Abstract Number: 2347 • 2017 ACR/ARHP Annual Meeting
High Interferon (IFN) Signatures and Overlapping Clinical Features Characterize Subgroups of Patients with Presumed IFN-Mediated Autoinflammatory Diseases
Background/Purpose: Many pediatric patients (pts.) with early-onset autoinflammatory disease (AID) phenotypes are mutation-negative for genetically known AIDs. Recent data suggest a role for Type-I interferon…Abstract Number: 2348 • 2017 ACR/ARHP Annual Meeting
A New Cause of Mendelian Lupus Due to IKZF1 Mutation Underlines the B Cell Landscape Heterogeneity in Monogenic Lupus
Background/Purpose: Next generation sequencing (NGS) represents a revolution in the field of molecular medicine, and offers a new approach to deciphering the pathogenesis of complex…Abstract Number: 2349 • 2017 ACR/ARHP Annual Meeting
Interferon Signature in Childhood Rheumatic Diseases
Background/Purpose: Several rheumatic diseases are characterized by overexpression of type I interferon(IFN)-inducible or viral response genes, termed the IFN signature. Recently this signature has been…Abstract Number: 2350 • 2017 ACR/ARHP Annual Meeting
Gastrointestinal Microbiota in New-Onset Juvenile Idiopathic Arthritis
Background/Purpose: Oral and gut microbes have been implicated in the pathogenesis of rheumatoid arthritis, spondyloarthropathy, and juvenile enthesitis-related arthritis (ERA). Pro-inflammatory microbes in the bacteroides…Abstract Number: 2351 • 2017 ACR/ARHP Annual Meeting
Are Sedentary Behavior and Reduced Physical Activity Associated with Long-Term Cardiovascular Risk in Individuals with Rheumatoid Arthritis?
Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk for cardiovascular disease (CVD) with subsequent morbidity and mortality1. It is well known that prolonged…Abstract Number: 2352 • 2017 ACR/ARHP Annual Meeting
Cardiovascular Safety during Treatment with Baricitinib in Rheumatoid Arthritis
Background/Purpose: Baricitinib (BARI) is an oral selective inhibitor of Janus kinase (JAK)1 and JAK2 approved in the EU for the treatment of active RA. Patients…Abstract Number: 2353 • 2017 ACR/ARHP Annual Meeting
The Relationship between Disease Activity, VEGF and E-Selectin Levels with Arterial Stiffness in Rheumatic Patients Treated with Biological Agents
Background/Purpose: Rheumatic diseases are chronic-inflammatory disease associated with endothelial damage, changes in vascular permeability and plaque formation. VEGF and E-selectin play an important role in…Abstract Number: 2354 • 2017 ACR/ARHP Annual Meeting
Inflammatory Markers in Relation to Risk Factors for Cardiovascular Disease in the Pre-Symptomatic Phase of Rheumatoid Arthritis
Background/Purpose: Individuals who later developed rheumatoid arthritis (RA) have increased levels and frequencies of risk factors for cardiovascular disease (CVD), years before onset of RA.…Abstract Number: 2355 • 2017 ACR/ARHP Annual Meeting
Arterial Wave Reflection and Subclinical Atherosclerosis in Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) increases atherosclerotic cardiovascular disease risk. Wave reflection occurs at arterial branching points, which are particularly prone to atherosclerosis. We hypothesised that…Abstract Number: 2356 • 2017 ACR/ARHP Annual Meeting
Disease Severity Impacts the Relationships of Apelin Concentrations with Arterial Function in Patients with Rheumatoid Arthritis
Background/Purpose: Patients with (RA) experience impaired inflammation induced arterial and endothelial function. Apelin can improve arterial function by enhancing the expression of endothelial nitric oxide…Abstract Number: 2357 • 2017 ACR/ARHP Annual Meeting
Retinal Vessel Morphological Associations with Systemic Inflammation and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is associated with a chronic inflammatory state, accelerated atherosclerosis and excess cardiovascular risk. Quantification of morphological changes in the retinal microvasculature…Abstract Number: 2358 • 2017 ACR/ARHP Annual Meeting
Chest Pain and Angina Pectoris in Rheumatoid Arthritis: Frequency and Prediction of Cardiovascular Mortality
Background/Purpose: Despite increased cardiovascular (CV) risk in rheumatoid arthritis (RA), chest pain and angina have received little attention among RA patients. We examined the frequency…Abstract Number: 2359 • 2017 ACR/ARHP Annual Meeting
Severity of Ischemic and Hemorrhagic Stroke in Patients with Rheumatoid Arthritis Compared with the General Population
Background/Purpose: Rheumatoid arthritis (RA) patients are at higher risk of developing stroke but whether their risks for severe strokes are unknown. Methods: All patients with…Abstract Number: 2360 • 2017 ACR/ARHP Annual Meeting
A Correlation Study between Expanded Cardiovascular Risk Prediction Score for Rheumatoid Arthritis and Nailfold Videocapillaroscopy
Background/Purpose: The most common cause of mortality in RA patients is the cardiovascular disease (CVD), with almost twice the risk for CVD events. Nailfold videocapillaroscopy…Abstract Number: 2361 • 2017 ACR/ARHP Annual Meeting
Associated Factors of Hypertension and Hyperglycemia Related to Steroid Pulse in Autoimmune Diseases
-Background/Purpose: Steroid pulses are widely used in treatment for multiple inflammatory pathologies. The prevalence of hyperglycemia is 55-98%, and hypertension 5-52.5%. (1-2); safety profile could…
ACR Meeting Abstracts