Abstracts Archive - Page 1389 of 2607 - ACR Meeting Abstracts

Abstract Number: 25 • 2017 ACR/ARHP Annual Meeting
A Novel Role for Galectin-3 Binding Protein in B Cell Biology and Antibody Secretion
Shinji Okitsu¹, Melinda Genest¹, Nuruddeen Lewis¹, Evgeni Tzvetkov¹, Yin Wu², Andrew Bender¹, Arnon Arazi³, Thomas Eisenhaure³, Edward Browne⁴, Alex Rolfe⁵, Jonathan Derry⁶, William Pendergraft III⁷, Nir Hacohen⁸, Julie DeMartino⁵ and Jaromir Vlach⁵, ¹TIP Immunology, EMD Serono Research and Development Institute, Billerica, MA, ²TIP Immunology, EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ³Broad Institute, Cambridge, MA, ⁴Massachusetts General Hospital, Boston, MA, ⁵EMD Serono Research and Development Institute, Billerica, MA, ⁶Iris Bioconsulting, Bainbridge Island, WA, ⁷Kidney Center, University of North Carolina, Chapel Hill, NC, ⁸Harvard Medical School, Boston, MA
Background/Purpose: Antibodies are important in protection against pathogens, but also harbor the potential to cause autoimmune disease when directed against self-antigens. Systemic lupus erythematosus (SLE)…
Abstract Number: 26 • 2017 ACR/ARHP Annual Meeting
Single B Cell Analysis Revealed the Relationship Among the Cytokine Profile, Antibody Affinity, and Pathogenic Roles of Autoantigen-Reactive B Cells in Systemic Sclerosis
Takemichi Fukasawa¹, Ayumi Yoshizaki², Satoshi Ebata¹, Kouki Nakamura¹, Ryosuke Saigusa¹, Takashi Yamashita¹, Yoshihide Asano³, Yutaka Kazoe⁴, Kazuma Mawatari⁴, Takehiko Kitamori⁴ and Shinichi Sato⁵, ¹Dermatology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan, ²Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ³Applied Chemistry, University of Tokyo, Graduate School of Medicine, Tokyo, Japan, ⁴Applied Chemistry, University of Tokyo, Graduate School of Engineering, Tokyo, Japan, ⁵Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan
Background/Purpose: Recent studies have indicated that B cells play critical roles in systemic autoimmunity and disease expression through various functions such as induction of the…
Abstract Number: 27 • 2017 ACR/ARHP Annual Meeting
Effects of High Titers of Anti-Chimeric Antibodies Following Rituximab
Roberta Fenoglio¹, Laura Solfietti¹, Savino Sciascia² and Dario Roccatello¹, ¹Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, ²Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy
Background/Purpose: Monoclonal antibodies (MoAbs) are highly successful in treating various immunological disorders. The development of anti-drug antibodies (ADA) against the therapeutic MoAb is relatively common.…
Abstract Number: 28 • 2017 ACR/ARHP Annual Meeting
Sapril and Sbcma As Potential Biomarkers of B Cell Hyperactivation in Rheumatoid Arthritis: A Cluster Analysis Approach
Javier Rodríguez-Carrio¹, Mercedes Alperi-López², Patricia López¹, Francisco Javier Ballina-García³ and Ana Suárez¹, ¹Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, ²Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, ³Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain
Background/Purpose: B cell compartment plays a key role in the pathogenesis of rheumatoid arthritis (RA). Activation and survival of B cell largely rely on the…
Abstract Number: 29 • 2017 ACR/ARHP Annual Meeting
BTK Inhibition Ameliorates Lupus-Associated Neuropsychiatric and Skin Disease
Samantha Chalmers¹, Jing Wen¹, Jessica Doerner¹, Ariel Stock², Carla Cuda³, Hadijat Makinde³, Harris Perlman⁴, Todd Bosanac⁵, Deborah Webb⁵, Gerald Nabozny⁶, Elliott Klein⁵, Jay S. Fine⁵, Meera Ramanujam⁵ and Chaim Putterman⁷, ¹Albert Einstein College of Medicine, Bronx, NY, ²Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, ³Northwestern University, Chicago, IL, ⁴Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University Feinberg School of Medicine,, Chicago, IL, ⁵Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁶[email protected], Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁷Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY
Background/Purpose: The importance of macrophages in the pathogenesis of cutaneous and neuropsychiatric systemic lupus erythematosus (SLE) is well established. Additionally, autoantibodies produced by autoreactive…
Abstract Number: 30 • 2017 ACR/ARHP Annual Meeting
Specificity of Salivary Gland-Derived Monoclonal Antibodies from Sjogren’s Syndrome Patients Using Human Proteome Arrays
Sherri Longobardi¹, Christina Lawrence², Kristi A. Koelsch³, Kenneth Smith², Constantin Georgescu², Michelle L. Joachims², Lida Radfar⁴, Astrid Rasmussen², Kathy L. Sivils², Jonathan Wren², R. Hal Scofield² and A. Darise Farris², ¹Graduate Program in Biological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Okalahoma City, OK, ⁴Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is a rheumatic autoimmune disease characterized by focal lymphocytic infiltrations in the lacrimal and salivary glands, autoantibodies to the ubiquitous Ro…
Abstract Number: 31 • 2017 ACR/ARHP Annual Meeting
Single Cell Analysis Revealed That the Response to Cyclophosphamide Therapy Is Regulated By B Cells in Systemic Sclerosis-Associated Interstitial Lung Disease
Satoshi Ebata¹, Ayumi Yoshizaki², Takemichi Fukasawa¹, Kouki Nakamura¹, Maiko Hirakawa¹, Takashi Yamashita¹, Shunsuke Miura³, Ryosuke Saigusa¹, Megumi Hirabayashi¹, Asako Yoshizaki¹, Kaname Akamata¹, Yoshihide Asano⁴, Yutaka Kazoe⁵, Kazuma Mawatari⁵, Takehiko Kitamori⁵ and Shinichi Sato⁶, ¹Dermatology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan, ²Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ³University of Tokyo, Graduate School of Medicine, Tokyo, Japan, ⁴Applied Chemistry, University of Tokyo, Graduate School of Medicine, Tokyo, Japan, ⁵Applied Chemistry, University of Tokyo, Graduate School of Engineering, Tokyo, Japan, ⁶Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of several organs. SSc-associated interstitial lung disease (ILD) is a frequent and severe complication…
Abstract Number: 32 • 2017 ACR/ARHP Annual Meeting
Longitudinal Associations between Rheumatoid Factor and Ex Vivo Cytokine Production Reveal Novel Mechanistic Insights into Rheumatoid Arthritis
John M. Davis III¹, Cynthia S. Crowson², Keith L. Knutson³, Sara J. Achenbach⁴, Terry M. Therneau⁵, Eric L. Matteson⁶, Sherine E. Gabriel⁷ and Peter J. Wettstein⁸, ¹Division of Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, ³Immunology, Mayo Clinic, Jacksonville, FL, ⁴Mayo Clinic, Rochester, MN, ⁵Biostatistics, Mayo Clinic, Rochester, MN, ⁶Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁷Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ⁸Immunology, Mayo Clinic, Rochester, MN
Background/Purpose: Positive rheumatoid factor (RF) and/or anti-citrullinated protein antibodies (ACPA) identify a major rheumatoid arthritis (RA) subgroup, characterized by greater propensity to erosive joint damage…
Abstract Number: 33 • 2017 ACR/ARHP Annual Meeting
B Cell Abnormalities in Patients with Chronic Cutaneous Lupus Erythematosus
Chungwen Wei¹, Aisha Hill², Kira Smith³, Ignacio Sanz¹, S. Sam Lim⁴ and Cristina Drenkard⁴, ¹Medicine, Emory University School of Medicine, Atlanta, GA, ²Medicine, Emory University School of Medicine, atlanta, GA, ³Emory University School of Medicine, Atlanta, GA, ⁴Division of Rheumatology, Emory University School of Medicine, Atlanta, GA
Background/Purpose: Lupus is a spectrum of disease with cutaneous lupus (CLE) without systemic features on one end and systemic lupus erythematosus (SLE) on the other.…
Abstract Number: 34 • 2017 ACR/ARHP Annual Meeting
IL-23 Regulates Development of Spontaneous Germinal Centers and Pathogenic Autoantibody Production in BXD2 Mice
Huixian Hong¹, Qi Wu², PingAr Yang², Bao Luo³, Jun Li⁴, Hao Li⁵, Daniel Cua⁶, Hui-Chen Hsu² and John D. Mountz^2,7, ¹University of Alabama at Birmingham， Division of Clinical Immunology and Rheumatology, Department of Medicine, Birmingham, AL, ²Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham， Division of Clinical Immunology and Rheumatology, Department of Medicine, Birmingham, AL, ³DIvision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham， Division of Clinical Immunology and Rheumatology, Department of Medicine, Birmingham, AL, ⁴Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham， Division of Clinical Immunology and Rheumatology, Department of Medicine, Birmingham, AL, ⁵Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁶Discovery Research, Merck Research Laboratory, Palo Alto, CA, ⁷University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham, AL
Background/Purpose: Targeting IL-23 to treat autoimmune disease and chronic inflammation is currently in development based on its pro-inflammatory function via regulating the activation of Th17…
Abstract Number: 35 • 2017 ACR/ARHP Annual Meeting
B-Cell Subset Differences in Inflammatory Rheumatic Diseases
Joao Lagoas Gomes^1,2, Dario Ligeiro³, Alice Lima³, Cristina Teixeira³, Alexandre Sepriano^4,5, Sofia Ramiro⁶, Carina Lopes⁷, Tiago Costa⁸, Manuela Costa⁸, Jaime Cunha Branco^1,2 and Fernando Pimentel-Santos^1,2, ¹Rheumatology, Hospital Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal, ²CEDOC, NOVA Medical School, Lisbon, Portugal, ³Centro de Sangue e Transplantação de Lisboa, Instituto Português do Sangue e Transplantação (IPST), I.P, Lisbon, Portugal, ⁴CEDOC, NOVA Medical School, Lisboa, Portugal, ⁵Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Rheumatology, Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands, ⁷Hospital de Egas Moniz-CHLO, Lisbon, Portugal, ⁸Rheumatology, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal
Background/Purpose: Targeting humoral immunity has been proved effective in several inflammatory rheumatic diseases (IRD). Though clinical trials have shown some efficacy of B-cell depletion in…
Abstract Number: 36 • 2017 ACR/ARHP Annual Meeting
GM-CSF-Producing B Cells: A Novel B Cell Subset Involved in the Pathogenesis of Systemic Sclerosis
Kazuhiko Higashioka¹, Yuri Ota¹, Tsuyoshi Nakayama¹, Koji Mishima¹, Masahiro Ayano¹, Yasutaka Kimoto², Hiroki Mitoma¹, Mitsuteru Akahoshi¹, Yojiro Arinobu¹, Koichi Akashi¹, Takahiko Horiuchi³ and Hiroaki Niro⁴, ¹Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan, ³Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, ⁴Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Background/Purpose: Systemic sclerosis (SSc) is a T helper type 2 (Th2)-driven autoimmune disease characterized by vasculopathy and fibrosis. There are still unmet needs in the…
Abstract Number: 37 • 2017 ACR/ARHP Annual Meeting
β2-Glycoprotein I Binds to Necroptotic Cells and Serves As a Target for SLE Autoantibodies
David Salem¹, Rebecca Subang¹, Maziar Divangahi¹, Christian Pineau², Sasha Bernatsky³, Jerrold S. Levine⁴ and Joyce Rauch⁵, ¹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Division of Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ³Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ⁴Section of Nephrology, Department of Medicine, University of Illinois at Chicago and Jesse Brown Veterans Affairs Medical Center, Chicago, IL, ⁵Division of Rheumatology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: β2-glycoprotein I (β2GPI), a phospholipid-binding protein, binds to apoptotic cells and serves as an antigenic target for autoantibodies from patients with systemic lupus erythematosus…
Abstract Number: 38 • 2017 ACR/ARHP Annual Meeting
Cytokine Production By CpG-Activated B Cells Require Glutaminolysis to Drive mTOR Activation, Aerobic Glycolysis and Mitochondrial Respiration
Matthew Cheung¹, Dongyue Huang¹, Emily Liu², Jennifer Ra² and Alfred Kim³, ¹Rheumatology, Washington University School of Medicine, Saint Louis, MO, ²IM/Rheumatology, Washington University School of Medicine, Saint Louis, MO, ³IM/Rheumatology, Washington University School of Medicine, St. Louis, MO
Background/Purpose: B cells contribute to disease pathophysiology through several mechanisms, including cytokine secretion. A wide variety of stimuli can activate B cells to produce cytokines…
Abstract Number: 39 • 2017 ACR/ARHP Annual Meeting
Protein Array Technology Identifies Rituximab-Treated Non-Responder Rheumatoid Arthritis Patients to Generate New Autoantibody Repertoires during Treatment
Zoltán Konthur¹, Melvin Michael Wiemkes², Thomas Häupl², Gerd R. Burmester² and Karl Skriner², ¹Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, ²Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany
Background/Purpose: Rituximab (RTX) has shown clinical efficacy but up to 40 % of RTX treated rheumatoid arthritis (RA) patients are poor responders (Ann-Rheum-Dis. 2005 Feb;64(2):246-52)…

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