Abstracts Archive - Page 1286 of 2425 - ACR Meeting Abstracts

Abstract Number: 1207 • 2017 ACR/ARHP Annual Meeting
Clinical Relevance of Structural Measures in Knee Osteoarthritis: Baseline Values and Change from Baseline Discriminate Patients Subsequently Receiving Knee Replacement
C. Kent Kwoh¹, Hans Guehring², Michael J Hannon³ and Aida Aydemir⁴, ¹University of Arizona Arthritis Center, Tuscan, AZ, ²Merck KGaA, Darmstadt, Germany, ³Medicine, University of Pittsburgh, Pittsburgh, PA, ⁴EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA
Background/Purpose: Structural measures of knee OA (KOA) progression include assessment of radiographic joint space width (JSW) and quantitative MRI (qMRI) measurement of cartilage thickness, both…
Abstract Number: 1208 • 2017 ACR/ARHP Annual Meeting
Levels of Serum Biomarkers from a Two-Year Multicentre Trial Are Associated with Treatment Response on Knee Osteoarthritis Cartilage Loss As Assessed By MRI: An Exploratory Study
Johanne Martel-Pelletier¹, Jean-Pierre Raynauld¹, François Mineau¹, François Abram², Patrice Paiement³, Philippe Delorme³ and Jean-Pierre Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ³ArthroLab Inc., Montreal, QC, Canada
Background/Purpose: There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in…
Abstract Number: 1209 • 2017 ACR/ARHP Annual Meeting
Phospholipase A2 Group 5 Is a Potential Therapeutic Target for Osteoarthritis Treatment
Ming Liu¹, Andrew Furey², Weidong Zhang³, Sergei Likhodi², Edward Randell², Proton Rahman⁴ and Guangju Zhai², ¹Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ²Memorial University of Newfoundland, St. John's, NF, Canada, ³Jilin University, Changchun, China, ⁴Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada
Background/Purpose: We recently discovered that lysophosphotidylcholines (lysoPCs) to phosphotidylcholines (PCs) ratio was associated with knee osteoarthritis (OA), suggesting that the conversion of PCs to lysoPCs…
Abstract Number: 1210 • 2017 ACR/ARHP Annual Meeting
Non-Responders to Total Joint Replacement Therapy in Osteoarthritis Patients and Novel Metabolic Markers
Guangju Zhai¹, Ming Liu², Quan Li¹, Andrew Furey¹, Weidong Zhang³, Sergei Likhodi¹, Edward Randell¹ and Proton Rahman⁴, ¹Memorial University of Newfoundland, St. John's, NF, Canada, ²Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ³Jilin University, Changchun, China, ⁴Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, and is the major source of joint pain and disability. The aim of the study…
Abstract Number: 1211 • 2017 ACR/ARHP Annual Meeting
Biomarkers Predictive of Pain Improvement in Knee Osteoarthritis Subjects Treated with the Anti-IL-1α/β Dual Variable Domain Immunoglobulin ABT-981
Sheng Feng¹, Su Chen¹, Li Wang¹, Charles Peterfy², Virginia B. Kraus³, Rajesh Kamath¹, Lanju Zhang¹, Yanping Luo¹, Lu Cui¹, Jeroen K. Medema¹ and Marc C. Levesque¹, ¹AbbVie Inc., North Chicago, IL, ²Spire Sciences, Inc., Boca Raton, FL, ³Duke University School of Medicine, Durham, NC
Background/Purpose: Development of disease-modifying drugs for OA has been challenging, partly due to lack of predictive biomarkers. Our primary objective was to identify baseline (BL)…
Abstract Number: 1212 • 2017 ACR/ARHP Annual Meeting
Relation of Incident Bisphosphonate Use to Bone Marrow Lesion Volume in Knee Osteoarthritis
Tuhina Neogi¹, Jeffrey Duryea², Na Lu¹, Jingbo Niu¹ and Yuqing Zhang¹, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA
Background/Purpose: Bone marrow lesions (BMLs) are important contributors to pain and progression of knee OA. There has been recent interest in bisphosphonates as a potential…
Abstract Number: 1213 • 2017 ACR/ARHP Annual Meeting
Prediction Model for the Two-Year Risk of Fracture Among Older US Women
Annette Adams¹, Akhila Balasubramanian², Hui Zhou³, Robert Platt⁴, Deborah Wenkert⁵, Steven Jacobsen³ and Eric Johnson⁶, ¹Kaiser Permanente Southern California, Pasadean, CA, ²Amgen Inc., Thousand Oaks, CA, ³Kaiser Permanente Southern California, Pasadena, CA, ⁴McGill University, Montreal, QC, Canada, ⁵Wenkert & Young, LLC, Thousand Oaks, CA, ⁶Kaiser Permanente Northwest, Portland, OR
Background/Purpose: Current algorithms for identifying patients at high risk of fracture focus on long-term risk. We developed simple 10- and 3-predictor models and points-based risk…
Abstract Number: 1214 • 2017 ACR/ARHP Annual Meeting
Fracture Incidence and Characteristics in Young Adults Age 18 to 49 Years: A Population-Based Study
Joshua N. Farr¹, L. Joseph Melton III¹, Sara J. Achenbach¹, Elizabeth J. Atkinson¹, Sundeep Khosla¹ and Shreyasee Amin², ¹Mayo Clinic, Rochester, MN, ²Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: While fractures in both the elderly and pediatric populations have been extensively investigated, comparatively little attention has been given to the age-group in between.…
Abstract Number: 1215 • 2017 ACR/ARHP Annual Meeting
Chest Radiography As a Screening Tool to Detect Fragile Spine Fractures
Yasuhiro Suyama¹, Mitsumasa Kishimoto², Taiki Nozaki³, Tetsuhiko Okabe⁴ and Masato Okada², ¹Rheumatology, JR Tokyo General Hospital, Tokyo, Japan, ²Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ³Radiology, St. Luke’s International Hospital, Tokyo, Japan, ⁴Radiology, Yokohama City University, Yokohama, Japan
Background/Purpose: Osteoporosis screening is essential in the management of rheumatoid arthritis, and evaluation of fragile spine fractures is one of the recommended examinations. Digital chest…
Abstract Number: 1216 • 2017 ACR/ARHP Annual Meeting
Odontoid Fractures in the Elderly: An Unknown Osteoporotic Fracture?
Veronique Breuil¹, Lauren Natella², Nicolas Bronsard³, Jeremy Allia³, Laurent Hekayem⁴, Liana Euller Ziegler⁵ and Fernand De Peretti⁶, ¹Rheumatology department, Nice, France, ²Rheumatology, CHU Nice, nice, France, ³Orthopedic, CHU Nice, Nice, France, ⁴Emergency, CHU Nice, Nice, France, ⁵151 rte de St Antoine de Gines, CHU de Nice -Université Nice Sophia Antipolis, Nice, France, ⁶orthopedic, CHU Nice, Nice, France
Background/Purpose: Current WHO definition of osteoporosis excludes cervical fractures. However, in atraumatic odontoid fractures, mainly reported by orthopedic surgeons, bone status has not been described…
Abstract Number: 1217 • 2017 ACR/ARHP Annual Meeting
Evaluation of Post Fracture Management in Males at a Veterans Affairs Health System
Nicola Berman¹, David Smith², Virginia Pike³, Craig Tenner⁴, Michael Pillinger¹ and Stephen Honig¹, ¹Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY, ²School of Medicine, New York University School of Medicine, New York, NY, ³Medicine/Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY, ⁴New York University School of Medicine, Internal Medicine, New York, NY
Background/Purpose: The worldwide incidence of hip fractures in men is rising, and by 2050 is projected to increase by 310%. Increased hip fracture rates may…
Abstract Number: 1218 • 2017 ACR/ARHP Annual Meeting
Caffeine Consumption and Risk of Osteoporosis: A Cross Sectional Study of 3, 210 Patients from the National Health and Nutrition Examination Survey
Nicola Berman¹, Teresa Attina², Bruce Cronstein¹, Stephen Honig¹ and Michael Pillinger¹, ¹Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY, ²Pediatrics, New York University School of Medicine, New York, NY
Background/Purpose: Adenosine regulates bone metabolism. In vitro studies suggest that direct stimulation of the adenosine A2A receptor increases osteoblasts and diminishes osteoclasts, and thus inhibition…
Abstract Number: 1219 • 2017 ACR/ARHP Annual Meeting
Associations between Muscle Mass and Function with Bone Microarchitecture and Bone Strength in Postmenopausal Women
Daniel Lobo¹, Jackeline C Alvarenga¹, Diogo S Domiciano², Fabiana Benatti¹, Bruno Gualano¹ and Rosa M R Pereira², ¹Rheumatology Division, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil, ²Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
Background/Purpose: Most studies on sarcopenia and osteoporosis involve elderly populations. However, because postmenopausal hypoestrogenism is able to negatively modulate bone and muscle mass, it is…
Abstract Number: 1220 • 2017 ACR/ARHP Annual Meeting
Effect of Anti-Diabetic Medications on Fracture Risk in Type II Diabetes Mellitus
Youmna Lahoud¹, Christine Peloquin¹, Yuqing Zhang² and Devyani Misra³, ¹Boston University School of Medicine, Boston, MA, ²School Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Medicine, Section of, Boston University School of Medicine, Boston, MA
Background/Purpose: Risk of osteoporotic fracture in type II Diabetes Mellitus is conflicting and possibly related to the anti-diabetic medication used. There is evidence to suggest…
Abstract Number: 1221 • 2017 ACR/ARHP Annual Meeting
Differences in BONE Metabolism between Intermittent and Continuous Treatment with LHRH Agonists in Prostate Cancer Patients
Karla Arevalo Ruales¹, Jose Ivorra Cortes¹, Cesar David Vera Donoso², Elena Grau Garcia¹, Cristina Alcañiz Escandell¹, Ines Canovas Olmos¹, Inmaculada Chalmeta Verdejo¹, Carlos Feced Olmos¹, Jorge Juan Fragio Gil¹, Roxana Gonzalez Mazario¹, Luis Gonzalez Puig¹, Eztizen Labrador Sanchez¹, Isabel Martinez Cordellat¹, Carmen Najera Herranz¹, Rosa Negueroles Albuixech¹, Jose Eloy Oller Rodriguez¹, Francisco Miguel Ortiz-Sanjuán¹, Elvira Vicens Bernabeu¹, David Hervás Marín³, Marta De la Rubia Navarro¹ and Jose Andres Roman Ivorra¹, ¹Rheumatology Department. Hospital Universitario y Politecnico La Fe, Valencia, Spain, ²Urology Department. Hospital Universitario y Politecnico La Fe, Valencia, Spain, ³Biostatistics Unit. IIS La Fe, Valencia, Spain
Background/Purpose: Prostate cancer is the most common male malignancy. It is hormone dependent and androgenic inhibition with LHRH agonists is one of the mainstays of…

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