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  • Abstract Number: 2842 • 2017 ACR/ARHP Annual Meeting

    Usefulness of Polymerase Chain Reaction for Diagnosing Whipple’S Disease in Rheumatology

    Marion Herbette1, Jean Baptiste Cren2, Laurie Joffres3, charlotte lucas4, Emilie Ricard5, Carine Salliot6, Jerome Guinard7, Aleth Perdriger8, Elisabeth Solau-Gervais9, Béatrice Bouvard10 and Alain Saraux11, 1Rheumatology, University Hospital, Brest, France, 2Rheumatology, University Hospital of Angers, Angers, France, 3University Hospital de Poitiers, Poitiers, France, 4Rheumatology, University Hospital, Rennes, France, 5Rheumatology, University Hospital, Orléans, France, 6department of Rheumatology, Orleans, France, 7Microbiology, CHU Angers, Angers, France, 8Service de Rhumatologie, CHRU de Rennes, Rennes, France, 9Rhumatologie, University Hospital, Poitiers, France, 10rheumatology, CHU Angers, Angers, France, 11Rheumatology, Brest University Medical School Hospital, Brest, France

    Background/Purpose: Whipple's disease should be considered in patients with recurrent episodes of seronegative arthritis in the large limb, various symptoms (fever, uveitis,...) or biological abnormalities…
  • Abstract Number: 2843 • 2017 ACR/ARHP Annual Meeting

    The Relationship between Serum Urate Concentration and Incident Gout: An Individual Participant Data Analysis

    Nicola Dalbeth1, Amanda Phipps-Green2, Christopher Frampton3, Tuhina Neogi4, William J. Taylor5 and Tony R. Merriman6, 1University of Auckland, Auckland, New Zealand, 2University of Otago, Dunedin, New Zealand, 3University of Otago, Christchurch, New Zealand, 4Boston University School of Medicine, Boston, MA, 5University of Otago, Wellington, New Zealand, 6Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand

    Background/Purpose: Elevated serum urate concentration (hyperuricemia) is considered to be a key risk factor for developing gout.  However, the relationship between serum urate and incident…
  • Abstract Number: 2844 • 2017 ACR/ARHP Annual Meeting

    Risk of Cardiovascular Events in Older Patients with Gout Initiating Febuxostat Versus Allopurinol: A Population-Based Cohort Study

    MaryAnn Zhang1, Jun Liu2, Eun Ha Kang3, Rishi J. Desai4, Tuhina Neogi5, Daniel H. Solomon1 and Seoyoung C. Kim1, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 2Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, 3Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea, Republic of (South), 4Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston, MA, 5Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA

    Background/Purpose: Gout, a disorder of uric acid deposition, is commonly treated with xanthine oxidase inhibitors like febuxostat and allopurinol.  While it is well-known that patients…
  • Abstract Number: 2845 • 2017 ACR/ARHP Annual Meeting

    Association between Serum Urate As a Surrogate Endpoint and Flares in People with Gout: An Ecological Study Based on a Systematic Review of Trials and Open Label Extensions

    Lisa K. Stamp1, Melanie Morillon2, William Taylor3, Nicola Dalbeth4, Marissa Lassere5, Jasvinder A. Singh6 and Robin Christensen7, 1University of Otago, Christchurch, New Zealand, 2Department of Medicine, Vejle Hospital, Denmark, Odense, Denmark, 3University of Otago, Wellington, New Zealand, 4University of Auckland, Auckland, New Zealand, 5University of New South Wales, Sydney, Australia, 6Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 7Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark

    Background/Purpose: The primary efficacy measure in urate lowering therapy (ULT) trials is usually serum urate (SU). However, it is unknown whether the strength of the…
  • Abstract Number: 2846 • 2017 ACR/ARHP Annual Meeting

    Cause-Specific Mortality in Gout: Novel Findings of Elevated Risk of Renal-Related and Decreased Risk of Dementia-Related Death

    Ana Beatriz Vargas-Santos1, Tuhina Neogi2, Geraldo Castelar-Pinheiro1 and Aleksandra Turkiewicz3, 1Internal Medicine - Rheumatology, State University of Rio de Janeiro, Rio de Janeiro, Brazil, 2Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, 3Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden

    Background/Purpose: There is recognized higher mortality among gout patients, with cardiovascular (CV) mortality having been previously reported. The present study aimed to examine cause-specific mortality…
  • Abstract Number: 2847 • 2017 ACR/ARHP Annual Meeting

    The Sons of Gout Study. Ultrasonographic Evaluation of Asymptomatic Monosodium Urate Crystal Deposition in Sons of People with Gout

    Abhishek Abhishek1, Wendy Jenkins1, Philip Courtney2, Adrian Jones3, Weiya Zhang4 and Michael Doherty5, 1Devision of Rheumatology, University of Nottingham, NG5 1PB, England, 2Department of Rheumatology, Notingham, United Kingdom, 3Rheumatology Unit, Nottingham City Hospital, Nottingham Notts, United Kingdom, 4Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 5Academic Rheumatology, University of Nottingham, Nottingham, Great Britain

    Background/Purpose: Hyperuricemia and gout aggregate in families. The objectives of this study were to estimate the prevalence of asymptomatic monosodium urate (MSU) crystal deposition in…
  • Abstract Number: 2848 • 2017 ACR/ARHP Annual Meeting

    Improving Gout Outcomes: The Randomized Evaluation of an Ambulatory Care Pharmacist-Led Intervention to Optimize Urate Lowering Pathways (RAmP-Up) Study

    Ted R. Mikuls1, TC Cheetham2, Gerald D. Levy3, Nazia Rashid4, Kimberly Low5, Brian W Coburn6, Kenneth Saag7, Lang Chen8 and Jeffrey R. Curtis9, 1Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 2Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, 3Internal Medicine/Rheumatology, Kaiser Permanente Southern California, Downey, CA, 4Pharmacy Analytic Services, Kaiser Permanente Southern California, Downey, CA, 5Kaiser Permanente Southern California, Panorama City, CA, 6Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 7Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 8University of Alabama at Birmingham, Birmingham, AL, 9Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose:   Allopurinol is a cornerstone therapy in gout management.  Despite this, allopurinol use is suboptimal as providers often fail to follow the treat-to-target paradigm…
  • Abstract Number: 2849 • 2017 ACR/ARHP Annual Meeting

    Pain and Functional Trajectories in Symptomatic Knee Osteoarthritis over a 12-Week Period of Non-Pharmacological Exercise Interventions

    Augustine Lee1, William F. Harvey2, Xingyi Han1, Lori Lyn Price3,4, Jeffrey B. Driban1, Raveendhara R. Bannuru1 and Chenchen Wang2, 1Rheumatology, Tufts Medical Center, Boston, MA, 2Rheumatology, Center of Integrative Medicine and Division of Rheumatology, Tufts Medical Center, Boston, MA, Boston, MA, 3Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, 4Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA

    Background/Purpose: Exercise is the recommended treatment for knee osteoarthritis (OA). However, heterogeneous patterns in treatment response are poorly understood. Our purpose was to identify pain…
  • Abstract Number: 2850 • 2017 ACR/ARHP Annual Meeting

    Jakinibs Decrease Chronic Low Back Pain and Increase Function: A Proof of Concept Trial

    Maria Greenwald1 and JoAnn Ball2, 1Desert Medical Advances, Palm Desert, CA, 2rheumatology, Desert Medical Advances, Palm Deseret, CA

    Background/Purpose: Low back pain (LBP) is ubiquitous and estimated to affect 26% of Americans in any 3 month period. Why would rheumatoid arthritis patients be…
  • Abstract Number: 2851 • 2017 ACR/ARHP Annual Meeting

    General and Abdominal Obesity As Risk Factors for Late-Life Mobility Limitation Among Women with Total Knee or Hip Replacement for Osteoarthritis

    Aladdin Shadyab1, Wenjun Li2, Charles Eaton3 and Andrea LaCroix4, 1Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, 2Medicine, University of Massachusetts Medical School, Worcester, MA, 3Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI, 4Family Medicine and Public Health, University of California, San Diego School of Medicine, La Jolla, CA

    Background/Purpose: The population is rapidly aging, and by 2060, more than 12 million women will be ages 85 years and older in the United States.…
  • Abstract Number: 2852 • 2017 ACR/ARHP Annual Meeting

    Widespread Pain Prior to Total Knee Replacement (TKR) Is Associated with Increased Risk of No Clinical Improvement in Pain Among Women

    Ernest Vina1, Di Ran2, Erin L. Ashbeck2 and C. Kent Kwoh3, 1Rheumatology, University of Arizona, Tucson, AZ, 2The University of Arizona Arthritis Center, Tucson, AZ, 3University of Arizona, Tucson, AZ

    Background/Purpose: Up to 47% of individuals may not have clinically significant improvement following joint replacement surgery. Evidence also suggests that women are less likely to…
  • Abstract Number: 2853 • 2017 ACR/ARHP Annual Meeting

    Is Frailty Associated with Adverse Events after Total Joint Arthroplasty?

    Lisa A. Mandl1,2, Abigail M. Schmucker3, Nathaniel Hupert4, Mayu Sasaki3, Charles N. Cornell5,6, Michael B. Cross5,6, Alejandro Gonzalez Della Valle5,6, Mark P. Figgie6,7, Seth A. Jerabek5,6, Jackie Szymonifka1 and Steven K. Magid8,9, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Medicine - Rheumatology, Weill Cornell Medicine, New York, NY, 3Quality Research Center, Hospital for Special Surgery, New York, NY, 4Medicine, Healthcare Policy and Research, Weill Cornell Medicine, New York, NY, 5Surgery, Hospital for Special Surgery, New York, NY, 6Surgery, Weill Cornell Medicine, New York, NY, 7Orthopaedics, Hospital for Special Surgery, New York, NY, 8Medicine - Rhuematology, Hospital for Special Surgery, New York, NY, 9Medicine, Weill Cornell Medicine, New York, NY

    Background/Purpose: The increased volume of TJA due to the aging population requires a better understanding of the effect of physiological frailty, in addition to chronological…
  • Abstract Number: 2854 • 2017 ACR/ARHP Annual Meeting

    Optimizing Data Capture for Performance – Metrics Using Smartphone App Technology

    James Willig1, Jeffrey R. Curtis2, Andrew Westfall3, Donald Lein4, Christian Ray Smith4, Jonathan Cortis5, Clayton Rice5 and Christopher Hurt4, 1Med - Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, 2Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, 3Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, 4University of Alabama at Birmingham, Birmingham, AL, 5CTS, Inc, Birmingham, AL

    Background/Purpose: Gait speed has been associated with many clinical outcomes (e.g. frailty, mortality, joint replacement need, etc.) relevant for rheumatologic conditions. Measuring Gait speed (stride…
  • Abstract Number: 2855 • 2017 ACR/ARHP Annual Meeting

    Subcutaneous Abatacept in Patients Aged 2–17 Years with Polyarticular Juvenile Idiopathic Arthritis and Inadequate Response to Biologic or Non-Biologic Disease-Modifying Antirheumatic Drugs: Pharmacokinetics, Effectiveness, Safety and Immunogenicity over 2 Years

    Hermine I. Brunner1, N Ruperto2, G Vega-Cornejo3, A Berman4, Inmaculada Calvo5, R Cuttica6, F Ávila-Zapata7, Michael Henrickson1, DJ Kingsbury8, D Viola9, V Keltsev10, K Minden11, John F. Bohnsack12, X Li13, M Nys14, R Wong13, S Banerjee13, Daniel J Lovell1 and Alberto Martini15, 1Cincinnati Children’s Hosp. Medical Center, Cincinnati, OH, 2Istituto G. Gaslini Pediatria II Reumatologia, Genoa, Italy, 3Clinica de Reumatología y Enfermedades Autoinmunes (CREA), Hospital México Americano, Guadalajara Jalisco, Mexico, 4Universidad Nacional de Tucuman and Centro Médico Privado de Reumatología, Tucuman, Argentina, 5Hospital Univ. La Fe, Valencia, Spain, 6Hospital General de Niños Pedro de Elizalde, Buenos Aires, Argentina, 7Star Medica Hospital, Yucatán, Mexico, 8Randall Children’s Hospital at Legacy Emanuel, Portland, OR, 9CAICI Institute, Rosario City, Santa Fe State, Argentina, 10GBUZ Samara region "Togliatti City Clinical Hospital No.5" Rheumatology Department, Togliatti, Russian Federation, 11German Rheumatism Research Center and Charité University Medicine, Berlin, Germany, 12University of Utah School of Medicine, Salt Lake City, UT, 13Bristol-Myers Squibb, Princeton, NJ, 14Bristol-Myers Squibb, Braine-l’Alleud, Belgium, 15Istituto G. Gaslini Pediatria II Reumatologia and University of Genova, Genoa, Italy

    Background/Purpose: IV abatacept (ABA) 10 mg/kg every 4 weeks is well tolerated and effective in reducing the signs and symptoms of polyarticular juvenile idiopathic arthritis…
  • Abstract Number: 2856 • 2017 ACR/ARHP Annual Meeting

    Evaluation of a Dosing Regimen for Tocilizumab in Patients Younger Than Two Years of Age with Systemic Juvenile Idiopathic Arthritis

    Navita L. Mallalieu1, Joy Hsu1, Karen Wang1, Sunethra Wimalasundera2, Wendy Douglass2, Chris Wells2, Inmaculada Calvo3, Rubén Cuttica4, Hans-Iko Huppertz5, Rik Joos6, Yukiko Kimura7, Diana Milojevic8, Margalit Rosenkranz9, Kenneth Schikler10, Tamas Constantin11 and Carine Wouters12, 1Roche Innovation Center, New York, NY, 2Roche Products, Ltd., Welwyn Garden City, United Kingdom, 3Hospital Universitario y Politécnico La Fe, Valencia, Spain, 4Hospital Gral de Niños Pedro Elizalde, Buenos Aires, Argentina, 5Professor Hess Children's Hospital, Bremen, Germany, 6ZNA, Antwerp, and UZ, Gent, Belgium, 7Hackensack University Medical Center, Hackensack, NJ, 8Tufts Medical Center, Boston, MA, 9Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 10University of Louisville Medical School, Louisville, KY, 11Semmelweis University, Budapest, Hungary, 12University Hospital Gasthuisberg, Leuven, Belgium

    Background/Purpose: Tocilizumab (TCZ) is approved for the treatment of systemic juvenile idiopathic arthritis (sJIA) based on clinical trials in patients ≥2 years of age. This…
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