Abstracts Archive - Page 1430 of 2607 - ACR Meeting Abstracts

Abstract Number: 641 • 2017 ACR/ARHP Annual Meeting
Children with Treatment-Naive Enthesitis-Related Arthritis Have Decreased Fecal Abundance of Faecalibacterium Prausnitzii A2-165 and Bacteroides Fragilis: A Multi-Center Collaborative Study
Matthew L. Stoll¹, Pamela F. Weiss², Jennifer E. Weiss³, Peter Nigrovic⁴, Barbara Edelheit⁵, S. Louis Bridges Jr.⁶, Maria I. Danila⁷, Charles Spencer⁸, Marilynn Punaro⁹, Kenneth Schikler¹⁰, Andreas Reiff¹¹, Ranjit Kumar¹², Randy Q. Cron¹, Casey D Morrow¹³ and Elliot J. Lefkowitz¹⁴, ¹Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Division of Rheumatology, Center for Pediatric Clincial Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, ³Hackensack University Medical Center, Hackensack, NJ, ⁴Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Pediatric Rheumatology, Connecticut Childrens Medical Center, Hartford, CT, ⁶Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, ⁷University of Alabama at Birmingham, Birmingham, AL, ⁸Rheumatology, Nationwide Childrens Hospital/OSU, Columbus, OH, ⁹Children's Health, Dallas, TX, ¹⁰University of Louisville Medical School, Louisville, KY, ¹¹Children’s Hospital of Los Angeles, Los Angeles, CA, ¹²Center for Clinical and Translational Sciences, University of Alabama at Birmingham, Birmingham, AL, ¹³Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, ¹⁴Microbiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Prior studies have demonstrated abnormalities in the composition of the gastrointestinal microbiota in pediatric and adult patients with spondyloarthritis (SpA.) In particular, diminished fecal…
Abstract Number: 642 • 2017 ACR/ARHP Annual Meeting
Downstream Effects of Apremilast in Human Arthritic Ex Vivo Models
Tue Wenzel Kragstrup^1,2, Søren Lomholt², Morten Aagaard Nielsen², Line Dam Heftdal², Peter H. Schafer³ and Bent Deleuran^2,4, ¹Randers Regional Hospital, Randers, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, ³Department of Translational Development, Celgene Corporation, Summit, NJ, ⁴Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: Apremilast (Otezla) is a PDE4 inhibitor approved for the treatment of psoriasis and psoriatic arthritis, but the mechanisms of action of apremilast are not…
Abstract Number: 643 • 2017 ACR/ARHP Annual Meeting
Mir-10b-5p Is a IL-22 Regulator in CD4+T Cells from Ankylosing Spondylitis
Tae-Jong Kim¹, So-Hee Jin², Liye Chen³, Mohammad Hussein Al-Mossawi³, Anna Ridley³, Takuya Sekine³, Davide Simone³, Hui Shi³, Frank Penkava³ and Paul Bowness³, ¹Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South), ²Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South), ³Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
Background/Purpose: Emerging data suggest that a single microRNA (miR) can profoundly alter the phenotype and outcome of immune responses, offering the prospect of therapeutic use.…
Abstract Number: 644 • 2017 ACR/ARHP Annual Meeting
Association of Osteonectin, Osteopontin and Osteocalcin with Inflammation and Cardiovascular Risk in Patients with Axial Spondyloarthritis
Fernanda Genre¹, Javier Rueda-Gotor², Juan Irure-Ventura³, Sara Remuzgo-Martínez¹, Alfonso Corrales¹, Begoña Ubilla¹, Veronica Mijares¹, Carlos Fernández-Díaz¹, Virginia Portilla¹, Ricardo Blanco¹, Javier Llorca⁴, J. Gonzalo Ocejo-Vinyals³, Raquel López-Mejías¹ and Miguel Angel González-Gay⁵, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ²Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ³Immunology Division, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁴Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, ⁵Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL and School of Medicine, University of Cantabria, Santander, Spain
Background/Purpose: A higher incidence of cardiovascular (CV) risk factors and atherosclerosis has been reported in axial spondyloarthritis (axSpA) patients1. Since axSpA (particularly AS) is an…
Abstract Number: 645 • 2017 ACR/ARHP Annual Meeting
An Oral Tyk2 Inhibitor Effectively Suppresses the Development of Murine Th17 Cells In Vivo and Prevents Joint Damage in Experimental Ankylosing Spondylitis
Eric Gracey^1,2, Melissa Lim², Zoya Qaiyum¹, Yuriy Baglaenko^1,2, Wenyan Miao³, Craig Masse³, William Westlin³ and Robert D Inman^1,4, ¹Department of Immunology, University of Toronto, Toronto, ON, Canada, ²Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ³Nimbus Therapeutics, Cambridge, MA, ⁴Toronto Western Hospital, University Health Network, toronto, ON, Canada
Background/Purpose: Th17 cells play an important role in the pathogenesis of ankylosing spondylitis (AS). Tyk2, a member of the Janus Kinase (JAK) family of signaling…
Abstract Number: 646 • 2017 ACR/ARHP Annual Meeting
Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Is a Susceptibility Factor for Early Axial Spa Meeting the ASAS Classification Criteria: Results from the Spondyloarthritis Caught Early and DEvenir des Spondyloarthrites Indifférenciées Récentes Cohorts
Anoek de Koning¹, Marjolijn Hameetman², Corinne Miceli-Richard³, Maxime Dougados⁴, Désirée van der Heijde⁵, Fina Kurreeman⁶ and Floris van Gaalen⁷, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, Hôpital Bicêtre, Paris, France, ⁴Department of Rheumatology, Rene Descartes University, Hôpital Cochin, Paris, France, ⁵Leiden University Medical Center, Leiden, Netherlands, ⁶Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, Leiden, Netherlands, ⁷Rheumatology, LUMC, Leiden, Netherlands
Background/Purpose: Genetic research in axSpA is performed in patients with longstanding ankylosing spondylitis (AS). Early axial spondyloarthritis (axSpA) is a diverse patient group in which…
Abstract Number: 647 • 2017 ACR/ARHP Annual Meeting
Gene Expression in Cellular Subsets in Psoriatic Disease
Anastasiya Muntyanu¹, Fatima Abji², Remy Pollock¹, Vinod Chandran² and Dafna D Gladman², ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis is an inflammatory musculoskeletal disease which develops in 30% of patients with psoriasis. Our previous peripheral blood microarray study identified CXCL10, NOTCH2NL,…
Abstract Number: 648 • 2017 ACR/ARHP Annual Meeting
Are Choline Metabolites Associated with Inflammation in Psoriatic Arthritis?
Roxana Coras^1,2, Arthur Kavanaugh², Doquyen Huynh³, Mohit Jain² and Monica Guma², ¹Medicine, Autonomous University of Barcelona, Barcelona, Spain, ²Medicine, University of California, San Diego, La Jolla, CA, ³Medicine, University of California, San Diego, San Diego, CA
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory disease affecting the joints and connective tissue and is associated with psoriasis of the skin and nails. In…
Abstract Number: 649 • 2017 ACR/ARHP Annual Meeting
Role of Eicosanoids As Biomarkers in Psoriatic Arthritis
Roxana Coras^1,2, Arthur Kavanaugh¹, Doquyen H. Huynh¹, Aladdin Shadyab³, Sara Marsal⁴, Oswald Quehenberger⁵ and Monica Guma¹, ¹Medicine, University of California, San Diego, La Jolla, CA, ²Medicine, Autonomous University of Barcelona, Barcelona, Spain, ³Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, ⁴Rheumatology Research Unit, Vall d'Hebron Hospital, Barcelona, Spain, ⁵Pharmacology, Medicine, University of California, San Diego, La Jolla, CA
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory disease affecting the joints and connective tissue and is associated with psoriasis of the skin and nails. There…
Abstract Number: 650 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation, Transcriptomics, and Proteomics of Psoriasis and Psoriatic Arthritis in Monozygotic Twins
Angela Ceribelli¹, Elvezia Maria Paraboschi², Natasa Isailovic¹, Elena Generali¹, Michela Robusto², Maria De Santis¹, Giulia Cardamone², Francesco Sacrini³, Antonio Costanzo³, Stefano Duga² and Carlo Selmi¹, ¹Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano (MI), Italy, ²Laboratory of Medical genetics and RNA biology, Humanitas Research Hospital, Rozzano, Italy, ³Dermatology Unit, Humanitas Research Hospital, Rozzano, Italy
Background/Purpose: Psoriatic disease is a chronic inflammatory disorder spanning from skin disease (PsO) to psoriatic arthritis (PsA) without known serum biomarkers. The genetic background is…
Abstract Number: 651 • 2017 ACR/ARHP Annual Meeting
Role of Mir-21-5p As a Potential Biomarker of Psoriatic Arthritis and Response to Treatment
Rohan Machhar¹, Justine (Yang) Ye¹, Vinod Chandran² and Dafna D Gladman³, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory arthritis occurring in patients with psoriasis. miRNA’s are small non coding RNAs whose main function, at a post…
Abstract Number: 652 • 2017 ACR/ARHP Annual Meeting
Investigating the Role of Mechanical Stress in Spondyloarthritis Pathogenesis
Breanna Nguyen¹, Robert Colbert² and Gerlinde Layh-Schmitt¹, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²NIAMS/NIH, Bethesda, MD
Background/Purpose: Mechanotransduction is a cell’s ability to translate mechanical stimuli into biochemical signals and has been implicated in signaling pathways involving differentiation and proliferation. Mechanical…
Abstract Number: 653 • 2017 ACR/ARHP Annual Meeting
Reduced Ubiquitination of Misfolded HLA-B27 Is Associated with Inefficient Degradation By ERAD and Autophagy
Fatemeh Navid¹, Gerlinde Layh-Schmitt¹, Keith A. Sikora² and Robert Colbert¹, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Pediatric Translational Research Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: The HLA class I allele, HLA-B27, is associated with spondyloarthritis (SpA), an immune-mediated inflammatory disease affecting the axial skeletal, skin, gut and eyes. HLA-B27…
Abstract Number: 654 • 2017 ACR/ARHP Annual Meeting
Effect of Anti Tnfα Drugs on the Frequency of Circulating CD19+CD24hiCD38hi Breg Cells in Ankylosing Spondylitis
M. Belén Bautista-Caro¹, Eugenio De Miguel¹, Diana Peiteado¹, Alejandro Villalba¹, Irene Monjo¹, Amaya Puig-Kröger², Paloma Sanchez-Mateos³, Emilio Martín-Mola¹ and Maria Eugenia Miranda-Carus¹, ¹Rheumatology, Hospital La Paz-IdiPAZ, Madrid, Spain, ²Immuno-oncology, Hospital Gregorio Marañon, Madrid, Spain, ³Immunology, Hospital Gregorio Marañon, Madrid, Spain
Background/Purpose: CD19+CD24hiCD38hi B cells demonstrate a regulatory capacity and their frequency is altered in the peripheral blood of patients with various autoimmune diseases. The pathogenic…
Abstract Number: 655 • 2017 ACR/ARHP Annual Meeting
Innate Lymphoid Cells – New Players in Psoriatic Arthritis
Alina Soare¹, Stefanie Weber², Lisa Maul³, Ana Maria Gheorghiu⁴, Ismail Housni⁵, Arnd Kleyer⁶, Markus Luber², Simon Rauber², David Simon⁶, Juergen Rech⁶, Georg Schett⁶, Jörg Distler¹ and Andreas Ramming⁷, ¹Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ²Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ³Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁴Carol Davila University of Medicine and Pharmacy,Internal Medicine and Rheumatology Department ,,Dr.I.Cantacuzino'' Clinical Hospital, Bucharest, Romania, ⁵Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany, ⁶Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, ⁷Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany
Background/Purpose: Innate lymphoid cells (ILCs) produce disease-related cytokines including IL-17 and IL-22 and are therefore of substantial interest in PsA. Spreading the disease from the…

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