ACR Meeting Abstracts

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  • Abstract Number: 1537 • 2017 ACR/ARHP Annual Meeting

    Determinants of Patient-Reported Improvement after Administration of Biological Treatment in Axial Spondyloarthritis: A Cross-Sectional Study

    Julianna Hirsch1, Michal Nudel2, Shira Ginsburg3, Haya Hussein3, Karina Zilber3, Lisa Kaly3, Doron Rimar3, Nina Boulman3, Abid Awisat3, Hily Wollach2, Michael Rozenbaum3, Itzhak Rosner3 and Gleb Slobodin3, 1Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Haifa, Israel, 2Mifrakim Tz'eirim, Haifa, Israel, 3Bnai-Zion Medical Center, Haifa, Israel

    Background/Purpose: Efficacy of biological treatment in patients with axial spondyloarthritis (SpA) varies and is dependent on both disease-related and patient-related factors. The goal of this…
  • Abstract Number: 1538 • 2017 ACR/ARHP Annual Meeting

    Comparative Effectiveness of Early Versus Delayed Anti-TNF-α Treatment in Axial Spondyloarthritis

    Herman F Mann1, Jakub Zavada2, Šárka Forejtová3, Lenka Szczukova4, Zlatuše Křístková4 and Karel Pavelka1, 1ATTRA, Prague, Czech Republic, Prague, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic, 3Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Czech Republic, Prague, Czech Republic, 4Institute of Biostatistics and Analyses. Faculty of Medicine, Masaryk University, Brno, Czech Republic

    Background/Purpose: Anti-TNF-α agents are the mainstay of pharmacotherapy for patients with axial spondyloarthritis (AxSpA) who failed treatment with NSAIDs. A little is known about the…
  • Abstract Number: 1539 • 2017 ACR/ARHP Annual Meeting

    High Retention Rate and Sustained Responses with Secukinumab 150mg in Patients with Active Ankylosing Spondylitis: 3-Year Results from a Phase 3 Study

    Alan J. Kivitz1, Helena Marzo-Ortega2, Clarence Legerton3, Joachim Sieper4, Ricardo Blanco5, Martin Cohen6, Evie Maria Delicha7, Susanne Rohrer7 and Hanno Richards7, 1Altoona Center for Clinical Research, Duncansville, PA, 2NIHR LBRC, LTHT and LIRMM, UoL, Leeds, United Kingdom, 3Low Country Rheumatology, Articularis Healthcare, Charleston, SC, 4University Clinic Benjamin Franklin, Berlin, Germany, 5Hospital Universitario Marqués de Valdecilla, Santander, Spain, 6McGill University, Montreal, QC, Canada, 7Novartis Pharma AG, Basel, Switzerland

    Background/Purpose: Secukinumab provided sustained improvement in the signs and symptoms of ankylosing spondylitis (AS) over 2 years in the MEASURE 2 study (NCT01649375).1,2 Here we…
  • Abstract Number: 1540 • 2017 ACR/ARHP Annual Meeting

    Comparison of Radiologic Parameters of Ankylosing Spondylitis Treated with Anti-TNF-α Versus Non-Steroidal Anti-Inflammatory Drugs and Sulfasalazine

    Seung Min Son, Orthopaedic surgery, Pusan National University Yangsan Hospital, Yangsan, Korea, Republic of (South)

    Background/Purpose: There are many studies about impact of TNF-inhibitors on radiographic progression but little data are available on the relationship between treatment agents and sagittal…
  • Abstract Number: 1541 • 2017 ACR/ARHP Annual Meeting

    First Line Biological Treatment in Ankylosing Spondylitis, Prescription Rates, Baseline Demographics and Disease Activity. a Collaboration between Biological Registers in the Five Nordic Counties

    Bente Glintborg1, Ulf Lindström2, Kalle Aaltonen3, Eirik K Kristianslund4, Björn Gudbjornsson5, Katerina Chatzidionysiou2, Johan Askling6, Dan Nordström7, Merete Lund Hetland8, Daniela Di Giuseppe9, Lene Dreyer10, Tanja Schjødt Jørgensen11, Lars Erik Kristensen10, Kari Eklund3, Gerdur Grondal12, Sofia Ernestam2, Jaana Joensuu3, Tore K Kvien13, Elisabeth Lie13, Karen M Fagerli13, Arni Jon Geirsson12, Helgi Jonsson12 and Lennart TH Jacobsson14, 1The DANBIO registry and the Danish Departments of Rheumatology, Copenhagen, Denmark, 2On behalf of the SRQ/ARTIS registry, Stockholm, Sweden, 3On behalf of the ROB-FIN registry, Helsinki, Finland, 4Dept. of Rheumatology, On behalf of the NOR-DMARD registry, Oslo, Norway, 5ICEBIO, Reykjavik, Iceland, Reykjavik, Iceland, 6Unit of Clinical Epidemiology, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, 7ROB-FIN, Helsinki, Finland, Helsinki, Finland, 8The DANBIO registry and the Danish Departments of Rheumatology, Glostrup, Denmark, 9Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, 10On behalf of the DANBIO registry, Copenhagen, Denmark, 11On behalf of the DANBIO registry, Copenhagen F, Denmark, 12On behalf of the ICEBIO registry, Reykjavik, Iceland, 13On behalf of the NOR-DMARD registry, Oslo, Norway, 14Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Large-scale observational cohorts identified in national biological registries may be used to study effectiveness of biological disease modifying drugs (bDMARDs) in ankylosing spondylitis (AS).…
  • Abstract Number: 1542 • 2017 ACR/ARHP Annual Meeting

    Inequity in Biologic DMARD Prescription for Spa across the Globe:  Results from the Multi-Centre, Cross-Sectional, ASAS Comospa Study

    Elena Nikiphorou1, Désirée van der Heijde2, Sam Norton3, Robert B.M. Landewé4, Anna Moltó5, Maxime Dougados6, Filip van Den Bosch7 and Sofia Ramiro8, 1LUMC, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Academic Rheumatology, King´s College London, London, United Kingdom, 4Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands, 5Paris Descartes University, Paris, France, 6Paris-Descartes University,, Paris, France, 7Rheumatology, Ghent University Hospital, Gent, Belgium, 8Rheumatology, Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands

    Background/Purpose: The value of biologic DMARDs (bDMARDs) in SpA is well recognized but global access to these treatments can be limited due to high cost…
  • Abstract Number: 1543 • 2017 ACR/ARHP Annual Meeting

    Real-World Effectiveness of TNF Inhibition in Spondyloarthritis. Data from a Large Nationwide Prospective Cohort – the British Society for Rheumatology Biologics Register for Ankylosing Spondylitis

    Gareth T. Jones1, Andrew Keat2, Ejaz Pathan3 and Gary J. Macfarlane1, 1Epidemiology Group, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom, 2Rheumatology., Northwick Park Hospital, London, United Kingdom, 3Department of Rheumatology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom

    Background/Purpose: TNF inhibition has revolutionised the treatment of axial spondyloarthritis (AxSpA). Much of what we know about the use of these drugs comes from randomised…
  • Abstract Number: 1544 • 2017 ACR/ARHP Annual Meeting

    The Effect of Extraarticular Manifestations on Tumor Necrotic Factor α Inhibitor Drug Survival in Patients with Ankylosing Spondylitis: Nationwide Data from the Korean College of Rheumatology Biologics (KOBIO) Registry

    Yunsuek Kim, Internal medicine, Soonchunhyang university Seoul hospital, Seoul, Korea, Republic of (South)

    Background/Purpose: The tumor necrosis factor α inhibitor (TNFi) therapy has been shown to be remarkably effective in ankylosing spondylitis (AS). However, almost 30% of AS…
  • Abstract Number: 1545 • 2017 ACR/ARHP Annual Meeting

    Evaluation of the Adherence to Recommendations for Tnfα Blockers Use and Its Impact over 5 Years of Follow-up in Early Axial Spondyloarthritis. Data from the DESIR Cohort

    Clementina López-Medina1,2, Maxime Dougados3, Eduardo Collantes-Estévez4 and Anna Molto5, 1Rheumatology Department, Reina Sofía University Hospital/ Maimonides Institute for Biomedical Research of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, 2Rheumatology Department, Cochin Hospital, Paris, France, 3Hôpital Cochin, Paris, France, 4Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 5Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France

    Background/Purpose: Several recommendations have been published for the use of TNFα blockers (TNFb) in patients with axial Spondyloarthritis (axSpA). However, there is only sparse data…
  • Abstract Number: 1546 • 2017 ACR/ARHP Annual Meeting

    Comparative Effectiveness of Secukinumab and Golimumab in Ankylosing Spondylitis: Assessed By Matching-Adjusted Indirect Comparison Using Pivotal Phase 3 Clinical Trial Data

    Walter P. Maksymowych1, Ernest Choy2, Yusuf Yazici3, Jessica A. Walsh4, Howard Thom5, Chrysostomos Kalyvas6, Todd Fox7, Kunal Gandhi8 and Steffen Jugl7, 1Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, 2Section of Rheumatology, Cardiff University, Cardiff, Great Britain, 3School of Medicine, New York University School of Medicine, New York City, NY, 4Division of Rheumatology, University of Utah, Salt Lake City, UT, 5School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, 6Real World Strategy and Analytics, MAPI Group, Houten, Netherlands, 7Novartis Pharma AG, Basel, Switzerland, 8Novartis Pharmaceuticals Corporation, East Hanover, NJ

    Background/Purpose: No data are available from head-to-head randomized controlled trials (RCTs) between secukinumab 150mg (SEC; an anti-IL-17A) and golimumab 50mg (GOL; a TNF inhibitor [TNFi])…
  • Abstract Number: 1547 • 2017 ACR/ARHP Annual Meeting

    Dose Tapering of TNFi in Patients with Axial Spondyloarthritis: An Observational Cohort Study from Nationwide Korean College of Rheumatology Biologic Registry (KOBIO)

    Jun Won Park1, Jin Kyun Park1, Kichul Shin2, Yong-Beom Park3, Eun Bong Lee1, Yeong Wook Song4 and Eun Young Lee1, 1Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), 2Kyungnam villa #102, Division of Rheumatology, Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea, Republic of (South), 3Yonsei University Severance Hospital, Seoul, Korea, Republic of (South), 4Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)

    Background/Purpose: To compare the clinical efficacy of dose-tapering strategy of tumor-necrosis factor inhibitor (TNFi) with that of standard-dose TNFi treatment in patients with spondyloarthritis (SpA)…
  • Abstract Number: 1548 • 2017 ACR/ARHP Annual Meeting

    Opioid Use in Patients with Ankylosing Spondylitis

    Victor S. Sloan1, Anna Sheahan1, Jeffrey Stark2 and Robert Y. Suruki1, 1UCB Pharma, Raleigh, NC, 2UCB Pharma, Smyrna, GA

    Background/Purpose: The use or misuse of opioids has become a major public health issue in the USA. It is estimated that the economic burden of…
  • Abstract Number: 1549 • 2017 ACR/ARHP Annual Meeting

    A Non-Medical Switch from Originator Infliximab to Biosimilar CT-P13 in 36 Patients with Ankylosing Spondylitis:  6 – Months Clinical Outcomes from the Czech Biologic Registry Attra

    Šárka Forejtová1, Jakub Zavada1, Lenka Szczukova2, Katerina Jarosova1, Tom Philipp3 and Karel Pavelka4, 1Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Czech Republic, Prague, Czech Republic, 2Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Brno, Czech Republic, 3Department of Rheumatology and Physiotherapy, Thomayer Hospital, Prague, Praha 4, Czech Republic, 4Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: A non-medical switch from originator (INX, Remicade) to biosimilar infliximab (CT-P13, Remsima) was conducted in 36 patients with ankylosing spondylitis (AS) in one clinical…
  • Abstract Number: 1550 • 2017 ACR/ARHP Annual Meeting

    One-Year Clinical Outcomes in 1623 Patients with Inflammatory Arthritis Who Switched from Originator to Biosimilar Etanercept – an Observational Study from the Danish Danbio Registry

    Bente Glintborg1, Emina Omerovic1, Kamilla Danebod1, Dorte Vendelbo Jensen1, Henrik Nordin1, Anne Gitte Loft1, Stavros Chrysidis1, Johnny Lillelund Raun1, Oliver Hendricks1, Hanne Lindegaard1, Jakob Espesen1, Susanne Jakobsen1, Inger Marie J. Hansen1, Jolanta Grydehøj1, Emil Dalgaard1, Dorte Dalsgaard Pedersen1, Natalia Manilo2, Lis Smedegaard Andersen3, Salome Kristensen1, Asta Linauskas1, Niels Steen Krogh4 and Merete Lund Hetland5, 1The DANBIO registry and the Danish Departments of Rheumatology, Copenhagen, Denmark, 2Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Frederiksberg, Copenhagen, Denmark, 3Department of Rheumatology, The DANBIO registry and the Danish Departments of Rheumatology, Copenhagen, Denmark, 4The DANBIO Registry, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, 5The DANBIO registry and the Danish Departments of Rheumatology, Glostrup, Denmark

    Background/Purpose: According to Danish national guidelines issued in April 2016, a non-medical switch from originator (ETA, Enbrel) to biosimilar Etanercept (SB4, Benepali) (50 mg s.c.)…
  • Abstract Number: 1551 • 2017 ACR/ARHP Annual Meeting

    Avoidance of Physical Activity Leads to Reduced Inflammatory Enthesitis on Ultrasound

    Kim Wervers1, Irene Herrings1, Jolanda J. Luime2, Marlies Moed1, Ilja Tchetverikov3, Andreas H. Gerards4, J.M.W. Hazes5 and Marijn Vis2, 1Erasmus Medical Centre, Rotterdam, Netherlands, 2Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands, 3Albert Schweitzer Hospital, Dordrecht, Netherlands, 4Sint Franciscus Vlietland Group, Schiedam, Netherlands, 5Department of Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands

    Background/Purpose: Enthesitis is one of the manifestations of psoriatic arthritis (PsA), but no clear definition for the diagnosis exists. To further evaluate the added value…
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