Abstracts Archive - Page 1368 of 2607 - ACR Meeting Abstracts

Abstract Number: 2727 • 2018 ACR/ARHP Annual Meeting
Prevalence of Clinical and Subclinical Ophthalmologic Manifestations in Association with Systemic Symptoms, Disease Activity and Damage in Patients with Granulomatosis with Polyangiitis
Andrea Hinojosa-Azaola¹, Annette García-Castro² and Alejandra Juárez-Flores³, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ³Ophthalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Ophthalmologic involvement in Granulomatosis with Polyangiitis (GPA) is present in 50-60% of the patients and can affect any part of the ocular glove and…
Abstract Number: 2728 • 2018 ACR/ARHP Annual Meeting
Validation of the Draft Classification Criteria of Granulomatosis with Polyangiitis (GPA) Amongst Indian Patients with ANCA Associated Vasculitis
Aman Sharma¹, Adarsh MB², GSRSNK Naidu³, Manish Rathi⁴, Kusum Sharma⁵, Varun Dhir⁶, Ritambhra Nada⁷, Ranjana Minz⁸ and Sanjay Jain⁹, ¹Clinical Immunology and Rheumatology Services, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, Chandigarh, India, ²Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, Chandigarh, India, ³PGIMER, cHANDIGARH, India, ⁴Department of Nephrology,, Postgraduate Institute of Medical Education and Research, Chandigarh, India, ⁵Department of Medical Microbiology,, PGIMER,, Chandigarh, India, ⁶Internal Medicine (Rheumatology Unit), Postgraduate Institute of Medical Education and Research, Chandigarh, India, Chandigarh, India, ⁷Postgraduate Institute of Medical Education and Research, Chandigarh, India, ⁸Department of Immunopathology,, PGIMER,, Chandigarh, India, ⁹Postgraduate Institute of Medical Education and Research, Chandigarh, India, CHANDIGARH, India
Background/Purpose: A draft classification criteria of GPA was proposed at ACR meeting in San Diego in 2017. The present criteria is a modification of ACR/EULAR…
Abstract Number: 2729 • 2018 ACR/ARHP Annual Meeting
Increased Risk of Cerebrovascular Accident Among Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Systematic Review and Meta-Analysis of Cohort Studies
Patompong Ungprasert¹, Karn Wijarnpreecha² and Wisit Cheungpasitporn³, ¹Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, ²Internal medicine, Bassett medical center, cooperstown, NY, ³Medicine, University of Mississippi Medical center, Jackson, MS
Increased Risk of Cerebrovascular Accident among Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Systematic Review and Meta-analysis of Cohort StudiesAbstractBackground/Purpose: An increased risk of cardiovascular…
Abstract Number: 2730 • 2018 ACR/ARHP Annual Meeting
Handgrip Strength Predicts the Risk of Bone Fracture and Severe Adverse Events in Patients with Systemic Necrotizing Vasculitis
Soledad Henriquez¹, Bertrand Dunogué², Raphaël Porcher³, Alexis Régent¹, Pascal Cohen⁴, Alice Bérezné¹, Sami Kolta⁵, Claire Le Jeunne¹, Luc Mouthon⁶, Christian Roux⁵, Loïc Guillevin⁷, Karine Briot⁸ and Benjamin Terrier⁹, ¹Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ²Internal Medicine, Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ³Université Paris Descartes Sorbonne Paris, Paris, France, ⁴Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, ⁵Department of Rheumatology, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁶Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France, ⁷Medecine Interne, Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁸Department of Rheumatology, Cochin Hospital and Epidemiology and Biostatistics Unit,Sorbonne Paris Cité Reserach Center,Paris Descartes University,INSERM U1153, Paris, France, ⁹National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France
Background/Purpose: Sarcopenia, characterized by progressive loss of both muscle mass and muscle strength, has been associated with poor outcomes in various diseases. Muscle weakness is…
Abstract Number: 2731 • 2018 ACR/ARHP Annual Meeting
Clinical Characteristics and Outcomes of ANCA-Vasculitides Associated Renal Disease in a Multi-Ethnic Population from a County Hospital
Shilpa Arora¹, Ambrish Athavale² and Peter Hart², ¹Medicine, John H Jr Stroger Hospital of Cook County, Chicago, IL, ²John H Jr Stroger Hospital of Cook County, Chicago, IL
Background/Purpose: Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and renal-limited vasculitis (RLV). We aimed to study the clinical features…
Abstract Number: 2732 • 2018 ACR/ARHP Annual Meeting
Peripheral Neuropathy Is More Common in Microscopic Polyangiitis Than in Granulomatosis with Polyangiitis: Data from a Single Tertiary Referral Center
Mehmet Nedim Taş¹, Mete Kara¹, Sertaç Ketenci¹, Mete Pekdiker², Raika Durusoy³, Fikret Bademkıran⁴, Gokhan Keser⁵ and Kenan Aksu⁵, ¹Rheumatology, Ege University Medical Faculty, izmir, Turkey, ²Adult Rheumatology, Ege University Medical Faculty, izmir, Turkey, ³Public Health, Ege University Medical Faculty, izmir, Turkey, ⁴Neurology, Ege University Medical Faculty, izmir, Turkey, ⁵Rheumatology, Ege University Medical Faculty, Izmir, Turkey
Background/Purpose: Among many other organs and systems, ANCA-associated vasculitis (AAV) may also affect nervous system in up to more than half of patients, resulting in…
Abstract Number: 2733 • 2018 ACR/ARHP Annual Meeting
From a Myth to a Menace: Increased Disease Severity and Poor Outcomes in an Urban Cohort of African-American Patients with ANCA-Associated Vasculitis
Kathleen Maksimowicz-McKinnon¹, Philip McCarthy², Sandeep Soman³ and John McKinnon³, ¹Rheumatology, Henry Ford Hospital, Detroit, MI, ²Michigan State University College of Osteopathic Medicine, East Lansing, MI, ³Henry Ford Hospital, Detroit, MI
Background/Purpose: Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a systemic inflammatory disorder frequently associated with significant disability and morbidity, which may lead to end-stage renal disease…
Abstract Number: 2734 • 2018 ACR/ARHP Annual Meeting
The Effect of Age at Diagnosis on Mortality in ANCA-Associated Vasculitides
Mete Kara¹, Mehmet Nedim Taş¹, Raika Durusoy², Sertaç Ketenci¹, Mete Pekdiker³, Hande Ece Öz⁴, Gülay Aşçı⁵, Gokhan Keser⁶ and Kenan Aksu⁴, ¹Rheumatology, Ege University Medical Faculty, izmir, Turkey, ²Public Health, Ege University Medical Faculty, izmir, Turkey, ³Adult Rheumatology, Ege University Medical Faculty, izmir, Turkey, ⁴Rheumatology, Ege University Medical Faculty, İzmir, Turkey, ⁵Nephrology, Ege University Medical Faculty, İzmir, Turkey, ⁶Rheumatology, Ege University Medical Faculty, Izmir, Turkey
Background/Purpose: Elderly patients with ANCA associated vasculitides (AAV) seem to have clinical differences compared to younger patients. The aim of this study is to compare…
Abstract Number: 2735 • 2018 ACR/ARHP Annual Meeting
Identifying ANCA-Associated Vasculitis Cases in Electronic Health Records Using Natural Language Processing
Zachary Wallace¹, John H. Stone² and Hyon K. Choi³, ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Rheumatology (Medicine), Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA
Background/Purpose: Epidemiologic studies of ANCA-associated vasculitis (AAV) using large data sets are often limited by the lack of validated definitions of AAV cases that can…
Abstract Number: 2736 • 2018 ACR/ARHP Annual Meeting
Value of Histology for Diagnosis and Classification in ANCA Associated Vasculitis
Julia Kronfeldner¹, Johanna Eifert¹, Stefanie Quickert¹, Peter Oelzner¹, Martin Busch¹, Claus Kroegel², Gunter Wolf¹, Benjamin Seeliger³ and Thomas Neumann^4,5, ¹Department of Internal Medicine III, Jena University Hospital, Jena, Germany, ²Department of Internal Medicine I, Jena University Hospital, Jena, Germany, ³Department of Respiratory Medicine, Medical School Hannover, Hannover, Germany, ⁴Internal Medicine III, Jena University Hospital, Jena, Germany, ⁵Department of Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland
Background/Purpose: Diagnosis of ANCA-associated vasculitis (AAV) and the classification of granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA) is based…
Abstract Number: 2737 • 2018 ACR/ARHP Annual Meeting
Opportunistic Infections in Medium and Small-Sized Vessel Vasculitis: Based on a Retrospectivestudy on 108 Patients
Raphaele Mestiri¹, Lafarge Antoine², Jean-Jacques Tudesq³, Marc Pineton de Chambrun⁴, Melanie Roriz⁵, Stéphane Bally⁶, Laurent Alric⁷, Damien Sène⁸, Thomas Quémeneur⁹, Cécile-Audrey Durel¹⁰, Brigitte Gilson¹¹, Alice Berezne¹², Anne-Marie Ruppert¹³, Raphaele Seror¹⁴, Philippe Guilpain¹⁵, Xavier Puéchal¹⁶, Luc Mouthon¹⁷, Loïc Guillevin¹⁶ and Benjamin Terrier¹⁸, ¹Internal Medicine, Cochin hospital, Paris, France, ²Medecine Interne, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France, ³Internal Medicine, CHU Montpellier, Montpellier, France, ⁴Université Pierre et Marie Curie, Paris, France, ⁵Université Paris-Diderot, Paris, France, ⁶Nephrology, CH Chambery, Chambery, France, ⁷Internal Medicine, CHU Toulouse, Toulouse, France, ⁸Lariboisière Hospital, Paris Diderot University, Paris, France, ⁹Department of Internal Medicine, CH of Valenciennes, France, Valenciennes, France, ¹⁰Internal Medicine, Hôpital Edouard Herriot, lyon, France, ¹¹Internal Medicine, CH Verdun, Verdun, France, ¹²Internal Medicine, CH Annecy, Annecy, France, ¹³Pulmonology, Tenon hospital, Paris, France, ¹⁴Hopitaux Universitaires Paris Sud, Kremlin Bicetre, France, Rheumatology, Université Paris Sud, Le Kremlin Bicetre, France, ¹⁵Montpellier, Montpellier, France, ¹⁶Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, ¹⁷Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France, ¹⁸Centre de Référence des Maladies Auto-immunes et Systémiques Rares, Vascularites Nécrosantes et Sclérodermie Systémique, Service de Médecine Interne, Hôpital Cochin, APHP, INSERM U1016, Université Paris Descartes, Paris, France
Background/Purpose: Overall survival has been markedly improved during the last decades in systemic vasculitis. In contrast, the use of immunosuppressive agents led to an increased…
Abstract Number: 2738 • 2018 ACR/ARHP Annual Meeting
A Randomized Phase 3 Trial Evaluating the Safety and Efficacy of Avacopan in Patients with New or Relapsing Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Peter A. Merkel¹, David Jayne², Thomas J. Schall³, Pirow Bekker³ and Jan Hillson³, ¹Division of Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ³ChemoCentryx, Mountain View, CA
A Randomized Phase 3 Trial Evaluating the Safety and Efficacy of Avacopan in Patients with New or Relapsing Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisPeter A. Merkel1, David…
Abstract Number: 2739 • 2018 ACR/ARHP Annual Meeting
Systemic Vasculitis: Incidence of Glucocorticoid Related Adverse Events
Luciano Fernando Lo Giudice¹, Marina Scolnik², Jose Maximiliano Martinez P³, Aurelia Luissi¹, Valeria Scaglioni² and Enrique R Soriano², ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Capital Federal, Argentina, ²Rheumatology Unit, Internal Medicine Service. Hospital Italiano Buenos Aires. Argentina, Buenos Aires, Argentina, ³Rheumatology, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: The glucocorticoid toxicity index (GTI) (Miloslavsky et al. Ann Rheum Dis 2017) is useful to assess impact on morbility associated with these drugs. It…
Abstract Number: 2740 • 2018 ACR/ARHP Annual Meeting
Clinical and Laboratory Characteristics of ANCA-Associated Vasculitis in Pediatric and Young Adult Patients: A Retrospective Review
Melissa Swee¹, Manish Suneja², Mandeep Gill³ and Bharat Kumar⁴, ¹Transplant Nephrology, University of Iowa, Iowa City, IA, ²Internal Medicine, University of Iowa, Iowa City, IA, ³Division of Nephrology, University of Iowa Hospitals and Clinics, Iowa City, IA, ⁴Internal Medicine-Division of Immunology, University of Iowa, Iowa City, IA
Background/Purpose: ANCA-associated vasculitis (AAV) is a heterogenous group of small-vessel vasculitides that typically affects the kidneys, respiratory tract, and other organ systems. The onset of…
Abstract Number: 2741 • 2018 ACR/ARHP Annual Meeting
Candidate Biomarkers in ANCA-Associated Vasculitis Identified Using a Proteomic Approach
Paul A. Monach¹, Hemang Parikh², Laurie Conklin³, Jesse Damsker⁴, Peter C. Grayson⁵, David Cuthbertson⁶, Simon Carette⁷, Nader A. Khalidi⁸, Curry L. Koening⁹, Carol Langford¹⁰, Carol A. McAlear¹¹, Larry W. Moreland¹², Christian Pagnoux¹³, Philip Seo¹⁴, Ulrich Specks¹⁵, Antoine G. Sreih¹⁶, Steven R. Ytterberg¹⁷, Eric Hoffman⁴ and Peter A. Merkel¹⁸, ¹Rheumatology, VA Boston Healthcare System, Boston, MA, ²University of South Florida, Tampa, FL, ³ReveraGen BioPharma, Rockville, MD, ⁴ReveraGen Biopharma, Rockville, MD, ⁵National Institute of Arthritis, Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD, ⁶Biostatistics and Informatics, Department of Pediatrics, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁷Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, ⁸Rheumatology, McMaster University, Hamilton, ON, Canada, ⁹Rheumatology, Division of Rheumatology, University of Utah, Salt Lake City, UT, ¹⁰Rheumatic and Immunologic Diseases, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ¹¹Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, ¹²Division of Rheumatology and Clinical Immunology, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ¹³Division of Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, ¹⁴Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ¹⁵Mayo Clinic College of Medicine, Rochester, MN, ¹⁶Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁷Rheumatology, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN, ¹⁸Division of Rheumatology and the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Concentrations of many circulating proteins are elevated during severe, active ANCA-associated vasculitis (AAV). Finding biomarkers associated with milder disease, a more clinically relevant need,…

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