Abstracts Archive - Page 1422 of 2425 - ACR Meeting Abstracts

Abstract Number: 49 • 2016 ACR/ARHP Annual Meeting
Efficacy of Mirogabalin on Patient-Reported Pain and Sleep Interference in Patients with Diabetic Neuropathic Pain: Secondary Outcomes of a Phase 2 Proof-of-Concept Study
Domenico Merante¹, Julio Rosenstock², Uma Sharma³, Karen Feins⁴, Ching Hsu⁵ and Aaron Vinik⁶, ¹Daiichi Sankyo Development Ltd, Gerrards Cross, Buckinghamshire, United Kingdom, ²Dallas Diabetes and Endocrine Center at Medical City, Dallas, TX, ³MMS Holdings Inc., Canton, MI, ⁴Daiichi Sankyo Pharma Development, Edison, NJ, ⁵Daiichi Sankyo Inc, Edison, NJ, ⁶Eastern Virginia Medical School, Norfolk, VA
Background/Purpose: Mirogabalin is a novel, preferentially selective a2d-1 ligand intended for treatment of pain associated with fibromyalgia and neuropathic pain. Mirogabalin efficacy and safety was…
Abstract Number: 50 • 2016 ACR/ARHP Annual Meeting
Tai Chi Significantly Modulates Resting State Functional Connectivity of the Cognitive Control Network in Fibromyalgia
Jian Kong¹, Kristen Jorgenson², zengjian wang², Emily Wolcott³, William F. Harvey⁴ and Chenchen Wang⁴, ¹Massachusetts General Hospital, Boston, MA, ²MGH, Boston, MA, ³Tufts Medical Center, Boston, MA, ⁴Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Fibromyalgia (FM) is a common and complex musculoskeletal pain syndrome with unsatisfactory treatment options. Studies suggest that Tai Chi mind-body exercise may be…
Abstract Number: 62 • 2016 ACR/ARHP Annual Meeting
Increased Frequency of Anti-Drug Antibodies in Patients Carrying Compatible IgG1 Allotypes and Treated with Anti-TNF Antibodies
Antonio Gonzalez¹, Rosario Lopez-Rodriguez¹, Ana Martinez², Chamaida Plasencia-Rodriguez², Andrea Jochems², Dora Pascual-Salcedo² and Alejandro Balsa², ¹Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ²Instituto de Investigación Hospital Universitario La Paz (IDIPAZ), Madrid, Spain
Background/Purpose: One of the causes of insufficient response to biological drugs is the production of anti-drug antibodies (ADA) (1). These antibodies can decrease the effectiveness…
Abstract Number: 63 • 2016 ACR/ARHP Annual Meeting
Identification of Immune Gene Modules in Good Responders to Adalimumab in Rheumatoid Arthritis
James OIiver¹, Darren Plant², Gisela Orozco¹, Samantha Smith¹, Kimme L. Hyrich³, Ann Morgan⁴, John Isaacs⁵, Anthony G. Wilson⁶ and Anne Barton^1,2, ¹Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal BRU, Central Manchester Foundation Trust, Manchester, United Kingdom, ³Arthritis Research UK, Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, Great Britain, ⁵Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle, United Kingdom, ⁶UCD School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland
Background/Purpose: Despite the revolutionary impact of TNF inhibitor (TNFi) therapy in rheumatoid arthritis (RA), up to 40% of patients fail to respond adequately. Whilst non-responder…
Abstract Number: 64 • 2016 ACR/ARHP Annual Meeting
Enrichment of Immune Pathways in Genes Under Geographically Restricted Adaptation in the Gullah African American Population of South Carolina
Paula S. Ramos¹, Satria Sajuthi², Wei-Min Chen³, Jasmin Divers², Jyotika K. Fernandes⁴, Gary S. Gilkeson⁴, Kelly J. Hunt⁵, Diane L. Kamen⁴, Uma Nayak³, W. Timothy Garvey⁶, Michèle M. Sale⁷ and Carl D. Langefeld², ¹Departments of Medicine and Public Health Sciences, Medical University of South Carolina, Charleston, SC, ²Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC, ³Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia, Charlottesville, VA, ⁴Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁵Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, ⁶Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL, ⁷Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA
Background/Purpose: The reasons for the ethnic disparities in rheumatologic and autoimmune diseases (ADs) are largely unknown. We posit that population-specific selection influencing the allele frequencies…
Abstract Number: 65 • 2016 ACR/ARHP Annual Meeting
Genetic Heterogeneity in the Risk of Lupus Nephritis According to Ancestry
Cristina Lanata¹, Kimberly Taylor², Joanne Nitiham³, Dara Torgerson⁴, Betty P. Tsao⁵, Eric F Morand⁶, Marta Alarcon-Riquelme⁷ and Lindsey A. Criswell¹, ¹Division of Rheumatology, UCSF, San Francisco, CA, ²University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ³Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ⁴University of California, San Francisco, SAN FRANCISCO, CA, ⁵Medicine/Rheumatology, Division of Rheumatology, UCLA, Los Angeles, CA, ⁶Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ⁷Arthritis & Clinical Immunology, Oklahoma Medical REsearch Foundtion, Oklahoma City, OK
Genetic heterogeneity in the risk of lupus nephritis according to ancestry Background/Purpose: Lupus nephritis (LN) is a severe consequence of systemic lupus erythematosus (SLE) that…
Abstract Number: 66 • 2016 ACR/ARHP Annual Meeting
Very Rare X Chromosome Abnormalities in SLE and SjöGren’s May Localize X Gene Dose Effect
Rohan Sharma¹, Valerie M Harris², Joshua Cavett³, Biji T Kurien³, Ke Liu⁴, Kristi A. Koelsch⁵, Lida Radfar⁶, David M. Lewis⁷, Donald U. Stone⁸, C. Erick Kaufman⁹, Shibo Li¹⁰, Barbara M. Segal¹¹, Daniel J Wallace¹², Michael Weisman¹³, Jennifer A. Kelly¹⁴, Bernado Pons-Estel¹⁵, Roland Jonsson¹⁶, Jacques-Eric Gottenberg¹⁷, Juan-Manuel Anaya¹⁸, Deborah S. Cunninghame-Graham¹⁹, Vivian P. Bykerk²⁰, Gideon Hirschfield²¹, Gang Xie²², Wan-Fai Ng²³, Gunnel Nordmark²⁴, Per Eriksson²⁵, Roald Omdal²⁶, Nelson L. Rhodus²⁷, Maureen Rischmueller²⁸, Michael D. Rohrer²⁹, Marie Wahren-Herlenius³⁰, Torsten Witte³¹, Xavier Mariette³², Christopher J. Lessard³³, John B. Harley³⁴, Kathy L. Sivils³³, Astrid Rasmussen³⁵, R. Hal Scofield³³, Swamy Venturopalli³⁶, Xianglan Lu¹⁰, Pamela Hughes³⁷, Andrew J.W. Huang³⁸ and Corinnine Miceli-Richard³⁹, ¹Medical Service, US Department of Veterans Affaris Medical Center, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴3333 Burnet Ave., University of Cincinnati & Cincinnati Childre, Cincinnati, OH, ⁵U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, ⁶Oral Diagnosis and Radiology Department, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁷Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁸King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, ⁹Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, ¹⁰Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹¹Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN, ¹²Cedars-Sinai Medical Center, West Hollywood, CA, ¹³Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹⁴Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁵Sanatorio Parque, Rosario, Argentina, ¹⁶Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ¹⁷Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ¹⁸Center for Autoimmune Diseases Research (CREA). School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia., Bogotá, Colombia, ¹⁹Department of Medical and Molecular Genetics, King's College London, London, United Kingdom, ²⁰Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ²¹Centre for Liver Research, Institute of Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, ²²Mount Sinai Hospital, Toronto, ON, Canada, ²³Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ²⁴Rheumatology, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, ²⁵University Hospital, Rheumatology clinic, Linköping, Sweden, ²⁶Department of internal medicine, Clinical Immunology unit, Stavanger, Norway, ²⁷Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, ²⁸Rheumatology, Queen Elizabeth Hospital, Adelaide, Australia, ²⁹Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN, ³⁰Department of Medicine, Experimental Rheumatology Unit, Solna, Sweden, ³¹Hannover Medical School, Hanover, Germany, ³²Rheumatology, Rheumatology department, Bicetre Hospital, Paris-Sud University, Le Kremlin Bicetre, France, ³³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³⁴Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Childrens Hospital, Cincinnati, OH, ³⁵Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, ³⁶Rheumatology, Cedars Syani Medical Center, Los Angeles, CA, ³⁷Division of Oral and Maxillofacial Surgery, Department of Developmental and Surgical Science, University of Minnesota School of Dentistry, Minneapolis, MN, ³⁸Washington University,, St Louis, MO, ³⁹Rheumatology, Université Paris-Sud, Paris, France
Background/Purpose: Sjögren’s syndrome and systemic lupus erythematosus (SLE) are chronic, autoimmune diseases that are related by clinical and serological manifestations as well as genetic risks.…
Abstract Number: 67 • 2016 ACR/ARHP Annual Meeting
Polymorphisms of ERAP1, IL23R and TRAILR1 Are Associated with MRI-Sacroiliitis in Early Axial Spondyloarthritis: Data from the French DESIR Cohort
Cécile Luxembourger¹, Yannick Degboé², Alain Cantagrel³, Delphine Nigon⁴, Pascal Claudepierre⁵, Arnaud CONSTANTIN⁶ and Adeline Ruyssen-Witrand⁷, ¹Rheumatology, Centre Hospitalier Universitaire, Toulouse Purpan, Toulouse, France, ²Rheumatology, Rheumatology Center, Purpan University Hospital, Toulouse, France, ³Rheumatology, INSERM CNRS UMR 1043, Paul Sabatier University Toulouse, Purpan Teaching Hospital, Toulouse, France, ⁴CHU Purpan, Toulouse, France, ⁵Hôpital Henri Mondor, Créteil, France, ⁶Rheumatology, CHU Purpan - Hôpital Pierre-Paul Riquet, Toulouse, France, ⁷Rheumatology Center, Purpan University Hospital, Toulouse, France
Polymorphisms of ERAP1, IL23R and TRAILR1 are associated With MRI-Sacroiliitis in Early Axial Spondyloarthritis: Data from the French DESIR Cohort Background/Purpose: Spondyloarthritis (SpA) is a…
Abstract Number: 68 • 2016 ACR/ARHP Annual Meeting
Epigenetic and Expression Analysis of Ankylosing Spondylitis Association Loci Point to Key Cell Types Driving Disease
Zhixiu Li¹, Katelin Haynes², Gethin P. Thomas³, Tony J. Kenna¹, Paul Leo¹ and Matthew A. Brown¹, ¹Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ²University of Queensland Diamantina Institute, Brisbane, Australia, Brisbane, Australia, ³Research Office, Charles Sturt University, Wagga, Australia, Wagga, Australia
Background/Purpose: Susceptibility to ankylosing spondylitis (AS) is primarily genetic; thus far 113 susceptibility variants for AS have been identified. However, most of the AS associated…
Abstract Number: 69 • 2016 ACR/ARHP Annual Meeting
IL-32 Promoter SNP rs4786370 Predisposed to Modified Lipoprotein Profiles in Patients with Rheumatoid Arthritis
Michelle S.M.A. Damen¹, Rabia Agca², Suzanne Holewijn³, Jacqueline de Graaf¹, Jéssica C. Dos Santos^1,4, Piet L van Riel⁵, J Fransen⁶, Marieke J.H. Coenen⁷, Mike T. Nurmohamed⁸, M.G. Netea¹, Charles Dinarello⁹, L.A.B. Joosten¹, Bas Heinhuis¹ and Calin Popa¹⁰, ¹Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ²Rheumatology, Amsterdam Rheumatology and immunology Center, Location Reade, Amsterdam, Netherlands, ³Rijnstate Ziekenhuis, Arnhem, Netherlands, ⁴Instituto de Patologia Tropical e Saúde Pública, Goiás, Brazil, ⁵Scientific Institute for Quality of Healthcare, Radboud University Medical Center, Nijmegen, Netherlands, ⁶Department of Rheumatolgy, Radboud UMC, Nijmegen, Netherlands, ⁷Human Genetics (855), Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁸Rheumatology, Amsterdam Rheumatology and immunology Center, Location VU University Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands, ⁹Department of Medicine, Division of Infectious Diseases, University of Colorado, Denver, CO, ¹⁰Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Patients with a chronic inflammatory disease such as rheumatoid arthritis (RA) are at higher risk of developing cardiovascular diseases (CVD). Interleukin (IL)-32 has previously…
Abstract Number: 70 • 2016 ACR/ARHP Annual Meeting
Identifying Distal Interactions Between RUNX1 and JIA Associated Single Nucleotide Polymorphisms By Chromosome Conformation Capture
Christopher Taylor¹, Anne Hinks², Amanda McGovern¹, Helen Ray-Jones³, Kate Duffus¹, Annie Yarwood⁴, Gisela Orozco⁵, Paul Martin⁶, Wendy Thomson⁷ and Stephen Eyre⁸, ¹Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom, ²ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ³Centre for Musculoskeletal Research, University of MAnchester, Manchester, United Kingdom, ⁴Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ⁵Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ⁶Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, United Kingdom, ⁷Arthritis Research UK Centre for Genetics and Genomics,The University of Manchester, Manchester, United Kingdom, ⁸The University of Manchester, Manchester, United Kingdom
Background/Purpose: 17 genetic loci have now been identified to confer susceptibility to JIA; several of these loci harbour genes involved in the IL2 pathway suggesting…
Abstract Number: 71 • 2016 ACR/ARHP Annual Meeting
A Rare Coding Allele in IFIH1 is Protective for Psoriatic Arthritis
Ashley Budu-Aggrey^1,2, John Bowes², Philip E. Stuart³, Matthew Zawistowski⁴, Lam C. Tsoi⁴, Rajan P. Nair⁵, Eleanor Korendowych⁶, Neil J McHugh⁶, James T. Elder⁵, Anne Barton^1,7,8 and Soumya Raychaudhuri⁹, ¹NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academy of Health Sciences, Manchester, United Kingdom, ²Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK, Manchester, United Kingdom, ³Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, ⁴Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, ⁵University of Michigan Medical School, Ann Arbor, MI, ⁶Royal National Hospital for Rheumatic Diseases and Dept Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ⁷Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ⁸The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom, ⁹Brigham and Women's Hospital, Boston, MA
Background/Purpose: Psoriatic Arthritis (PsA) is an inflammatory arthritis associated with psoriasis estimated to present in approximately 14% of psoriasis patients in the UK. As a…
Abstract Number: 72 • 2016 ACR/ARHP Annual Meeting
Longitudinal Expression of CXCL10 in Psoriasis Patients That Develop Psoriatic Arthritis
Fatima Abji¹, Remy Pollock², Kun Liang³, Vinod Chandran⁴ and Dafna D Gladman⁵, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁴Rheumatology, University of Toronto, Toronto, ON, Canada, ⁵University of Toronto, Toronto, ON, Canada
Longitudinal Expression of CXCL10 in Psoriasis Patients that Develop Psoriatic Arthritis Patients Fatima Abji1, Remy Pollock1 Kun Liang2, Vinod Chandran1,3, Dafna D. Gladman1,3 1University of…
Abstract Number: 73 • 2016 ACR/ARHP Annual Meeting
Dysregulation of Hypomethylated Age-Related CpG Sites Characterize T-Cells and Monocytes from Treatment Naive Rheumatoid Arthritis Subjects
Ines Colmegna¹, Marie Forest², Aurelie Labbe³, Sasha Bernatsky⁴, Jose Navarro⁵, Tomi Pastinen⁶, Celia Greenwood⁷ and Marie Hudson⁸, ¹Medicine, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada, ³Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, QC, Canada, ⁴Division of Rheumatology, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁵Experimental Medicine, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁶Human Genetics, McGill University, Montreal, QC, Canada, ⁷Centre for Clinical Epidemiology, Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada, ⁸Medicine/Rheumatology, Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada
Background/Purpose: In the general population, an increase in chronological age is associated with differential DNA methylation of particular CpGs in a highly conserved fashion. Since…
Abstract Number: 74 • 2016 ACR/ARHP Annual Meeting
Arthritis-Associated DNA Hypermethylation Provokes Increased Antibody Expression in Mouse Model of Rheumatoid Arthritis
Daniel M. Tóth¹, Timea Ocskó¹, Adrienn Markovics¹, Attila Balog², Katalin Mikecz¹, Tibor T. Glant¹ and Tibor A. Rauch¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rheumatology, Albert Szent-Gyorgyi University, Szeged, Hungary
Background/Purpose: Although a number of epigenetic alterations have been revealed in rheumatoid arthritis (RA), it remained an open question whether these epimutations play role in…

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