ACR Meeting Abstracts

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  • Abstract Number: 1642 • 2017 ACR/ARHP Annual Meeting

    Role of Plaque in Predicting Cardiovascular Events in Women with Lupus over a 20 Year Followup

    Erika Joyce1, Linda Santelices2, Jennifer Mall2, Kristy Huysman2, Amy Xiaoqin Tang3, Michael Anderson2, Jennifer Elliott4, Amy H. Kao5,6 and Susan Manzi2, 1Internal Medicine, Allegheny Health Network, Pittsburgh, PA, 2Medicine, Allegheny Health Network, Pittsburgh, PA, 3Lupus Center of Excellence, Allegheny Health Network Research Institute, Pittsburgh, PA, 4Allegheny Health Network, Pittsburgh, PA, 5EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 6EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA), Billerica, MA

    Background/Purpose: The increased risk of premature cardiovascular disease (CVD) in systemic lupus erythematosus (SLE) patients has been well reported. Multiple series have demonstrated a higher…
  • Abstract Number: 1643 • 2017 ACR/ARHP Annual Meeting

    15 Year Comparative Analysis of Cardiovascular Events in Female Subjects with Lupus Versus Controls

    Erika Joyce1, Kristy Huysman2, Linda Santelices2, Michael Anderson2, Amy H. Kao3, Jennifer Elliott4, Jennifer Mall2, Amy Xiaoqin Tang5 and Susan Manzi2, 1Internal Medicine, Allegheny Health Network, Pittsburgh, PA, 2Medicine, Allegheny Health Network, Pittsburgh, PA, 3EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 4Allegheny Health Network, Pittsburgh, PA, 5Lupus Center of Excellence, Allegheny Health Network Research Institute, Pittsburgh, PA

    Background/Purpose: The multi-organ sequelae of systemic lupus erythematosus (SLE) may include nephritis, alveolar hemorrhage, and cardiovascular disease. Our long term follow up of female SLE…
  • Abstract Number: 1644 • 2017 ACR/ARHP Annual Meeting

    Less Than Seven Hours of Sleep per Night Is Associated with Transitioning to Systemic Lupus Erythematosus

    Kendra A. Young1, Melissa E. Munroe2, Joel M. Guthridge3, Diane L. Kamen4, Gary S. Gilkeson5, Michael Weisman6, David Karp7, John B. Harley8, Daniel J. Wallace6, Judith A. James9 and Jill M. Norris10, 1Epidemiology, University of Colorado Denver, Aurora, CO, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, OKC, OK, 4Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 5Department of Medicine, Medical University of South Carolina, Charleston, SC, 6Cedars-Sinai Medical Center Division of Rheumatology, Los Angeles, CA, 7Rheumatology, UT Southwestern Med Ctr, Dallas, TX, 8Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 9Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 10Department of Epidemiology, Colorado School of Public Health, Aurora, CO

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a relatively unknown etiology. The quality and quantity of sleep has been shown to…
  • Abstract Number: 1645 • 2017 ACR/ARHP Annual Meeting

    Tobacco Exposure and Relationship with Severe Damage in Systemic Lupus Erythematosus Patients

    Micaela Ana Cosatti1, Sebastian Muñoz2, Natalia Tamborenea3, Mercedes Argentina García4, Ana Curti5, Ana Maria Capuccio6, Oscar Rillo7, Patricia Imamura8,9,10, Emilce Schneeberger11, Fernando Dal Pra12, Marcela Ballent13, Mario Luis Cousseau14, Jorge Velasco Zamora15, Veronica Saurit16, Sergio M.A. Toloza17,18, Maria Danielsen19, Veronica Bellomio20, Cesar Graf21, Sergio Paira22, Javier Cavallasca23, Bernado Pons-Estel24, Jose Moreno25, Monica Patricia Diaz26, Paula Alba27, Marcela Verando28, Guillermo Tate3, Eduardo Mysler29, Judith Sarano30, Emma Civit31, Fabian Risueño32, Pablo Alvarez Sepúlveda33, Maria Silvia Larroude6, Marcos Mendez34, Andrea Conforti35, Debora Sohn36, Danith Medina Bornachera37, Samanta Malm- Green38, Analia Alvarez39, Claudia Andrea Helling40, Susana Roverano41, Gisela Pendón42, M. Mayer43, Josefina Marin44, Cecilia Catoggio45, Alicia Eimon46 and Cecilia N. Pisoni47, 1Section Rheumatology and Immunology, CEMIC, CABA, Argentina, 2Rheumatology Unit, Hospital “Dr. Juan A. Fernández”, CABA, Argentina, 3OMI, Buenos Aires, Argentina, 4Rheumatology Unit, HIGA San Martín La Plata, La Plata, Argentina, 5rheumatology, Hospital de Clínicas José de San Martin, CABA, Argentina, 6Hospital Cesar Milstein, CABA, Argentina, 7Hospital Pirovano, CABA, Argentina, 8IMAI, Caba, Argentina, 9Rheumatology, Hosp Italiano de Buenos Aires, Buenos Aires, Argentina, 10Internal Medicine, Rheumatology Section, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 11Rheumatology Section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 12Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Buenos Aires, Argentina, 13Hospital RamónSantamarina, Tandil, Argentina, 14Policlínica Privada Paz, Tandil, Argentina, 15Instituto Médico CER, Quilmes, Argentina, 16Rheumatology, Hospital Privado Córdoba, Cordoba, Argentina, 17Medicine, Hospital San Juan Bautista, Catamarca, Argentina, 18Hospital San Juan Bautista, Ciudad de San Fernando del Valle de Catamarca, Argentina, 19Rheumatology, Hospital Regional, Santiago del Estero, Argentina, 20Hospital Ángel Cruz Padilla, Tucuman, Argentina, 21Centro Médico Mitre, Paraná, Argentina, 22Reumatologia, Hospital J M Cullen, Santa Fe, Argentina, 23Hospital José Bernardo Iturraspe, San Francisco, Argentina, 24GLADEL, Rosario, Santa Fe, Argentina, 25Instituto Médico CER, San Juan, Argentina, 26Centro Traumatológico Bariloche, Bariloche, Argentina, 27Universidad Nacional de Cordoba, Rheumatology Unit Cordoba and Materno Neonatal Hospital, Córdoba, Argentina, 28Hospital General de Agudos Bernardino Rivadavia, CABA, Argentina, 29Organización Médica de Investigación, Buenos Aires, Argentina, 30Rheumatology Unit, Instituto de Investigaciones Medicas Alfredo Lanari, Buenos Aires, Argentina, 31Hospital del Carmen, Godoy Cruz, Argentina, 32ITEMedica, Bahia Blanca, Argentina, 33Hospital Central de San Isidro, Buenos Aires, Argentina, 34Consultorios Pilar, Madryn, Argentina, 35OSEP Mendoza, Mendoza, Argentina, 3631Consultorio privado de reumatología, Buenos Aires, Argentina, 37Hospital Penna, CABA, Argentina, 38Hospital Bernardino Rivadavia, CABA, Argentina, 39Hospital Penna, Bahía Blanca, Argentina, 40URUGUAY 725, Omi, CABA, Argentina, 41Hospital José Maria Cullen, Santa Fe, Argentina, 42Hospital Ricardo Gutierrez, La Plata, Argentina, 43Hospital Británico, Buenos Aires, Argentina, 44Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 45Rheumatology and Immunology, Rheumatology and Immunology, CEMIC, Buenos Aires, Argentina, 46CEMIC, Buenos Aires, Argentina, 47Internal Medicine, CEMIC, Rheumatology and Immunology, CEMIC, Buenos Aires, Argentina

    Background/Purpose: to assess relationship between smoking exposure and organ damage accrual measured by Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for Systemic…
  • Abstract Number: 1646 • 2017 ACR/ARHP Annual Meeting

    Cardiovascular disease in Systemic Lupus Erythematosus. The road to hell is paved with good intentions

    Sophie Mavrogeni1 and Loukia Koutsogeorgopoulou2, 1CMR Department, Onassis Cardiac Surgery Center, Athens, Greece, 2Department of Pathophysiology, Rheumatology Unit, National Kapodistrian University of Athens, Athens, Greece

    Background/Purpose: Accurate diagnosis of cardiovascular involvement in systemic lupus erythematosus (SLE) remains challenging, because echocardiography (echo), the cornerstone tool used, has serious limitations. We hypothesized…
  • Abstract Number: 1647 • 2017 ACR/ARHP Annual Meeting

    A Lupus Low Disease Activity State Is Associated with Reduced Flare, Lower Organ Damage Accrual, and Better Quality of Life in Patients with Systemic Lupus Erythematosus

    Ji-Hyoun Kang1, Kyung-Eun Lee2, Dong-Jin Park1 and Shin-Seok Lee1, 1Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South), 2Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South)

    Background/Purpose: To identify the potential predictors of a lupus low disease activity state (LLDAS), and the relationship between LLDAS and disease flare, organ damage, and…
  • Abstract Number: 1648 • 2017 ACR/ARHP Annual Meeting

    Assessment of Outcome in Lupus Nephritis Patients: A Retrospective Analysis of a Single Center Cohort over 20 Years

    Lihi Shemesh Eisen1, Talia Weinstein2, Irena Litinsky3, David Levartovsky1, Ilana Kaufman1, Marina Anouk4, Valerie Aloush4, Jonathan Wollman5, Jacob N. Ablin6, Uri Arad1, Mark Berman1, Victoria Furer1, Ari Polachek7, Ofir Elalouf8, Sara Borok Lev-Ran1, Reut Zemach9, Tali Eviatar1, Michael Zisapel1, Hagit Sarvagyl-Maman10, Dan Caspi11, Ori Elkayam4 and Daphna Paran4, 1Rheumatology, Tel-Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 2Nephrology, Tel-Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 3Rheumatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 4Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 5Rheumatology, Tel-Aviv Sourasky Medical Center and the Sackler Faculty of Medicine ,Tel-Aviv University, Tel-Aviv, Israel, 6Internal Medicine H, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 7Rheumatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv Univrsity, Tel Aviv, Israel, 8Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 9Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 10Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel-aviv, Israel, 11Rheumatology, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel

    Background/Purpose: Lupus Nephritis (LN) is a severe SLE manifestation, leading to a six-fold increased risk of death. This study aims to assess the outcome of…
  • Abstract Number: 1649 • 2017 ACR/ARHP Annual Meeting

    Sleep Disturbances in Systemic Lupus Erythematosus (SLE)

    Patricia P. Katz1, Sofia Pedro2 and Kaleb Michaud3, 1Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 2National Data Bank for Rheumatic Diseases, Wichita, KS, 3University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Sleep disturbances (SD) are reported to be common in SLE, but relatively few studies have addressed the issue. We examined the frequency and severity…
  • Abstract Number: 1650 • 2017 ACR/ARHP Annual Meeting

    The Montreal Cognitive Assessment Questionnaire (MoCA): A Promising Screening Tool for Cognitive Dysfunction in SLE

    Nathalie Chalhoub and Michael Luggen, Division of Immunology, Allergy, and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH

    Background/Purpose: Cognitive dysfunction (CD) is among the most common neuropsychiatric manifestations in SLE. However, the diagnosis is oftentimes delayed and occasionally overlooked because of the…
  • Abstract Number: 1651 • 2017 ACR/ARHP Annual Meeting

    Screening in Patients at High Risk of Hydroxychloroquine Retinal Toxicity

    Anna Viola Taulaigo1, Maria Francisca Moraes-Fontes1, Eunice Patarata2, Sara Guerreiro Castro2 and Arnaldo Dias-Santos3, 1Unidade de Doenças Auto-imunes, Hospital Curry Cabral, Centro Hospitalar de Lisboa Central, Lisbon, Portugal, 2Unidade de Doenças Auto-imunes, Hospital Curry Cabral, Centro Hospitalar de Lisboa Central (CHLC), Lisbon, Portugal, Lisbon, Portugal, 3Serviço de Oftalmologia, Hospital de Santo António dos Capuchos, CHLC, Lisbon, Portugal, Lisbon, Portugal

    Background/Purpose: Despite effectiveness and favourable safety profile, antimalarials have the potential to cause irreversible macular retinopathy and vision loss. Screening methods still vary among clinicians…
  • Abstract Number: 1652 • 2017 ACR/ARHP Annual Meeting

    Trajectories of Quality of Life in an Iception Cohort of Lupus Patients and Their Determinants

    William Fung1, Lily Lim2, Jiandong Su3 and Zahi Touma4, 1Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Hospital for Sick Children, Toronto, ON, Canada, 3University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 4Rheumatology, University of Toronto, Division of Rheumatology, Institute of Health Policy, Management and Evaluation, Toronto, ON, Canada

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic disease with varying disease activity levels and morbidities over time; this can affect patients’ health related quality…
  • Abstract Number: 1653 • 2017 ACR/ARHP Annual Meeting

    Factors Influencing on Health-Related Quality of Life in Female Systemic Lupus Erythematosus Patients with Fibromyalgia

    Kyung Min Ko1, Jun-Ki Min2 and Su-Jin Moon3, 1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 2Bucheon St. Mary's Hospital, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Bucheon, Korea, Republic of (South), 3Bucheon St. Mary's Hospital, Division of rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Bucheon, Korea, Republic of (South)

    Background/Purpose: Health-related quality of life (HRQoL) among systemic lupus erythematosus (SLE) patients is reduced, and fibromyalgia contribute to the decreased HRQoL. The objective of the…
  • Abstract Number: 1654 • 2017 ACR/ARHP Annual Meeting

    Predictive Factors According to Type of Infection in Systemic Lupus Erythematosus Patients: Data from a Multi-Ethnic, Multi-National, Latin-American Cohort

    Victor R. Pimentel-Quiroz1, Manuel Ugarte-Gil1, Guillermo J. Pons-Estel2, Daniel Wojdyla3, Mario Cardiel4, Virginia Pascual-Ramos5, Ignacio Garcia-De La Torre6, Leonor Barile7, Mary Carmen Amigo8, Luis H. Silveira9, Maria Josefina Sauza del Pozo10, Marlene Guibert-Toledano11, Gil A. Reyes12, Antonio Iglesias-Gamarra13, Gloria Vasquez14, José Fernando Molina15, Jose A Gómez-Puerta16, Luis Alonso Gonzalez17, Rosa Chacón-Díaz18, Maria H Esteva Spinetti19, Isaac Abadi19, Eduardo M. Acevedo-Vásquez20, Jose Alfaro-Lozano21, Ines Segami22, Loreto Massardo23, Oscar Neira23, Emilia Sato24, Eloisa Bonfa25, Eduardo Borba26, Graciela S. Alarcón27 and Bernardo Pons-Estel28, 1Peru, GLADEL, Lima, Peru, 2GLADEL, Rosario, Argentina, 3GLADEL consultant, Rosario, Argentina, 4Centro de Investigación Clínica de Morelia SC, Morelia, Mexico, 5Instituto Nacional de Ciencias Médicas y Nutrició, Mexico City, Mexico, 6Immunology & Rheumatology, Centro de Est. de Invest. Bas. y Clin., S.C., Guadalajara, JAL, Mexico, 7GLADEL, Mexico, Mexico, 8Centro Medico ABC, Mexico, Mexico, 9Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City DF, Mexico, 10Servicio de Reumatología, Instituto Mexicano de Seguro Social, Hospital de Especialidades Nº 25, Monterrey, Mexico, 11Centro de Investigaciones Médico Quirúrgicas, Habana, Centro de Investigaciones Médico Quirúrgicas, Habana, La Habana, Cuba, 12GLADEL, Havana, Cuba, 13Clinical Development, Nordic Bioscience, Herlev, Denmark, 14GLADEL, Colombia, Antioquia, Colombia, 15GLADEL, Colombia, Antoquia, Colombia, 16Grupo de Reumatología, Universidad de Antioquia, Medellín, Colombia, 17Medicarte IPS, Medellín, Colombia, 18Servicio de Reumatología, Hospital Universitario de Caracas, Centro Nacional de Enfermedades Reumáticas, Caracas, Venezuela, 19GLADEL, Caracas, Venezuela (Bolivarian Republic of), 20Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru, 21Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, 22GLADEL, Peru, Lima, Peru, 23GLADEL, Santiago, Chile, 24Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 25Rheumatology Divison, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 26Faculdade de Medicina, Hospital das Clínicas. Universidade de São Paulo, São Paulo, Brazil, 27University of Alabama at Birmingham, Birmingham, AL, 28GLADEL, Rosario, Santa Fe, Argentina

    Background/Purpose: While infections are a one of the main causes of mortality in systemic lupus erythematosus (SLE), the type of infections and the factors predisposing…
  • Abstract Number: 1655 • 2017 ACR/ARHP Annual Meeting

    Interferon b Blockade Rescues Human BM-MSC Osteoblastogenesis Defects in Systemic Lupus Erythematosus

    Lin Gao1, Jennifer H. Anolik2 and R. John Looney3, 1medicine- allergy, immunology and rheumatology, University of Rochester Medical Center, Rochester, NY, 2Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 3University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Bone marrow mesenchymal stromal cells (BM-MSCs) are multipotent stem cells that can differentiate into chondrocytes, osteoblasts and adipocytes. SLE has been implicated as a…
  • Abstract Number: 1656 • 2017 ACR/ARHP Annual Meeting

    Type I Interferon Drives the Dysregulation of Plasmacytoid and Myeloid Dendritic Cells in Systemic Lupus Erythematosus and Antiphospholipid Syndrome

    Lucas L. van den Hoogen1, Aridaman Pandit1, Giovanni Palla2, Marzia Rossato3, Ruth D.E. Fritsch-Stork4, Joel A.G. van Roon5 and Timothy R.D.J. Radstake1, 1Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Rheumatology and Clinical Immunology, Laboratory of Translational Medicine, University Medical Center Utrecht, Utrecht, Netherlands, 3Department of Rheumatology & Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Dendritic cells (DC) are the sentinel cells of the immune system that potently activate T-cells, making them important players in the pathophysiology of systemic…
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