Abstracts Archive - Page 1386 of 2425 - ACR Meeting Abstracts

Abstract Number: 2707 • 2017 ACR/ARHP Annual Meeting
Estrogen Downregulates the Expression of Serine Arginine Splicing Factor 1 (SRSF1) in Human T Lymphocytes
Elena N. Cravens¹, Takayuki Katsuyama¹, Andrew R. Gillooly², George C. Tsokos¹ and Vaishali R. Moulton¹, ¹Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Medicine/ Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multifactorial etiopathogenesis that primarily afflicts women in the childbearing years. Hormones especially estrogen are…
Abstract Number: 2708 • 2017 ACR/ARHP Annual Meeting
Placental Growth Factor Regulates the Generation of T-Helper 17 Cells to Link Angiogenesis with Autoimmunity
Seung-Ah Yoo Sr.¹, Min-cheol Kang Sr.², Mingyo Kim Sr.³, Jin-Sun Kong Sr.¹, Ki-Myo Kim Sr.¹, junghee Koh Sr.¹, Chul-Soo Cho⁴, Seung-Hyo Lee Sr.⁵, Zae Young Ryoo Sr.⁶ and Wan-Uk Kim Sr.^1,7, ¹The Catholic University of Korea, Center for Integrative Rheumatoid Transcriptomics and Dynamics, seoul, Korea, Republic of (South), ²School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, seoul, Korea, Republic of (South), ³Graduate School of Medical Science and Engineering, BioMedical Research Center, KAIST Institute for the BioCentury, seoul, Korea, Republic of (South), ⁴Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁵Graduate School of Medical Science and Engineering, BioMedical Research Center, KAIST Institute for the BioCentury, SEOUL, Korea, Republic of (South), ⁶School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, SEOUL, Korea, Republic of (South), ⁷The Catholic University of Korea, Department of Internal Medicine, seoul, Korea, Republic of (South)
Background/Purpose: T-helper (Th) cells actively communicate with adjacent cells by secreting soluble mediators, and yet crosstalk between Th cells and endothelial cells is poorly understood.…
Abstract Number: 2709 • 2017 ACR/ARHP Annual Meeting
Histone Deacetylase 1 (HDAC1): A Novel Therapeutic Target for Patients with Rheumatoid Arthritis
Lisa Goschl^1,2, Michael Bonelli³, Victoria Saferding⁴, Teresa Peglej², Sylvia Knapp⁵, Johan Bäcklund⁶, Christoph Bock⁵, Patrick Matthias⁷, Kiyoshi Hirahara⁸, Clemens Scheinecker¹, Günter Steiner⁹, Josef S. Smolen¹ and Wilfried Ellmeier², ¹Medical University of Vienna, Devision of Rheumatology, Vienna, Austria, ²Medical University of Vienna,Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Vienna, Austria, ³Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Medical University of Vienna, Austria, Vienna, Austria, ⁵CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, ⁶Karolinska Institute,Department of Medical Biochemistry and Biophysics, Stockholm, Sweden, ⁷Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, ⁸Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan, ⁹Medical University of Vienna, Dvision of Rheumatology, Vienna, Austria
Background/Purpose: Autoreactive T cells drive the inflammatory process, which leads to an irreversible destruction of the joints. Gene transcription and regulation of proinflammatory cytokine production…
Abstract Number: 2710 • 2017 ACR/ARHP Annual Meeting
CXCR3+CCR6+CD4+ T Cells (Th1Th17) and RF As Novel Predictive Markers for Clinical Response to Abatacept Treatment in Patients with Rheumatoid Arthritis: The 52-Week Analysis
Koji Mishima¹, Shunichiro Ota², Kazuhiko Higashioka¹, Tsuyoshi Nakayama³, Masahiro Ayano¹, Yasutaka Kimoto⁴, Hiroki Mitoma¹, Mitsuteru Akahoshi¹, Yojiro Arinobu¹, Yasushi Inoue⁵, Kensuke Oryoji⁶, Takuya Sawabe⁷, Shuji Nagano⁸, Hiroaki Nishizaka⁹, Seiji Yoshizawa¹⁰, Shigeru Yoshizawa¹¹, Takeshi Otsuka¹², Akira Ueda¹³, Yoshifumi Tada¹⁴, Hitoshi Nakashima¹⁵, Takahiko Horiuchi¹⁶, Koichi Akashi¹ and Hiroaki Niro³, ¹Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Department of Rheumatology, Shimonoseki City Hospital, Yamaguchi, Japan, ³Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan, ⁴Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan, ⁵Department of Rheumatology, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan, ⁶The Center for Rheumatology, Matsuyama Red Cross Hospital, Ehime, Japan, ⁷Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, Hiroshima, Japan, ⁸Center for Rheumatology, Iizuka Hospital, Fukuoka, Japan, Iizuka City, Japan, ⁹Kitakyushu Municipal Medical Center, Kitakyushu, Japan, ¹⁰Hamanomachi Hospital, Fukuoka, Japan, ¹¹Department of Rheumatology, Fukuoka Hospital, National Hospital Organization, Fukuoka, Japan, ¹²Munakata Medical Association Hospital, Munakata, Japan, ¹³Department of Internal Medicine, Miyazaki Prefectural Hospital, Miyazaki, Japan, ¹⁴Rheumatology, Saga University, Saga, Japan, ¹⁵Div of Nephrol & Rheumatol, Dept of Int Med, Faculty of Medicine, Fukuoka University, Fukuoka, Japan, ¹⁶Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: The advent of biological therapy has made a remarkable progress in the management of rheumatoid arthritis (RA). Abatacept (ABA), a non-TNF inhibitor, is a…
Abstract Number: 2711 • 2017 ACR/ARHP Annual Meeting
Mucosal-Associated Invariant T Cells Are an Important Source of TNF in Rheumatoid Arthritis
Diahann Jansen¹, Elizabeth Klinken¹, Hendrik Nel¹, Soi Cheng Law¹, Hester Koppejan², Marjolijn Hameetman³, Ligong Liu⁴, Alexandra Corbett⁵, Sidonia Eckle⁵, David Fairlie⁴, Rene E.M. Toes⁶, Floris van Gaalen⁷, Jamie Rossjohn^8,9,10, James McCluskey⁵ and Ranjeny Thomas¹, ¹The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Australia, ²Department of Rheumatology, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia, ⁵Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Australia, ⁶Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁷Rheumatology, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁸Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Australia, ⁹Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom, ¹⁰Infection and Immunity Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
Background/Purpose: CD8+ T cells have been described to comprise up to 40% of the rheumatoid arthritis (RA) synovial T cell compartment but their pathogenic function…
Abstract Number: 2712 • 2017 ACR/ARHP Annual Meeting
Autoimmune Arthritis in IL-1 Receptor Antagonist-Deficient Mice Is Associated with a Pathogenic Conversion of Foxp3+ Regulatory T Cells into Th17 Cells
Anais Levescot¹, Nathan Nelson-Maney², Allyn Morris³, Ricardo Grieshaber Bouyer⁴, Pui Lee⁵ and Peter Nigrovic⁶, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, boston, MA, ²Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Division of Rheumatology, Immunology, and Allergy, BWH, Boston, MA, ⁵Harvard Medical School, Boston, MA, ⁶Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: IL-1β blockade is a highly effective therapy for systemic juvenile idiopathic arthritis (sJIA). However, the rate of inactive disease attained in these trials is…
Abstract Number: 2713 • 2017 ACR/ARHP Annual Meeting
CD318 Is a New Ligand for CD6
Gospel Enyindah-Asonye¹, Yan Li¹, Danislav Spassov², Katie Hebron³, Andries Zijlstra⁴, Mark Moasser², Benlian Wang⁵, Nora Singer⁶, David A. Fox⁷ and Feng Lin⁸, ¹Department of Immunology, Lerner Research Institute of the Cleveland Clinic, Cleveland, OH, ²Department of Medicine, University of California, San Francisco, San Francisco, CA, ³Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, ⁴Departemnt of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN, ⁵Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH, ⁶Division of Rheumatology, MetroHealth Medical Center, Cleveland, OH, Cleveland, OH, ⁷Rheumatology/Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, ⁸Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: CD6, an important regulator of T cells, has one known ligand, CD166, but studies performed during the treatment of autoimmune conditions and in vitro…
Abstract Number: 2714 • 2017 ACR/ARHP Annual Meeting
The Paracaspase MALT1 Plays a Central Role in the Pathogenesis of Rheumatoid Arthritis
Elisabeth Gilis¹, Jens Staal², Rudi Beyaert² and Dirk Elewaut³, ¹Molecular Immunology and Inflammation Unit, VIB Inflammation Research Center, Ghent, Belgium, Gent, Belgium, ²Molecular Immunology and Inflammation Unit, VIB Inflammation Research Center, Ghent, Belgium, ³VIB Inflammation Research Center, University of Ghent, Ghent, Belgium
Background/Purpose: One of the hallmarks of many inflammatory arthritides is their strong linkage with MHC-signalling, which is mirrored by the marked role for adaptive immunity.…
Abstract Number: 2715 • 2017 ACR/ARHP Annual Meeting
NKTR-358: A Selective, First-in-Class IL-2 Pathway Agonist Which Increases Number and Suppressive Function of Regulatory T Cells for the Treatment of Immune Inflammatory Disorders
John Langowski, Peter Kirk, Murali Addepalli, Thomas Chang, Vidula Dixit, Grace Kim, Yolanda Kirksey, Peiwen Kuo, Myong Lee, Mekhala Maiti, Werner Rubas, Paul Sims, Yuan Song, Yinyan Tang, Laurie VanderVeen, Ping Zhang, Stephen Doberstein and Jonathan Zalevsky, Nektar Therapeutics, San Francisco, CA
Background/Purpose: Impaired IL-2 production and regulatory T cell (Treg) dysfunctions have been implicated as an immunological mechanism in multiple autoimmune diseases. While low-dose IL-2 can…
Abstract Number: 2716 • 2017 ACR/ARHP Annual Meeting
Gastrointestinal Involvement in Adult IgA Vasculitis (Henoch–Schönlein purpura): Initial Manifestations and Outcomes
Alexandra Audemard-Verger¹, Aurélie Baldolli², Zahir Amoura³, Patrice Cacoub⁴, Sébastien Sanges⁵, Francois Maurier⁶, Bertrand Lioger⁷, Nihal Martis⁸, Etienne Riviere⁹, Geoffroy Urbanski¹⁰, Evangeline Pillebout¹¹, Loïc Guillevin for the French Vasculitis Study Group¹² and Benjamin Terrier¹³, ¹Internal Medicine, Caen, France, ²Internal Medicine, CHU, Caen, France, ³Department of Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France, ⁴Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, ⁵Université Lille Nord de France, Faculté de Médecine Henri Warembourg, Lille, Lille, France, ⁶Internal Medicine, Sainte-Blandine de Metz Hospital, Metz, France, ⁷GICC UMR 7292, University François Rabelais, Tours, France, ⁸Internal medicine, Nice, France, ⁹Internal Medicine, CHU, Bordeaux, France, ¹⁰Internal Medicine, CHU, Angers, France, ¹¹Nephrology, Saint Louis, Paris, France, ¹²Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Auto-Inflammatoires Systémiques Rares, Hôpital Cochin, Paris, France, ¹³Internal Medicine, Cochin University Hospital, Paris, France
Background/Purpose: Gastrointestinal (GI) involvement during adult IgA vasculitis (IgAV) occurs in roughly half the cases. In many other systemic vasculitides, GI involvement represents a poor-prognosis…
Abstract Number: 2717 • 2017 ACR/ARHP Annual Meeting
Late Onset of IgA Vasculitis Is Associated with More Severe Renal Involvement
Alexandra Audemard-Verger¹, Aurélie Baldolli², Noemie Le Gouellec³, Loic Raffray⁴, Alban Deroux⁵, Julie Goutte⁶, Bertrand Lioger⁷, Zahir Amoura⁸, Patrice Cacoub⁹, Sébastien Sanges¹⁰, Evangeline Pillebout¹¹, Loïc Guillevin for the French Vasculitis Study Group¹² and Benjamin Terrier¹³, ¹Internal Medicine, Caen, France, ²Internal Medicine, CHU, Caen, France, ³Internal Medicine, Lille, France, ⁴Internal Medicine, CHU de Bordeaux, Bordeaux, France, ⁵Internal Medicine, CHU de Grenoble, Grenoble, France, ⁶Internal Medicine, Saint Etienne, France, ⁷GICC UMR 7292, University François Rabelais, Tours, France, ⁸Department of Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France, ⁹Internal Medicine Department, University Hospital “Pitié-Salpêtrière”, “Pierre et Marie Curie Paris VI” University, Paris, France, ¹⁰Université Lille Nord de France, Faculté de Médecine Henri Warembourg, Lille, Lille, France, ¹¹Nephrology, Saint Louis, Paris, France, ¹²Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Auto-Inflammatoires Systémiques Rares, Hôpital Cochin, Paris, France, ¹³Internal Medicine, Cochin University Hospital, Paris, France
Background/Purpose: Immunoglobulin A vasculitis (IgAV), formerly called Henoch–Schönlein purpura, is a small-vessel vasculitis characterized by immune-complex deposits with predominant IgA. Although the disease is often…
Abstract Number: 2718 • 2017 ACR/ARHP Annual Meeting
Is Smoking Important in Adult IgA Vasculitis?
Alojzija Hočevar¹, Ziga Rotar¹, Vesna Jurcic² and Matija Tomšič³, ¹Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Institute of Pathology, University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia, ³University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia
Background/Purpose: Nicotine may predispose to kidney injury by increasing the oxidative stress, and there is known association between smoking and the progression of chronic kidney…
Abstract Number: 2719 • 2017 ACR/ARHP Annual Meeting
Can Annexin A1 Expression on Neutrophils Distinguish Adult IgA Vasculitis from Other Small Vessel Vasculitides?
Tadeja Kuret¹, Katja Lakota^1,2, Polona Žigon¹, Manca Ogrič¹, Boris Lestan¹, Snezna Sodin Semrl^1,2, Saša Čučnik^1,3, Matija Tomšič^1,4 and Alojzija Hočevar¹, ¹Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Faculty of Mathematics, Natural Science and Information Technology, University of Primorska, Koper, Slovenia, ³Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia, ⁴University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia
Background/Purpose: Immunoglobulin A vasculitis (IgAV, formerly Henoch–Schönlein purpura) is a small vessel, immune complex vasculitis characterized by dominant IgA deposits in the vascular wall. Clinical…
Abstract Number: 2720 • 2017 ACR/ARHP Annual Meeting
Behcet’s Disease in Southeastern Michigan: A Single Center Comparative Study
Nathan Kilian¹ and Amr H Sawalha², ¹Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Behçet’s disease is a heterogeneous immune-mediated disease, with clinical variability across ethnicities and geographic locations. In this study, we describe and analyze the clinical…
Abstract Number: 2721 • 2017 ACR/ARHP Annual Meeting
Anti-IL6-Receptor Tocilizumab in Refractory Uveitis Associated to Extraocular Manifestations in Patients with Behçet’s Disease. Multicenter Study
Belén Atienza-Mateo¹, José Luis Martín-Varillas¹, Lucia C. Domínguez-Casas¹, Nuria Vegas-Revenga¹, Vanesa Calvo-Río¹, Natalia Palmou Fontana², Ricardo Blanco³, Javier Loricera¹, MC Gonzalez-Vela⁴, Emma Beltrán⁵, Lucía Martínez Costa⁶, Elia Valls Pascual⁶, Marisa Hernández Garfella⁵, Antonio Atanes⁷, Miguel Cordero Coma⁸, Joan Miquel Nolla Solé⁹, Carmen Carrasco Cubero¹⁰, Enar Pons¹¹ and Miguel Angel González-Gay², ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ²Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria., Santander, Spain, ³Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁴Pathology Anatomy, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ⁵Hospital General Universitario de Valencia, Valencia, Spain, ⁶Hospital Peset, Valencia, Spain, ⁷Hospital Universitario de A Coruña, A Coruña, Spain, ⁸Hospital de León, León, Spain, ⁹Hospital Universitari de Bellvitge, Barcelona, Spain, ¹⁰Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, ¹¹Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria., Santander, Spain
Background/Purpose: To assess the efficacy of Tocilizumab (TCZ) in refractory uveitis associated to extraocular manifestations due to Behçet’s disease (BD). Methods: Multicenter study of patients…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].