Abstract Number: 1990 • 2018 ACR/ARHP Annual Meeting
Luteolin Modulates Glyco-Lipo-Oxidative Protein Modifications and Inhibits Inflammatory Cytokine Release in Human Osteoarthritic Articular Chondrocytes: Comparison with Colchicine
Background/Purpose: The progressive destruction of osteoarthritic articular cartilage has been attributed to multifactorial cellular events, including increased oxidative modifications in proteins, abnormal inflammatory and catabolic…Abstract Number: 1991 • 2018 ACR/ARHP Annual Meeting
Measuring Balance in an Experimental Mouse Model of Osteoarthritis
Background/Purpose: Destabilization of the medial meniscus (DMM) in mice results in experimental osteoarthritis, characterized by progressive joint damage (severe damage by week 12) and associated…Abstract Number: 1992 • 2018 ACR/ARHP Annual Meeting
The Effect of 4E-BP1 on Osteoarthritis-Related Gene Expression in TGF-β1-Stimulated Chondrocytes
Background/Purpose: Initiation of protein synthesis is regulated by a repressor of cap-dependent translation, eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), which prevents eukaryotic initiation factor…Abstract Number: 1993 • 2018 ACR/ARHP Annual Meeting
Evaluation of Cartilage Degeneration and Osteoarthritis Pain on Female and Male Mouse Model of Osteoarthritis
Background/Purpose: The prevalence of radiographic and symptomatic osteoarthritis (OA) is higher in women, but in animal study, male mice were more frequently used to explore…Abstract Number: 1994 • 2018 ACR/ARHP Annual Meeting
Osteoarthritis Severity Is Reduced By Intra-Articular Administration of Hydrogen Sulfide
Background/Purpose: Hydrogen sulphide (H2S) is recognized as a therapeutic target in osteoarthritis (OA). Exogenous supplementation with synthetic salts in in vitro models of OA has…Abstract Number: 1995 • 2018 ACR/ARHP Annual Meeting
Heparan Sulfates from Human Osteoarthritic Cartilage Display Increased Sulfation Pattern, Decrease the Protein Binding Capacity to FGF-2 and Increase the Binding to VEGF and Induce Changes of Human Mesenchymal Stem Cell Behavior
Background/Purpose: The major Glycosaminoglycan (GAGs) component of the cartilage ECM are Chondroitin Sulfates (CS) and Keratan sulfates (KS). Heparan Sulfates (HS) are also present in…Abstract Number: 1996 • 2018 ACR/ARHP Annual Meeting
Adenosine A2A Receptor (A2AR) Stimulation Enhances Mitochondrial Metabolism and Mitigates Reactive Oxygen Species-Mediated Mitochondrial Injury
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 10% of the US population. With age and injury, chondrocytes have diminished mitochondrial…Abstract Number: 1997 • 2018 ACR/ARHP Annual Meeting
Adenosine A2A Receptors Maintain Chondrocyte and Cartilage Homeostasis By Maintaining Expression of Anti-Inflammatory Regulators (Nur-77) and Suppressing Expression of Pro-Inflammatory Mediators
Background/Purpose: We have recently reported that adenosine A2A receptor (A2AR) knockout mice develop spontaneous osteoarthritis (OA) and intra-articular injection of adenosine prevents OA progression in…Abstract Number: 1998 • 2018 ACR/ARHP Annual Meeting
Autophagy-Related Molecules Detected in Blood and Cartilage Are Biomarkers of Joint Damage in OA
Background/Purpose: In osteoarthritis (OA), defects in cellular homeostasis, and in particular in autophagy, are evident and precede joint damage. We have shown that there is…Abstract Number: 1999 • 2018 ACR/ARHP Annual Meeting
Aberrant Expression of the GluN2B N-Methyl D-Aspartate Receptor Subunit in Osteoarthritic Chondrocytes Causes Disease-Associated Changes in Chondrocyte Phenotype through Altered Expression of Core Components of the Chondrocyte Circadian Clock
Background/Purpose: Circadian clocks are key regulators of cell behaviour. Disruption to cell clocks is implicated in a range of diseases. Expression of two core clock…Abstract Number: 2000 • 2018 ACR/ARHP Annual Meeting
Interleukin-1β, Oxidative Stress and Basic Calcium Phosphate Crystals Induce Osteoarthritis-like Changes in Chondrocyte Phenotype By Altering the Expression of PERIOD2, a Core Component of the Chondrocyte Circadian Clock
Background/Purpose: Almost all cells contain a circadian clock. Cell clocks are key regulators of cell activity and cell differentiation. In osteoarthritis (OA), chondrocytes inappropriately undergo…Abstract Number: 2001 • 2018 ACR/ARHP Annual Meeting
Adenosine A2A Receptor Stimulation Regulates Autophagy in Chondrocytes
Background/Purpose: Osteoarthritis (OA) is a debilitating condition characterized by chondrocyte dysfunction and loss of cartilage. Autophagy, a homeostatic process that occurs in times of cellular…Abstract Number: 2002 • 2018 ACR/ARHP Annual Meeting
Dynamic Compression of Articular Cartilage Explants Increases Formation and Decreases Degradation of Type II Collagen
Background/Purpose: Mechanical loading is recognized as a major factor in initiation and progression of osteoarthritis (OA). Conversely loading is believed to play an essential role…Abstract Number: 2003 • 2018 ACR/ARHP Annual Meeting
Chondrocyte Size in Articular Cartilage As a Marker of Osteoarthritis Severity
Background/Purpose: Terminal differentiating growth plate chondrocytes are mainly characterized by an increase of their cell size and by the expression of hypertrophic markers such as…Abstract Number: 2004 • 2018 ACR/ARHP Annual Meeting
Effective Inhibition of Metalloproteases By a Viscosupplement Based on a Hyaluronic Acid Amide (HYADD®4)
Background/Purpose: Osteoarthritis (OA) is a disease which results in the degeneration of articular cartilage. The progression of OA involves inflammation in the early stage of…
ACR Meeting Abstracts