Abstracts Archive - Page 1325 of 2607 - ACR Meeting Abstracts

Abstract Number: 2081 • 2018 ACR/ARHP Annual Meeting
Dysregulated MiR-125a Promotes Joint Angiogenesis in Psoriatic Arthritis through Altered Bioenergetics
Sarah M. Wade¹, Nil Ohnesorge², Hayley Mc-Loughlin¹, Monika Biniecka¹, Trudy McGarry³, Breandán Kennedy⁴, Douglas J. Veale² and Ursula Fearon³, ¹Department of Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ²Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, ³Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ⁴Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin, Ireland
Background/Purpose: Psoriatic arthritis (PsA) is characterised by an early vascular phase essential for pannus growth, immune responses and disease progression. Recently, numerous studies have highlighted…
Abstract Number: 2082 • 2018 ACR/ARHP Annual Meeting
ERAP1 Deficiency Partially Relieves HLA-B27-Induced ER Stress and IL-23 Expression, but Does Not Restore Dendritic Cell Function in Experimental Spondyloarthritis
Tri Tran¹, Vance Holt², Tejpal Gill¹, Joshua R. Bennett², Joel Taurog³ and Robert Colbert⁴, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Dept Int Med-Rheum Dis Div, University of Texas Southwestern Medical Center, Dallas, TX, ⁴National Institute of Arthritis and Musculuskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Preliminary results suggest that endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) deficiency partially protects HLA-B27/human b2m transgenic (B27-Tg) rats from spondyloarthritis (SpA) as evidenced by…
Abstract Number: 2083 • 2018 ACR/ARHP Annual Meeting
Epistasis between HLA-B27 and ERAP1 Affects Gut Microbial Dysbiosis and Arthritis in Experimental Spondyloarthritis
Tejpal Gill¹, Tri Tran¹, Stephen R. Brooks² and Robert Colbert³, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Biodata Mining and Discovery Section, Office of Science and Technology, NIAMS/NIH, Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Common variants in endoplasmic reticulum (ER)-associated aminopeptidase-1 (ERAP1) affect susceptibility to spondyloarthritis (SpA) in HLA-B27-positive human subjects, with loss-of-function/expression conferring protection. Using HLA-B27/human b2-microglobulin…
Abstract Number: 2084 • 2018 ACR/ARHP Annual Meeting
Targeting the Voltage-Gated K+ Channels: T Cell Targeted Therapies for Spondyloarthritis
Siba P. Raychaudhuri¹, Smriti K. Raychaudhuri² and Heike Wulff³, ¹Rheumatology Section, Sacramento Veterans Affairs Medical Center, Sacramento, CA, ²Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA, ³Pharmacology, School of Medicine, University of California Davis, Davis, CA
Background/Purpose: TCR (T cell receptor) engagement triggers intracellular Ca++ influx through voltage-independent Ca2+ channels. This crucial Ca2+-influx is only possible by a counterbalancing K+ efflux…
Abstract Number: 2085 • 2018 ACR/ARHP Annual Meeting
Response Gene to Complement-32 Promotes Kidney Damage in Immune Complex –Mediated Glomerulonephritis
Anamaria Talpos-Caia^1,2, Vinh Nguyen^2,3, Alexandru Tatomir^3,4, Sun-sang Sung⁵, John Papadimitriou⁶, Sergei Atamas^2,3, Irina G. Luzina^2,3, Simona Rednic¹, Horea Rus^3,4 and Violeta Rus^2,3, ¹Rheumatology, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania, ²Medicine, Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD, ³Research Service, Veteran Affairs Medical Center, Baltimore, MD, ⁴Neurology, University of Maryland School of Medicine, Baltimore, MD, ⁵Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia School of Medicine, Charlottesville, VA, ⁶Pathology, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Response Gene to Complement (RGC)-32 is a cell cycle regulator widely expressed in normal tissues including brain, kidney, spleen, thymus, multiple tumors and in…
Abstract Number: 2086 • 2018 ACR/ARHP Annual Meeting
4-Phenylbutyric Acid Mediates Therapeutic Effect in Systemic Lupus Erythematosus: Observations in an Experimental Murine Lupus Model
Yunjung Choi¹, Ji-hyun Jung², Eun-Kyeong Lee², Myeung Su Lee³, Changhoon Lee⁴ and Wan-Hee Yoo⁵, ¹Division of Rheumatology, Department of Internal Medicine, Research Institute of Clinical Medicine of chonbuk national university-Biomedical Research Institute of chonbuk national university hospital, jeonju, Korea, Republic of (South), ²Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea, Republic of (South), ³Department of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South), ⁵Division of Rheumatology, Department of Internal Medicine, Research Institute of Clinical Medicine of chonbuk national university-Biomedical Research Institute of chonbuk national university hospital, Jeonju, Korea, Republic of (South)
Background/Purpose: The purpose of the present study was to investigate whether ER stress inhibition by 4-phenylbutyric acid (4-PBA) ameliorates lupus manifestations in an experimental lupus…
Abstract Number: 2087 • 2018 ACR/ARHP Annual Meeting
Kidney Tissue Damage in Mice with Single and Combined Abnormalities in Complement, Interferon and Apoptotic Cell Clearance
Sladjana Skopelja-Gardner¹, YuFeng Peng², Payton Hermanson², Lucrezia Colonna², Xizhang Sun³, Lena Tanaka⁴, Anne Davidson⁵, David Salant⁶ and Keith B. Elkon⁷, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ²Division of Rheumatology, University of Washington, Seattle, WA, ³Rheumatology, University of Washington, Seattle, WA, ⁴Medicine/Rheumatology, University of Washington, Seattle, WA, ⁵Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ⁶Boston University, Boston, MA, ⁷University of Washington, Seattle, WA
Background/Purpose: Lupus nephritis (LN) affects ~70% of systemic lupus erythematosus (SLE) patients and is one of the main contributors to morbidity and mortality. While defective…
Abstract Number: 2088 • 2018 ACR/ARHP Annual Meeting
Human TLR8 at the Interface between Innate and Adaptive Immunity in Systemic Lupus Erythematosus
Naomi I. Maria¹, Megan Woods², Shani Martinez¹, Chirag Raparia², Weiqing Huang² and Anne Davidson², ¹Center for Autoimmunnity, Musculoskeletal & Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ²Center for Autoimmunity, Musculoskeletal & Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Infiltrating macrophages are one of the hallmarks of renal inflammation and kidney damage in lupus nephritis (LN). Surprisingly overexpression of TLR8, but not other…
Abstract Number: 2089 • 2018 ACR/ARHP Annual Meeting
The Differential Impact of the Abrogation of the Costimulatory Molecule CD137 Ligand on Renal and Cerebral Manifestations in C57BL/6.Faslpr-/- mice
Anselm Mak¹, Bhushan Dharmadhikari², Lik Wei Wong², Saji Kumar Sreedharan² and Herbert Schwarz², ¹Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, ²Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Background/Purpose: Costimulatory molecules which mediate cross-talks between leukocytes, have been identified to play a pathogenetic pivotal role in systemic lupus erythematosus (SLE). Abrogation of the…
Abstract Number: 2090 • 2018 ACR/ARHP Annual Meeting
Identification of a Role for Monocytes in Murine Lupus Associated Diffuse Alveolar Hemorrhage By Mass Cytometry
Nathan Nelson-Maney¹, Pui Lee², Anais Levescot³, Yuelong Huang⁴ and Peter Nigrovic⁵, ¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ²Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, boston, MA, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a life-threatening pulmonary complication of systemic lupus erythematosus. The inciting pathology is thought to be pulmonary capillaritis but the…
Abstract Number: 2091 • 2018 ACR/ARHP Annual Meeting
Mucosal-Associated Invariant T (MAIT) Cells As a Potential Therapeutic Target for Systemic Lupus Erythematosus
Goh Murayama¹, Asako Chiba², Atsushi Nomura³, Hirofumi Amano¹, Ken Yamaji¹, Naoto Tamura¹ and Sachiko Miyake^4,5, ¹Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Juntendo Univ Sch of Med, Juntendo University School of Medicine, Tokyo, Japan, ³JUNTENDO UNIVERSITY SCHOOL OF MEDICINE, Tokyo, Japan, ⁴Division of Immunology/NCNP, Natl Institute of Neuroscience, Kodaira Tokyo, Japan, ⁵Immunology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate T cells that are restricted by the nonpolymorphic MHC-related molecule-1 (MR1) and express a semi-invariant TCRα chain:…
Abstract Number: 2092 • 2018 ACR/ARHP Annual Meeting
Glucocorticoid-Induced Leucine Zipper (GILZ) Is a Novel Checkpoint Regulator of Type I Interferon (IFN) Production in SLE
Champa Nataraja¹, Eric Morand¹, Jacinta Lee¹, Taylah Bennett¹, Jacqueline Flynn¹, James Harris¹ and Sarah Jones², ¹Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia, ²School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia
Background/Purpose: Glucocorticoids (GC) remain the frontline treatment in Systemic Lupus Erythematosus (SLE) despite their predictable metabolic adverse effects. Type I interferons (IFN), produced by TLR7…
Abstract Number: 2093 • 2018 ACR/ARHP Annual Meeting
Glucocorticoid-Induced Leucine Zipper (GILZ) Deficiency Worsens Autoimmunity in the Lyn-Deficient Murine Model of Lupus By Disinhibiting the Type I Interferon (IFN) Pathway
Champa Nataraja¹, Eric Morand¹, Jacinta Lee¹, Taylah Bennett¹, Jacqueline Flynn¹, James Harris¹ and Sarah Jones², ¹Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia, ²School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease associated with B cell hyperactivity driven by dysregulated type I IFN. Lyn-deficient mice develop lupus-like…
Abstract Number: 2094 • 2018 ACR/ARHP Annual Meeting
Examining T Cell Exhaustion in Murine Systemic Lupus Erythematosus
Jeremy Tilstra¹, Lyndsay Avery², Ashley Menk², Rachael Gordon², Shuchi Smita³, Lawrence Kane³, Maria Chikina², Greg Delgoffe³ and Mark Shlomchik⁴, ¹Rheumatology, Univ of Pittsburgh Medical Center, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Department of Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: While T cells are important for the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis, little is known about how T cells function…
Abstract Number: 2095 • 2018 ACR/ARHP Annual Meeting
Neutralizing CXCL13 Attenuates Neuropsychiatric Disease in Lupus-Prone Mice
Michelle Huang¹, Ariel Stock² and Chaim Putterman³, ¹Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, ²Albert Einstein College of Medicine, Bronx, NY, ³Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Despite the many lupus patients affected by neuropsychiatric signs and symptoms, the pathogenesis of neuropsychiatric disease in SLE remains unclear. MRL-lpr/lpr mice, a classic…

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