Abstracts Archive - Page 1449 of 2607 - ACR Meeting Abstracts

Abstract Number: 926 • 2017 ACR/ARHP Annual Meeting
Relationship of Traumatic Knee Injuries to Early-Onset Knee Osteoarthritis in Young Military Officers
Yvonne M. Golightly¹, Maryalice Nocera², John Cantrell², Jordan B. Renner³ and Stephen W. Marshall⁴, ¹Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Injury Prevention Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³UNC School of Medicine, University of North Carolina, Chapel Hill, NC, ⁴Epidemiology, University of North Carolina, Chapel Hill, NC
Background/Purpose: Traumatic knee injuries, such as tears and ruptures of the anterior cruciate ligament (ACL) and/or menisci, are associated with osteoarthritis (OA). Surprisingly little is…
Abstract Number: 927 • 2017 ACR/ARHP Annual Meeting
Do Familiarity with Centers for Disease Control Guidelines, Continuing Education, and Provider Characteristics Influence Adherence to Chronic Pain Management Practices and Opioid Prescribing?
Kim Jones¹, Ronald Friend², Robert M. Bennett¹ and Jean McCalmont³, ¹Schools of Nursing and Medicine, Oregon Health & Science University, Portland, OR, ²School of Nursing, Oregon Health & Science University, Portland, OR, ³Nursing, Oregon Health & Science University, Portland, OR
Background/Purpose: 1) To evaluate providers’ experience and knowledge with chronic pain management and opioid use with actual utilization of the Centers for Disease Control’s 2016…
Abstract Number: 928 • 2017 ACR/ARHP Annual Meeting
Online Consultation for Chinese Patients with Rheumatic Diseases Based on Smart System of Disease Management (SSDM) Mobile Tool: A Study of Medical Economics
Fei Xiao¹, Rui Wu², Zhenchun Zhang³, Weiqi Min⁴, Yanchun Tang⁵, Xinwang Duan⁶, Lingfei Mo⁷, Zhaojun Guo⁸, Yanping Zhao⁹, Henglian Wu¹⁰, Xia Xu¹¹, Feng Jiang¹², Jing Yu¹³, Jianhong Qiang¹⁴, Yan Wang⁹, Ruijie Wu¹⁵, Anbing Zhang¹⁶, Limei Gu¹⁷, Hui Xiao¹, Yuhua Jia¹, Yuan Liu¹, Bing Wu¹, Chunhui Shi¹ and Fengchun Zhang¹⁸, ¹Gothic Internet Technology Corporation, Shanghai, China, ²The First Affiliated Hospital of Nanchang University, Nanchang, China, ³People's Hospital of Linyi, Shandong, Linyi, China, ⁴Heze Municiple Hospital, Heze, China, ⁵Yantai YuHuangDing Hospital, Yantai, China, ⁶Department of rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang, China, ⁷The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China, ⁸The First People's Hospital of Huainan City, Huainan, China, ⁹First Affiliated Hospital of Harbin Medical University, Harbin, China, ¹⁰Dongguan Donghua Hospital, Dongguan, China, ¹¹Changhai Hospital, Shanghai, China, ¹²Huzhou Third People's Hospital, Huzhou, China, ¹³The First Hospital Affiliated with the University of Traditional Chinese Medicine in Liaoning Province, Shenyang, China, ¹⁴Yan'an People's Hospital, Yan'an, China, ¹⁵The Second Affiliated Hospital of Shanxi Medical College, Taiyuan, China, ¹⁶Xiangyang Central Hospital, Xiangyang, China, ¹⁷Central People's Hospital of Siping, Siping, China, ¹⁸Peking Union Medical College Hospital, Beijing, China
Background/Purpose: China doesn’t have efficient primary medical care and referral system. Patients can choose any hospitals or any doctors they like to seek medical care.…
Abstract Number: 929 • 2017 ACR/ARHP Annual Meeting
Variation in SLE-Related Pain – a Seven Year Follow-up Study
Eva Waldheim¹, Sofia Ajeganova², Stefan Bergman³, Johan Frostegård⁴ and Elisabet Welin Henriksson^5,6, ¹Karolinska Institutet, Stockholm, Sweden, ²Rheumatology unit, Department of Medicine,, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden, ³University of Gothenburg, Gothenburg, Sweden, ⁴Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ⁵Department of Medical and Health Sciences, Linkoping University, Linköping, Sweden, ⁶Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: We have previously shown that 24% of the patients in a SLE-cohort study (n=84) reported high levels of SLE-related pain (VAS≥40 mm), and also…
Abstract Number: 930 • 2017 ACR/ARHP Annual Meeting
Efficacy and Safety of Modified-Release Prednisone in Managing Moderate Activity SLE during Pregnancy: An Implemented Case-Control Study
Marianna Meroni¹, Véronique Laure Ramoni², Massimiliano Parodi³, Paolo Stobbione³ and Maurizio Cutolo⁴, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino-IST, University of Genova, Genoa, Italy, Genova, Italy, ²Division of Rheumatology, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, Italy, Pavia, Italy, ³Rheumatology Unit, Internal Medicine Department, A.O. S.S. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy, Alessandria, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino-IST, University of Genova, Genoa, Italy, Genoa, Italy
Background/Purpose: Systemic lupus erythematosus (SLE) can affect young women and pregnancy still represents a challenge. Prednisone is safely used, at low doses (<7.5 mg daily),…
Abstract Number: 931 • 2017 ACR/ARHP Annual Meeting
Dose-Response Effects of Tai Chi and Physical Therapy Exercise Interventions in Symptomatic Knee Osteoarthritis
Augustine Lee¹, William F. Harvey², Lori Lyn Price^3,4, Xingyi Han¹, Jeffrey B. Driban¹, Maura D. Iversen^5,6, Raveendhara R. Bannuru¹ and Chenchen Wang², ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Rheumatology, Center of Integrative Medicine and Division of Rheumatology, Tufts Medical Center, Boston, MA, Boston, MA, ³Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ⁴Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Department of Physical Therapy, Movement & Rehabilitation Sciences, Northeastern University, Boston, MA
Background/Purpose: Therapeutic exercise is the recommended non-pharmacological treatment for knee osteoarthritis (OA). However, the optimal treatment dose and clinically meaningful treatment durations remain unclear. Our…
Abstract Number: 932 • 2017 ACR/ARHP Annual Meeting
Association of Varus Knee Thrust during Walking to Worsening Knee Pain over Two Years
Alexandra Wink¹, K. Douglas Gross², Carrie Brown³, Michael C. Nevitt⁴, Cora E. Lewis⁵, James Torner⁶, Leena Sharma⁷ and David T. Felson⁸, ¹Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, ²Clinical Epidem Rsrch, Boston University School Medicine, Boston, MA, ³Boston University School of Public Health, Boston, MA, ⁴Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶University of Iowa, Iowa City, IA, ⁷Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁸Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Varus knee thrust is an abrupt change in frontal plane tibiofemoral alignment observed during gait. Thrust has been linked to radiographic knee OA progression…
Abstract Number: 933 • 2017 ACR/ARHP Annual Meeting
Longitudinal Association between Sleep Quality and Knee Pain in the Multicenter Osteoarthritis Study
Zhaoli (Joy) Dai¹, Carrie Brown², Tuhina Neogi³ and David T. Felson³, ¹Boston University School of Medicine, Boston, MA, ²Boston University School of Public Health, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Sleep and pain have been shown to be reciprocally related. Studies have suggested a stronger effect of sleep impairment on chronic pain such as…
Abstract Number: 934 • 2017 ACR/ARHP Annual Meeting
Effectiveness of FX006 Intra-Articular Injection in Patients with Knee Osteoarthritis Who Present with and without Clinical Inflammation at Baseline: A Pooled Analysis of Data from 3 Double-Blind, Randomized, Parallel-Group Clinical Trials
Herbert S. B. Baraf¹, Christian Lattermann², Deryk G. Jones³, Philip G. Conaghan⁴, Joelle Lufkin⁵, James Johnson⁶, Scott Kelley⁵ and Neil Bodick⁵, ¹Center for Rheumatology and Bone Research, Wheaton, MD, ²University of Kentucky, Orthopaedic Surgery and Sports Medicine, Lexington, KY, ³Ochsner Sports Medicine Institute, New Orleans, LA, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵Flexion Therapeutics, Inc., Burlington, MA, ⁶Summit Analytical, Denver, CO
Background/Purpose: Inflammation is a key contributor to osteoarthritis (OA).1 OA pain is mediated by interactions between inflammatory cytokines and other features including local tissue damage,…
Abstract Number: 935 • 2017 ACR/ARHP Annual Meeting
Results from a 52 Week Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of a Novel, Intra-Articular, Wnt Pathway Inhibitor (SM04690) for the Treatment of Knee Osteoarthritis
Yusuf Yazici¹, Timothy E. McAlindon², Allan Gibofsky³, Nancy E. Lane⁴, Daniel J. Clauw⁵, Eddie Armas⁶, Nebojsa Skrepnik⁷, Christopher J. Swearingen¹, Anita DiFrancesco¹, Jeymi Tambiah¹ and Marc Hochberg⁸, ¹Samumed, LLC, San Diego, CA, ²Division of Rheumatology, Tufts Medical Center, Boston, MA, ³Rheumatology, Weill Cornell Medicine, and Hospital for Special Surgery, New York, NY, ⁴Center for Musculoskeletal Health, University of California at Davis, Hillsborough, CA, ⁵Chronic Pain & Fatigue Research Center, University of Michigan, Ann Arbor, MI, ⁶Well Pharma Medical Research, Miami, FL, ⁷Tuscon Orthopedics Institute, Tuscon, AZ, ⁸Head, Division of Rheumatology & Clinical Immunology; Vice Chair, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, disability and joint deformity due to articular cartilage degradation and bone remodeling. Wnt signaling is involved in…
Abstract Number: 936 • 2017 ACR/ARHP Annual Meeting
Knee Confidence Trajectories over 8 Years and Factors Associated with Poor Trajectories: Data from the Osteoarthritis Initiative
Alison H. Chang, Julia (Jungwha) Lee, Orit Almagor, Joan S. Chmiel, Kirsten C. Moisio, Karen W. Hayes, Julie Szymaszek and Leena Sharma, Northwestern University, Chicago, IL
Background/Purpose: Lack of knee confidence, a frequent complaint, has been associated with function decline in knee OA. Given its key role in weight-bearing activities, a…
Abstract Number: 937 • 2017 ACR/ARHP Annual Meeting
Treatment Response in Polyarticular JIA Is Associated with Transcriptional Changes and Chromatin Reorganization in CD4+ T Cells
Evan Tarbell¹, Kaiyu Jiang², Yanmin Chen², Tao Liu³ and James Jarvis⁴, ¹Biochemistry, University at Buffalo, Buffalo, NY, ²Pediatrics, University at Buffalo, Buffalo, NY, ³Biochemistry, University at Buffalo Jacobs School of Medicine, Buffalo, NY, ⁴Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY
Background/Purpose: To identify transcriptional changes in CD4+ T cells as children with polyarticular JIA transition from active disease to remission, and to identify underlying changes…
Abstract Number: 938 • 2017 ACR/ARHP Annual Meeting
A Germline Macrophage Activation Syndrome-Associated Nlrc4 Mutation Causes Chronic, Systemic, Non-Hematopoietic IL-18 Elevation and Intestinal MHC-II Upregulation
Eric Weiss¹, Corinne Schneider² and Scott Canna³, ¹RK Mellon Institute, Children’s Hospital of Pittsburgh, Pittsburgh, PA, ²Pediatrics, Children's Hospital Pittsburgh, Pittsburgh, PA, ³NIAMS, National Institutes of Health, Bethesda, MD
Background/Purpose: Patients prone to the development of Macrophage Activation Syndrome (MAS) can have extreme and often chronic elevation in the pro-inflammatory cytokine interleukin-18 (IL-18). In…
Abstract Number: 939 • 2017 ACR/ARHP Annual Meeting
Stimulator of Interferon Genes (STING)-Induced Endothelial-Mesenchymal Transition (EndMT) Contributes to Interstitial Lung Disease in Sting-Associated Vasculopathy with Onset in Infancy (SAVI) Patients
Louise Malle¹, Dan Yang², Adriana Almeida de Jesus¹, Guibin Chen², Bernadette Marrero¹, Gina A. Montealegre Sanchez¹, Yin Liu³, Gregor Dueckers⁴, Suzanne Ramsey⁵, Joseph Fontana⁶, Rachel VanTries¹, Yan Huang¹, Laisa Santiago⁷, Benito Gonzalez⁸, Paul Brogan⁹, Juergen Brunner¹⁰, Ebun Omoyinmi¹¹, Athimalaipet V. Ramanan¹², Amy Paller¹³, Olcay Y. Jones¹⁴, Seza Ozen¹⁵, Stephen R. Brooks¹⁶, Manfred Boehm¹⁷ and Raphaela Goldbach-Mansky¹, ¹Translational Autoinflammatory Disease Studies (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, ²Center for Molecular Medicine, NHLBI/NIH, Bethesda, MD, ³Scientific Review Branch, NIAMS/NIH, Bethesda, MD, ⁴Helios Kliniken - Kinderklinik, HELIOS Klinikum Krefeld, Krefeld, Germany, ⁵Pediatric Rheumatology, IWK Health Centre, Dalhousie University, Halifax, NS, Canada, ⁶Cardiovascular and Pulmonary Branch, NHLBI/NIH, Bethesda, MD, ⁷Johns Hopkins All Children's Hospital Rheumatology, Saint Petersburg, FL, ⁸Luis Calvo Mackenna Hospital, Santiago, Chile, ⁹Infection Inflammation and Rheumatology, UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, ¹⁰Division of Pediatric Rheumatology, Medical University Innsbruck, Innsbruck, Austria, ¹¹University College London Institute of Child Health, London, United Kingdom, ¹²Bristol Royal Hospital for Children, Bristol, United Kingdom, ¹³Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IN, ¹⁴Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, ¹⁵Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ¹⁶Biodata Mining and Discovery Section, Office of Science and Technology, NIAMS/NIH, Bethesda, MD, ¹⁷Center for Molecular Medicine, NHLBI/ NIH, Bethesda, MD
Background/Purpose: Pulmonary fibrosis, is a life-threatening complication of the monogenic autoinflammatory interferonopathy, STING-Associated Vasculopathy with onset in Infancy (SAVI) that is caused by gain-of-function mutations…
Abstract Number: 940 • 2017 ACR/ARHP Annual Meeting
IL1RN Variation Is Associated with Systemic Juvenile Idiopathic Arthritis and Predicts Non-Response to Anakinra Treatment
Emily Shuldiner¹, Victoria Arthur¹, Anne Hinks², Patricia Woo³, Wendy Thomson², Elaine F. Remmers⁴ and Michael J. Ombrello¹, ¹Translational Genetics and Genomics Unit, NIAMS, NIH, Bethesda, MD, ²Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ³University College London, London, United Kingdom, ⁴Genetics and Genomics Branch, NIH, NIAMS, Bethesda, MD
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a childhood inflammatory disease whose pathophysiology is poorly understood. sJIA is phenotypically heterogeneous with variable manifestations and responses…

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