Abstracts Archive - Page 1398 of 2425 - ACR Meeting Abstracts

Abstract Number: 2887 • 2017 ACR/ARHP Annual Meeting
Long-Term Follow-up Report on Japanese Patients with Severe Systemic Sclerosis after Autologous Hematopoietic Stem Cell Transplantation
Hiroyuki Nakamura¹, Shinsuke Yasuda¹, Atsushi Noguchi², Toshio Odani³, Yuichiro Fujieda¹, Masaru Kato¹, Kenji Oku¹, Junichi Sugita⁴, Toshiyuki Bohgaki¹, Tomoyuki Endo⁴, Takanori Teshima⁴ and Tatsuya Atsumi¹, ¹Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ²Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, ³Third Department of Internal Medicine, Obihiro-Kosei General Hospital, Hokkaido, Japan, ⁴Department of Hematology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Background/Purpose: Systemic sclerosis (SSc) comprises diverse clinical phenotypes with variable disease courses. Some SSc patients take miserable and fatal clinical course due to rapid progressive…
Abstract Number: 2888 • 2017 ACR/ARHP Annual Meeting
Corticosteroid-Sparing Benefit of Intravenous Immunoglobulins in Systemic Sclerosis-Associated Inflammatory Myopathy: A Retrospective Study of 54 Patients
Benjamin Chaigne¹, Simao Rodeia², Nouria Benmostefa^2,3,4, Alice Bérezné⁵, Pascal Cohen⁶, Alexis Regent⁷, Benjamin Terrier⁶, Nathalie Costedoat-Chalumeau⁸, Loïc Guillevin⁹, Claire Le Jeunne⁶ and Luc Mouthon¹⁰, ¹Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes Rares d’Ile de France, hôpital Cochin, DHU Authors, Assistance Publique-Hôpitaux de Paris, Paris, France, ²Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes Rares d’Ile de France, DHU Authors, hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France, ³Service de Médecine Interne CHU de Sétif, Algérie, Sétif, Algeria, ⁴Faculté de Médecine, Université de Sétif 1, Sétif, Algeria, ⁵Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ⁶Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, ⁷National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁸Service de médecine interne Pôle médecine, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares de l’île de France, Paris, France, ⁹Internal medicine, Cochin University Hospital, paris, France, ¹⁰Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France ;Université Paris Descartes Sorbonne Paris, Paris, France
Background/Purpose: Little is known about systemic sclerosis (SSc)-associated myopathy (SScAM) treatment. Intravenous immunoglobulin (IVIg) are used off-label in SScAM. Herein we aimed to evaluate the…
Abstract Number: 2889 • 2017 ACR/ARHP Annual Meeting
Aminaphtone Ameliorates Clinical Symptoms and Increases Skin Blood Perfusion in Patients with Both Primary and Secondary Raynaud Phenomenon: A Six-Month Open Study
Alberto Sulli¹, Maurizio Cutolo², Carmen Pizzorni², Sabrina Paolino², Elisa Alessandri², Emanuele Gotelli² and Barbara Ruaro², ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino, Genoa, Italy, Genova, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino, Genoa, Italy, Genoa, Italy
Background/Purpose: Current treatments for Raynaud's phenomenon (RP) have limited efficacy, which was mainly demonstrated by physician/patient reported outcomes. Aminaphtone is a vasoactive drug recently suggested…
Abstract Number: 2890 • 2017 ACR/ARHP Annual Meeting
Performance of Machine Learning Methods Using Electronic Medical Records to Predict Varicella Zoster Virus Infection
Milena Gianfrancesco¹, Gabriela Schmajuk², Sara Murray³, Dana Ludwig³, Awni Hannun⁴, Anand Avati⁴, Suzanne Tamang⁵ and Jinoos Yazdany⁶, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²San Francisco VA Medical Center, University of California San Francisco, San Francisco, CA, ³University of California, San Francisco, San Francisco, CA, ⁴Computer Science, Stanford University, Palo Alto, CA, ⁵Stanford Center for Population Health Science, Stanford University, Palo Alto, CA, ⁶Medicine/Rheumatology, University of California San Francisco, San Francisco, CA
Background/Purpose: Varicella zoster virus infections (VZV) can be associated with significant morbidity in immunosuppressed hosts. However, methods do not exist to systematically identify which patients…
Abstract Number: 2891 • 2017 ACR/ARHP Annual Meeting
Do Certain Dmards Increase Risk of New-Onset Type 2 Diabetes in RA Patients? a Disease Risk Score Analysis Using Administrative Databases
E Alemao, Z Guo and L Burns, Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: Data on the association between RA and type 2 diabetes mellitus (T2DM) are inconsistent, suggesting RA treatments such as glucocorticoids (GCs) and hydroxychloroquine could…
Abstract Number: 2892 • 2017 ACR/ARHP Annual Meeting
Persistently Frequent Emergency Department (ED) Utilization Among Systemic Lupus Erythematosus (SLE) Patients
Jiha Lee¹, Lisa Gale Suter^1,2 and Liana Fraenkel^1,3, ¹Rheumatology, Rheumatology, Yale University School of Medicine, New Haven, CT, New Haven, CT, ²Medicine, Rheumatol., TAC S541, Rheumatology, VA Connecticut Healthcare System, West Haven, CT, New Haven, CT, ³Medicine, Section of Rheumatology, Rheumatology, VA Connecticut Healthcare System, West Haven, CT, New Haven, CT
Background/Purpose: SLE patients frequently utilize the ED irrespective of their access to care, which raises concern for inadequate quality of care in the outpatient setting.…
Abstract Number: 2893 • 2017 ACR/ARHP Annual Meeting
The Use of Natural Language Processing to Identify, Retrieve, Report, and Correct Observational Data on US Veterans Enrolled in the Veterans Affairs Rheumatoid Arthritis Registry
Grant Cannon¹, Jorge Rojas¹, Neill Bell², Andreas Reimold³, Ted R. Mikuls⁴, Namrata Singh⁵, Gail S. Kerr⁶, Pascale Schwab⁷, Jennifer Barton⁷, Liron Caplan⁸, Joshua Baker⁹, Angelo L. Gaffo¹⁰, J. Steuart Richards¹¹, Deana Lazaro¹², Vikas Majithia¹³ and Brian Sauer¹, ¹Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ²Salt Lake City VA Medical Center and University of Utah, Dallas VA Medical Center, Dallas, TX, ³Dallas VA Medical Center and University of Texas Southwestern, Dallas, TX, ⁴VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁵VA Nebraska-Western Iowa Health Care System and University of Iowa, Omaha, IA, ⁶Washington DC VA Medical Center, Georgetown and Howard University Hospitals, Washington, DC, ⁷Portland VA Medical Center and University of Oregon, Portland, OR, ⁸Denver VA Medical Center and Univerity of Colorado, Denver, CO, ⁹Philadelphia VA Medical Center and University of Pennsylvania, Philadelphia, PR, ¹⁰Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, AL, ¹¹Pittsburgh VA Medical Center and University Of Pittsburgh, Pittsburgh, PA, ¹²Brooklyn VA Medical Center and SUNY Downstate, Brooklyn, NY, ¹³Jackson VA Medical Center and University of Mississippi, Jackson, MS
Background/Purpose: The Veterans Affairs (VA) Rheumatoid Arthritis (RA) (VARA) registry is an observational cohort study at 12 VA medical centers that prospectively collects clinical…
Abstract Number: 2894 • 2017 ACR/ARHP Annual Meeting
Synchronous Telemedicine Care in Rheumatology for a Dispersed Veterans Affairs Health System
Patrick R. Wood¹ and Liron Caplan², ¹Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Rural Veterans with inflammatory arthritis (IA) lack access because of geographic and other barriers. A national shortage of rheumatologists exists, particularly in rural settings,…
Abstract Number: 2895 • 2017 ACR/ARHP Annual Meeting
Predictors of Hospitalization, Length of Stay and Costs of Care Among Children with Juvenile Dermatomyositis in the United States
Michael C. Kwa¹, Jonathan I. Silverberg² and Kaveh Ardalan^3,4, ¹Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Departments of Pediatrics and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Division of Rheumatology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL
Background/Purpose: Juvenile dermatomyositis (JDM) is a rare autoimmune disease that causes significant morbidity and quality of life impairment. Little is known about JDM inpatient burden…
Abstract Number: 2896 • 2017 ACR/ARHP Annual Meeting
Human Cartilage Influences the Crystallization of Monosodium Urate; Understanding the Link between Gout and Osteoarthritis
Ashika Chhana¹, Bregina Pool², Ally Choi¹, Ryan Gao¹, Mark Zhu¹, Jillian Cornish², Jacob Munro³ and Nicola Dalbeth⁴, ¹Medicine, University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³Orthopaedics, Auckland City Hospital, Auckland, New Zealand, ⁴University of Auckland, Auckland, New Zealand
Background/Purpose: Monosodium urate (MSU) crystal deposition and gout flares frequently affect joints that have been damaged or are affected by osteoarthritis. The aim of…
Abstract Number: 2897 • 2017 ACR/ARHP Annual Meeting
A Non-Coding Genetic Variant Maximally Associated with Serum Urate Levels Is Functionally Linked to HNF4A-Dependent PDZK1 Expression
Tony R. Merriman¹, Sarada Ketharnathan², James Boocock³, Amanda Phipps-Green², Jisha Antony², Megan Leaask², Justin O'Sullivan⁴ and Julia Horsfield², ¹Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ²University of Otago, Dunedin, New Zealand, ³University of California Los Angeles, Los Angeles, CA, ⁴University of Auckland, Auckland, New Zealand
A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expressionBackground/Purpose: Genome-wide association studies have revealed several dozen genetic…
Abstract Number: 2898 • 2017 ACR/ARHP Annual Meeting
New Mouse Model of Gout Risk Variant, ABCG2 Q141K, Reveals Unexpectedly Severe Molecular and Functional Defect in ABCG2 Mediated Intestinal Uric Acid Secretion
Kazi M. Hoque and Owen M. Woodward, Physiology, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Gout is a common arthritic disease resulting from deposition of monosodium urate crystals in joints and is a consequence of having elevated circulating uric…
Abstract Number: 2899 • 2017 ACR/ARHP Annual Meeting
Trapped Crystals in Synovial Fluid: Neutrophil Extracellular Traps (NETs) from Bench to Bed-Side
Estrella Garcia Gonzalez, Orso Maria Luccherini, Alessandra Gamberucci, Alessandra Ali, Antonella Simpatico, Sauro Lorenzini, Marco Bardelli, Mauro Galeazzi and Enrico Selvi, Rheumatology Unit - Policlinico le Scotte, Siena, Italy
Background/Purpose: Recent data show that neutrophils are able to release chromatin and granular enzymes in web-like structures called neutrophil extracellular traps (NETs). The release of NETs has a physiological…
Abstract Number: 2900 • 2017 ACR/ARHP Annual Meeting
Osteoarthritis-Associated Calcium-Containing Crystals and Biomaterial Microparticles Both Drive M1 Macrophage Polarization in a Syk and MAP Kinase-Dependent Manner
Geraldine M. McCarthy¹, Olwyn Mahon², Sarah O'Hanlon³, Daniel Kelly⁴ and Aisling Dunne⁵, ¹Div of Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland, ²School of Biochemistry and Immunology,, ,Trinity College Dublin, Dublin, Ireland, ³School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland, ⁴Trinity Center for Bioengineering, ,Trinity College Dublin, Dublin, Ireland, ⁵School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
Background/Purpose: Intra-articular basic calcium phosphate (BCP) crystals are associated with advanced osteoarthritis (OA) andsynovitis. OA-associated synovium exhibits increased numbers of macrophages compared with non-OA joints.…
Abstract Number: 2901 • 2017 ACR/ARHP Annual Meeting
Anti-Inflammatory Mechanism of Lubricin/Proteoglycan 4 (PRG4) in Monosodium Urate (MSU)-Crystal Induced Arthritis in THP-1 Macrophages Is Mediated By NALP3 Inflammasome.
Anthony M. Reginato¹, Changqi Sun², Tannin Schmidt³, Elsaid Khalid⁴ and Gregory Jay⁵, ¹Division of Rheumatology, The Warren Alpert School Of Medicine of Brown University, Providence, RI, ²Division of Rheumatology, Rhode Island Hosital/The Warren Alpert School of Medicine of Brown University, Providence, RI, ³Kinesiology and Schulich School of Engineering, University of Calgary, Calgary, AB, Canada, ⁴Department of Biomedical and Phramaceutical Science, Chapman University School of Pharmacy, Irvine, CA, ⁵Emergency Medicine and Engineering, The Warren Alpert Medical School Brown University, Providence, RI
Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocytes. PRG4 has a multifaceted homeostatic role in the joint including…

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