Li Wang4, Jessica Suboticki4 and Edward Keystone5, 1University of California San Diego, La Jolla, CA, 2University of Montreal, Montreal, QC, Canada, 3University of Texas Medical Branch, Galveston, TX, 4AbbVie Inc., North Chicago, IL, 5Mt. Sinai Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: For patients (pts) with rheumatoid arthritis (RA), quantification of radiographic progression, through measures such as modified total Sharp score (mTSS), is not routinely captured…
  • Abstract Number: 507 • 2016 ACR/ARHP Annual Meeting

    Comparison of Body Mass Index, Anti-Citrullinated Peptides Antibodies Status and Periodontal Condition in First Degree Relatives Individuals to Rheumatoid Arthritis

    Sonia Unriza-Puin1, Wilson Bautista-Molano2,3, Gloria Lafaurie4, Rafael R. Valle-Oñate5, Phillipe Chalem6, Lorena Chila3, Juan Manuel Bello7 and Consuelo Romero Sanchez3,8, 1Unit of Oral Basic Investigation, School of Dentistry, Universidad El Bosque, Bogota, Colombia, 2Rheumatology Department School of Medicine HMC / UMNG, Bogotá, Colombia, 3Unit of Oral Basic Investigation, School of Dentistry, Universidad El Bosque, Bogotá, Colombia, 4Unit of Oral Basic Investigation-UIBO, School of Dentistry, Universidad El Bosque, Bogotá, Colombia, 5Rheumatology, Rheumatology Department School of Medicine HMC / UMNG, Bogota, Colombia, 6Fundación Instituto de Reumatología Fernando Chalem, Bogotá, Colombia, 7Rheumatology Department School of Medicine HMC / UMNG, Bogota, Colombia, 8Rheumatology, School of Medicine HMC / UMNG, Bogota, Colombia

    Background/Purpose:  Association studies in rheumatoid arthritis (RA) have been focused in the pre-clinical phases of the disease in asymptomatic individuals with higher risk to develop…
  • Abstract Number: 508 • 2016 ACR/ARHP Annual Meeting

    Before Clinically Detectable Arthritis Develops, ACPA-Positive and ACPA-Negative Arthralgia Patients Have Different Symptoms

    Leonie E Burgers1, Hanna W van Steenbergen1, Lukas Mangnus2, Tom WJ Huizinga1 and Annette HM van der Helm-van Mil1, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose:  Anti-citrullinated protein antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) have different genetic risk factors and underlying biological mechanisms. Therefore, we hypothesized that patients’ characteristics…
  • Abstract Number: 509 • 2016 ACR/ARHP Annual Meeting

    Association of Anti-Citrullinated Protein Antibody Positivity and Titer Levels to Low Hand BMD, and the Consequence of Low Hand BMD on DAS28 (CRP) Remission in Established RA: Findings from a US Observational Cohort

    H Ahmad1, E Alemao1, Z Guo1, M Frits2, Michael Weinblatt2 and N A Shadick2, 1Bristol-Myers Squibb, Princeton, NJ, 2Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Hand bone mineral density (BMD) loss is an independent predictor of radiographic joint progression,1 and a potential indicator of vertebral and non-vertebral fracture risk.2…
  • Abstract Number: 510 • 2016 ACR/ARHP Annual Meeting

    C-Reactive Protein and Disease Activity in Rheumatoid Arthritis: Impact of Obesity and Adiposity

    Michael D. George1, Jon T. Giles2, Patricia P. Katz3, Said Ibrahim4, Grant W. Cannon5, Bryant R. England6, Liron Caplan7, Brian Sauer8, Kaleb Michaud9, Ted R Mikuls10 and Joshua F. Baker1, 1Rheumatology, University of Pennsylvania, Philadelphia, PA, 2Rheumatology, Columbia University Medical Center, NY, NY, 3Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 4Medicine, University of Pennsylvania, Philadelphia, PA, 5Salt Lake City VA Medical Center and University of Utah Division of Rheumatology, Salt Lake City, UT, 6Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 7Denver Veterans Affairs Medical Center and UC Denver SOM, Denver, CO, 8IDEAS Center and Division of Epidemiology, HSR&D SLC VA Medical Center and University of Utah, Salt Lake City, UT, 9University of Nebraska Medical Center, Omaha, NE, 10Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: C-reactive protein (CRP) is used to assess disease activity in rheumatoid arthritis (RA), and previous work suggests that adiposity also impacts CRP levels. This…
  • Abstract Number: 511 • 2016 ACR/ARHP Annual Meeting

    Complement C3 and C4 Levels and Its Correlation with Disease Activity in Rheumatoid Arthritis Patients

    Julia Sosa1, Silvia Beatriz Papasidero2, María Alejandra Medina1, Diana Klajn3, Rafael Chaparro del Moral2, José Angel Caracciolo4, Luciana Casalla5, Lucía Zárate5, Nieves Capozzi5, Josefina Marcos6, Mercedes Argentina García6, Ana Quinteros7, Maria Olga Leal7, Dora Lia Vásquez7, María Inés Stancich8, Analia Alvarez9, Carolina Sanchez Andía9, Karin Kirmayr10, María de los Ángeles Correa11 and A. Constantino12, 1Rheumatology Department, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, 2Rheumatology Department, Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, 3Research Committee, Research Committee, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, 4Rhematology Department, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, 5Rheumatology Section, Hospital Posadas, Buenos Aires, Argentina, 6Rheumatology Unit, HIGA San Martín La Plata, La Plata, Argentina, 7Centro Integral De Reumatologia, Tucumán, Argentina, 8Rheumatology Department, Hospital Nacional De Clínicas, Córdoba, Argentina, 9Rheumatology Department, Hospital Penna, Buenos Aires, Argentina, 10Rheumatology Department, Sanatorio San Carlos, Buenos Aires, Argentina, 11Rheumatology Department, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 12Hospital Nacional De Clínicas, Córdoba, Argentina

    COMPLEMENT C3 AND C4 LEVELS AND ITS CORRELATION WITH DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS PATIENTS   Background/Purpose: Cytokines play a major role in the pathogenesis…
  • Abstract Number: 512 • 2016 ACR/ARHP Annual Meeting

    Anti-Cyclic Citrullinated Protein Antibody (ACPA) Positivity in General Population and Follow-up Results for ACPA Positive Persons

    Yoichiro Haji1, Ryo Rokutanda2, Mitsumasa Kishimoto2 and Masato Okada2, 1Rheumatology, Daido Hospital, Nagoya, Japan, 2Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan

    Background/Purpose: To evaluate anti-cyclic citrullinated protein antibody positivity in the general population and to identify its prognosis. Methods: Anti-cyclic citrullinated protein antibody (ACPA) were measured…
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