Abstracts Archive - Page 137 of 2425 - ACR Meeting Abstracts

Abstract Number: 0053 • ACR Convergence 2024
Fasting Reduces an IL-17+/IFNg+ T Helper Cell-inducing Gut Pathobiont in Patients with Rheumatoid Arthritis
Márcia Pereira¹, Katja Stuhlträger², Natalie Scherff³, Anika Rajput Khokhar⁴, Sylvio Redanz¹, Hebah Ebid⁵, Bérénice Hansen⁵, Cédric C. Lacny⁵, Ulrike Löschberger², Stefan Bletz⁶, Jochen G. Schneider⁷, Paul Wilmes⁷, Christian S. Kessler⁴, Andreas Michalsen⁴, Alexander Mellmann³ and Martin Kriegel¹, ¹Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Münster, Germany, ²Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Muenster, Germany, ³Institute of Hygiene, University Hospital Münster, Münster, Germany, Muenster, Germany, ⁴Institute of Social Medicine, Epidemiology and Health Economics, Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Berlin, Germany, ⁵4University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg, ⁶Institute of Hygiene, University Hospital Münster, Germany, Muenster, Germany, ⁷University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg
Background/Purpose: The mucosal origins hypothesis suggests rheumatoid arthritis (RA) is triggered at mucosal sites in genetically predisposed hosts1. Animal models support that microbiota‐induced Th17 cells are…
Abstract Number: 2029 • ACR Convergence 2024
Iron Deficiency in Familial Mediterranean Fever: A Study on 211 Adult Patients from the JIR Cohort
Ilenia Di Cola¹, Lea Savey², Marion Delplanque³, Rim bourguiba³, Alessandra Bartoli⁴, Zohra Aknouche³, Fatima Bensalek³, Isabelle Kone Paut⁵, Linda Rossi Semerano⁵, Isabelle Melki⁶, Brigitte Bader-Meunier⁷, Bénédicte Neven⁶, PIERRE QUARTIER⁸, Guilaine Boursier⁹, Irina Giurgea¹⁰, Laurence Cuisset¹¹, Gilles Grateau³, Veronique Hentgen¹² and Sophie Georgin-lavialle¹³, ¹University of L'Aquila, L'Aquila, Italy, ²Internal Medicine Department, Tenon Hospital, AP-HP, Paris, France, france, France, ³Internal Medicine Department, Tenon Hospital, AP-HP, Paris, France, Paris, France, ⁴Internal Medicine Department, Tenon Hospital, AP-HP, Paris, France, italy, Italy, ⁵Kremlin Bicêtre hospital, Le Kremlin Bicêtre, France, ⁶Necker Hospital, Paris, France, ⁷Necker Hospital, Assistance Publique Hopitaux de Paris, Paris, France, ⁸Université Paris-Cite, IMAGINE Institute, Necker Children’s Hospital, Paris Cedex 15, France, ⁹University of Montpellier, Montpellier, ¹⁰Trousseau hospital, Paris, France, ¹¹Cochin hospital, Paris, France, ¹²Laboratoire de Génétique des Maladies Rares et Autoinflammatoires, Département de Génétique Médicale, Maladies Rares et Médecine Personnalisée, CEREMAIA, CHU de Montpellier, Univ Montpellier, Montpellier, France, Le Chesnay, France, ¹³Sorbonne Université, Department of internal medicine, Tenon Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France
Background/Purpose: Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease worldwide. Fatigue is known to trigger FMF attacks. So far, no association has…
Abstract Number: 1965 • ACR Convergence 2024
Artificial Intelligence Assisted Interpretation of Lung Ultrasound Imaging for the Detection of Interstitial Lung Disease
Robert Fairchild¹, Diane Mar², Mariani Deluna³, Matthew Baker⁴, suzanne Tamang⁵, Henry Guo³, David Fiorentino⁴ and Lorinda Chung⁶, ¹Stanford University, San Francisco, CA, ²VA Palo Alto / Stanford, Palo Alto, CA, ³Stanford University, Palo Alto, CA, ⁴Stanford University, Menlo Park, CA, ⁵Stanford University, Atherton, CA, ⁶Stanford University, Woodside, CA
Background/Purpose: Interstitial lung disease (ILD) is a serious complication of SSc and inflammatory myopathy (IM), necessitating accurate and early detection for improved outcomes. Lung ultrasound…
Abstract Number: 1978 • ACR Convergence 2024
Insertional and Midportion Achilles Tendinopathy Have Differences in Presence of Calcifications and Neovascularization
Andy Smith¹, Hayley Powell Smitheman¹ and Karin Silbernagel², ¹University of Delaware, Newark, DE, ²University of Delaware, Avondale, PA
Background/Purpose: Achilles tendinopathy is the clinical diagnosis of a painful injury to the Achilles tendon associated with pain during tendon loading and structural changes within…
Abstract Number: 1785 • ACR Convergence 2024
Comparative Immuno-Metabolomics Shows Singular Changes in Systemic Lupus Erythematosus Metabolic Phenotype Induced by T-Cell Activation
Martin Stradner¹, Fernanda Monedeiro², Elmar Zuegner², Barbara Prietl³, Monika Oberhuber⁴, Michael Khalil⁵, Christoph Magnes², Hans-Peter Brezinsek¹, Angela Libiseller³ and Thomas Pieber³, ¹Div. of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ²Joanneum Research, Graz, Austria, ³Div. of Endocrinology, Medical University of Graz, Graz, Austria, ⁴CBmed, Graz, Austria, ⁵Dept. of Neurology, Medical University of Graz, Graz, Austria
Background/Purpose: Metabolic processes have a critical role in regulating immune cell function, therefore being relevant to understanding the pathogenesis and progression of autoimmune diseases. Here…
Abstract Number: 1083 • ACR Convergence 2024
Comparison of a Handheld Ultrasound Device with Cart-Based Ultrasound for the Assessment of Gout Lesions in People with Established Gout
Rachel Murdoch¹, Lene Terslev², Julia Martin³, Borislav Mihov¹, Gregory Gamble¹, Søren Torp-Pedersen⁴, Anne Horne¹ and Nicola Dalbeth¹, ¹University of Auckland, Auckland, New Zealand, ²Rigshospitalet-Glostrup & COPECARE, Glostrup, Denmark, ³Te Whatu Ora Te Toka Tumai, Auckland, New Zealand, ⁴Rigshospitalet, Copenhagen, Denmark
Background/Purpose: Ultrasound is frequently used in rheumatology practice to assist with the diagnosis of rheumatic and musculoskeletal diseases. In patients with gout, it allows visualization…
Abstract Number: 0086 • ACR Convergence 2024
Evaluating the Efficacyof B Cell Targeting Drug Candidates Using a Humanized BAFF Transgenic SLE Mouse Model
Juan Liang, Shuxin Xu, Qiuping Xu and Yuxi Zhang, GemPharmatech, San Diego
Background/Purpose: B-cell-activating factor (BAFF) plays a critical role in B cell survival, and its elevated expression can contribute to the presence of autoreactive B cells,…
Abstract Number: 0069 • ACR Convergence 2024
Activation of Cardiovascular Inflammation and Wnt Signaling in Spondyloarthritis: Insights from the HLA-B27 Transgenic Rat Model
Su-Ah Yoon, Chorong Kim, Hansun Song, Mie Jin Lim and Seong-Ryul Kwon, College of Medicine, Inha University, Incheon, Republic of Korea
Background/Purpose: Despite the well-documented link between cardiovascular (CV) disease and spondyloarthritis (SpA), no animal studies have empirically validated this connection or integrated SpA, vascular inflammation,…
Abstract Number: 0094 • ACR Convergence 2024
Small GTPase Rab4A Regulates Mouse Behavior Through Altered Serum Serotonin Levels and Microglial mTORC1 Activation in Lupus-prone B6.TC Mice
Thomas Winans¹, Xiaojing Wang², Joshua Lewis², Jessica Nolan¹, Laurence Morel³ and Andras Perl⁴, ¹SUNY Upstate Medical University, Syracuse, ²SUNY Upstate Medical University, Syracuse, NY, ³University of Texas health San Antonio, San Antonio, TX, ⁴SUNY, Syracuse, NY
Background/Purpose: Rab4A is a small GTPase that is overexpressed in patients and mice with systemic lupus erythematosus (SLE, PubMed ID: 23897774; PubMed ID 31805010). Rab4A…
Abstract Number: 0098 • ACR Convergence 2024
Anti-HSP90α as a Protective Natural Antibody Against Secondary Antiphospholipid Syndrome in Systemic Lupus Erythematosus
Marina Barguil Macedo¹, Jorge Armando Gonzalez-Chapa¹, Anders Bengtsson², Iva Gunnarsson³, Elisabet Svenungsson⁴ and Christian Lood¹, ¹University of Washington, Seattle, WA, ²Lund University, Lund, Sweden, ³Karolinska Institute, Stockholm, Sweden, ⁴Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Heat shock protein 90 alpha (HSP90α) is an epichaperone present ubiquitously inside the cell, whose dimers function as a foldase that helps the correct…
Abstract Number: 0113 • ACR Convergence 2024
Plasma Proteomics Analysis Identifies Thromboinflammatory Signature Associated with Clinical Antiphospholipid Syndrome: Results from Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Registry
Alexander Pine¹, Vittorio Pengo², Savino Sciascia³, Nina Kello⁴, Rosario Lopez Pedrera⁵, H Michael Belmont⁶, David Branch⁷, Laura Andreoli⁸, Michelle Petri⁹, Ricard Cervera¹⁰, Jason Knight¹¹, Pierluigi Meroni¹², Hannah Cohen¹³, Rohan Willis¹⁴, Maria Laura Bertolaccini¹⁵, Alfred Lee¹⁶, Doruk Erkan¹⁷ and Anish Sharda¹⁶, ¹Yale School of Medicine/VA Connecticut, West Haven, CT, ²Thrombosis Research Laboratory, Department of Cardio-Thoracic-Vascular Sciences and Public Health, University of Padova, Padova, Italy, ³University of Turin, Torino, Turin, Italy, ⁴Northwell Health, Brooklyn, NY, ⁵IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁶NYU School of Medicine, New York, NY, ⁷University of Utah and Intermountain Healthcare, Salt Lake City, UT, ⁸University of Brescia, Brescia, Italy, ⁹Johns Hopkins University School of Medicine, Timonium, MD, ¹⁰Hospital Clinic de Barcelona, Barcelona, Spain, ¹¹University of Michigan, Ann Arbor, MI, ¹²IRCCS Istituto Auxologico Italiano 100%, Cusano Milanino, Milan, Milan, Italy, ¹³University College London Hospitals NHS Foundation Trust, London, United Kingdom, ¹⁴University of Texas Medical Branch, Galveston, TX, ¹⁵King's College London, London, United Kingdom, ¹⁶Yale School of Medicine, New Haven, CT, ¹⁷Hospital for Special Surgery, New York, NY
Background/Purpose: Antiphospholipid syndrome (APS) is an autoimmune disease with thromboembolic and obstetric morbidity arising via a model of immunothrombosis. Patients may present with thrombotic (tAPS),…
Abstract Number: 0048 • ACR Convergence 2024
Role of the Chemokine CCL22 in Rheumatoid Arthritis Development
Marcelo Afonso¹, Masa Filipovic¹, Alexandra Argyriou², Alexandra Circiumaru³, Mikael Ringh¹, Konstantin Carlberg¹, Vijay Joshua¹, Szu-Jing Chen¹, Marianne Engström¹, Heidi Wähämaa¹, Tomas Ekström¹, Marc H Wadsworth II⁴, Ravi Kumar¹, Aaron Winkler⁵, Vivianne Malmström¹, Anca Catrina¹, Karine Chemin¹, Aase Hensvold¹ and Bence Réthi¹, ¹Karolinska Institutet, Stockholm, Sweden, ²Karolinska Institutet, Solna, Sweden, ³Division for Rheumatology, Karolinska Institutet; Center for Rheumatology, Academic Specialist Center, Stockholm region, Stockholm, Sweden, ⁴Pfizer, Cambridge, ⁵Pfizer Inc., Cambridge, MA
Background/Purpose: Understanding alterations of the immune homeostasis in individuals at risk of rheumatoid arthritis (RA) can be a key to achieve earlier diagnosis and prevention.…
Abstract Number: 0101 • ACR Convergence 2024
Metabolomic Profiling Reveals a Role for Citric Acid Cycle Dysfunction in Antiphospholipid Syndrome Neutrophils
Ajay Tambralli¹, Megan Radyk¹, Kaitlyn Sabb¹, Li Zhang¹, Harrison Wong¹, Emily Becker¹, Srilakshmi Yalavarthi¹, Claire Hoy¹, Cyrus Sarosh², Jacqueline Madison¹, Yu Zuo¹, Jason Knight¹ and Costas Lyssiotis¹, ¹University of Michigan, Ann Arbor, MI, ²University of Michigan, Temperance, MI
Background/Purpose: As early effectors of the immune response, neutrophils must access energy rapidly. Neutrophils rely on glycolysis for antimicrobial functions such as phagocytosis and reactive…
Abstract Number: 0100 • ACR Convergence 2024
Association Between the Active Form of Plasminogen Activator Inhibitor 1 (PAI-1) and Endothelial Cell Activation in Antiphospholipid Syndrome
Yuzhou Gan¹, Wenying Liang², Mark Warnock³, Srilakshmi Yalavarthi², Cyrus Sarosh⁴, Ajay Tambralli², Jacqueline Madison², Yu Zuo², Daniel Lawrence³ and Jason Knight², ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan, Ann Arbor, MI, ³Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, ⁴University of Michigan, Temperance, MI
Background/Purpose: Plasminogen activator inhibitor 1 (PAI-1), a SERPIN-type inhibitor, is best known for regulating fibrinolysis, where it inhibits the activity of tissue and urokinase plasminogen…
Abstract Number: 0077 • ACR Convergence 2024
Characteristics of Axial Spondyloarthritis in Patients with Onset Chronic Low Back Pain After Age 45
Fatma Zohra Yasmina Heddi¹, Zahira Lamri², kheireddine khelif², Amina Benammar² and wafa Zahdour², ¹Oran University Hospital, Rheumatology Department/ University of Oran 1, Faculty of Medicine, Oran, Oran, Algeria, ²Oran University Hospital, Rheumatology Department/ University of Oran 1, Faculty of Medicine, Oran, Algeria
Background/Purpose: The onset of axial spondyloarthritis (axSpA), as defined by the Assessment of SpondyloArthritis International Society (ASAS) criteria is unusual after the age of 45…

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