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  • Abstract Number: 1372 • 2017 ACR/ARHP Annual Meeting

    A Single Immunosignature Test Accurately Discriminates RA from Related Autoimmune and Inflammatory Disorders

    Theodore M. Tarasow1, Robert Gerwien1, Jonathan Melnick1, Scott A. Melville1 and Chaim Putterman2, 1HealthTell, Inc., San Ramon, CA, 2Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY

    Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory autoimmune disease primarily targeting the synovium. RA is B-cell driven, and is associated with autoantibody production. The…
  • Abstract Number: 1373 • 2017 ACR/ARHP Annual Meeting

    Ultrasound of Subtalar Joint Synovitis in Patients with Rheumatoid Arthritis: Results of an Omeract Reliability Exercise Using Consensual Definitions

    George A. W. Bruyn1, Heidi Siddle2, Petra Hanova3, Felicie Costantino4, Annamaria Iagnocco5, Andrea Delle Sedie6, Marwin Gutierrez7, Hilde B. Hammer8, Elizabeth Jernberg9, Damien Loeuille10, Carlos Pineda11, Mihaela Cosmina Micu12, Ingrid Moller13, bethan richards14, Maria S. Stoenoiu15, Takeshi Suzuki16, Lene Terslev17, Violeta Vlad18, Robert Wonink19, MA D'Agostino20 and Richard J. Wakefield21, 1Dept of Rheumatology, MC Groep hospitals, Lelystad, Netherlands, 2University of Leeds, Leeds, United Kingdom, 3Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 4Hôpital Universitaire Ambroise Pare, Paris, France, 5Academic Rheumatology Unit, Università degli Studi di Torino, Torino, Italy, 6Department Rheumatology, University of Pisa, Pisa, Italy, 7Rheumatology, Instituto Nacional de Rehabilitación, Mexico City, Mexico, 8Dept. of Rheumtology, Diakonhjemmet Hospital, Oslo, Norway, 9University of Washington, Seattle, WA, 10Rheumatology, CHRU Vandoeuvre les Nancy, Nancy, France, 11Instituto Nacional de Rehabilitation, Mexico, Mexico, 12Division of Rheumatology, Department of Rehabilitation II, Clinical Rehabilitation Hospital, Cluj Napoca, Romania, 13Instituto de Poal, Barcelona, Spain, 14University of New South Wales, Sydney, Australia, 15Service de Rhumatologie, Cliniques Universitaires Saint-Luc,Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain,, Brussels, Belgium, 16Division of Allergy and Rheumatology, Japanese Red Cross Medical Center, Tokyo, Japan, 17Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, 18RCRD Research Center, Bucharest, Romania, 19Bergman Clinics, Naarden, Netherlands, 20Rheumatology, Versailles-Saint Quentin en Yvelines University, Boulogne-Billancourt, France, 21University of Leeds, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom

    Background/Purpose: To evaluate the intra- and interobserver reliability of the ultrasonographic (US) assessment of subtalar joint (STJ) synovitis in patients with rheumatoid arthritis (RA). Methods:…
  • Abstract Number: 1374 • 2017 ACR/ARHP Annual Meeting

    Flares in Patients with Rheumatoid Arthritis Are Strongly Associated with Worse Clinical Outcomes  but Are Difficult to Predict

    Katie Bechman1, L. Tweehuysen2, James Galloway3, Andrew P. Cope4 and Margaret Ma1, 1Academic Rheumatology Department, Kings College London, London, United Kingdom, 2Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 3King's College Hospital, Department of Rheumatology, London, London, United Kingdom, 4Academic Department of Rheumatology in the Division of Immunology, Infection and Inflammatory Diseases (DIIID), King's College London, London, Great Britain

    Background/Purpose: Disease flares in RA are associated with radiographic progression1 and functional deterioration2. Predicting flare is of direct relevance to clinical practice, particularly in patients…
  • Abstract Number: 1375 • 2017 ACR/ARHP Annual Meeting

    Foot Arthritis : Poor Prognosis Factor in RA

    Sung-Hae Chang1, Sung Won Lee2, Mi-Il Kang3 and Seong Yong Kim4, 1Soonchunhyang University Cheonan Hospital, Cheonan, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Department of Rheumatology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea, Republic of (South), 3Dankuk University Hospital, Cheonan, Korea, Republic of (South), 4Application Statistics, Hoseo University, Cheonan, Korea, Republic of (South)

    Background/Purpose: The objective of the current study is to evaluate the clinical importance of foot and ankle joint arthritis.Methods: Data from Korean Biologic Registry (KoBio)…
  • Abstract Number: 1376 • 2017 ACR/ARHP Annual Meeting

    Diagnostic Performance of 7 Different Anti-Cyclic Citrullinated Peptide Antibody and 6 Rheumatoid Factor Assays in a Primary Diagnostic, Consecutive Rheumatological Population in a Secondary Care Hospital

    Lieve Van Hoovels1, Julie Jacobs1, Bert Vander Cruyssen2, Stefanie Van den Bremt1, Patrick Verschueren3 and Xavier Bossuyt4, 1Laboratory medicine, OLV Hospital, Aalst, Belgium, 2Rheumatology, OLV hospital, Aalst, Belgium, 3Division of Rheumatology, University Hospital Leuven, Leuven, Belgium, 4Laboratory medicine, University Hospital Leuven, Leuven, Belgium

    Background/Purpose: The clinical diagnosis of rheumatoid arthritis (RA) remains a challenge, making serological markers most interesting. The 2010 ACR/EULAR classification criteria for RA take into…
  • Abstract Number: 1377 • 2017 ACR/ARHP Annual Meeting

    The Serum Levels of Semaphorin 4D Are Associated with Disease Activity As Well As Radiographic Progression in Patients with Rheumatoid Arthritis

    Ji Hyoun Kim1, You-Jung Ha2, Sang Wan Chung3, Eun Ha Kang2, Yeong Wook Song4,5 and Yun Jong Lee6, 1Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Korea, Republic of (South), 3Department of Internal Medicine, Department of Internal Medicine, Sarang Hospital, Incheon, Korea, Republic of (South), 4Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South), 5WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Medical Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), 6Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea, Republic of (South)

    Background/Purpose: Progranulin (PGRN) and semaphorins (sema) are known to be involved in immune responses as well as bone remodeling process. The aim of this study…
  • Abstract Number: 1378 • 2017 ACR/ARHP Annual Meeting

    Low HDL Level As a Clinical Marker of Disease Activity in Rheumatoid Arthritis Patients

    Rocío Gamboa-Cárdenas1, Manuel Ugarte-Gil2, Francisco Zevallos1, Mariela Medina1, Zoila Rodriguez-Bellido1, Claudia Elera-Fitzcarrald1, Omar Sarmiento-Velasquez1, Cristina Reategui-Sokolova1, Victor Pimentel-Quiroz1, José Alfaro1, Mariano Cucho-Venegas1, Risto Perich-Campos3 and Cesar A. Pastor-Asurza1, 1Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, 2Peru, GLADEL, Lima, Peru, 3Rheumatology, Hospital Guillermo Almenara Irigoyen, Lima, Peru

    Background/Purpose: In contrast to high evidence of HDL inflammatory function in cardiovascular risk in rheumatoid arthritis (RA) patients, there is scarce data about the total…
  • Abstract Number: 1379 • 2017 ACR/ARHP Annual Meeting

    Epithelial Neutrophil-Activating Peptide 78/C-X-C Motif Chemokine 5 in the Insulin Resistance of Patients with Rheumatoid Arthritis

    Hiurma Sanchez-Perez1, Beatriz-Segura Tejera2, De Vera-González AM3, Alejandra González Delgado4, Jose M Olmos5, José Luis Hernandez6, Begoña Ubilla7, Raquel Lopez-Mejías8, Miguel Angel González-Gay9 and Ivan Ferraz-Amaro10, 1Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, La Laguna. Tenerife, Spain, 2Rheumatology section, Hospital Germans Trias i Pujol, Badalona, Spain, 3Central Laboratory Division, University Hospital of Canary Islands, Tenerife, Spain, 4Central Laboratory Division. Hospital Universitario de Canarias, Tenerife, Spain., Tenerife, Spain, 5Division of Internal Medicine. Hospital Universitario Marqués de Valdecilla, IDIVAL.Universidad de Cantabria. RETICEF, Santander, Spain, 6Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 7Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, 8Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 9Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Johannesburg, South Africa, 10Rheumatology, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain

    Background/Purpose: It is known that the chemokine molecule CXCL5 (C-X-C motif chemokine 5 or epithelial neutrophil activating peptide 78 -ENA78-) is a link between obesity,…
  • Abstract Number: 1380 • 2017 ACR/ARHP Annual Meeting

    Serum Galectin-3 in Rheumatoid Arthritis Compared with Healthy Controls and Subjects with Prediabetes before and after High-Intensity Interval Training

    Brian J. Andonian1, David Bartlett2, Virginia B. Kraus3, Janet Huebner2, William E. Kraus4 and Kim M. Huffman5, 1Rheumatology, Duke University Medical Center, Durham, NC, 2Duke University, Durham, NC, 3Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 4Duke University School of Medicine, Durham, NC, 5School of Medicine, Division of Rheumatology, Immunology and Molecular Physiology and Durham VA Medical Center, Duke University, Durham, NC

    Background/Purpose: Rheumatoid arthritis (RA) is associated with significant cardiovascular disease (CVD), sarcopenic obesity, and mortality. Galectin-3 is a biomarker associated with inflammation, fibrosis, and increased…
  • Abstract Number: 1381 • 2017 ACR/ARHP Annual Meeting

    Skeletal Muscle Cytokine and Myostatin Responses to High-Intensity Interval Training in Rheumatoid Arthritis Contrasted with Prediabetes Mellitus

    Brian J. Andonian1, David Bartlett2, Virginia B. Kraus3, Janet Huebner2, William E. Kraus4 and Kim M. Huffman5, 1Rheumatology, Duke University Medical Center, Durham, NC, 2Duke University, Durham, NC, 3Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 4Duke University School of Medicine, Durham, NC, 5School of Medicine, Division of Rheumatology, Immunology and Molecular Physiology and Durham VA Medical Center, Duke University, Durham, NC

    Background/Purpose: Sarcopenic obesity and the associated risk of cardiovascular disease (CVD) and mortality in rheumatoid arthritis (RA) may be related to dysregulated skeletal muscle remodeling…
  • Abstract Number: 1382 • 2017 ACR/ARHP Annual Meeting

    Characteristics of Patients with Rheumatoid Arthritis and Atlanto-Axial Pannus

    Jessica Williams1, Andrew Joyce2, Glenn Gaviola1, Zacharia Isaac1,2 and Joerg Ermann3, 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, 3Harvard Medical School, Boston, MA

    Background/Purpose: Formation of pannus, an inflammatory tissue mass, in the atlanto-axial joint of the cervical spine is an important sequela of rheumatoid arthritis (RA). Atlanto-axial…
  • Abstract Number: 1383 • 2017 ACR/ARHP Annual Meeting

    IMPACT of Smoking in the Expression of Periodontitis and Anticitrullinated Protein Antibodies in Rheumatoid Arthritis

    Jerián González Febles1, Jorge Luis Garnier Rodríguez2, Fernando Sánchez-Alonso3, Sagrario Bustabad4, Federico Díaz-González5, Mariano Sanz Alonso1 and Beatriz Rodriguez Lozano6, 1Periodontology, Universidad Complutense de Madrid, Madrid, Spain, 2Odontology, Dental Clinic Garnier, S/C Tenerife, Spain, 3Unidad de Investigación, Spanish Society of Rheumatology, Madrid, Spain, 4Rheumatology, Servicio de Reumatología. Hospital Universitario de Canarias, La Laguna, Tenerife, Spain, 5Servicio de Reumatología. Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 6Rheumatology, Hospital de Canarias, S/C Tenerife, Spain

    Background/Purpose: Environmental, genetic and epigenetic factors can induce citrullination of structural peptides by the enzyme PAD, which induce anti-citrullinated protein antibodies (ACPA) preceding RA. Among…
  • Abstract Number: 1384 • 2017 ACR/ARHP Annual Meeting

    Physician Global Assessments for Disease Activity in Rheumatoid Arthritis Are All over the Map!

    Matthew Turk1 and Janet E. Pope2, 1Biochemistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada, 2Department of Medicine, Division of Rheumatology, University of Western Ontario, St Joseph's Health Care, London, ON, Canada

    Background/Purpose: Assessments of disease activity in rheumatoid arthritis (RA) determine the course of treatment. Physician global assessments of disease activity (MD globals) are important outcomes…
  • Abstract Number: 1385 • 2017 ACR/ARHP Annual Meeting

    Decisional Conflict in Doctor – Patient Discussions about Disease Modifying Anti-Rheumatic Drugs

    Rohit Nallani1 and Richard W Martin2, 1Michigan State University, College of Human Medicine, Grand Rapids, MI, 2Medicine, Rheumatology, Michigan State University, College of Human Medicine, Grand Rapids, MI

    Background/Purpose: There are few published studies describing patient-physician discussions about initiating new rheumatoid arthritis (RA) medications in real world settings. The purpose of this study…
  • Abstract Number: 1386 • 2017 ACR/ARHP Annual Meeting

    Tenosynovitis in the Forefoot at Disease Presentation Is Specific for RA: Results from a Cross-Sectional MRI Study in Early Arthritis

    Yousra J. Dakkak1, Debbie M. Boeters2, Annette H.M. van der Helm-van Mil2 and M. Reijnierse3, 1Rheumatology, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The foot is a preferential location for rheumatoid arthritis (RA)-manifestation, but physical examination of the metatarsophalangeal (MTP) joints is difficult. Magnetic Resonance Imaging (MRI)…
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