Abstracts Archive - Page 137 of 2607 - ACR Meeting Abstracts

Abstract Number: 1080 • ACR Convergence 2025
Are Minority Populations Truly Vaccine Hesitant? A Provider-Based Approach to RSV Vaccine Uptake Suggests Otherwise.
pavana sakhamuri¹, Stephen Lindsey², Cathryn Leggio³ and Ellen Mire⁴, ¹LSUHSC, Dept of Rheumatology, Lafayette, LA, ²LSUHSC, Dept of Rheumatology, NEW ORLEANS, LA, ³University Medical center, NEW ORLEANS, LA, ⁴LSUHSC, Dept of Medicine, NEW ORLEANS, LA
Background/Purpose: Respiratory Syncytial Virus (RSV) is a leading cause of hospitalization and mortality in older adults and young children, particularly those with chronic illnesses or…
Abstract Number: 0062 • ACR Convergence 2025
Neddylation as a Therapeutic Target in Autoimmune Arthritis: Evidence from SKG Mice
Sho Sendo¹, Alfonso Del Peral Fanjul², Kazuma Nishisaka², Hirotaka Yamada¹, Takaichi Okano¹, Keisuke Nishimura¹, Yo Ueda¹ and Jun Saegusa², ¹Kobe University Hospital, Kobe, Japan, ²Kobe University, Kobe, Japan
Background/Purpose: Neddylation, NEDD8 conjugating process, is a post-translational modification that plays a crucial role in regulating ubiquitination by targeting cullin (CUL)-ring E3 ubiquitin ligases. Our…
Abstract Number: 2024 • ACR Convergence 2025
Racial Disparities in Outcomes Among Patients With Neuromyelitis Optica: A Global Population-Based Study
Chukwuemelie Okeke¹, Justin Riley Lam², Queeneth Edwards³ and Ufuoma Mamoh⁴, ¹Maimonides Medical Center, Brooklyn, NY, ²Jefferson Einstein Hospital, Philadelphia, PA, ³Department of Epidemiology and Biostatistics, Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, GA, ⁴Medstar Health Georgetown University Internal Medicine Residency Program, Baltimore, MD
Background/Purpose: Neuromyelitis optica (NMO) is a rare, chronic, immune-mediated, demyelinating disorder predominantly affecting the optic nerve and spinal cord. Despite increasing awareness, racial disparities in…
Abstract Number: 1964 • ACR Convergence 2025
Performance of Artificial Intelligence-Based Salivary Gland Ultrasound in Sjögren Syndrome
Otto Olivas¹, Mónica García-Sevilla², Lucía Cubero², Javier Pascau² and Esperanza Naredo³, ¹Department of Rheumatology and Joint and Bone Research Unit. Fundación Jiménez Díaz University Hospital and Health Research Institute FJD-UAM, Madrid, Spain, Madrid, Madrid, Spain, ²Department of Bioengineering, Carlos III University of Madrid, Leganes, Madrid, Spain and Health Research Institute Gregorio Marañón, Madrid, Spain, Madrid, Madrid, Spain, ³Department of Rheumatology and Joint and Bone Research Unit. Fundación Jiménez Díaz University Hospital and Health Research Institute FJD-UAM, Madrid, Spain, MADRID, Spain
Background/Purpose: To develop a deep learning model for classifying ultrasound images of salivary glands (SG) [parotid (PG) and submandibular (SMG)] based on the Outcome Measures…
Abstract Number: 1978 • ACR Convergence 2025
Utilizing a Gap to Target Function in the Pediatric Rheumatology Care and Outcomes Improvement Network Registry Dashboard of Quality Measures
Julia Harris¹, Catherine Bingham², Sheetal Vora³, Kerry Ferraro⁴, Erik Friedrichsen⁵, Cagri Yildirim-Toruner⁶, Ted Wimmel⁷, Delores Mincarelli⁸, Magen Phillips⁹ and Esi Morgan¹⁰, ¹Children's Mercy Kansas City, Overland Park, KS, ²Penn State Children's Hospital, Hershey, PA, ³Atrium Health Levine Children's Hospital, Charlotte, NC, ⁴Pediatric Rheumatology Care and Outcomes Improvement Network, Cincinnati, ⁵Seattle Children's Hospital, Burien, WA, ⁶Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁷Hive Solutions, LLC, Cincinnati, OH, ⁸Hive Solutions, LLC, Newport, KY, ⁹Hive Solutions, LLC, Blue Ash, OH, ¹⁰Seattle Children's Hospital, Seattle, WA
Background/Purpose: The Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) is a multi-site learning health network organized to improve outcomes of juvenile idiopathic arthritis (JIA).…
Abstract Number: 1783 • ACR Convergence 2025
Nerve Growth Factor Causes Sensitization, Nociceptor Sprouting, Synovitis, And Osteophyte Formation In Naïve Murine Joints
alia obeidat¹, michael Newton², Jun Li¹, Baofeng Hu³, Shingo Ishihara⁴, Lindsey Lammlin², Lucas Junginger², Easton Farrell², Frank Ko¹, Richard Miller⁵, Carla Scanzello⁶, Tristan Maerz⁷, Rachel Miller⁸ and Anne-Marie Malfait⁹, ¹Rush University Medical Center, Chicago, ²University Of Michigan, Ann Arbor, ³University of Pennsylvania, Wynnewood, PA, ⁴Rush University, Chicago, ⁵Northwestern University, Chicago, ⁶University of Pennsylvania, Philadelphia, ⁷University of Michigan, Ann Arbor, MI, ⁸Rush University Medical Center, Chicago, IL, ⁹rush university, CHICAGO, IL
Background/Purpose: The neurotrophin, nerve growth factor (NGF), a key mediator of pain and inflammation, is increased in joints with osteoarthritis (OA). Neutralizing NGF with monoclonal…
Abstract Number: 1090 • ACR Convergence 2025
Quantitative Immunoglobulin Screening Prior to Rituximab Initiation: A Retrospective Cohort Study
Amelia Khoo and Anokhi Saklecha, Yale University, New Haven, CT
Background/Purpose: Rituximab, a monoclonal antibody which binds to the CD20 antigen of B cells, is used in the treatment of many rheumatologic conditions. Due to…
Abstract Number: 0025 • ACR Convergence 2025
Expansion and Transcriptional Reprogramming of CD14⁺ and CD16⁺ Monocytes in Behçet’s Disease
Elio Carmona¹, Rabia Deniz², Cemal Bes³, Haner Direskeneli⁴, Ahmet Gul⁵ and Amr Sawalha⁶, ¹Division of Pediatric Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Pittsburgh, ²University of Health Sciences Basaksehir Çam and Sakura City Hospital, Istanbul, Turkey, ³University of Health Sciences, Basaksehir Çam and Sakura City Hospital, Istanbul, Turkey, ⁴Marmara University, ISTANBUL, Turkey, ⁵Istanbul University, Istanbul, Turkey, ⁶University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Behçet’s disease (BD) is a chronic, relapsing inflammatory disease characterized by complex immunopathogenesis and limited treatment options. Monocytes are known to play a significant…
Abstract Number: 0061 • ACR Convergence 2025
IL-22 Contributes to Autoantibody-induced Arthritis Via Modulation of Inflammatory Cytokine and Chemokine Expression in the Inflamed Synovium of a Murine Model
Shinjiro Kaieda¹, Suzuna Sugi¹, Takuma Koga², Takashi Kinoshita¹ and Tomoaki Hoshino¹, ¹Kurume university School of Medicine, Kurume, Japan, ²Kurume Universty School of Medicine, Kurume, Japan
Background/Purpose: IL-22 is a key cytokine involved in modulating tissue responses during inflammation and is markedly upregulated in inflammatory diseases, such as psoriasis, inflammatory bowel…
Abstract Number: 0087 • ACR Convergence 2025
Integrative Metabolomic and Inflammatory Profiling in Rheumatoid Arthritis: Disease activity, therapeutic modulation, and underlying hepatic mechanisms
Laura muñoz-Barrera¹, Carlos Pérez Sánchez², Rafaela Ortega-Castro³, Sagrario Corrales¹, Tomás Cerdó¹, Ismael Sanchez-Pareja¹, Pilar Font⁴, Jerusalen Calvo Gutierrez⁵, M Carmen Abalos-Aguilera⁶, Desiree Ruiz-Vilchez⁷, Pedro Seguí-Azpilcueta⁸, Christian Merlo-Ruiz⁶, Jose Javier Pérez Venegas⁹, DOLORES RUIZ MONTESINOS¹⁰, Carmen Maria Romero Barco¹¹, Antonio Fernández-Nebro¹², Natalia Mena Vázquez¹³, FRANCISCO JAVIER GODOY NAVARRETE¹⁴, ALBA MARIA CABEZAS LUCENA¹⁵, MARIA ANGELES AGUIRRE ZAMORANO¹, Nuria Barbarroja¹⁶, Alejandro Escudero¹⁷ and Chary López pedrera¹⁸, ¹Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Córdoba, Spain, ²Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain/ CobiomicBioscience S.l, Cordoba, Spain, Cordoba, Spain, ³Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Andalucia, Spain, ⁴Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, SpainBiomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Spain, ⁵Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Sevilla, Spain, ⁶Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Córdoba, Spain, ⁷Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, ⁸Radiology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba/University of Cordoba, Spain, Córdoba, United Kingdom, ⁹Virgen Macarena University Hospital, Sevilla, Spain, Sevilla, Spain, ¹⁰Virgen Macarena University Hospital, Sevilla, Spain, Cordoba, ¹¹Virgen de la Victoria Hospital Malaga, Spain, Malaga, Spain, ¹²Hospital Regional Universitario de Malaga, Malaga, Spain, Malaga, Spain, ¹³Hospital Regional Universitario de Malaga, Malaga, Spain, Málaga, Spain, ¹⁴Jaen University Hospital, Spain, Jaen, Spain, ¹⁵Jaen University Hospital, Spain, Jaen, ¹⁶Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain/CobiomicBioscience S.l, Cordoba, Spain, Cordoba, Spain, ¹⁷Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Córdoba, Andalucia, Spain, ¹⁸Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Spain
Background/Purpose: Lipid metabolism plays a key role in immune cell plasticity, influencing activation, differentiation and function. Inflammation alters this metabolism, contributing to disease progression. Extensive…
Abstract Number: 0089 • ACR Convergence 2025
Expansion of PD-1hi Tfh and Tph cells in the peripheral blood of seropositive clinically suspect arthralgia patients: association with progression to rheumatoid arthritis
Maria-Eugenia Miranda-Carus¹, Mariana Gutierrez-Riart², Beatriz Nieto-Carvalhal³, Laura Nuño², Alejandro Villalba¹, Diana Peiteado¹, Irene Monjo Henry¹, Marta Novella-Navarro¹ and Eugenio de Miguel¹, ¹Hospital Universitario La Paz, Madrid, Spain, ²Hospital Universitario La Paz, Madrid, ³Hospital Universitario La Paz, Mdrid
Background/Purpose: Subjects with clinically suspect arthralgia (CSA) are at risk for developing rheumatoid arthritis (RA) and therapeutic interventions may prevent or delay progression. Still, a…
Abstract Number: 0038 • ACR Convergence 2025
DNA Methylation Signatures of Smoking in Labial Salivary Gland Tissue in a Sjögren’s Disease Cohort
Priya Bhatt¹, Mary Horton², Caroline Shiboski³, Lisa Barcellos⁴ and Lindsey Criswell², ¹Mayo Clinic Alix School of Medicine, Toledo, ²NIH/NHGRI, Bethesda, MD, ³University of California San Francisco, San Francisco, CA, ⁴UC Berkeley, Berkeley
Background/Purpose: Cigarette smoking has been linked to the development of several autoimmune diseases, including Sjögren’s Disease (SjD). Since DNA methylation (DNAm) is altered by cigarette…
Abstract Number: 0091 • ACR Convergence 2025
Clonal Hematopoiesis of Indeterminate Potential (CHIP) in Rheumatoid Arthritis: associations with treatment response and comorbidities
Athena Chin¹, susan branford², Annabelle Small³, malcolm Smith¹, monika Kutyna⁴, Robert King⁵, Susanna Proudman⁶, Devendra Hiwase⁷ and Mihir Wechalekar⁸, ¹Flinders Medical Centre, KURRALTA PARK, South Australia, Australia, ²SA Pathology, Adelaide, ³Flinders University, Bedford Park, South Australia, Australia, ⁴South Australian Health and Medical Research Institute, Adelaide, ⁵Flinders Medical Centre, Adelaide, South Australia, Australia, ⁶Royal Adelaide Hospital and University of Adelaide, Medindie, South Australia, Australia, ⁷Royal Adelaide Hospital, Adelaide, ⁸Flinders Medical Centre and Flinders University, Bedford Park, South Australia, Australia
Background/Purpose: Clonal hematopoiesis (CH) of indeterminate potential (CHIP) is defined as the detection of recurrent somatic mutations, at a variant allele frequency (VAF) < ![if…
Abstract Number: 0093 • ACR Convergence 2025
Soluble CD13 engages protease-activated receptor 4 to promote synovial inflammation and angiogenesis in rheumatoid arthritis
Chenyang Lu¹, Megan N Mattichak², Simin Xu¹, William D Brodie³, Neha Khanna², Hafsa Amin², Qi Wu², Phillip Campbell², David Fox⁴ and Pei-Suen Tsou⁵, ¹Division of Rheumatology, Department of Internal Medicine, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, Guangzhou, China (People's Republic), ²Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA, Ann Arbor, ³Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Ann Arbor, ⁴University of Michigan, Dexter, MI, ⁵University of Michigan, Ann Arbor, MI
Background/Purpose: Soluble CD13 (sCD13), the soluble form of aminopeptidase N/CD13, exhibits potent chemoattractant, angiogenic, and arthritogenic properties. While we previously identified certain G protein-coupled receptors…
Abstract Number: 0070 • ACR Convergence 2025
Integrating Synovial Protein Signatures and Serum Profiles to Predict Disease Activity and Treatment Response in Early Rheumatoid Arthritis
Chary López pedrera¹, Sagrario Corrales², Julio Osuna³, Rafaela Ortega-Castro⁴, Jerusalén Calvo⁵, Lourdes Ladehesa⁶, Ismael Sanchez-Pareja², Laura muñoz-Barrera², Desiree Ruiz-Vilchez⁷, Christian Merlo⁸, MARIA ANGELES AGUIRRE ZAMORANO², Nuria Barbarroja⁹, Tomás Cerdó², Marta Alarcon-Riquelme¹⁰, Carlos Pérez Sánchez¹¹, Alejandro Escudero Contreras⁵ and Concepción Aranda-Valera⁵, ¹Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Spain, ²Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Córdoba, Spain, ³IMIBIC/Reina Sofia Hospital/University of Cordoba, Spain., Córdoba, Republic of Korea, ⁴Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Andalucia, Spain, ⁵IMIBIC / Reina Sofia Hospital / University of Cordoba, Córdoba, Spain, ⁶IMIBIC-Reina Sofia Hospital-University of Cordoba, Cordoba, Spain, Cordoba, Spain, ⁷Department of Rheumatology, Reina Sofía University Hospital / Maimonides Institute for Biomedical Research of Córdoba (IMIBIC) / Department of Medical and Surgical Sciences, Faculty of Medicine, University of Córdoba, Spain, Cordoba, Spain, ⁸Rheumatology Service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba/ Reina Sofia University Hospital, Córdoba, Spain, Cordoba, Spain, ⁹Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain/CobiomicBioscience S.l, Cordoba, Spain, Cordoba, Spain, ¹⁰Fundación Progreso y Salud, Andalusian Government, Granada, Spain, ¹¹Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain/ CobiomicBioscience S.l, Cordoba, Spain, Cordoba, Spain
Background/Purpose: The analysis of synovial tissue has been instrumental in advancing our understanding of Rheumatoid Arthritis (RA) pathogenesis. As an alternative, the identification of serum…

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