ACR Meeting Abstracts

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  • Abstract Number: 1477 • 2017 ACR/ARHP Annual Meeting

    Patient-Reported Outcomes As Independent Measures of Treatment Success with Sirukumab, an Anti-IL6 Cytokine Monoclonal Antibody, in Patients with Active Rheumatoid Arthritis: Post-Hoc Analysis of 2 Placebo-Controlled Phase 3 Trials

    Vibeke Strand1, Rita Ganguly2, Nan Li3, Prasheen Agarwal3, Shihong Sheng3, Kaiyin Fei3, Kelly McQuarrie3 and Sharon Popik3, 1Division of Immunology/Rheumatology, Stanford University, Stanford, CA, 2GlaxoSmithKline, Collegeville, PA, 3Janssen Research & Development, LLC, Spring House, PA

    Background/Purpose: Sirukumab, a selective, high-affinity, human anti–IL-6 monoclonal antibody, is in development for rheumatoid arthritis (RA) and other diseases.  Effects of sirukumab on RA symptoms…
  • Abstract Number: 1478 • 2017 ACR/ARHP Annual Meeting

    Inadequate Clinical Response to Sirukumab, an Anti-IL-6 Monoclonal Antibody, Can be Predicted after a Single Dose of Treatment in Patients with Rheumatoid Arthritis

    Shruti Daga1, Daniel Aletaha2, Benjamin Hsu3, Jennifer Gilbride4, Jacquie Christie5, Matthew Loza3, Bidisha Dasgupta3, Kim Campbell3, Kurt Brown6, Ravi Rao5 and Paul P. Tak5, 1GlaxoSmithKline, Uxbridge, United Kingdom, 2Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 3Janssen Research & Development, LLC, Spring House, PA, 4Sum of Squares Ltd, Hertfordshire, United Kingdom, 5GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom, 6GlaxoSmithKline, Collegeville, PA

    Background/Purpose: Response to therapy in rheumatoid arthritis (RA) is heterogeneous. Early identification of patients (pts) who are unlikely to achieve a meaningful clinical response may…
  • Abstract Number: 1479 • 2017 ACR/ARHP Annual Meeting

    Difference in Clinical Presentation between Female and Male Patients with Primary Sjogren’s Syndrome at Diagnosis and in Long-Term Follow-up

    Jorge Ramírez1, Marika Kvarnstrom2, Susanna Brauner3, Chiara Baldini4, Per Eriksson5, Thomas Mandl6, Katrine Brække Norheim7, Svein Joar Johnsen8, Daniel S. Hammenfors9,10, Malin V. Jonsson11, Kathrine Skarstein12,13, Johan G. Brun9,10, Lars Rönnblom14, Helena Forsblad D’Elia15, Sara Magnusson Bucher16, Elke Theander17, Roald Omdal8, Roland Jonsson9,10, Gunnel Nordmark18 and Marie Wahren-Herlenius19, 1Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Solna, Sweden, 2Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 3Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 4Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, 5Division of Rheumatology, Department of Clinical Experimental Medicine, Linköping University, Linköping, Sweden, Linköping, Sweden, 6Department of Rheumatology, Skåne University Hospital, Malmö, Sweden, Lund, Sweden, 7Department of Internal Medicine, Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, Stavanger, Norway, 8Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, Stavanger, Norway, 9Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, Bergen, Norway, 10Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, Bergen, Norway, 11Section for Oral and Maxillofacial Radiology, Department of Clinical Dentistry, University of Bergen, Bergen, Norway, Bergen, Norway, 12Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, 13Department of Pathology, Haukeland University Hospital, Bergen, Bergen, Norway, 14Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, 15Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden., Umeå, Sweden, 16Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden, Örebro, Sweden, 17Department of Rheumatology, Skåne University Hospital, Malmö, Sweden, Malmö, Sweden, 18Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, 19Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden

    Background/Purpose: Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune…
  • Abstract Number: 1480 • 2017 ACR/ARHP Annual Meeting

    Risk of Ischemic Stroke in Sjögren’s Syndrome Patients: A Systematic Review and Meta-Analysis

    Jirapat Teerakanok1, Daniel Cordoba2, Sakolwan Suchartlikitwong3 and Kenneth Nugent4, 1Internal medicine, Texas Tech University health and sciences center, Lubbock, TX, 2Internal Medicine, Texas Tech University Health and Sciences Center, Lubbock, TX, 3Internal medicine, Texas Tech University Health Sciences Center, Lubbock, TX, 4Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX

    Background/Purpose: Primary Sjögren’s syndrome (SS) is an autoimmune disease of the exocrine glands with lymphocytic infiltration into lacrimal and salivary glands. Autoimmune diseases increase cardiovascular…
  • Abstract Number: 1481 • 2017 ACR/ARHP Annual Meeting

    Risk of Ischemic Heart Disease in Sjögren’s Syndrome Patients: A Systematic Review and Meta-Analysis of Observational Studies

    Jirapat Teerakanok1, Sakolwan Suchartlikitwong2, Thammasak Mingbunjerdsuk3, Praveen Ratanasrimetha3, Yuttiwat Vorakunthada3 and John S. Pixley3, 1Internal medicine, Texas Tech University health and sciences center, Lubbock, TX, 2Internal medicine, Texas Tech University Health Sciences Center, Lubbock, TX, 3Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX

    Background/Purpose: Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are associated with an increased risk of ischemic heart disease (IHD). The risk of IHD in…
  • Abstract Number: 1482 • 2017 ACR/ARHP Annual Meeting

    Preliminary Population-Based Incidence and Prevalence Estimates of Primary Sjogren’s Syndrome from the Manhattan Lupus Surveillance Program

    Peter M. Izmirly1, Isabella Wan2, Sara Sahl3, Jill P. Buyon4, H. Michael Belmont5, Jane E. Salmon6, Anca Askanase7, Joan Bathon8, Laura Geraldino-Pardilla7, Yousaf Ali9, Ellen M. Ginzler10, Chaim Putterman11, Caroline Gordon12, Charles G. Helmick13 and Hilary Parton14, 1Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 2Medicine/Rheumatology, New York University School of Medicine, New York, NY, 3Pediatrics, Harbor-University of California at Los Angeles Medical Center, Torrance, CA, 4Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 5Medicine, New York University School of Medicine, New York, NY, 6Division of Rheumatology, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 7Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, 8Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, 9Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, 10Rheumatology, Division of Rheumatology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, 11Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY, 12Rheumatology Research Group, Institute of Inflammation and Ageing,, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, 13Centers for Disease Control and Prevention, Atlanta, GA, 14Bureau of Epidemiology Services, New York City Department of Health and Mental Hygiene, Long Island City, NY

    Background/Purpose: The extant epidemiologic data of Primary Sjögren’s Syndrome (pSS) remains limited with few published estimates for the general population and little data regarding racial/ethnic…
  • Abstract Number: 1483 • 2017 ACR/ARHP Annual Meeting

    Incidence of Cancer in a Cohort of Patients with Primary Sjögren Syndrome

    Martin Brom1, Sebastian Moyano1, Marina Scolnik2 and Enrique R. Soriano3, 1Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 2Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, CABA, Argentina, 3Rheumatology Unit, Internal Mecine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: Several neoplasia have been associated with Sjögren Syndrome (SS), being non-Hodgkin lymphoma the most frequent one. Our objective was to evaluate the incidence of…
  • Abstract Number: 1484 • 2017 ACR/ARHP Annual Meeting

    Association between Primary Sjogren’s Syndrome, Arterial Stiffness and Subclinical Atherosclerosis: A Systematic Review and Meta-Analysis

    Wai Chung Yong, Anawin Sanguankeo and Sikarin Upala, Bassett Medical Center, Cooperstown, NY

    AbstractBackground/Purpose: In rheumatoid arthritis and systemic lupus erythematosus, cardiovascular disease is frequently a major cause of mortality or morbidity. Studies have shown that acute systemic…
  • Abstract Number: 1485 • 2017 ACR/ARHP Annual Meeting

    Association between Primary Sjogren’s Syndrome, Cardiovascular and Cerebrovascular Events: A Systematic Review and Meta-Analysis

    Wai Chung Yong, Anawin Sanguankeo and Sikarin Upala, Bassett Medical Center, Cooperstown, NY

    AbstractBackground/Purpose: Studies have demonstrated that acute systemic inflammation and chronic systemic vasculitis are associated with endothelial dysfunction and atherosclerotic plaque formation, subsequently leading to cardiovascular…
  • Abstract Number: 1486 • 2017 ACR/ARHP Annual Meeting

    Interstitial Lung Disease in Primary Sjögren’s Syndrome : Clinical Presentation, Serological Biomarkers and Long Term Outcome

    Chiara Baldini1, Ilaria Puxeddu2, Martina Orlandi3, Francesco Ferro4, Elena Elefante4, Nicoletta Luciano4, Marco Matucci-Cerinic3, Paola Migliorini2 and Marta Mosca4, 1Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, 2Allergology and Clinical Immunology Unit, University of Pisa, Pisa, Italy, 3Rheumatology Unit, University of Florence, Florence, Italy, 4Rheumatology Unit, University of Pisa, Pisa, Italy

    Background/Purpose: Interstitial lung disease (ILD) is a rare but potentially severe manifestation of primary Sjögren’s syndrome (pSS). The aims of this study were to: 1)…
  • Abstract Number: 1487 • 2017 ACR/ARHP Annual Meeting

    Salivary Gland Ultrasonography (SGUS) and Subclinical Parotid Involvement: Usefulness of Sgus in the Identification of a Subset of Patients with Sjögren’s Syndrome at Higher Risk for Extraglandular Disease Manifestations

    Chiara Baldini1, Nicoletta Luciano2, Francesco Ferro2, Elena Elefante2, Rosaria Talarico3, Chiara Tani2 and Marta Mosca2, 1Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, 2Rheumatology Unit, University of Pisa, Pisa, Italy, 3Rheumatology Unit, University of Pisa, PISA, Italy

    Background/Purpose: Salivary gland ultrasonography (SGUS) has recently appeared as a promising tool for the diagnosis and the early stratification of patients affected by primary Sjögren’s…
  • Abstract Number: 1488 • 2017 ACR/ARHP Annual Meeting

    Correlation between Lung Ultrasound, HRCT Findings and  Pulmonary Function Tests  in Primary Sjögren’s Syndrome (pSS)-Associated  Interstitial Lung Disease

    Francesco Ferro1, Alessandra Bulleri2, Andrea Delle Sedie1, Simone Barsotti1, Nicoletta Luciano1, Elisa Cioffi3, Elena Elefante1, Gianfranco Puppo4, Marta Mosca1 and Chiara Baldini5, 1Rheumatology Unit, University of Pisa, Pisa, Italy, 2Radiology Unit, University of Pisa, Pisa, Italy, 3Rheumatology Unit, Rheumatology Unit, University of Pisa, Pisa, Italy, 4Pneumology Unit, University of Pisa, Pisa, Italy, 5Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy

    Background/Purpose: Recently, pleural irregularity (PI), a new lung ultrasound (US) sign, has been proposed as an emerging tool for the diagnosis of interstitial lung disease…
  • Abstract Number: 1489 • 2017 ACR/ARHP Annual Meeting

    Development and Validation of a Questionnaire to Assess Healthcare Utilization and Access in Cohorts of Patients with Primary Sjögren’s Syndrome

    Chiara Seghieri1, Chiara Baldini2, Luca Quartuccio3, Francesco Ferro4, Saviana Gandolfo5, Salvatore De Vita6 and Stefano Bombardieri4, 1Istituto di Management Scuola Superiore Sant'Anna, Pisa, Italy, 2Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, 3Rheumatology Clinic, DSMB, University of Udine, Udine, Italy, Udine, Italy, 4Rheumatology Unit, University of Pisa, Pisa, Italy, 5Rheumatology Clinic, Medical Area Department, University of Udine, Udine, Italy, 6Rheumatology Clinic, Academic Hospital S. M. della Misericordia, Medical Area Department, University of Udine, Italy, Udine, Italy

    Background/Purpose: The geographic variation in healthcare service utilization and quality across and within countries is well documented. Part of this geographic variation is linked to…
  • Abstract Number: 1490 • 2017 ACR/ARHP Annual Meeting

    Cardiovascular Morbidity and Mortality in Primary Sjögren Syndrome: A Systematic Review and Meta-Analysis

    Aurélie Beltai1, Cédric Lukas2, Cécile Gaujoux-Viala3, Bernard Combe4, Jacques Morel4 and Thomas Barnetche5, 1Department of rheumatology, Teaching hospital Lapeyronie and University of Montpellier, Montpellier, France, 2Rheumatology, CHU Lapeyronie and EA2415, Montpellier University, University of Montpellier, France, 3Rheumatology, Nîmes University Hospital and EA2415 Montpellier University, Nîmes, France, 4Rheumatology, CHU Lapeyronie and Montpellier University, Montpellier, France, 5Rheumatology, CHU Pellegrin, Bordeaux, France, Bordeaux, France

    Background/Purpose: It is well documented that patients with immune-mediated inflammatory diseases (IMID) like rheumatoid arthritis are exposed at an increased risk of cardiovascular disease. Primary…
  • Abstract Number: 1491 • 2017 ACR/ARHP Annual Meeting

    Is There a Seasonal Effect on Fatigue, Pain, and Dryness in Primary Sjögren’s Syndrome?  Data from the Prospective Assess Cohort and  from 3 Randomized Controlled Trials

    Pierre-Marie DURET1, Nicolas MEYER2, Alain Saraux3, Valérie Devauchelle-Pensec4, Jean Sibilia5, Raphaele Seror6, Véronique Le-Guern7, Claire Larroche8, Aleth Perdriger9, Xavier Mariette10 and Jacques-Eric Gottenberg11, 1Rhumatology, Hautepierre Hospital, STRASBOURG, France, 2clinical research, Hautepierre Hospital, STRASBOURG, France, 3Rheumatology, Brest University Hospital, Brest, France, 4Department of Rheumatology, Brest University Hospital, Brest, France, 5Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 6Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, Paris, France, 7service de médecine interne, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 8Internal Medicine, Paris, France, 9Service de Rhumatologie, CHRU de Rennes, Rennes, France, 10Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, 11CNRS, Immunopathologie et Chimie Thérapeutique/Laboratory of Excellence Medalis, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France

    Background/Purpose: A seasonal effect was reported on fatigue and pain in rheumatoid arthritis. We speculated that fall and winter could be associated with increased fatigue…
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