ACR Meeting Abstracts

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  • Abstract Number: 391 • 2016 ACR/ARHP Annual Meeting

    A Single Centre Experience from India on the Safety and Efficacy of Cipla Etanercept and Intas Etanercept and Its Comparison with Reference Etanercept(Enbrel) in Children with JIA

    Abhay Shivpuri1, Sumidha Mittal2, Manjari Agarwal3 and Sujata Sawhney4, 1Division of Pediatric Rheumatology,Institute of Child Health, Post Doctoral Fellow, New Delhi, India, 2Post Doctoral Fellow, New Delhi, India, 3Institute of Child Health, Attending Consultant, New Delhi, India, 4Paediatric rheumatology, Senior Consultant, New Delhi, India

    Background/Purpose: Cost is a major impediment for use of biologic response modifiers (BRMs). Biosimilars/Intended copies, priced at almost half the reference molecule might be the…
  • Abstract Number: 392 • 2016 ACR/ARHP Annual Meeting

    Safety and Clinical Response of Weekly Adalimumab in the Treatment of Juvenile Idiopathic Arthritis, Pediatric Chronic Uveitis and Other Childhood Rheumatic Diseases

    Colleen K. Correll1, Danielle R. Bullock1, Rachel Cafferty1 and Richard K Vehe2, 1Pediatrics, University of Minnesota, Minneapolis, MN, 2University of Minnesota Masonic Children’s Hospital, Minneapolis, MN

    Background/Purpose: Every other week adalimumab is used to treat juvenile idiopathic arthritis (JIA) and other pediatric rheumatic diseases. It is common for pediatric rheumatologists to…
  • Abstract Number: 393 • 2016 ACR/ARHP Annual Meeting

    Association of Sex, Race and Ethnicity on Disease Outcomes in Juvenile Idiopathic Arthritis Patients

    Vivek Joseph1, Tracy R. Andrews2, Esi Morgan3, Ronald Laxer4, cagri Toruner5, Tzielan Lee6,7, Beth S. Gottlieb8, C. April Bingham9, Sheetal S. Vora10, Jon M. Burnham11, Judyann C. Olson12, Murray H. Passo13, Michelle Batthish14, Meredith Riebschleger15 and Jennifer E. Weiss16, 1Internal Medicine, Rutgers New Jersey Medical School, Bloomfield, NJ, 2Biostatistics, David & Alice Jurist Institute, Hackensack University Medical Center, hackensack, NJ, 3Pediatric Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, 4Div of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 5Rheumatology, Nationwide Children's Hospital, Columbus, OH, 6Dept of Pediatric Rheumatology, Stanford Univ School of Med, Palo Alto, CA, 7Pediatric Rheumatology, Stanford University School of Medicine, Palo Alto, CA, 8Pediatric Rheumatology, The Steven and Alexandra Cohen Children's Medical Center of New York, The Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY, 9Penn State Health Children's Hospital, Hershey, PA, 10Pediatric Rheumatology, Medical College of Wisconsin, Milwaukee, WI, 11Pediatric Rheumatology, Children's Hospital Philadelphia, Philadelphia, PA, 12Ped/MACC Fund Research Ctr, Medical College of Wisconsin, Milwaukee, WI, 13Division of Rheumatology PTD, Medical University of South Carolina, Charleston, SC, 14Division of Pediatric Rheumatology, McMaster Children's Hospital, Hamilton, ON, Canada, 15Pediatric Rheumatology, University of Michigan, CS Mott Children's Hospiatl, Ann Arbor, MI, 16Hackensack Univ Med Ctr, Hackensack, NJ

    Background/Purpose: JIA patients are predominantly non-Hispanic white and studies have shown that race and ethnicity may be associated with worse disease.  This study assesses the…
  • Abstract Number: 394 • 2016 ACR/ARHP Annual Meeting

    Effect of BMI on Symptoms and Outcomes in Juvenile Idiopathic Arthritis Patients

    Jennifer E. Weiss1, Tracy Andrews2, Esi Morgan3, Ronald Laxer4, Cagri Yildirim-Toruner5, C. April Bingham6, Beth Gottlieb7, Tzielan Lee8, Sheetal S. Vora9, Jon M. Burnham10, Judyann C. Olson11, Murray Passo12, Michelle Batthish13 and Meredith Riebschleger14, 1Hackensack Univ Med Ctr, Hackensack, NJ, 2Biostatistics, David & Alice Jurist Institute, Hackensack University Medical Center, hackensack, NJ, 3Pediatric Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, 4Div of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 5Rheumatology, Nationwide Children's Hospital, Columbus, OH, 6Penn State Health Children's Hospital, Hershey, PA, 7Pediatric Rheumatology PTD, Cohen Children's Medical Center of New York, Lake Success, NY, 8Dept of Pediatric Rheumatology, Stanford Univ School of Med, Palo Alto, CA, 9Pediatric Rheumatology, Medical College of Wisconsin, Milwaukee, WI, 10Pediatric Rheumatology, Children's Hospital Philadelphia, Philadelphia, PA, 11Ped/MACC Fund Research Ctr, Medical College of Wisconsin, Milwaukee, WI, 12Pediatric Rheumatology, Medical University of South Carolina, Charleston, SC, 13Division of Pediatric Rheumatology, McMaster Children's Hospital, Hamilton, ON, Canada, 14Pediatric Rheumatology, University of Michigan, CS Mott Children's Hospiatl, Ann Arbor, MI

    Background/Purpose: Children with JIA are at risk for cardiovascular disease and obesity compounds this risk.  There is limited data on the prevalence of elevated BMI…
  • Abstract Number: 395 • 2016 ACR/ARHP Annual Meeting

    The Influence of Early Achievement of “Clinically Inactive Disease” or “Minimal Disease Activity” on Long-Term Disability Outcomes in JIA

    Stephanie J.W.Shoop1,2, Suzanne M.M. Verstappen3, Janet E. McDonagh4, Wendy Thomson5,6, Kimme L. Hyrich3,7 and CAPS, 1Central Manchester University Hospitals NHS Foundation Trust and University of Manchester Partnership, NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, 2The University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, 3Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, 4Faculty of Medical and Human Sciences, Centre for MSK Research, Manchester, United Kingdom, 5Arthritis Research UK Centre for Genetics and Genomics,The University of Manchester, Manchester, United Kingdom, 6NIHR Manchester Musculoskeletal Biomedical Research Unit, Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, 7Arthritis Research UK, Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Different definitions of clinically inactive disease (CID) for JIA have recently been shown to identify different groups of children. It is unclear whether long-term…
  • Abstract Number: 396 • 2016 ACR/ARHP Annual Meeting

    Performance of Disease Activity Measures in Juvenile Spondyloarthritis in a Placebo Controlled Trial with Infliximab

    Sofia Ramiro1, Julio Casasola2, Désirée van der Heijde3, RBM Landewé4 and Rubén Burgos-Vargas5, 1Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Hospital General de Mexico, Mexico, Mexico, 3Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 4Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands, 5Rheumatology, Hospital General de Mexico, Mexico city, Mexico

    Background/Purpose: Several outcome measures in trials with juvenile-onset spondyloarthritis (Jo-SpA) have been borrowed from trials in juvenile idiopathic arthritis and from adult spondyloarthritis, but a…
  • Abstract Number: 397 • 2016 ACR/ARHP Annual Meeting

    Comorbidities Associated with Pediatric Psoriatic Arthritis

    Cynthia Manos1, Rui Xiao2, Alexis Ogdie3, Timothy Brandon4 and Pamela F. Weiss5,6, 1Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, 2Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, 3University of Pennsylvania, Philadelphia, PA, 4Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, 5Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 6Division of Rheumatology, Center for Pediatric Clincial Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: In adults, psoriatic arthritis (PsA) is associated with an increased prevalence of obesity, hypertension, and diabetes.  It is not yet known if pediatric patients…
  • Abstract Number: 398 • 2016 ACR/ARHP Annual Meeting

    Predictors of Clinical Remission with Etanercept in Pediatric Patients with Extended Oligoarticular, Enthesitis-Related Arthritis and Psoriatic Arthritis: Findings from the Clipper Study

    Nicolino Ruperto1, Alessandro Consolaro2, Gerd Horneff1, Rubén Burgos-Vargas1, Tamas Constantin1, Ivan Foeldvari1, Jelena Vojinovic1, Joke Dehoorne1, Violeta Vladislava Panaviene1, Gordana Susic1, Valda Stanevicha1, Katarzyna Kobusinska1, Zbigniew Zuber3, Richard Mouy1, Ingrida Rumba-Rozenfelde1, Pavla Dolezalová1, Chantal Job-deslandre4, Nico M Wulffraat1, Ronald Pedersen5, Jack F Bukowski6, Tina Hinnershitz7, Bonnie Vlahos8 and Alberto Martini9, 1Paediatric Rheumatology International Trials Organisation (PRINTO), Genoa, Italy, 2Istituto Giannina Gaslini, Genoa, Italy, 3St Louis Children’s Hospital ODS Rheumatology and Neurology, Krakow, Poland, 4Pediatria II, Reumatologia, PRINTO, Istituto Giannina Gaslini, Genoa, Italy, 5Department of Biostatistics, Pfizer, Collegeville, PA, 6Clinical Affairs, Pfizer, Collegeville, PA, 7Specialty Care MDG, Pfizer, Collegeville, PA, 8GIPB - Clinical Sciences, Pfizer, Collegeville, PA, 9PRINTO-IRCCS, Genoa, Italy

    Background/Purpose: Etanercept (ETN) is approved in the EU for the treatment of children with juvenile idiopathic arthritis (JIA) categories of polyarticular, extended oligoarticular (eoJIA), enthesitis-related…
  • Abstract Number: 399 • 2016 ACR/ARHP Annual Meeting

    Enthesitis in Juvenile Idiopathic Arthritis (JIA)

    Dax G. Rumsey1, Jaime Guzman2, Alan Rosenberg3, Adam Huber4, Rosie Scuccimarri5, Dean Eurich6 and Research in Arthritis in Canadian Children Emphasizing Outcomes (ReACCh-Out) Investigators, 1Paediatrics, University of Alberta, Edmonton, AB, Canada, 2Rheumatology, BC Children's Hospital, Vancouver, BC, Canada, 3Pediatrics, Pediatrics, Saskatoon, SK, Canada, 4IWK Health Centre, Halifax, NS, Canada, 5Division of Pediatric Rheumatology, Montreal Children's Hospital / McGill University Health Centre, Montreal, QC, Canada, 6University of Alberta, Edmonton, AB, Canada

    Enthesitis in Juvenile Idiopathic Arthritis (JIA) Background/Purpose: The characteristics of enthesitis,  a feature  in some children with juvenile idiopathic arthritis (JIA),  t has not been…
  • Abstract Number: 400 • 2016 ACR/ARHP Annual Meeting

    Foot Involvement in Enthesitis-Related Arthritis Subtype of Juvenile Idiopathic Arthritis: Clinical, Radiological and Functional Assessment

    Sanat Phatak1, Namita Mohindra2, Abhishek Zanwar1 and Amita Aggarwal1, 1Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Background/Purpose: Though foot involvement is common in juvenile idiopathic arthritis (JIA), it is often neglected by patients and physicians alike. The involvement could occur due…
  • Abstract Number: 401 • 2016 ACR/ARHP Annual Meeting

    Humoral Immune Response after a Booster Dose with Tdap in Children and Adolescents with Juvenile Idiopathic Arthritis on Anti-TNF and in Healthy Controls

    Aline Nicacio1, Octavio Peracchi2, Juliana Yamada3, Fernanda Spina3, Brunna Alvarenga3, Maria Isabel Pinto3 and Maria Teresa Terreri4, 1Pediatric Rheumatology Unit, Department of Pediatrics, Federal University of Sao Paulo, Sao Paulo, Brazil, Sao Paulo, Brazil, 2Pediatric Rheumatology, Federal University of Sao Paulo, Department of Pediatrics, Sao Paulo, Brazil, Sao Paulo, Brazil, 3Federal University of Sao Paulo, Department of Pediatrics, Sao Paulo, Brazil, Sao Paulo, Brazil, 4Pediatric Rheumatology Unit, Federal University of São Paulo, São Paulo, Brazil

    Background/Purpose:  Pertussis cases have increased worldwide and knowledge on immune response after adult Tdap vaccine is scarce. This study evaluated the humoral immune response profile…
  • Abstract Number: 402 • 2016 ACR/ARHP Annual Meeting

    The Risk of Hospitalized Infection Associated with Initiation of Abatacept Versus TNF Inhibitors in Juvenile Idiopathic Arthritis

    Timothy Beukelman1, Fenglong Xie2, John Baddley3, Lang Chen2, Melissa Mannion4, Kenneth G. Saag5, Jie Zhang6 and Jeffrey R. Curtis5, 1Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3University of Alabama at Birmingham, Birmingham, AL, 4Pediatrics, University of Alabama at Birmingham, Birmingham, AL, 5Division Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 6Epidemilogy, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: The comparative risk of infection with newer biologic agents, such as abatacept (ABA), in the treatment of juvenile idiopathic arthritis (JIA) has not been…
  • Abstract Number: 403 • 2016 ACR/ARHP Annual Meeting

    High Rate of Serious Infection in Juvenile Idiopathic Arthritis Under Biologic Therapy in a Real Life Setting

    Juliana Brunelli1, Ana Renata Schmidt1, Adriana M E Sallum2, Cláudia Goldenstein-Schainberg3, Eloisa Bonfa4, Clovis A Silva5 and Nadia E Aikawa6, 1Pediatric Rheumatology, University of São Paulo, São Paulo, Brazil, 2Pediatric Rheumatology Unit, University of São Paulo, São Paulo, Brazil, 3Rheumatology Division, University of São Paulo, São Paulo, Brazil, 4Rheumatology Divison, Hospital das Clinicas, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, 5Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 6Pediatric Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Most data about infections associated to biologic therapy in juvenile idiopathic arthritis (JIA) derive from registries designed to identify general adverse events that have…
  • Abstract Number: 404 • 2016 ACR/ARHP Annual Meeting

    Disease Activity and Damage in Juvenile Idiopathic Arthritis: Comparison Between “Methotrexate” and “Biologic” Era

    Gabriella Giancane1, Valentina Muratore2, Valentina Marzetti3, Neus Quilis4, Belen Serrano5, Alessandra Alongi5, Adele Civino6, Lorenzo Quartulli7, Alessandro Consolaro2, Alberto Martini2 and Angelo Ravelli2, 1Pediatria II, Reumatologia, PRINTO, Istituto Giannina Gaslini, Genoa, Italy, 2Istituto Giannina Gaslini, Genoa, Italy, 3IRCCS G. Gaslini, Genoa, Italy, 4Pediatria II Reumatologia, IRCCS G. Gaslini, Genoa, Italy, 5Pediatria II, IRCCS G. Gaslini, Genoa, Italy, 6Azienda Ospedaliera Card G Panico, Tricase, Italy, 7UOC Pediatria - AO "Card.G.Panico", Tricase, Italy

    Background/Purpose:  The introduction of biologic agents at the beginning of the 2000s has represented a major advance in the management of juvenile idiopathic arthritis (JIA).…
  • Abstract Number: 405 • 2016 ACR/ARHP Annual Meeting

    Patterns of Medication Use in Children with Juvenile Idiopathic Arthritis: Results from the Childhood Arthritis & Rheumatology Research Alliance Registry

    Sarah Ringold1, Yukiko Kimura2, Laura E. Schanberg3, Marc D. Natter4, Fenglong Xie5, Norman Ilowite6, Jason Jones7, Kelly Mieszkalski8, Timothy Beukelman9 and for the CARRA Registry Investigators, 1Pediatrics, Seattle Children's Hospital, Seattle, WA, 2Hackensack University Medical Center, Hackensack, NJ, 3Pediatrics, Duke Medical Center, Durham, NC, 4Intelligent Health Labs, Children's Hospital Boston, Boston, MA, 5Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 6Division of Pediatric Rheumatology, Children's Hospital at Montefiore, Bronx, NY, 7Childhood Arthritis and Research Rheumatology Alliance (CARRA), Durham, NC, 8Childhood Arthritis and Rheumatology Research Alliance (CARRA), Durham, NC, 9Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry is a multicenter, prospective observational study collecting data from children with rheumatic diseases in order…
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