ACR Meeting Abstracts

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  • Abstract Number: 1552 • 2017 ACR/ARHP Annual Meeting

    Persistency of Tumor Necrosis Factor Inhibitor Therapy in US Patients with Ankylosing Spondylitis: Data from the Corrona Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registry

    Philip J Mease1, Désirée van der Heijde2, Chitra Karki3, Mei Liu3, Yujin Park4 and Jeffrey D. Greenberg5, 1Swedish Medical Center and University of Washington, Seattle, WA, 2Leiden University Medical Center, Leiden, Netherlands, 3Corrona, LLC, Southborough, MA, 4Novartis Pharmaceuticals Corporation, East Hanover, NJ, 5New York University School of Medicine, New York, NY

    Background/Purpose: There are limited data regarding persistency of TNF inhibitor (TNFi) therapies in patients with ankylosing spondylitis (AS) treated in real-world clinical practice. The objective…
  • Abstract Number: 1553 • 2017 ACR/ARHP Annual Meeting

    Discontinuation of Tumor Necrosis Factor Inhibitor Therapy in US Patients with Ankylosing Spondylitis: Data from the Corrona Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registry

    Philip J Mease1, Désirée van der Heijde2, Chitra Karki3, Mei Liu3, Yujin Park4 and Jeffrey D. Greenberg5, 1Swedish Medical Center and University of Washington, Seattle, WA, 2Leiden University Medical Center, Leiden, Netherlands, 3Corrona, LLC, Southborough, MA, 4Novartis Pharmaceuticals Corporation, East Hanover, NJ, 5New York University School of Medicine, New York, NY

    Background/Purpose: There is a need to better characterize patients with ankylosing spondylitis (AS) who discontinue vs continue TNF inhibitor (TNFi) therapies in real-world clinical settings.…
  • Abstract Number: 1554 • 2017 ACR/ARHP Annual Meeting

    Discontinuation and Switching Patterns By TNFi Line of Therapy in Patients with Psoriatic Arthritis—Results from the Corrona Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registry

    Philip J Mease1, Chitra Karki2, Mei Liu2, YouFu Li3, Peter Hur4 and Jeffrey D. Greenberg5, 1Swedish Medical Center and University of Washington, Seattle, WA, 2Corrona, LLC, Southborough, MA, 3University of Massachusetts Medical School, Worcester, MA, 4Novartis Pharmaceuticals Corporation, East Hanover, NJ, 5New York University School of Medicine, New York, NY

    Background/Purpose: Few real-world studies have characterized the use of first- vs second-line tumor necrosis factor inhibitors (TNFis) in US patients with psoriatic arthritis (PsA). This…
  • Abstract Number: 1555 • 2017 ACR/ARHP Annual Meeting

    Treatment Changes By Joint Activity and Skin Severity in Patients with Comorbid Psa and Pso

    Philip J Mease1, Carol J. Etzel2, Jeffrey Lisse3, April W Armstrong4, William J Huster3, Sabrina Rebello2, Rhiannon Dodge2, Talia M Muram3, Sarah Al Sawah3, Mwangi J Murage3, Jeffrey D Greenberg2 and William Malatestinic3, 1Swedish Medical Center and University of Washington, Seattle, WA, 2Corrona, LLC, Southborough, MA, 3Eli Lilly and Company, Indianapolis, IN, 4Keck School of Medicine, University of Southern California, Los Angeles, CA

    Background/Purpose: Treatment of both joint and skin symptoms is important for overall disease management of patients with psoriatic arthritis and comorbid psoriasis1,2. The objective of…
  • Abstract Number: 1556 • 2017 ACR/ARHP Annual Meeting

    Efficacy of Biologics and New Anti-Inflammatory Agents Used in the Treatment of Active Psoriatic Arthritis: Systematic Literature Review and Network Meta-Analysis of the Evidence.

    Mahdi Gharaibeh1, Yingxin Xu2, Joseph Lee3, Madhura Chitnis2 and David Collier4, 1Amgen Inc., Thousand Oaks, CA, 2Evidera, Bethesda, MD, 3videra, Bethesda, MD, 4Amgen, Inc, Terni, Italy

    Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. Biologics are usually the first-line FDA-approved disease-modifying anti-rheumatic drug (DMARD) treatment; however, no published…
  • Abstract Number: 1557 • 2017 ACR/ARHP Annual Meeting

    Treatment Patterns in Psoriatic Arthritis: Experience from a Real-World Setting

    Martin Brom1, Sebastian Moyano1, Florencia Beatriz Mollerach2, Luciano Fernando Lo Giudice3, Maria Laura Acosta Felquer1, Marina Scolnik4, Santiago Ruta4 and Enrique R Soriano5, 1Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 2Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 3Rheumatology section, Internal Medicine Unit, Hospital Italiano de Buenos Aires and Fundacion PM Catoggio, CABA, Argentina, 4Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, CABA, Argentina, 5Argentina, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: Both EULAR (European League Against Rheumatism) and GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis) recently published treatment guidelines for Psoriatic…
  • Abstract Number: 1558 • 2017 ACR/ARHP Annual Meeting

    Changes in Blood Pressure with TNF Inhibitors for Psoriatic Arthritis

    Birju D. Bhatt1, J. Lynn Palmer2, Jeffrey R. Curtis3, Sathya Velkuru4 and Joel Kremer5, 1Medicine, div-of Rheumatology, Albany Medical College, Albany, NY, 2Corrona Research Foundation, Albany, NY, 3Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, 4Medicine, Albany Medical College, Albany, NY, 5Albany Medical College and the Center for Rheumatology, Albany, NY

    Background/Purpose:  Psoriasis is a complex disorder with cutaneous and rheumatological manifestations affecting 2-3% of the population of the Western world. The prevalence of hypertension (HTN)…
  • Abstract Number: 1559 • 2017 ACR/ARHP Annual Meeting

    Residual Disease Activity in Psoriatic Arthritis Triggers Treatment Adjustment in Only a Quarter of Patients in Daily Clinical Practice

    Leonieke van Mens1, Sadaf Atiqi2, Inka Fluri2, Marleen van de Sande3, Arno van Kuijk4 and Dominique Baeten1, 1AMC, Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands, 2Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands, 3Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 4Reade, Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands

    Background/Purpose: With expanding therapeutic possibilities for the treatment of psoriatic arthritis (PsA) it will be increasingly important to determine residual disease and define when to…
  • Abstract Number: 1560 • 2017 ACR/ARHP Annual Meeting

    Predictors of Long-Term Modified Minimal Disease Activity Response in Peripheral Spondyloarthritis Patients Treated with Adalimumab

    Laura C Coates1, Sonya Abraham2, William Tillett3, Philip J Mease4, Sofia Ramiro5, Tianshuang Wu6, Xin Wang6, Aileen L. Pangan6 and In-Ho Song6, 1University of Leeds and Leeds Teaching Hospitals NHS Trust, Leeds, Great Britain, 2NIHR/Wellcome CRF, Imperial College Healthcare NHS Trust, London, United Kingdom, 3Royal National Hospital for Rheumatic Diseases and University of Bath, Bath, United Kingdom, 4Swedish Medical Center and University of Washington, Seattle, WA, 5Rheumatology, Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands, 6AbbVie Inc., North Chicago, IL

    Background/Purpose : There is a lack of validated outcome measures in non-psoriatic peripheral spondyloarthritis (pSpA). Therefore, a modified version of the minimal disease activity (mMDA)1…
  • Abstract Number: 1561 • 2017 ACR/ARHP Annual Meeting

    Network Meta-Analysis of Targeted Immunomodulators in the Treatment of Biologic-NaïVe Psoriatic Arthritis

    Vibeke Strand1, M. Elaine Husni2, Rakesh Singh3, Keith Betts4, Yan Song5, Jenny Griffith3 and Arijit Ganguli3, 1Stanford University, Palo Alto, CA, 2Cleveland Clinic, Cleveland, OH, 3AbbVie Inc., North Chicago, IL, 4Analysis Group, Inc., Los Angeles, CA, 5Analysis Group, Inc., Boston, MA

    Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory condition characterized by peripheral arthritis and psoriatic skin lesions requiring therapies that control both skin and joint symptoms.…
  • Abstract Number: 1562 • 2017 ACR/ARHP Annual Meeting

    Biological DMARD Efficacy in Psoriatic Arthritis: A Systematic Review and Meta-Analysis on ACR Response Criteria, PASI Response Criteria, HAQ-DI, Enthesitis and Dactylitis Outcomes

    Numa Simons1, Yannick Degboé1, Thomas Barnetche2, Alain Cantagrel1, Adeline Ruyssen-Witrand1 and Arnaud Constantin1, 1Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, 2FHU ACRONIM, Pellegrin Hospital, Bordeaux University, Bordeaux, France

    Background/Purpose: We are currently witnessing a diversification of the available biotherapies (bDMARDs) for psoriatic arthritis (PsA), with the arrival of new classes of medication. Those…
  • Abstract Number: 1563 • 2017 ACR/ARHP Annual Meeting

    Long-Term Effects of TNF-Alpha Inhibitors on Bone Mineral Density and the Incidence of Vertebral Fractures in Patients with Ankylosing Spondylitis

    Kim Beek1, Mignon van der Weijden1, WF Lems2, Christiaan van Denderen3, M. Nurmohamed4 and Irene van der Horst - Bruinsma5, 1Rheumatology, Amsterdam Rheumatology immunology Centre/VUmc and Reade, Amsterdam, Netherlands, 2Amsterdam Rheumatology and immunology Center | VU University Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands, 3Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 4Rheumatology, Amsterdam Rheumatology and immunology Center, Reade, Amsterdam, Netherlands, 5ARC, Amsterdam, Netherlands, Amsterdam, Netherlands

    Background/Purpose: Ankylosing Spondylitis (AS) is not only characterized by pathological bone formation leading to ankylosis, but also by bone loss which may lead to vertebral…
  • Abstract Number: 1564 • 2017 ACR/ARHP Annual Meeting

    Treatment Patterns, Survival and Long-Term Effectiveness of Biological Agents in Psoriatic Arthritis Patients

    Marina Natalia Fornaro1, Fernando Dal Pra2, Emilce E Schneeberger2, Osvaldo Luis Cerda2, Margarita Landi2, María de los Angeles Correa3, Rodrigo Garcia Salinas4, Sebastian Magri5, Raul Sueldo6, María Julia Santa Cruz7, Emilio Buschiazzo8 and Gustavo Citera9, 1Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, buenos aires, Argentina, 2Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Buenos Aires, Argentina, 3Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Buenos Aires, Argentina, 4Section of Rheumatology, Hospital Italiano de La Plata, Buenos Aires, Argentina, La Plata, Argentina, 5Section of Rheumatology, Hospital Italiano de La Plata, La Plata, Argentina, 6Section of Rheumatology, Hospital Angel Cruz Padilla, Tucumán, Argentina, 7Section of Rheumatology, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, 8Section of Rheumatology, Hospital Señor del Milagro, Salta, Argentina, Salta, Argentina, 9Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Buenos Aires, Argentina

    Background/Purpose: The incorporation of biological disease modifying drugs (b-DMARD) has substantially improved the outcome of patients with Psoriatic Arthritis (PsA). Our aim was to evaluate…
  • Abstract Number: 1565 • 2017 ACR/ARHP Annual Meeting

    Depression and Fatigue in Patients with Ankylosing Spondylitis

    Ji Hui Shin1, Sun Ju Ahn2 and Tae-Hwan Kim3, 1rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), 2Medical Research Coordinator, Hanyang Univerity Hospital for Rheumatic Disease Research Center, Seoul, Korea, Republic of (South), 3Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South)

    Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory disease that leads to bony ankyloses. The disease occurs in early adulthood, a critical stage in life,…
  • Abstract Number: 1566 • 2017 ACR/ARHP Annual Meeting

    Elevated IL-1 Expression Levels in Mesenchymal Stem Cells Derived from Spondyloarthitis Patients Might be Linked to Increased Osteoblast Mineralization

    Gerlinde Layh-Schmitt1, Breanna Nguyen1, Emily Lazowick1, Stephen R. Brooks2 and Robert Colbert1, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2NIAMS/NIH, Biodata Mining & Discovery, Bethesda, MD

    Background/Purpose:  Axial spondyloarthritis (AxSpA) is an immune–mediated inflammatory disease involving the spine and sacroiliac joint. AxSpA is characterized by vertebral trabecular bone loss and progressive…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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