ACR Meeting Abstracts

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  • Abstract Number: 2722 • 2017 ACR/ARHP Annual Meeting

    Long Term Follow-up and Optimization of Infliximab in Refractory Uveitis of Behçet’s Disease. Multicenter Study of 103 Cases

    Belén Atienza-Mateo1, José Luis Martín-Varillas1, Lucia C. Domínguez-Casas1, Nuria Vegas-Revenga1, Vanesa Calvo-Río1, Emma Beltrán2, Juan Sánchez-Burson3, Marina Mesquida4, Alfredo Adán4, M Victoria Hernández4, Javier López-Longo5, Marisa Hernández Garfella2, Elia Valls Pascual6, Lucía Martínez Costa6, Agustí Sellas-Fernandez7, José L. García-Serrano8, José-Luis Callejas-Rubio8, Norberto Ortego8, José M. Herreras9, Alejandro Fonollosa10, Olga Maíz11, Ana Blanco12, Ignacio Torre13, C. Fernandez-Espartero14, V. Jovani15, D. Peiteado Lopez16, David Díaz Valle17, Esperanza Pato17, J. Cruz18, C. Fernandez-Cid18, Elena Aurrecoechea19, M. García20, Miguel A. Caracuel21, Antonio Atanes22, F. Francisco23, Santos Insúa24, S. Gonzalez-Suárez25, A. Sánchez-Andrade26, L. Linares27, F. Romero-Bueno28, A. J. García29, R. Almodovar30, Enrique Mínguez31, Carmen Carrasco Cubero32, E. Raya Álvarez8, M. Alcalde-Villar33, C. Fernández-Carbadillo34, FA. Pagés35, MC Gonzalez-Vela36, Rosalia Demetrio37, Enar Pons37, Jose L. Hernández38, Miguel Angel González-Gay39 and Ricardo Blanco40, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 2Hospital General Universitario de Valencia, Valencia, Spain, 3Hospital de Valme, Sevilla, Spain, 4Hospital Clinic, Barcelona, Spain, 5Hospital Gregorio Marañón, Madrid, Spain, 6Hospital Peset, Valencia, Spain, 7Hospital Vall d´Hebron, Barcelona, Spain, 8Hospital San Cecilio, Granada, Spain, 9Hospital Universitario IOBA, Valladolid, Spain, 10Hospital de Cruces, Bilbao, Spain, 11Hospital Donosti, San Sebastian, Spain, 12Ophthalmology, Hospital Universitario Donostia. San Sebastian. Spain, San Sebastián, Spain, 13Hospital Basurto, Bilbao, Spain, 14Hospital Universitario de Móstoles, Madrid, Spain, 15Hospital General Alicante, Alicante, Spain, 16Hospital Universitario La Paz, Madrid, Spain, 17Hospital Clínico San Carlos, Madrid, Spain, 18Hospital Pontevedra, Pontevedra, Spain, 19Hospital Sierrallana, Torrelavega, Spain, 20Hospital La Princesa, Madrid, Spain, 21Hospital Córdoba, Córdoba, Spain, 22Hospital Universitario de A Coruña, A Coruña, Spain, 23Hospital Doctor Negrín, Las Palmas de Gran Canaria, Spain, 24Hospital Universitario Santiago de Compostela, Santiago de Compostela, Spain, 25Hospital Cabueñes, Gijón, Spain, 26Hospital Lucus Augusti, Lugo, Spain, 27Hospital Arrixaca, Murcia, Spain, 28Fundación Jiménez Díaz, Madrid, Spain, 29Hospital 12 de Octubre, Madrid, Spain, 30Hospital Universitario Fundación Alcorcón, Madrid, Spain, 31Hospital Clínico Zaragoza, Zaragoza, Spain, 32Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, 33Hospital Severo Ochoa, Madrid, Spain, 34Hospital General Universitario de Elda, Alicante, Spain, 35Complejo Asistencial de Palencia, Palencia, Spain, 36Pathology Anatomy, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 37Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria., Santander, Spain, 38Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 39Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Johannesburg, South Africa, 40Hospital Universitario Marqués de Valdecilla, Santander, Spain

    Background/Purpose: Uveitis is a severe manifestation of Behçet Disease (BD). The treatment is based on corticosteroids and conventional immunosuppressive drugs. In refractory cases, anti-TNFα had…
  • Abstract Number: 2723 • 2017 ACR/ARHP Annual Meeting

    Adalimumab Therapy Optimization in Refractory Uveitis Due to Behçet’s Disease after Achieving Remission. interventional Versus Control Group

    Belén Atienza-Mateo1, José Luis Martín-Varillas1, Nuria Vegas-Revenga1, Lucia C. Domínguez-Casas1, Vanesa Calvo-Río1, Emma Beltrán2, Juan Sánchez-Burson3, Marina Mesquida4, Alfredo Adán4, M Victoria Hernández4, Marisa Hernández Garfella2, Elia Valls Pascual5, Lucía Martínez Costa5, Agustí Sellas-Fernandez6, Miguel Cordero Coma7, Manuel Díaz-Llopis8, Roberto Gallego8, David Salom8, Norberto Ortego9, José L. García-Serrano9, José-Luis Callejas-Rubio9, José M. Herreras10, Ángel M García-Aparicio11, Olga Maíz12, Ana Blanco13, Ignacio Torre14, David Díaz Valle15, Esperanza Pato15, Elena Aurrecoechea16, Miguel A. Caracuel17, Fernando Gamero18, Enrique Mínguez19, Carmen Carrasco Cubero20, Alejandro Olive21, Julio Vázquez22, Oscar Ruiz Moreno23, Fernando Jiménez-Zorzo24, Javier Manero24, Myriam Gandia Martinez25, Esteban Rubio-Romero26, F. Javier Toyos-Sáenz de Miera27, Javier López-Longo28, JM Nolla29, Marcelino Revenga30, Rosalia Demetrio31, Enar Pons31, Miguel Angel González-Gay1 and Ricardo Blanco32, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 2Hospital General Universitario de Valencia, Valencia, Spain, 3Hospital de Valme, Sevilla, Spain, 4Hospital Clinic, Barcelona, Spain, 5Hospital Peset, Valencia, Spain, 6Hospital Vall d´Hebron, Barcelona, Spain, 7Hospital de León, León, Spain, 8Hospital Universitario La Fe, Valencia, Spain, 9Hospital San Cecilio, Granada, Spain, 10Hospital Universitario IOBA, Valladolid, Spain, 11Hospital Donosti, San Sebastián, Spain, 12Hospital Donosti, San Sebastian, Spain, 13Ophthalmology, Hospital Universitario Donostia. San Sebastian. Spain, San Sebastián, Spain, 14Hospital Basurto, Bilbao, Spain, 15Hospital Clínico San Carlos, Madrid, Spain, 16Hospital Sierrallana, Torrelavega, Spain, 17Hospital Córdoba, Córdoba, Spain, 18Hospital San Pedro Alcántara, Cácerer, Spain, 19Hospital Clínico Zaragoza, Zaragoza, Spain, 20Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, 21Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, 22Hospital de Ferrol, A Coruña, Spain, 23Ophthalmology and Rheumatology., Ophtalmology. Hospital Miguel Servet. Zaragoza. Spain, Zaragoza, Spain, 24Hospital Miguel Servet, Zaragoza, Spain, 25Hospital Puerta del Mar, Cádiz, Spain, 26Hospital Universitario Virgen del Rocío, Sevilla, Spain, 27Hospital Universitario Virgen Macarena, Sevilla, Spain, 28Hospital Gregorio Marañón, Madrid, Spain, 29Hospital Universitari de Bellvitge, Barcelona, Spain, 30Hospital Universitario Ramón y Cajal, Madrid, Spain, 31Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria., Santander, Spain, 32Hospital Universitario Marqués de Valdecilla, Santander, Spain

    Background/Purpose: Adalimumab (ADA) therapy has been approved by the EMA and the FDA in non-infectious and non-anterior uveitis. After loading, the maintenance dose is 40…
  • Abstract Number: 2724 • 2017 ACR/ARHP Annual Meeting

    Apremilast for Refractory Mucocutaneous Ulcers of Behçet’s Disease. National Multicenter Study of 14 Cases

    Belén Atienza-Mateo1, José Luis Martín-Varillas1, Javier Loricera1, Nuria Vegas-Revenga1, Lucia C. Domínguez-Casas1, Jose L. Hernández2, Clara Moriano3, Maria Dolores García-Armario4, Iván Castelvi5, Francisca Sivera6, Jaime Calvo-Alen7, Isabel de la Morena8, Francisco Ortiz-Sanjuán9, José Andrés Román-Ivorra9, Ana Pérez-Gómez10, MC Gonzalez-Vela11, Miguel Angel González-Gay1 and Ricardo Blanco12, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 2Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 3Complejo Asistencial Universitario de León, León, Spain, 4Hospital de Xàtiva, Xàtiva, Spain, 5Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, 6Hospital General Universitario de Elda, Elda, Spain, 7Hospital Universitario Araba, Vitoria, Spain, 8Hospital General Universitario de Valencia, Valencia, Spain, 9Hospital La Fe, Valencia, Spain, 10Hospital Príncipe de Asturias, Alcalá de Henares, Spain, 11Pathology Anatomy, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 12Hospital Universitario Marqués de Valdecilla, Santander, Spain

    Background/Purpose: Behçet´s disease (BD) is characterized by recurrent oral and/or genital ulcers accompanied by ocular, cutaneous, articular, gastrointestinal, and/or neurologic manifestations. Oral and/or genital aphthous…
  • Abstract Number: 2725 • 2017 ACR/ARHP Annual Meeting

    Understanding Vasculitis Patients’ Ability to Work with Numbers

    Cole Rodman1, Mary-Kate Tompkins1, Holly Steigelman2, Brad H. Rovin3, Stacy P. Ardoin4, Ellen Peters5 and Alexa Meara6, 1The Ohio State University, Columbus, OH, 2The Ohio State University Wexner Medical Center, Columbus, OH, 3Ohio State University Medical Center, Columbus, OH, 4Pediatric & Adult Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 5Decision Research, Eugene, OR, 6Internal Medicine/Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: In the case of a complex disease like vasculitis, the patient is often tasked with understanding complicated care plans and managing myriad medications. Without…
  • Abstract Number: 2726 • 2017 ACR/ARHP Annual Meeting

    Differentiating Features of Primary Angiitis of Central Nervous System and Reversible Cerebral Vasoconstriction Syndrome: Clinical and Radiological Evaluation

    Didem Saygin1, Russell Cerejo2, Priya Sundaram-Simonelli3, Gabor Toth4, Stephen Jones3, Leonard H. Calabrese5 and Rula A Hajj-Ali6, 1Internal Medicine, Department of Internal Medicine, Cleveland Clinic, Cleveland, Cleveland, OH, 2Cleveland Clinic, Cleveland, OH, 3Neuroradiology, Cleveland Clinic, Cleveland, OH, 4Cerebrovascular Center, Cleveland Clinic, Cleveland, OH, 5Rheumatic & Immunologic Disease and Infectious Disease, Cleveland Clinic Foundation, Cleveland, OH, 6Rheumatic and Immunologic Disease, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Primary angiitis of central nervous system (PACNS) is an isolated vasculitis affecting small-sized cerebral blood vessels. One of the major mimickers of PACNS is…
  • Abstract Number: 2727 • 2017 ACR/ARHP Annual Meeting

    Assessment of Damage and Prognosis in Patients with Adult IgA Vasculitis: Retrospective Multicentered Cohort Study

    Fatma Alibaz-Oner1, Ahmet Omma2, Alper Sari3, Omer Karadag4, Dondu Uskudar Cansu5, Cemal Bes6, Fatih Yildiz7, Mustafa Ferhat Oksuz8, Sema Yilmaz9, Atalay Dogru10, Ayse Balkarli8, Sibel Bakirci11 and Haner Direskeneli12, 1Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey, 2Department of Internal Medicine, Division of Rheumatology, Ankara Numune Training and Research Hospital, Ankara, Turkey, 3Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey, 4Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 5Rheumatology, Osmangazi University, School of Medicine, Eskısehir, Turkey, 6Rheumatology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey, 7Rheumatology, Van EAH, Adana, Turkey, 8PsART study group, Ankara, Turkey, 9Department of Rheumatology, Selcuk University School of Medicine, Konya, Turkey, 10Rheumatology, Suleyman Demirel University, School of Medicine, Isparta, Turkey, 11Fellow in Rheumatology, Antalya, Turkey, 12Rheumatology, Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey

    Background/Purpose: IgA Vasculitis is a leukocytoclastic vasculitis involving small vessels with depositions of immune complexes containing IgA. IgA Vasculitis is a predominantly pediatric vasculitis. There…
  • Abstract Number: 2728 • 2017 ACR/ARHP Annual Meeting

    Serum Levels of Interleukin-36 Receptor Antagonist in Behçet’s Patients

    Pelin Ünsal1, Pamir Cerci2, Şükrü Alper Açıkgöz2, Göksal Keskin2 and Ümit Ölmez2, 1Ankara University School of Medicine, Ankara, Turkey, 2Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey

    Background/Purpose: Behcet's disease (BD) is a systemic vasculitis disorder of unknown etiology with recurrent exacerbations and remissions. The etiopathogenesis of the disease is still unclear.…
  • Abstract Number: 2729 • 2017 ACR/ARHP Annual Meeting

    Surgical Therapies in the Treatment of Pulmonary Artery Involvement in Behcet’s Syndrome

    Hasan Tuzun1, Gul Guzelant2, Ozkan Demirhan3, Buge Oz4, Izzet Fresko2, Vedat Hamuryudan2, Hasan Yazici2 and Emire Seyahi2, 1Istanbul University, Cerrahpasa Medical Faculty, Department of Cardiovascular Surgery, Istanbul, Turkey, 2Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 3Istanbul Bilim University, Medical Faculty, Department of Thoracic Surgery, Istanbul, Turkey, 4Istanbul University, Cerrahpasa Medical Faculty, Department of Pathology, Istanbul, Turkey

    Background/Purpose: The mainstay treatment of pulmonary artery involvement (PAI) in Behcet’s syndrome (BS) is immunosuppresion and corticosteroids (1). The role of surgical intervention in the…
  • Abstract Number: 2730 • 2017 ACR/ARHP Annual Meeting

    Clinical Features and Treatment of Central Nervous System Vasculitis Associated with Acute Posterior Multifocal Placoid Pigment Epitheliopathy

    Hiromichi Tamaki1 and Rula A Hajj-Ali2, 1Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Cleveland, OH, 2Rheumatic and Immunologic Disease, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Acute posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE) is a rare inflammatory eye disease and some appear to develop central nervous system vasculitis (CNSV). This…
  • Abstract Number: 2731 • 2017 ACR/ARHP Annual Meeting

    The Utility of Unbiased Metagenomic Next Generation Sequencing in the Management of Patients with CNS Vasculitis

    Hiromichi Tamaki1, Michael R Wilson2, Leonard H. Calabrese3, Joseph L. DeRisi4 and Rula A Hajj-Ali5, 1Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Cleveland, OH, 2Department of Neurology, UCSF, San Francisco, CA, 3Rheumatic & Immunologic Disease, Cleveland Clinic Foundation, Cleveland, OH, 4Biochemistry and Biophysics, UCSF, San Francisco, CA, 5Rheumatology, Cleveland Clinic Foundation, Cleveland, OH

    Background/Purpose: In the clinical approach to CNS vasculitis, exclusion of infection is of major concern as some microbes can cause vasculitis, and infections can complicate…
  • Abstract Number: 2732 • 2017 ACR/ARHP Annual Meeting

    Recommendations for the Management of Neuro-Behcet’s Disease By the Japanese National Research Committee for Behcet’s Disease

    Hirotoshi Kikuchi1, Tetsuji Sawada2, Masato Okada3, Mitsuhiro Takeno4, Masataka Kuwana4, Yoshiaki Ishigatsubo5, Izumi Kawachi6, Hideki Mochizuki7, Susumu Kusunoki8 and Shunsei Hirohata9, 1Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 2Rheumatology, Tokyo Medical University, Shinjuku Tokyo, Japan, 3Immuno-Rheumatology Center, St. Luke’s International Hospital, Tokyo, Japan, 4Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 5Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 6Department of Neurology, Niigata University Medical and Dental Hospital, Niigata, Japan, 7Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan, 8Department of Neurology, Kinki University School of Medicine, Osaka, Japan, 9Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan

    Background/Purpose: Central nervous system involvement is one of the most serious complications in Behçet’s disease (BD). This condition is referred to as neuro-Behçet’s disease (NB)…
  • Abstract Number: 2733 • 2017 ACR/ARHP Annual Meeting

    Clinical Characteristics and Treatment Outcomes of Patients with Behçet’s Disease and Vascular Involvement

    In Young Kim1, Yeong Hee Eun2, Ji young Chai3, Hyungjin Kim1, Jaejoon Lee1, Eun-Mi Koh1, Duk-Kyung Kim4 and Hoon-Suk Cha1, 1Department of Medicine,Division of Rheumatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South), 2Department of Medicine,Division of Rheumatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, MN, Korea, Republic of (South), 3Department of Rheumatology, Bundang Jesaeng Hospital, Seongnam, Korea, Republic of (South), 4Department of Medicine,Division of Cardiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South)

    Background/Purpose: The international Chapel Hill Consensus Conference (CHCC) categorized Behçet’s disease (BD) as variable vessel vasculitis, which was defined as vasculitis that can affect vessels…
  • Abstract Number: 2734 • 2017 ACR/ARHP Annual Meeting

    A Comparison of Current Practice to New Vasculitis Treatment Guidelines

    Ishrat Gill1, Norman Madsen2, Imran Hassan3 and Elaine Yacyshyn4, 1Medicine, University of Alberta, Sherwood Park, AB, Canada, 2Medicine, Rheumatology, University of Alberta, Edmonton, AB, Canada, 3EPICORE Centre, University of Alberta, Edmonton, AB, Canada, 4Medicine, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Appropriate treatment for Anti-Neutrophilic Cytoplasm Antibodies (ANCA) Associated Vasculitis (AAV) requires induction and maintenance of remission, while balancing side effects from treatment. The CanVasc…
  • Abstract Number: 2735 • 2017 ACR/ARHP Annual Meeting

    Is There an Association between Adult IgA Vasculitis and Cancer?

    Jaka Ostrovrsnik1, Ziga Rotar1, Rok Jese1, Matija Tomšič1,2 and Alojzija Hočevar1, 1Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 2University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia

    Background/Purpose: An increased incidence rate of cancer has been reported in adult patients with IgA vasculitis (IgAV). These conclusions are mostly based on observations in…
  • Abstract Number: 2736 • 2017 ACR/ARHP Annual Meeting

    Long-Term Survival in Systemic Necrotizing Vasculitides

    Sabine Jardel1, Xavier Puéchal2, Alain Le Quellec3, Matthieu Groh2, Mohamed Hamidou4, Francois Maurier5, Olivier Aumaître6, Achille Aouba7, Thomas Quémeneur8, Jean-François Subra9, Vincent Cottin10, Pascal Godmer11, Patrice Cacoub12, Philippe Delaval13, Anne-Laure Fauchais14, Eric Hachulla15, Delphine Maucort-Boulch16, Loïc Guillevin2 and Jean-Christophe Lega17, 1Lyon 1 University, Lyon, France, 2National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 3Montpellier, Montpellier, France, 4Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France, 5Internal Medicine, Sainte-Blandine de Metz Hospital, Metz, France, 6CHU Pitié-Salpêtrière - Department of Internal Medicine 2. Referal center for SLE/APS, Paris, France, 7Department of Internal Medicine, Caen University Hospital, Caen, France, 8Service de néphrologie, médecine interne et vasculaire, Hôpital de Valenciennes, Valenciennes, France, 9Angers, Angers, France, 10Louis Pradel Hospital, Claude Bernard University Lyon 1, Lyon, France, 11Medecine Interne, CH Vannes, Vannes, France, 12Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, 13Rennes, Rennes, France, 14Internal Medicine, Internal Medicine, Limoges, France, 15CHU Lille, Département de Médecine Interne et Immunologie Clinique, F-59000 Lille, France, Lille, France, 16Biostatistics and bioinformatics, Centre Hospitalier Lyon Sud - Claude Bernard University Lyon 1, Lyon, France, 17Department of Internal and Vascular Medicine, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France

    Background/Purpose: The aim of the study was to describe the evolution of mortality over recent decades in systemic necrotizing vasculitides, including polyarteritis nodosa (PAN), granulomatosis…
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