Abstracts Archive - Page 1438 of 2607 - ACR Meeting Abstracts

Abstract Number: 761 • 2017 ACR/ARHP Annual Meeting
Increased Expression of the TNF Superfamily Member LIGHT/TNFSF14 and Its Receptor (TNFRSF14) in Patients with Systemic Sclerosis
Otylia Kowal-Bielecka¹, Ewa Gindzienska-Sieskiewicz¹, Oliver Distler², Joanna Reszec³, Suzana Jordan², Pawel Bielecki⁴, Andzrzej Sieskiewicz⁴, Agnieszka Sulik¹ and Krzysztof Kowal^5,6, ¹Department of Rheumatology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Department of Medical Pathomorphology, Department of Medical Pathomorphology, Medical University of Bialystok, Bialystok, Poland, ⁴Department of Otolaryngology, Medical University of Bialystok, Bialystok, Poland, ⁵Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland, ⁶Department of Experimental Allergology and Immunology, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: The TNF Superfamily member LIGHT (TNFSF14) regulates immune response and angiogenesis. Moreover, recent studies indicate that interactions of LIGHT with its receptor, TNFRSF14, might…
Abstract Number: 762 • 2017 ACR/ARHP Annual Meeting
M10, a Caspase Cleavage Product of the Hepatocyte Growth Factor Receptor, Downregulates Bone Morphogenetic Protein-9-Induced Smad1/5/8 Phosphorylation and Collagen Production in Human Lung Fibroblasts
Atsushi Noguchi, Ilia Atanelishvili, Tanjina Akter, Richard M. Silver and Galina S. Bogatkevich, Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: We recently identified M10, a caspase cleavage product of the hepatocyte growth factor receptor, as an anti-fibrotic peptide that interacts with Smad2 and inhibits…
Abstract Number: 763 • 2017 ACR/ARHP Annual Meeting
Mechanisms of Insulin-like Growth Factor-II-Mediated Fibrosis
Sara Garrett¹, Justin Thomas², Eileen Hsu³ and Carol A. Feghali-Bostwick⁴, ¹Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ²Eisenhower Medical Center, Rancho Mirage, CA, ³Kaiser Permanente Medical Group, Mclean, VT, ⁴Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC
Background/Purpose: Previous work has shown that insulin-like growth factor (IGF)-II is increased in fibrosing lung diseases, including idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis (SSc)-associated…
Abstract Number: 764 • 2017 ACR/ARHP Annual Meeting
Application of a Novel Computational Approach to Identify New Targets and Pathways for Therapeutic Intervention in Scleroderma
Elma Kurtagic, Joel Pradines, Anthony Manning and Ishan Capila, Research, Momenta Pharmaceuticals, Inc., Cambridge, MA
Background/Purpose: Systemic Sclerosis (SSc) is a complex autoimmune disease with chronic progressive course and high interpatient variability. It is characterized by inflammation, vascular dysfunction and…
Abstract Number: 765 • 2017 ACR/ARHP Annual Meeting
Proteomic Analysis of Scleroderma Associated Joint Disease
Chan Kim¹, Julio Mantero², Robert A. Lafyatis³ and Robert W. Simms⁴, ¹Rheumatology and Clinical Epidemiology, Boston University School of Medicine, Boston, MA, ²Arthritis Center, Boston University School of Medicine, Boston, MA, ³Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Rheumatology, Boston University School of Medicine, Boston, MA
Background/Purpose: The pathophysiology of joint disease in scleroderma, a heterogeneous multisystem disease mostly characterized by fibrosis, is unknown. We performed proteomic analysis of serum in…
Abstract Number: 766 • 2017 ACR/ARHP Annual Meeting
Increased Plasma Levels of Hsp90 Are Associated with More Severe Organ Involvement in Patients with Systemic Sclerosis
Hana Storkanova¹, Sabina Oreska¹, Maja Spiritovic^1,2, Karel Pavelka¹, Jiri Vencovsky¹, Jörg Distler³, Ladislav Senolt¹, Radim Becvar¹ and Michal Tomcik¹, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ²Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic, ³Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Our previous study demonstrated that Heat shock protein 90 (Hsp90) is overexpressed in the skin of patients with systemic sclerosis (SSc), in cultured SSc…
Abstract Number: 767 • 2017 ACR/ARHP Annual Meeting
Elevated MeCP2 Expression in Diffuse Cutaneous Systemic Sclerosis Dermal Fibroblasts Is Associated with Anti-Fibrotic Effects
Ye He¹, Pei-Suen Tsou², Dinesh Khanna³ and Amr H Sawalha², ¹Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic Sclerosis (SSc) is a multisystem autoimmune connective tissue disorder characterized by vascular injury and fibrosis of the skin and internal organs. Methyl-CpG-binding protein…
Abstract Number: 768 • 2017 ACR/ARHP Annual Meeting
A Positive Feedback Loop between Estrogen and IL-6 Leads to Fibrosis in Human Skin
DeAnna Baker Frost¹ and Carol A. Feghali-Bostwick², ¹Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC
Background/Purpose: Systemic Sclerosis (SSc) is a disease characterized by an increase in the synthesis of extracellular matrix (ECM) components in various organs, including the skin,…
Abstract Number: 769 • 2017 ACR/ARHP Annual Meeting
Proteomic Analysis of Human Fibroblasts in Systemic Sclerosis Reinforces the Role of Transforming Growth Factor-ß and Points Toward Epidermal Growth Factor Receptor / Phosphatidylinositol 3 Kinase Pathway Inhibition
Benjamin Chaigne¹, Guilhem Clary², Morgane Le Gall³, Nicolas Dumoitier⁴, Sebastien Lofek⁵, Philippe Chafey², Pia Moinzadeh⁶, Thomas Krieg⁷, Christopher Denton⁸ and Luc Mouthon⁹, ¹Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes Rares d’Ile de France, hôpital Cochin, DHU Authors, Assistance Publique-Hôpitaux de Paris, Paris, France, ²INSERM U1016, Institut Cochin,, Paris, France, ³INSERM U1016 Institut Cochin, Paris, France, ⁴INSERM U1016, Institut Cochin, Equipe Neutrophiles et Vascularites, Paris, France, ⁵INSERM U1016, paris, France, ⁶Department of Rheumatology, UCL Division of Medicine, London, United Kingdom, ⁷Universität zu Köln, Köln, Germany, ⁸Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom, ⁹Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France ;Université Paris Descartes Sorbonne Paris, Paris, France
Background/Purpose: Systemic sclerosis (SSc) is a rare autoimmune connective tissue disorder characterized by autoimmunity, vasculopathy and fibrosis. Fibrosis is due to an exaggerated activation of…
Abstract Number: 770 • 2017 ACR/ARHP Annual Meeting
Integrating Analysis of Skin RNA in Situ Hybridization Using Rnascope and Whole Skin Gene Expression in Systemic Sclerosis Skin to Localize Key Pathogenic Drivers of Skin Fibrosis
Corrado Campochiaro¹, Emma C. Derrett-Smith¹, Voon H. Ong², Gail Pearse³, Katherine Nevin³, Shaun Flint³, Mary Morse³, Nicolas Wisniacki⁴ and Christopher Denton⁵, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, London, United Kingdom, ²Rheumatology, UCL Division of Medicine, London, United Kingdom, ³GlaxoSmithKline, Stevenage, United Kingdom, ⁴ImmunoImflammation, GlaxoSmithKline, Stevenage, United Kingdom, ⁵Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom
Background/Purpose: Skin gene expression profiling can distinguish SSc from normal skin and can detect different subsets of disease. Previous studies have reported a cross-sectional relationship…
Abstract Number: 771 • 2017 ACR/ARHP Annual Meeting
Serological Biomarkers of Collagen Formation Is Increased in Systemic Sclerosis
Pernille Juhl¹, Mette Mogensen², Line Iversen², Tonny Karlsmark², Morten Karsdal³, Anne-C. Bay-Jensen⁴ and Anne Sofie Siebuhr⁵, ¹Nordic Bioscience, Herlev, Denmark, ²Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, ³Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, ⁴Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark, ⁵Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, Herlev, Denmark
Background/Purpose: Systemic sclerosis (SSc) is a multisystem, autoimmune disease characterized by immune dysregulation, vasculopathy and excessive fibrosis of the skin and internal organs. Fibrosis is…
Abstract Number: 772 • 2017 ACR/ARHP Annual Meeting
Molecular Mechanism for the Therapeutic Effect of Extracorporeal Shock Wave Therapy on Digital Ulcers of Systemic Sclerosis
Yukiko Kamogawa¹, Hiroshi Fujii¹, Tsuyoshi Shirai¹, Tomonori Ishii² and Hideo Harigae¹, ¹Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan, ²Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan
Background/Purpose: Digital ulcers (DUs) are the most common skin manifestations in systemic sclerosis (SSc). DUs in SSc are not usually caused by vasculitis and are…
Abstract Number: 773 • 2017 ACR/ARHP Annual Meeting
The Immunophenotyping of Peripheral Blood Associates with Nailfold Microvascular Changes in Patients with Systemic Sclerosis
Satoshi Kubo¹, Shingo Nakayamada², Maiko Yoshikawa¹, Yusuke Miyazaki¹, Hiroko Yoshinari³, Yurie Satoh³, Yasuyuki Todoroki³, Kazuhisa Nakano², Shigeru Iwata⁴, Kentaro Hanami¹, Shunsuke Fukuyo³, Ippei Miyagawa⁵, Minoru Satoh⁶ and Yoshiya Tanaka⁷, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³University of Occupational and Environmental Health, Japan, Fukuoka, Japan, ⁴First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁵University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁶Department of Clinical Nursing, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan, ⁷The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
The immunophenotyping of peripheral blood associates with nailfold microvascular changes in patients with systemic sclerosisBackground/Purpose: Systemic sclerosis (SSc) is a complex disease with autoimmunity and…
Abstract Number: 774 • 2017 ACR/ARHP Annual Meeting
The αV Integrin Inhibitor Abituzumab Inhibits Myofibroblast Differentiation
Eileen Samy¹, Yin Wu¹, Georgianna Higginbotham², Roland Grenningloh² and Daigen Xu², ¹TIP Immunology, EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ²EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA
Background/Purpose: Scleroderma is a progressive fibrotic multi-organ disease characterized by the hardening and tightening of the skin and connective tissues. TGF-β1 is a potent mediator…
Abstract Number: 775 • 2017 ACR/ARHP Annual Meeting
Transcriptome Sequencing Reveals Genetic Polymorphisms Associated with Ssc Gene Expression Subtypes
Guoshuai Cai¹, Bhaven K. Mehta², Mengqi Huang², Jennifer Franks¹, Tammara A. Wood¹, Kathleen D. Kolstad³, Marianna Stark⁴, Antonia Valenzuela⁵, David Fiorentino⁶, Robert W. Simms⁷, Nicole Orzechowski⁸, Lorinda Chung⁹ and Michael L. Whitfield², ¹Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Rheumatology, Stanford University Medical Center, Stanford, CA, ⁴Stanford University, Stanford, CA, ⁵Immunology and Rheumatology, Stanford University, Palo Alto, CA, ⁶Department of Dermatology, Stanford University School of Medicine, Palo Alto, CA, ⁷Rheumatology, Boston University School of Medicine, Boston, MA, ⁸Dartmouth-Hitchcock Medical Center, Lebanon, NH, ⁹Rheumatology, Stanford University Medical Center, Palo Alto, CA
Background/Purpose: Systemic sclerosis (SSc) is a complex disease characterized by substantial genotypic and phenotypic heterogeneity. Four molecular gene expression subsets have been identified from SSc…

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