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  • Abstract Number: 2287 • 2017 ACR/ARHP Annual Meeting

    Biosimilar Use in Children and Young People with Juvenile Idiopathic Arthritis in a Real-World Setting in the United Kingdom

    Diederik De Cock1, Lianne Kearsley-Fleet1, Eileen Baildam2, Michael W. Beresford3,4, Helen E. Foster5, Taunton R. Southwood6, Wendy Thomson7,8 and Kimme L. Hyrich1,8, 1Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, 2Clinical Academic Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, 3Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, United Kingdom, 4Alder Hey Children's NHS Foundation Trust Hospital, Institute of Translational Medicine (Child Health), University of Liverpool, Liverpool, United Kingdom, 5Institute of Cellular Medicine and Paediatric Rheumatology, Newcastle University and Great North Children's Hospital, Newcastle Upon Tyne, United Kingdom, 6School of Immunity and Infection,Institute of Clinical Sciences,University of Birmingham, Birmingham, United Kingdom, 7Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, 8National Institute of Health Research Manchester Musculoskeletal Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom

    Background/Purpose: Despite their increasing use in adults, there is little to no data available on the use of biosimilar drugs in children with JIA, despite…
  • Abstract Number: 2288 • 2017 ACR/ARHP Annual Meeting

    Successful Treatment of Methotrexate Intolerance in Juvenile Idiopathic Arthritis Using Eye Movement Desensitization and Reprocessing (EMDR)

    Lea Höfel, Bruno Eppler, Elisabeth Schnöbel-Müller, Johannes Peter Haas and Boris Hügle, German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany

    Background/Purpose: Methotrexate (MTX) is commonly used in the treatment of children with juvenile idiopathic arthritis (JIA). It frequently has to be discontinued due to intolerance…
  • Abstract Number: 2289 • 2017 ACR/ARHP Annual Meeting

    Individualized Prediction of Early Remission on Medication in Juvenile Idiopathic Arthritis

    Jaime Guzman1, Andrew Henrey2, Thomas Loughin2, Kiem Oen3, Natalie J. Shiff4, Roberta Berard5, Roman Jurencak6, Adam Huber7, Kerstin Gerhold8, Susanne Benseler9, Ciarán M. Duffy10 and Lori Tucker1, 1BC Children's Hospital, Vancouver, BC, Canada, 2Statistics and Actuarial Science, Simon Fraser University, Burnaby, BC, Canada, 3Department of Pediatrics and Child Health University of Manitoba, Winnipeg, MB, Canada, 4University of Florida, Gainesville, FL, 5Pediatrics, Children's Hospital, London Health Sciences Centre, London, ON, Canada, 6University of Ottawa, Ottawa, ON, Canada, 7IWK Health Centre, Halifax, NS, Canada, 8Pediatrics, University of Manitoba, Winnipeg, MB, Canada, 9Pediatric Rheumatology, University of Calgary, Alberta Children's Hospital, Calgary, AB, Canada, 10Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada

    Background/Purpose:   The Research in Arthritis in Canadian Children emphasizing Outcomes cohort (ReACCh-Out) showed a 45% chance of attaining inactive disease within a year of…
  • Abstract Number: 2290 • 2017 ACR/ARHP Annual Meeting

    Comparing Effectiveness of Early Initiation of Biologic Treatment for Newly Diagnosed Juvenile Idiopathic Arthritis Using a Novel Statistics Causal Inference Method Applied to Observational Data

    Bin Huang1, Esi Morgan2, Chen Chen2, Jinzhong Liu2, Michelle Adams2, Timothy Beukelman3, Hermine I. Brunner4 and Daniel J Lovell5, 1Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Cincinnati Children's Hospital, Cincinnati, OH, 3Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 4Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5PRCSG, Cincinnati, OH

    Background/Purpose: We compare the effectiveness of two approaches to treat Juvenile idiopathic arthritis (JIA): early combination of biologic and non-biologic disease modifying anti rheumatic drugs…
  • Abstract Number: 2291 • 2017 ACR/ARHP Annual Meeting

    Three Treatment Strategies in Recent Onset DMARD Naive Juvenile Idiopathic Arthritis:  First Results of Clinical Outcome after 24 Months

    Petra Hissink Muller1,2, Danielle Brinkman1,3, Dieneke Schonenberg-Meinema4, Yvonne Koopman-Keemink5, Wytse van den Bosch6, Isabel Brederije1, Peter Bekkering7, Taco Kuijpers4, Marion van Rossum8, Lisette van Suijlekom-Smit2, J Merlijn van den Berg4, CF Allaart9 and Rebecca ten Cate1, 1Pediatric Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Pediatric Rheumatology, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands, 3Pediatrics, Alrijne Hospital, Leiderdorp, Netherlands, 4Department of Pediatric Hematology, Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital AMC, University of Amsterdam, Amsterdam, Netherlands, 5Department of Pediatrics, Hagaziekenhuis Juliana Children's Hospital, The Hague, Netherlands, 6Department of Pediatrics, Haaglanden Medical Center, The Hague, Netherlands, 7Department of Physiotherapy, Prinses Maxima Pediatric Oncology Center, Utrecht, Netherlands, 8Department of Pediatric Rheumatology, Amsterdam Rheumatology and Immunology Center location Reade Amsterdam, Amsterdam, Netherlands, 9Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The BeSt treatment strategy for children with juvenile idiopathic arthritis (JIA) has not been determined. The aim of the BeSt for Kids study was…
  • Abstract Number: 2292 • 2017 ACR/ARHP Annual Meeting

    Effectiveness of Common Treatment Strategies for Juvenile Arthritis in Usual Practice:  Results from the Research in Arthritis in Canadian Children Emphasizing Outcomes Cohort

    Amieleena Chhabra1, Adam Huber2,3, Natalie J. Shiff4, Gilles Boire5, Kiem Oen6 and Jaime Guzman1, 1BC Children's Hospital, Vancouver, BC, Canada, 2IWK Health Centre, Halifax, NS, Canada, 3Dalhousie University, Halifax, NS, Canada, 4University of Florida, Gainesville, FL, 5Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, 6Department of Pediatrics and Child Health University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: The efficacy of medications in randomized trials may differ substantially from their effectiveness (degree of beneficial effect under “real world” clinical settings). Reliable estimates…
  • Abstract Number: 2293 • 2017 ACR/ARHP Annual Meeting

    Can We Predict Achievement of Clinically Inactive Disease and Sustained Remission in Children with Juvenile Idiopathic Arthritis?

    Stephanie Shoop-Worrall1, Suzanne M Verstappen2, Janet E. McDonagh3, Wendy Thomson4 and Kimme L. Hyrich1, 1The University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, 2Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, 3Faculty of Medical and Human Sciences, Centre for MSK Research, Manchester, United Kingdom, 4Arthritis Research UK Centre for Genetics and Genomics,The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Identifying predictors for clinically inactive disease (CID) and sustained remission would allow rapid escalation of therapies for children less likely to achieve these states.…
  • Abstract Number: 2294 • 2017 ACR/ARHP Annual Meeting

    Utilizing the Pediatric Rheumatology Care and Outcomes Improvement Network to Assess Practice Pattern Variation in Juvenile Idiopathic Arthritis

    Emily A. Smitherman1, Janalee Taylor2, Esi M. Morgan1 and C. April Bingham3, 1Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Pediatrics, Penn State College of Medicine, Hershey, PA

    Background/Purpose: Despite modern treatment options for patients with juvenile idiopathic arthritis (JIA), rates of clinical inactive disease (CID) remain low. The Pediatric Rheumatology Care and…
  • Abstract Number: 2295 • 2017 ACR/ARHP Annual Meeting

    Methotrexate As First Line Therapy in Juvenile Idiopathic Arthritis-Associated Uveitis: Myth or Reality

    Jacopo Agnolucci1, Maria Elisabetta Zannin1, Giorgia Martini1, Alessandra Meneghel2 and Francesco Zulian2, 1Department of Woman and Child Health, University of Padua, Padua, Italy, 2University of Padua, Department of Woman and Child Health, Padua, Italy

    Background/Purpose: Methotrexate (MTX) is the most used immunomodulatory drug in Juvenile Idiopathic Arthritis-associated uveitis (JIA-U) although its efficacy has been shown only in retrospective studies…
  • Abstract Number: 2296 • 2017 ACR/ARHP Annual Meeting

    Infliximab Use in JIA and Uveitis: Does Methotrexate Help or Hinder?

    Ryan Funk1, Valentina Shakhnovich2, Leon van Haandel3 and Mara L Becker4, 1University of Kansas Medical Center, Kansas City, KS, 2Gastroenterology and Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, MO, 3Clinical Pharmacology, Medical Toxicology, and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, MO, 4Rheumatology, Children's Mercy Kansas City, Kansas City, MO

    Background/Purpose: Infliximab (IFX) effectiveness is impacted in part by immunogenicity and the development of drug neutralizing anti-drug antibodies, thus methotrexate is commonly co-administered to minimize…
  • Abstract Number: 2297 • 2017 ACR/ARHP Annual Meeting

    Golimumab Versus Tocilizumab in Uveitis Related to Refractory Juvenile Idiopathic Arthritis. National Multicenter Study of 33 Patients

    Lucia C. Domínguez-Casas1, Vanesa Calvo-Río1, Inmaculada Calvo2, Mª Isabel González-Fernández3, Berta Lopez Montesinos3, Marina Mesquida4, Alfredo Adan4, M. Victoria Hernández4, Olga Maiz-Alonso5, Ana Blanco6, Antonio Atanes7, Beatriz Bravo8, Consuelo Modesto9, Gisela Díaz-Cordovés10, Miguel Cordero-Coma11, David Diaz-Valle12, Carlos Fernández-Cid13, Juan Cruz14, Oscar Ruiz Moreno15, MC Gonzalez-Vela16, Rosalía Demetrio-Pablo17, Nuria Vegas-Revenga1, Carlos Fernández-Díaz1, Jose L. Hernández18, Miguel Angel González-Gay1 and Ricardo Blanco1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 2Pediatric Rheumatology, Rheumatology. Hospital Universitario La Fe. Valencia. Spain, Valencia, Spain, 3Rheumatology. Hospital Universitario La Fe. Valencia. Spain, Valencia, Spain, 4Hospital Clinic. Barcelona. Spain, Barcelona, Spain, 5Hospital Universitario Donostia. San Sebastian. Spain, Donostia, Spain, 6Ophtamology. Hospital Donostia. San Sebastian. Spain, San Sebastian, Spain, 7Rheumatology, Complejo Hospitalario Universitario A Coruña (CHUAC). Spain, A Coruna, Spain, 8Rheumatology. Hospital Universitario Virgen de las Nieves. Granada. Spain, Granada, Spain, 9Hospital Universitari Vall d'Hebron. Barcelona. Spain, Barcenola, Spain, 10Rheumatology, Hospital Regional Universitario de Málaga. Spain, Málaga, Spain, 11Ophthalmology, Hospital de León. Spain, León, Spain, 12Hospital Clínico San Carlos. Madrid. Spain, Madrid, Spain, 13Ophtalmology. Hospital de Pontevedra. Pontevedra. Spain, Pontevedra, Spain, 14Rheumatology. Hospital de Pontevedra. Pontevedra. Spain, Pontevedra, Spain, 15Ophthalmology and Rheumatology., Ophtalmology. Hospital Miguel Servet. Zaragoza. Spain, Zaragoza, Spain, 16Pathology Anatomy, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 17Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 18Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain

    Background/Purpose: Uveitis is a severe manifestation of Juvenil Idiopathic Arthritis (JIA). Systemic treatment is based on conventional immunosuppresants. Anti-TNFa are used in refractory cases, mainly…
  • Abstract Number: 2298 • 2017 ACR/ARHP Annual Meeting

    Etanercept, Adalimumab and Methotexate Utilization By Juvenile Idopathic Arthritis Patients and the Occurrence of Uveitis

    Katherine Roshak1, Joan M Sopczynski2, Ricardo Suehiro2 and Lisa Marshall1, 1Inflammation & Immunology Global Medical Affairs, Pfizer, Collegeville, PA, 2Pfizer, Collegeville, PA

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is a chronic arthritis with onset before 16 years of age, that persists for at least 6 weeks, and has…
  • Abstract Number: 2299 • 2017 ACR/ARHP Annual Meeting

    Clinical Features and Characteristics of Juvenile Idiopathic Arthritis-Associated Uveitis in Japan:the First Report from the Pediatric Rheumatology Association of Japan (PRAJ)

    Junko Yasumura1, Masato Yashiro2, Nami Okamoto3, Kosuke Shabana4, Hiroaki Umebayashi5, Naomi Iwata6, Tomohiro Kubota7, Mao Mizuta8, Kenichi Nishimura9, Yuka Okura10, Masaki Shimizu8, Minako Tomiita11, Syuji Takei7 and Masaaki Mori12, 1Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan, 2Department of Pediatrics, Okayama University Hospital, Okayama, Japan, 3Pediatrics, Graduate School of Medicine, Osaka Medical College, Takatsuki, Japan, 4Department of Pediatrics, Graduate School of Medicine, Osaka Medical College, Takatsuki, Japan, 5Department of Rheumatics, Miyagi Children’s Hospital, Sendai, Japan, 6Department of Immunology and Infectious Diseases, Aichi Children’s Health and Medical Center, Obu, Japan, 7Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan, 8Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan, 9Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 10Department of Pediatrics, KKR Sapporo Medical Center, Sapporo, Japan, 11Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Japan, 12Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

    Background/Purpose: Several reports examined ethnic differences of Juvenile Idiopathic Arthritis -associated uveitis (JIA-U), however, there were no information from Japan. Therefore, PRAJ underwent multi-center surveillance…
  • Abstract Number: 2300 • 2017 ACR/ARHP Annual Meeting

    Predictive Value of Magnetic Resonance Imaging in Patients with Juvenile Idiopathic Arthritis in Clinical Remission

    Clara Malattia1, Marta Mazzoni Sr.2, Stefania Viola Sr.2, Angela Pistorio3, Francesca Magnaguagno4, Alessia Urro Jr.2, Angelo Ravelli5 and Alberto Martini6, 1Pediatria2 Reumatologia, Istituto Giannina Gaslini, Genoa, Italy, 2Pediatria 2 Reumatologia, Istituto Giannina Gaslini, Genova, Italy, 3Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Genoa, Italy, 4UO Radiologia, Istituto Giannina Gaslini, Genoa, Italy, 5University of Genova, IRCCS Istituto Giannina Gaslini, Genova, Italy, 6Istituto Giannina Gaslini, Genoa, Italy

    Background/Purpose: MRI studies on RA revealed that subclinical synovitis is common in patients in clinical remission and it is responsible for structural damage progression. MRI-detected…
  • Abstract Number: 2301 • 2017 ACR/ARHP Annual Meeting

    Assessing the Utility and Impact of Musculoskeletal Ultrasound in a Large Pediatric Rheumatology Clinic

    Onengiya Harry1, Jennifer L. Huggins2, Janalee Taylor3, Michael J. Holland4 and Tracy Ting5, 1Cincinnati Childrens' Hospital Medical Center, Cincinnati, OH, 2Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5Rheumatology/MLC 4010, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Musculoskeletal ultrasound (MSUS) use in the care of pediatric rheumatology patients is increasing. Yet, despite the growing availability of MSUS, it remains unclear how…
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