Abstracts Archive - Page 1329 of 2607 - ACR Meeting Abstracts

Abstract Number: 2141 • 2018 ACR/ARHP Annual Meeting
Development of a Pediatric Glucocorticoid Toxicity Index
Paul Brogan¹, Raymond P. Naden², Stacy P. Ardoin³, Jennifer C. Cooper⁴, Fabrizio De Benedetti⁵, Jean-Francois Dicaire⁶, Despina Eleftheriou⁷, Brian M. Feldman⁸, Jon Goldin⁹, Seth E. Karol¹⁰, Eli Miloslavsky¹¹, Fiona Price-Kuehne¹², David Skuse⁹, Constantine A. Stratakis¹³, Nicholas Webb¹⁴ and John H. Stone¹⁵, ¹Infection Inflammation and Rheumatology, UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, ²New Zealand Ministry of Health, New Zealand Ministry of Health, Auckland, New Zealand, ³The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Pediatrics, Divison of Rheumatology, University of California, San Francisco, San Francisco, CA, ⁵IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, ⁶Pinnacle Inc., Quebec, QC, Canada, ⁷Infection, Inflammation and Rheumatology, UCL Institute of Child Health, London, United Kingdom, ⁸Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁹Psychiatry, Great Ormond Street Hospital / University College London, London, United Kingdom, ¹⁰Oncology, St. Jude's Children's Hospital, Memphis, TN, ¹¹Division of Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ¹²Rheumatology, Cambridge University Hospitals, Cambridge, United Kingdom, ¹³National Institute of Child Health and Human Development, Bethesta, MD, ¹⁴Pediatrics, Manchester University, Manchester, United Kingdom, ¹⁵Rheumatology (Medicine), Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: A Glucocorticoid Toxicity Index app (GTI 2.0) is now used as a clinical trial outcome measure in adults, but glucocorticoid (GC) toxicity issues in…
Abstract Number: 2142 • 2018 ACR/ARHP Annual Meeting
Exposure to Disease Modifying Antirheumatic Drugs during Pregnancy in Women with Inflammatory Arthritis and the Risk of Serious Maternal Infection: A Population-Based Cohort Study
Mary A. De Vera^1,2,3, Nicole W. Tsao^1,2,3, Eric C. Sayre² and Alyssa Howren^1,2,3, ¹Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³Collaboration for Outcomes Research and Evaluation (CORE), Vancouver, BC, Canada
Background/Purpose: Infection risk is one of the concerns regarding therapy with conventional disease modifying antirheumatic drugs (csDMARDs) and to our knowledge no research has examined…
Abstract Number: 2143 • 2018 ACR/ARHP Annual Meeting
Lymphoproliferative Malignancy in Psoriatic Arthritis and the Role of Systemic Immunosuppressive Therapies
Linh Truong¹ and Maida Wong², ¹Internal Medicine, University of California, Irvine, Orange, CA, ²Division of Rheumatology, University of California, Irvine, Orange, CA
Background/Purpose: Psoriatic arthritis (PsA) is a systemic inflammatory disease that can have musculoskeletal (PsA-MsK) or concurrent MsK and skin (PsA-MsK/skin) manifestations, and the skin disease…
Abstract Number: 2144 • 2018 ACR/ARHP Annual Meeting
Epidemiological Characterisitics of Psoriatric Arthritis: A Nationwide Study of Inpatient Hospitalisations in 2014
Vagishwari Murugesan and Jennifer Tran, Internal Medicine, Medstar Washington Hospital Center, Washington, DC
Background/Purpose:: Psoriatic arthritis is a seronegative inflammatory arthritis associated with Psoriasis. Using the National Inpatient Sample (NIS) we studied the epidemiological characteristics of inpatients admissions…
Abstract Number: 2145 • 2018 ACR/ARHP Annual Meeting
Increased Risk of Heart Failure with Prolonged Use of Hydroxychloroquine in Patients with Rheumatoid Arthritis
Elena Myasoedova¹, Reto Kurmann², Cynthia S. Crowson³, John M. Davis III¹ and Rekha Mankad², ¹Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ²Cardiovascular Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, ³Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN
Background/Purpose: Hydroxychloroquine (HCQ) is commonly prescribed for patients with rheumatoid arthritis (RA). Cardiotoxicity is a rare but potentially life-threatening side effect of HCQ and may…
Abstract Number: 2146 • 2018 ACR/ARHP Annual Meeting
A Meta-Analysis of the Prevalence and Risk Factors for Retinal Toxicity in Rheumatologic Patients on Hydroxychloroquine Therapy
Amanda Worme¹, Leonardo Tamariz², Ana Palacio², Zsuzsanna Nemeth³ and Mathew Farbman⁴, ¹Internal Medicine, University of Miami Miller School of Medicine at Holy Cross Hospital, Fort Lauderdale, FL, ²Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, ³Health Informatics, University of Miami Miller School of Medicine, Miami, FL, ⁴Rheumatology, University of Miami Miller School of Medicine at Holy Cross Hospital, Fort Lauderdale, FL
Background/Purpose: HCQ is one of the most common DMARD(s) used in treatment of several rheumatologic diseases, including RA and SLE. Although rare, retinal toxicity remains…
Abstract Number: 2147 • 2018 ACR/ARHP Annual Meeting
Associations between Current Cigarette Smoking and SLE-Related Cytokine and Chemokine Biomarkers Among U.S. Female Nurses without SLE
Cianna Leatherwood¹, Xinyi Liu¹, Susan Malspeis², Andrea Roberts³, Jeffrey A. Sparks¹, Elizabeth Karlson¹, Candace H. Feldman¹, Judith A. James⁴, Laura Kubzansky⁵ and Karen Costenbader¹, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Harvard T.H. Chan School of Public Health, Boston, MA, ⁴OMRF & OUHSC, Oklahoma City, OK, ⁵Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA
Background/Purpose: Current cigarette smoking and recent cessation (within 4 years), compared to no smoking or remote cessation, have been associated with increased anti-dsDNA+ SLE…
Abstract Number: 2148 • 2018 ACR/ARHP Annual Meeting
Prevalence and Incidence of FMF in Germany – Results of the First Retrospective Analysis of Representative Claims Data
Ivan Foeldvari¹, Katharina Boehm², Thomas Kramps² and Lukas Mayerhoff³, ¹Hamburg Centre for Pediatric Rheumatology, Hamburg, Germany, ²Novartis Pharma GmbH, Nuremberg, Germany, ³Elsevier GmbH, Munich, Germany
Background/Purpose: Familial Mediterranean fever (FMF) is a rare hereditary autoinflammatory disease that predominantly affects, but is not limited to, persons of Middle Eastern ancestry. In…
Abstract Number: 2149 • 2018 ACR/ARHP Annual Meeting
Assessing the Prevalence of Localized Scleroderma in Childhood Using Dministrative Claims Data from the United States
Timothy Beukelman¹, Fenglong Xie² and Ivan Foeldvari³, ¹Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³Hamburg Center for Pediatric and Adolescent Rheumatology, Hamburg, Germany
Background/Purpose: Juvenile Localised Scleroderma (jlSc) is believed a rare autoimmune disease, which occurs 10 times more often then systemic sclerosis in childhood and is believed…
Abstract Number: 2150 • 2018 ACR/ARHP Annual Meeting
Association of Poverty Income Ratio with Physical Functioning in a Cohort of Patients with Systemic Lupus Erythematosus
Courtney Hoge¹, C. Barrett Bowling², S. Sam Lim³, Cristina Drenkard⁴ and Laura Plantinga⁵, ¹Department of Epidemiology, Emory University, Atlanta, GA, ²Durham Veterans Affairs Medical Center, Durham, NC, ³Emory University School of Medicine, Atlanta, GA, ⁴Medicine/Rheumatology, Emory University, Atlanta, GA, ⁵Department of Medicine, Emory University School of Medicine, Atlanta, GA
Background/Purpose: Lower socioeconomic status (SES) has been shown to be associated with poor physical functioning in systemic lupus erythematosus (SLE) patients; however, previous studies have…
Abstract Number: 2151 • 2018 ACR/ARHP Annual Meeting
The Impact of Obesity on SLE Disease Activity
Phildrich Teh¹, Bishoy Zakhary², Arezoo Haghshenas³ and Vaneet K. Sandhu³, ¹Internal Medicine, University of California, Riverside, Riverside, CA, ²Office of Research, Riverside University Health System, Moreno Valley, CA, ³Division of Rheumatology, Loma Linda University, Loma Linda, CA
Background/Purpose: Obesity is associated with increased disease severity in multiple autoimmune conditions, likely via formation of pro-inflammatory adipokines [1]. However, the role of obesity in…
Abstract Number: 2152 • 2018 ACR/ARHP Annual Meeting
A Comparison of the American College of Rheumatology (ACR) and Systemic Lupus International Collaborating Clinics Classification (SLICC) Criteria to Detect Patients with Systemic Lupus Erythematosus (SLE) in Electronic Health Record (EHR) Data
Theresa L. Walunas¹, Anika S. Ghosh², Kathryn L. Jackson³, Ahn H. Chun², Daniel L. Erickson², Karen Mancera-Cuevas⁴, Abel N. Kho² and Rosalind Ramsey-Goldman⁵, ¹Department of Medicine, Division of General Internal Medicine and Geriatrics, Northwestern University, Chicago, IL, ²Northwestern University, Chicago, IL, ³Center for Health Information Partnerships, Northwestern University, Chicago, IL, ⁴Rheumatology, Northwestern University, Chicago, IL, ⁵FSM, Northwestern University, Chicago, IL
Background/Purpose: Systemic Lupus Erythematosus is a systemic autoimmune disease that has diverse manifestations that can occur over a long period of time. The complexity of…
Abstract Number: 2153 • 2018 ACR/ARHP Annual Meeting
The Effect of Socioeconomic Status on Treatment Outcomes in Lupus Nephritis: Private Versus Public Insurance
Arezoo Haghshenas¹, Phildrich Teh², Kristal Choi³, Abigail Benitez⁴, Lorena Salto³, Mathew Firek⁵, Karina Torralba⁶ and Vaneet K. Sandhu¹, ¹Division of Rheumatology, Loma Linda University, Loma Linda, CA, ²Internal Medicine, University of California, Riverside, Riverside, CA, ³Loma Linda University, Loma Linda, CA, ⁴Rheumatology, Loma Linda University, Loma Linda, CA, ⁵Riverside university health system, Moreno valley, CA, ⁶Loma Linda University Medical Center, Loma Linda, CA
Background/Purpose: Despite therapeutic advancements, lupus nephritis (LN) remains a major cause of mortality among patients with SLE. Loma Linda University Health serves a region in…
Abstract Number: 2154 • 2018 ACR/ARHP Annual Meeting
Biosimilar Infliximab Treated-Patients with Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis in France: Characteristics and Clinical Outcomes
Hubert Marotte¹, NADIR MAMMAR² and Bruno Fautrel³, ¹University Hospital of Saint Etienne,, Saint Etienne, France, ²Pfizer, PARIS, France, ³Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), UMR S 1136, Sorbonne Université, GRC-UPMC 08, Paris, France
Background/Purpose: CT-P13 was the first monoclonal antibody biosimilar to infliximab (IFX) approved in France. Reflect trial has been set up to evaluate in real life…
Abstract Number: 2155 • 2018 ACR/ARHP Annual Meeting
Diagnosis of Systemic Sclerosis in the United Kingdom: An Observational Study Using the Clinical Practice Research Datalink
Alicia Gayle¹, Nils Schoof², Margarida Alves², Deborah Clarke³, Chris Poole¹, Christina Raabe², Prithwiraj Das¹ and Toby Maher⁴, ¹Boehringer Ingelheim Ltd., Bracknell, United Kingdom, ²Boehringer Ingelheim International GmbH, Ingelheim, Germany, ³Department of Medical Affairs, Boehringer Ingelheim Ltd., Bracknell, United Kingdom, ⁴University College London and Royal Brompton Hospital, London, United Kingdom
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease that is characterised by fibroblast dysfunction and excess extracellular matrix deposition that leads to skin thickening and…

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