Abstracts Archive - Page 1421 of 2607 - ACR Meeting Abstracts

Abstract Number: 506 • 2017 ACR/ARHP Annual Meeting
The Selective JAK1 Inhibitor Upadacitinib Has No Effect on Pharmacokinetics of the Hormonal Contraceptives Levonorgestrel and Ethinylestradiol
Mohamed-Eslam F. Mohamed¹, Sheryl Trueman¹, Tian Feng², Alan Friedman³ and Ahmed A. Othman², ¹Clinical Pharmacology and Pharmacometrics, AbbVie, North Chicago, IL, ²AbbVie, North Chicago, IL, ³AbbVie Inc., North Chicago, IL
Background/Purpose: Upadacitinib is a selective JAK1 inhibitor being developed for the treatment of several inflammatory diseases, including rheumatoid arthritis (RA). Upadacitinib showed favorable efficacy and…
Abstract Number: 507 • 2017 ACR/ARHP Annual Meeting
Tofacitinib Monotherapy Improves Left Ventricular Mass and Cardiac Output in Patients with Rheumatoid Arthritis
Kensuke Kume¹, Kanzo Amano², Susumu Yamada¹, Toshikatsu Kanazawa³ and Kazuhiko Hatta⁴, ¹Rheumatology, Hiroshima Clinic, Hiroshima, Japan, ²rheumatology., hiroshima clinic, Hiroshima, Japan, ³rheumatology, hiroshima clinic, hiroshima, Japan, ⁴Rheumatology, Hatta Clinic, Kure, Japan
Background/Purpose: Rheumatologists need to develop primary prevention strategies for cardiovascular disease (CVD) in rheumatoid arthritis (RA) patients. We reported tofacitinib (Tofa) plus methotrexate improved left…
Abstract Number: 508 • 2017 ACR/ARHP Annual Meeting
Improved Patient-Reported Outcomes in Patients with Rheumatoid Arthritis Who Failed Adalimumab or Placebo Treatment and Were Rescued with Baricitinib
Bruno Fautrel¹, Peter C. Taylor², Kaleb Michaud³, Himanshu Patel⁴, Baojin Zhu⁴, Carol L Gaich⁴, Jiaying Guo⁴, Amanda Quebe⁴ and Yoshiya Tanaka⁵, ¹Paris VI Pierre et Marie Curie University, Paris, France, ²Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ³Rheumatology, National Data Bank for Rheumatic Diseases & University of Nebraska Medical Center, Omaha, NE, ⁴Eli Lilly and Company, Indianapolis, IN, ⁵The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: In the Phase 3 RA-BEAM study, baricitinib (BARI) 4 mg once daily showed significant clinical improvements compared with placebo (PBO) and adalimumab (ADA).1 Switching…
Abstract Number: 509 • 2017 ACR/ARHP Annual Meeting
Long-Term Safety and Efficacy of Upadacitinib (ABT-494), an Oral JAK-1 Inhibitor in Patients with Rheumatoid Arthritis in an Open Label Extension Study
Mark C. Genovese¹, Joel Kremer², Sheng Zhong³ and Alan Friedman³, ¹Stanford University Medical Center, Palo Alto, CA, ²Albany Medical College, Albany, NY, ³AbbVie Inc., North Chicago, IL
Background/Purpose: Upadacitinib (UPA, ABT-494) is a selective, oral JAK-1 inhibitor studied in two phase 2 randomized controlled trials (RCTs) in patients (pts) with rheumatoid arthritis…
Abstract Number: 510 • 2017 ACR/ARHP Annual Meeting
Association between Clinical Response and Normalization of Patient-Reported Outcome Measures in Rheumatoid Arthritis: Post-Hoc Analysis from Two Phase 2b Filgotinib Studies
Mark C. Genovese¹, Annegret Van der Aa², Corinne Jamoul², Chantal Tasset², Pille Harrison², René Westhovens³ and Arthur Kavanaugh⁴, ¹Stanford University Medical Center, Palo Alto, CA, ²Galapagos NV, Mechelen, Belgium, ³University Hospitals Leuven on behalf of the CareRA Study Group, Leuven, Belgium, ⁴Medicine, University of California, San Diego, La Jolla, CA
Background/Purpose: Filgotinib (GLPG0634, GS-6034) is an oral, selective JAK1 inhibitor that has demonstrated safety and efficacy data in two 24-week placebo-controlled phase 2B studies as…
Abstract Number: 511 • 2017 ACR/ARHP Annual Meeting
Safety Profile of Baricitinib for the Treatment of Rheumatoid Arthritis up to 5.5 Years: An Updated Integrated Safety Analysis
Mark C. Genovese¹, Josef S. Smolen², Tsutomu Takeuchi³, David Hyslop⁴, William L. Macias⁴, Terence P. Rooney⁴, Lei Chen⁴, Christina L. Dickson⁴, Jennifer Riddle Camp⁴, Tracy Cardillo⁴, Taeko Ishii⁵ and Kevin Winthrop⁶, ¹Stanford University Medical Center, Palo Alto, CA, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ⁴Eli Lilly and Company, Indianapolis, IN, ⁵Eli Lilly and Company, Kobe, Japan, ⁶Oregon Health & Science University, Portland, OR
Background/Purpose: Baricitinib (bari), an oral, selective inhibitor of Janus kinase (JAK) 1 and JAK 2, is approved in the EU for the treatment of moderately…
Abstract Number: 512 • 2017 ACR/ARHP Annual Meeting
Efficacy Response to Baricitinib Based on Baseline Characteristics in Patients Who Are Inadequate Responders to Conventional DMARD
Maxime Dougados¹, Terence P. Rooney², Li Xie², Rena Klar³, Christina L. Dickson², Ana Pinto Correia², Yoshiya Tanaka⁴, Michael Schiff⁵ and Edward C. Keystone⁶, ¹Department of Rheumatology, Rene Descartes University, Hôpital Cochin, Paris, France, ²Eli Lilly and Company, Indianapolis, IN, ³Quintiles IMS Holdings, Inc., Durham, NC, ⁴The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, ⁵University of Colorado, Greenwood Village, CO, ⁶University of Toronto, Toronto, ON, Canada
Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease and some patients (pts) have an inadequate response (IR) to conventional DMARDs (csDMARDs). Baricitinib is an oral,…
Abstract Number: 513 • 2017 ACR/ARHP Annual Meeting
Time to Achieve Moderate/Low Disease Activity and Remission in RA Patients on Baricitinib Compared to Adalimumab, Methotrexate, and Placebo
Edward C. Keystone¹, Maxime Dougados², Eric M. Ruderman³, Baojin Zhu⁴, Pedro Lopez-Romero⁵, Hanne Lund⁶, Anabela Cardoso⁴, Douglas E. Schlichting⁴, Pindaro Martinez Osuna⁴, Robert Ortmann⁴ and Tore K. Kvien⁷, ¹University of Toronto, Toronto, ON, Canada, ²Rene Descartes University, Cochin Hospital, Paris, France, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Eli Lilly and Company, Indianapolis, IN, ⁵Europe Research Center, Eli Lilly and Company, Madrid, Spain, ⁶Eli Lilly Norge A.S., Oslo, Norway, ⁷Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Baricitinib (BARI), an oral, selective Janus kinase (JAK)1/2 inhibitor1, has shown efficacy in DMARD naïve RA patients (pts)2 and in pts with inadequate response…
Abstract Number: 514 • 2017 ACR/ARHP Annual Meeting
BMS-986195, a Novel, Rapidly Acting, Covalent Inhibitor of Bruton’s Tyrosine Kinase: Safety, Pharmacokinetic and Pharmacodynamic Profiles in Healthy Participants
IM Catlett, L Wei, N Zheng, A Liu, B He, I Girgis and M Nowak, Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: Bruton’s tyrosine kinase (BTK) is an attractive, novel therapeutic target for autoimmune disease, as it is required for signal transduction and activation via B-cell…
Abstract Number: 515 • 2017 ACR/ARHP Annual Meeting
Leukopenia and Tumor Necrosis Factor Alpha Inhibitor Therapy
Wenlu Xiong¹, Rochella A. Ostrowski², William Adams³ and Rodney Tehrani⁴, ¹Rheumatology, Vanderbilt University Medical Center, Nashville, TN, ²Rheumatology, Loyola University Medical Center, Maywood, IL, ³Clinical Research Office, Loyola University Medical Center, Maywood, IL, ⁴Rheumatology & Immunology, Loyola University Medical Center, Maywood, IL
- Background/Purpose: Tumor necrosis factor (TNF) alpha, a key proinflammatory cytokine in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), has been a major target in…
Abstract Number: 516 • 2017 ACR/ARHP Annual Meeting
Efficacy of Adding Iguratimod Therapy in Rheumatoid Arthritis　Patients Who Had Inadequate Response to Biologic Dmards
Toshiaki Miyamoto, Rheumatology, SEIREI HAMAMATSU GENERAL HOSPITAL, Hamamatsu, Japan
Background/Purpose: Iguratimod (IGU) was approved in June 2012 and recommended by JCR guideline 2014 in the treatment of rheumatoid arthritis (RA). Although there have been…
Abstract Number: 517 • 2017 ACR/ARHP Annual Meeting
Evaluation of the Effectiveness of Injectable Methotrexate for the Treatment of Rheumatoid Arthritis
Jenny Wan¹, Michele Spence², Fang Niu², Rita Hui³, Stephen Cheng¹, Logan Saito⁴ and Antony Lin⁵, ¹Kaiser Permanente Drug Information Services - California Regions, Downey, CA, ²Kaiser Permanente Pharmacy Outcomes Research Group, Downey, CA, ³Kaiser Permanente Pharmacy Outcomes Research Group, Oakland, CA, ⁴Kaiser Permanente Southern California Clinical Pharmacy Services, Downey, CA, ⁵Rheumatology, Kaiser Permanente Fontana Medical Center, Fontana, CA
Background/Purpose: Systemic methotrexate (MTX) is the first-line disease-modifying antirheumatic drug (DMARD) for treating early and established rheumatoid arthritis (RA). When compared to oral MTX, subcutaneous…
Abstract Number: 518 • 2017 ACR/ARHP Annual Meeting
The Occurrence of Shingles and the Effect of Zoster Vaccination with the Use of Methotrexate in Rheumatoid Arthritis Patients
Antony Lin¹, Qiaowu Li², Jiaxiao Shi², Serena Lin³, Danielle Wang⁴, Jenny Wan⁵, Kevin Lee³, Hung-Fu Tseng² and TC Cheetham⁶, ¹Southern California Permanente Medical Group, Pasadena, CA, ²Department of Research and Evaluation, Kaiser Permanente, Pasadena, CA, ³Stanford University, Stanford, CA, ⁴UCI Medical Center, Irvine, CA, ⁵Kaiser Permanente Drug Information Services - California Regions, Downey, CA, ⁶Western University of Health Sciences, Pomona, CA
Background/Purpose: To investigate the efficacy and safety of zoster vaccines administered in rheumatoid arthritis(RA) patients taking methotrexate(MTX). Methods: By reviewing data through the…
Abstract Number: 519 • 2017 ACR/ARHP Annual Meeting
Filgotinib, a Selective Janus Kinase 1 Inhibitor, Has No Effect on QT Interval in Healthy Subjects
Kacey Anderson¹, Hao Zheng², Chohee Yun³, Ellen Kwan⁴, Ann Qin¹, Florence Namour⁵, Brian P. Kearney¹ and Yan Xin¹, ¹Clinical Pharmacology, Gilead Sciences, Inc., Foster City, CA, ²Gilead Sciences, Inc., Foster City, CA, ³Clinical Research, Gilead Sciences, Inc, Foster City, CA, ⁴Clinical Operations, Gilead Sciences, Inc, Foster City, CA, ⁵Galapagos NV, Romainville, France
Background/Purpose: Filgotinib is a potent and selective Janus kinase 1 (JAK1) inhibitor being developed to treat inflammatory diseases. Safety pharmacology studies and Phase 1 studies…
Abstract Number: 520 • 2017 ACR/ARHP Annual Meeting
Clinical and Structural Responses of Patients with Active Rheumatoid Arthritis (RA) Using Step-up Dosing of Tofacitinib in a Treat to Target Approach
Norman Gaylis¹, Joanne Sagliani¹ and Steven Needell², ¹Arthritis & Rheumatic Disease Specialties, Aventura, FL, ²Boca Radiology, Boca Raton, FL
Background/Purpose: Tofacitinib has been shown to reduce the clinical signs and symptoms of some RA patients at an approved dose of 5 mg bid. Studies…

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