Abstract Number: 1582 • 2017 ACR/ARHP Annual Meeting
RORγt Inhibition Selectively Targets Pathogenic Subsets of Human iNKT and γδ-T Cells Enriched in Spondyloarthritis While Preserving Tissue Protective IL-22 Responses
Background/Purpose: Dysregulated IL-23/IL-17 responses have been linked to a myriad of inflammatory diseases including psoriasis, psoriatic arthritis and other forms of spondyloarthritides (SpA). IL-23/IL-17 inflammation…Abstract Number: 1583 • 2017 ACR/ARHP Annual Meeting
Increase in Arginase Activity and Related Arginine Metabolites in Patients with Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA): Potential Mechanisms for Endothelial Dysfunction
Background/Purpose: A high prevalence of CVD exists among patients with PsA and RA. The cardiovascular morbidity and mortality are hypothesized to be due in part…Abstract Number: 1584 • 2017 ACR/ARHP Annual Meeting
Chlamydia-Infected Macrophages: “Trojan Horses” for Dissemination of IL-23 and TNF-Mediated Inflammation in SKG Mouse Reactive Arthritis
Background/Purpose: The sterile inflammatory arthritis associated with spondylitis, uveitis and rash, known as reactive arthritis, commences a few weeks after certain gastrointestinal or genitourinary infections,…Abstract Number: 1585 • 2017 ACR/ARHP Annual Meeting
Role of Corticosteroids in Subclinical Atherosclerosis in SLE: A Systematic Review and Meta-Analysis
Background/Purpose: Atherosclerosis in SLE results from a complex interplay between traditional risk factors, SLE-specific factors, chronic inflammation and multifaceted effects of SLE therapeutics. In particular,…Abstract Number: 1586 • 2017 ACR/ARHP Annual Meeting
Resistant Hypertension Is Associated with Inflammation, Renal Function, and Increased Mortality in Patients with Systemic Lupus Erythematosus
Background/Purpose: Resistant hypertension (RHTN) is defined as blood pressure that remains >140/90 mm Hg despite concurrent use of three different antihypertensive drugs. RHTN has an…Abstract Number: 1587 • 2017 ACR/ARHP Annual Meeting
Mycobacterial Infection in Systemic Lupus Erythematosus: Clinical Significance and Associated Factors. Data from the Registry of Patients with SLE of the Spanish Society of Rheumatology (RELESSER)
Background/Purpose: The aim of this work is to study the prevalence of mycobacterial infection (M.I.), the associated factors and their clinical significance in patients included…Abstract Number: 1588 • 2017 ACR/ARHP Annual Meeting
“Neoplasia in Patients with Systemic LUPUS Erythematosus in Spain: Relesser Registry DATA”
Background/Purpose: There is limited evidence on the risk of neoplasia in autoimmune diseases such as systemic lupus erythematosus. The objective of this study is to…Abstract Number: 1589 • 2017 ACR/ARHP Annual Meeting
A Multicriteria Decision Analysis for the Development of New Systemic Lupus Erythematosus Classification Criteria
Background/Purpose: EULAR and ACR are supporting multi-phase development of SLE classification criteria based on weighted criteria and a continuous probability scale. Prior steps included criteria…Abstract Number: 1590 • 2017 ACR/ARHP Annual Meeting
Prolonged Antimalarial Treatment Increases the Risk for Severe Brady-Arrhythmias in Systemic Lupus Erythematosus
Background/Purpose: Severe brady-arrhythmias [complete atrioventricular block (cAVB) and sick sinus syndrome (SSS)] have a prevalence of 0.04% and 0.8% in the general population respectively and…Abstract Number: 1591 • 2017 ACR/ARHP Annual Meeting
Monophasic Disease Course Pattern in Systemic Lupus Erythematosus
Background/Purpose: Disease course in systemic lupus erythematosus (SLE) is believed to follow three distinct patterns over time, namely relapsing-remitting, persistently active and prolonged quiescent. We…Abstract Number: 1592 • 2017 ACR/ARHP Annual Meeting
Antimalarial-Induced Cardiomyopathy in Systemic Lupus Erythematosus
Background/Purpose: Antimalarials (AM) are currently recommended for the management of all patients with systemic lupus erythematosus (SLE) without specific contra-indications. Their main adverse effect is…Abstract Number: 1593 • 2017 ACR/ARHP Annual Meeting
Development of Quality Indicator Set of Systemic Lupus Erythematosus in Japan
Background/Purpose: A QI set for systemic lupus erythematosus (SLE) was developed in the United States. However, this does not necessarily conform to the Japanese medical…Abstract Number: 1594 • 2017 ACR/ARHP Annual Meeting
Bone Turnover Markers in Adults with Systemic Lupus Erythematosus
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a systemic inflammatory disease which has an increased risk for comorbid osteoporosis, related to the disease and long term…Abstract Number: 1595 • 2017 ACR/ARHP Annual Meeting
Prevalence and Predictors of Depression in Patients with Systemic Lupus Erythematosus: Results from the Korean Lupus Network (KORNET) Registry
Background/Purpose: Depression is more common in patients with systemic lupus erythematosus (SLE) than in the general population. However, few studies have investigated predictors of depression…Abstract Number: 1596 • 2017 ACR/ARHP Annual Meeting
Effect of the Metabolic Syndrome on Organ Damage, Renal Function and Mortality in Patients with Systemic Lupus Erythematosus: A Longitudinal Analysis
Background/Purpose: To study the effect of the metabolic syndrome (MetS) on organ damage, renal function and mortality in patients with SLE. Methods: Consecutive patients who…