Abstracts Archive - Page 1292 of 2607 - ACR Meeting Abstracts

Abstract Number: 1585 • 2018 ACR/ARHP Annual Meeting
Primary Sjögren’s Syndrome Stratification Based on the Severity of Patient-Reported Fatigue
Saviana Gandolfo, Elena Doriguzzi Breatta, Cinzia Fabro and Salvatore De Vita, Rheumatology Clinic, Academic Hospital S. M. della Misericordia, Medical Area Department, University of Udine, Italy, Udine, Italy
Background/Purpose: Fatigue is one of the most common symptoms reported by patients affected by primary Sjögren’s syndrome (pSS), and a major contributor to impaired quality…
Abstract Number: 1586 • 2018 ACR/ARHP Annual Meeting
Expression of JAK Proteins and Autophagy Markers in Sjögren’s Syndrome Patients
María-José Barrera^1,2, Sergio Aguilera³, Isabel Castro², Patricia Carvajal², Sergio González⁴, Claudio Molina¹, Ulises Urzua² and María-Julieta González², ¹Facultad de Odontología, Universidad San Sebastián, Santiago, Chile, ²Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile, ³Reumatologia, Clinica Indisa, Santiago, Chile, ⁴Facultad de Odontología, Universidad Mayor, Santiago, Chile
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune epitheliitis that mainly affects the salivary and lachrymal glands. The glandular hypofunction has been associated to loss of…
Abstract Number: 1587 • 2018 ACR/ARHP Annual Meeting
Pathogenic Role of Interleukin 27 in the Nonobese Diabetic Mouse Model of Sjögren Syndrome
Scott Lieberman¹, Jennifer Barr², Xiaofang Wang² and Yi-Guang Chen³, ¹Division of Rheumatology, Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, ²Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, ³Pediatrics, Medical College of Wisconsin, Milwaukee, WI
Background/Purpose: Sjögren syndrome is an immunologically complex autoimmune disease characteristically targeting the lacrimal and salivary glands leading to progressively worsening oral and ocular health and…
Abstract Number: 1588 • 2018 ACR/ARHP Annual Meeting
Risk of Cancer in Patients with Psoriasis/Psoriatic Arthritis: A Population-Based Study in the Province of British Columbia
Julia Tan¹, J. Antonio Avina-Zubieta², Alyssa Dominique³, Hamid Tavakoli⁴ and Teresa A Simon³, ¹Medicine, University of British Columbia, Vancouver, BC, Canada, ²Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ³Bristol-Myers Squibb, Princeton, NJ, ⁴Arthritis Research Canada, Vancouver, BC, Canada
Background/Purpose: Psoriasis (PsO) is a relapsing chronic autoimmune disease of the skin. Up to one-third of patients (pts) also develop inflammatory arthritis, known as psoriatic…
Abstract Number: 1589 • 2018 ACR/ARHP Annual Meeting
Cardiac Biomarkers and Carotid Atherosclerosis and Its Progression in Psoriatic Disease
Lihi Eder¹, Vinod Chandran², Iain B. McInnes³, Richard J. Cook⁴, Dafna D Gladman⁵, Paul Welsh⁶, Naveed Sattar⁷ and Paula Harvey⁸, ¹Women's College Research Institute, University of Toronto, Women's College Hospital, Toronto, ON, Canada, ²Krembil Research Institute & University of Toronto, Toronto, ON, Canada, ³University of Glasgow, Glasgow, United Kingdom, ⁴Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁵Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁶nstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom, ⁷Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom, ⁸Cardiology, Women's College Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Laboratory biomarkers indicative of cardiac ischemia or dysfunction improve cardiovascular (CV) risk stratification in the general population. Their utility in patients with psoriatic disease…
Abstract Number: 1590 • 2018 ACR/ARHP Annual Meeting
Metabolomics Profile Predicts Carotid Atherosclerosis Progression in Psoriatic Disease
Lihi Eder¹, Paula Harvey², Paul Welsh³, Vinod Chandran⁴, Iain B. McInnes⁵, Richard J. Cook⁶, Dafna D Gladman⁷ and Naveed Sattar⁸, ¹Women's College Research Institute, University of Toronto, Women's College Hospital, Toronto, ON, Canada, ²Cardiology, Women's College Hospital, University of Toronto, Toronto, ON, Canada, ³nstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom, ⁴Krembil Research Institute & University of Toronto, Toronto, ON, Canada, ⁵University of Glasgow, Glasgow, United Kingdom, ⁶Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁷Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁸Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Metabolomic profiling of patients with psoriatic disease (PsD) offers unparalleled opportunity to unravel the molecular and clinical interactions linking PsD with cardiovascular (CV) risk.…
Abstract Number: 1591 • 2018 ACR/ARHP Annual Meeting
Is Enthesitis a Marker of Disease Severity in Early Psoriatic Arthritis?
Lihi Eder¹, Chandra Farrer² and Dana Jerome³, ¹Women's College Research Institute, University of Toronto, Women's College Hospital, Toronto, ON, Canada, ²Rheumatology, Women's College Hospital, Toronto, ON, Canada, ³University of Toronto, Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Enthesitis is a key feature in psoriatic arthritis (PsA) affecting approximately a third of the patients. Ultrasound improves the detection of enthesitis compared to…
Abstract Number: 1592 • 2018 ACR/ARHP Annual Meeting
Frequency and Pattern of the Uveitis in Spondyloarthritis with Biological Therapy
Itziar Calvo Zorrilla¹, Edurne Guerrero Basterretxea¹, Oihane Ibarguengoitia¹, David Montero¹, Maria Luz Garcia Vivar¹, Esther Ruíz Lucea², Ignacio Torre Salaberri², Olaia Begoña Fernandez Berrizbeitia², Juan Maria Blanco Madrigal², Ana Rosa Inchaurbe Pellejero¹, Clara Eugenia Perez Velasquez², Natalia Rivera-García³, Maria Jesus Allande Lopez Linares³, Iñigo Gorostiza-Hormaetxe⁴ and Eva Galíndez Agirregoikoa², ¹Rheumatology, Rheumatology Department; Basurto University Hospital, Bilbao, Spain, ²Rheumatology Department; Basurto University Hospital, Bilbao, Spain, ³Rheumatology, University Hospital of Basurto, Bilbao, Spain, ⁴Research Department, Basurto University Hospital, Bilbao, Spain
Background/Purpose: Uveitis is the most frequent extra-articular manifestation (EAM) of spondyloarthritis (SpA). Its prevalence is approximately 30% and increases with the duration of the SpA. The…
Abstract Number: 1593 • 2018 ACR/ARHP Annual Meeting
Extra-Articular Manifestations, Neoplasms and Cardiovascular Events in a Series of Spondyloarthritis from a Single Center
Itziar Calvo Zorrilla¹, Edurne Guerrero Basterretxea¹, Oihane Ibarguengoitia¹, David Montero¹, Maria Luz Garcia Vivar¹, Esther Ruíz Lucea², Ignacio Torre Salaberri², Olaia Begoña Fernandez Berrizbeitia², Juan Maria Blanco Madrigal², Ana Rosa Inchaurbe Pellejero¹, Clara Eugenia Perez Velasquez², Natalia Rivera-García³, Maria Jesus Allande Lopez Linares³, Iñigo Gorostiza-Hormaetxe⁴ and Eva Galíndez Agirregoikoa², ¹Rheumatology, Rheumatology Department; Basurto University Hospital, Bilbao, Spain, ²Rheumatology Department; Basurto University Hospital, Bilbao, Spain, ³Rheumatology, University Hospital of Basurto, Bilbao, Spain, ⁴Research Department, Basurto University Hospital, Bilbao, Spain
Background/Purpose: Spondyloarthritis(SpA) is characterized by axial, peripheral and extra-articular manifestation(EAMs). Its frequency depends on the series, being the psoriasis(Ps), uveitis and inflammatory bowel disease(IBD) the…
Abstract Number: 1594 • 2018 ACR/ARHP Annual Meeting
Liver Enzyme Elevation in Patients with Ankylosing Spondylitis Treated with TNF Inhibitor: A Single-Center Historical Cohort Study
Su Jin Choi, Ji Seon Oh, Seokchan Hong, Yong-Gil Kim, Chang Keun Lee and Bin Yoo, Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of (South)
Background/Purpose: TNF inhibitors have been known to cause liver enzyme elevation in rheumatologic disease. However, liver enzyme elevation could be affected easily by other causes…
Abstract Number: 1595 • 2018 ACR/ARHP Annual Meeting
Malignancy in Psoriatic Disease
Anastasiya Muntyanu¹, Ker-Ai Lee², Justine Y. Ye³, Ari Polachek³, Vinod Chandran⁴, Richard J. Cook² and Dafna D Gladman¹, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ³Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Medicine, Krembil Research Institute, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: There are conflicting data between studies of psoriasis and psoriatic arthritis (PsA), and there have been recent concerns about the potential of anti-TNF agents…
Abstract Number: 1596 • 2018 ACR/ARHP Annual Meeting
Atherosclerotic Cardiovascular Disease in Psoriatic Arthritis: Evaluation of Risk Factor Management and Use of Aspirin and Statin for Prevention in a Primary Care Setting
Linh Truong¹, Nicole Ridolfi¹ and Maida Wong^2,3, ¹Internal Medicine, University of California, Irvine, Orange, CA, ²Department of Medicine, University of California, Irvine, orange, CA, ³Division of Rheumatology, Tibor Rubin Veterans Affairs Medical Center Long Beach, Long Beach, CA
Background/Purpose: There is accumulating evidence that shows an increased prevalence of atherosclerotic cardiovascular disease (ASCVD) risk factors among the psoriatic arthritis (PsA) population. The aim…
Abstract Number: 1597 • 2018 ACR/ARHP Annual Meeting
Bone Mineral Density and Serum Biomarkers of Bone Turnover in Ankylosing Spondylitis Patients Treated with Secukinumab: 2-Year Data from the Pivotal Phase 3 Study
Jürgen Braun¹, Bjoern Buehring¹, Xenofon Baraliakos¹, Lianne S. Gensler², Brian Porter³, Abhijit Shete⁴, Erhard Quebe-Fehling⁵ and Sibylle Haemmerle⁵, ¹Ruhr-University Bochum, Herne, Germany, ²University of California, San Francisco, CA, ³Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA, East Hanover, NJ, ⁴Novartis Pharma AG, Basel, Switzerland, Basel, Switzerland, ⁵Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Low bone mass is common in ankylosing spondylitis (AS) and patients (pts) with AS have an increased risk of bone fracture.1-3 Treatment of AS…
Abstract Number: 1598 • 2018 ACR/ARHP Annual Meeting
Depression and Anxiety Reduce Probability of Achieving a State of Minimal Disease Activity in Patients with Psoriatic Arthritis
Antonio Wong Lam¹, Justine Y. Ye², Dafna D Gladman¹ and Vinod Chandran², ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Depression and/or anxiety are comorbidities associated with psoriatic arthritis (PsA) that may affect treatment response. We aimed to determine whether the presence of depression/anxiety…
Abstract Number: 1599 • 2018 ACR/ARHP Annual Meeting
Performance of Referral Strategies for Spondyloarthritis: A Population-Based Nationwide Study
Alexandre Sepriano^1,2, Sofia Ramiro^1,2, Filipe Araújo³, Pedro Machado⁴, Ana M. Rodrigues^1,5, Nélia Gouveia^1,5, Mónica Eusébio⁵, Helena Canhão^5,6 and Jaime Cunha Branco^1,5, ¹CEDOC, NOVA Medical School, Lisbon, Portugal, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Hospital Ortopédico de Sant ‘Ana, Cascais, Portugal, ⁴University College London - MRC Centre for Neuromuscular Diseases, London, United Kingdom, ⁵EpiReumaPt Study Group, Lisbon, Portugal, ⁶EPIDOC, Nova Medical School, Faculdade Ciências Médicas, Lisboa, Portugal
Background/Purpose: Several strategies have been proposed to promote early referral of patients with SpA, but consensus on the ‘best’ strategy is yet to be achieved.…

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