Abstracts Archive - Page 1268 of 2425 - ACR Meeting Abstracts

Abstract Number: 937 • 2017 ACR/ARHP Annual Meeting
Treatment Response in Polyarticular JIA Is Associated with Transcriptional Changes and Chromatin Reorganization in CD4+ T Cells
Evan Tarbell¹, Kaiyu Jiang², Yanmin Chen², Tao Liu³ and James Jarvis⁴, ¹Biochemistry, University at Buffalo, Buffalo, NY, ²Pediatrics, University at Buffalo, Buffalo, NY, ³Biochemistry, University at Buffalo Jacobs School of Medicine, Buffalo, NY, ⁴Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY
Background/Purpose: To identify transcriptional changes in CD4+ T cells as children with polyarticular JIA transition from active disease to remission, and to identify underlying changes…
Abstract Number: 938 • 2017 ACR/ARHP Annual Meeting
A Germline Macrophage Activation Syndrome-Associated Nlrc4 Mutation Causes Chronic, Systemic, Non-Hematopoietic IL-18 Elevation and Intestinal MHC-II Upregulation
Eric Weiss¹, Corinne Schneider² and Scott Canna³, ¹RK Mellon Institute, Children’s Hospital of Pittsburgh, Pittsburgh, PA, ²Pediatrics, Children's Hospital Pittsburgh, Pittsburgh, PA, ³NIAMS, National Institutes of Health, Bethesda, MD
Background/Purpose: Patients prone to the development of Macrophage Activation Syndrome (MAS) can have extreme and often chronic elevation in the pro-inflammatory cytokine interleukin-18 (IL-18). In…
Abstract Number: 939 • 2017 ACR/ARHP Annual Meeting
Stimulator of Interferon Genes (STING)-Induced Endothelial-Mesenchymal Transition (EndMT) Contributes to Interstitial Lung Disease in Sting-Associated Vasculopathy with Onset in Infancy (SAVI) Patients
Louise Malle¹, Dan Yang², Adriana Almeida de Jesus¹, Guibin Chen², Bernadette Marrero¹, Gina A. Montealegre Sanchez¹, Yin Liu³, Gregor Dueckers⁴, Suzanne Ramsey⁵, Joseph Fontana⁶, Rachel VanTries¹, Yan Huang¹, Laisa Santiago⁷, Benito Gonzalez⁸, Paul Brogan⁹, Juergen Brunner¹⁰, Ebun Omoyinmi¹¹, Athimalaipet V. Ramanan¹², Amy Paller¹³, Olcay Y. Jones¹⁴, Seza Ozen¹⁵, Stephen R. Brooks¹⁶, Manfred Boehm¹⁷ and Raphaela Goldbach-Mansky¹, ¹Translational Autoinflammatory Disease Studies (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, ²Center for Molecular Medicine, NHLBI/NIH, Bethesda, MD, ³Scientific Review Branch, NIAMS/NIH, Bethesda, MD, ⁴Helios Kliniken - Kinderklinik, HELIOS Klinikum Krefeld, Krefeld, Germany, ⁵Pediatric Rheumatology, IWK Health Centre, Dalhousie University, Halifax, NS, Canada, ⁶Cardiovascular and Pulmonary Branch, NHLBI/NIH, Bethesda, MD, ⁷Johns Hopkins All Children's Hospital Rheumatology, Saint Petersburg, FL, ⁸Luis Calvo Mackenna Hospital, Santiago, Chile, ⁹Infection Inflammation and Rheumatology, UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, ¹⁰Division of Pediatric Rheumatology, Medical University Innsbruck, Innsbruck, Austria, ¹¹University College London Institute of Child Health, London, United Kingdom, ¹²Bristol Royal Hospital for Children, Bristol, United Kingdom, ¹³Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IN, ¹⁴Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, ¹⁵Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ¹⁶Biodata Mining and Discovery Section, Office of Science and Technology, NIAMS/NIH, Bethesda, MD, ¹⁷Center for Molecular Medicine, NHLBI/ NIH, Bethesda, MD
Background/Purpose: Pulmonary fibrosis, is a life-threatening complication of the monogenic autoinflammatory interferonopathy, STING-Associated Vasculopathy with onset in Infancy (SAVI) that is caused by gain-of-function mutations…
Abstract Number: 940 • 2017 ACR/ARHP Annual Meeting
IL1RN Variation Is Associated with Systemic Juvenile Idiopathic Arthritis and Predicts Non-Response to Anakinra Treatment
Emily Shuldiner¹, Victoria Arthur¹, Anne Hinks², Patricia Woo³, Wendy Thomson², Elaine F. Remmers⁴ and Michael J. Ombrello¹, ¹Translational Genetics and Genomics Unit, NIAMS, NIH, Bethesda, MD, ²Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ³University College London, London, United Kingdom, ⁴Genetics and Genomics Branch, NIH, NIAMS, Bethesda, MD
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a childhood inflammatory disease whose pathophysiology is poorly understood. sJIA is phenotypically heterogeneous with variable manifestations and responses…
Abstract Number: 941 • 2017 ACR/ARHP Annual Meeting
Ro/SSA Autoantibody Exposed Neonates Have an Expansion of NK Cells and a Discernible Type II IFN Signature with High IFNγ in Peripheral Blood
Margarita Ivanchenko¹, Malin Hedlund¹, Gudny Ella Thorlacius¹, Vijole Ottosson¹, Karine Chemin², Sven-Erik Sonesson³ and Marie Wahren-Herlenius¹, ¹Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ³Pediatric Cardiology Unit, Department of Women´s and Children´s Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: Congenital heart block (CHB) may develop in the fetus of women with Ro/SSA autoantibodies. The mothers are commonly diagnosed with Sjögren’s syndrome or SLE.…
Abstract Number: 942 • 2017 ACR/ARHP Annual Meeting
Role of the Pyrin Inflammasome in Resistance to Yersinia Pestis: A Possible Selective Advantage for Carriers of MEFV Mutations
Yong Hwan Park¹, Wonyong Lee¹, Lawton Chung², James Bliska², Daniel L. Kastner¹ and Jae Jin Chae³, ¹Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ²Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY, ³Inflammatory disease section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
Background/Purpose: Mutations in MEFV, encoding pyrin, cause the prototypic autoinflammatory disease, familial Mediterranean fever (FMF). The carrier frequency of FMF-associated MEFV mutations is extraordinarily high…
Abstract Number: 943 • 2017 ACR/ARHP Annual Meeting
The Course of the Forced Vital Capacity during Treatment for Systemic Sclerosis-Related Interstitial Lung Disease Predicts Long-Term Survival in 2 Independent Cohorts
Elizabeth R. Volkmann¹, Donald P. Tashkin¹, Myung Sim¹, Dinesh Khanna², Michael Roth³, Philip J. Clements³, Daniel E. Furst¹, Lynette Keyes-Elstein⁴, Ashley Pinckney⁴, Ellen Goldmuntz⁵, Robert Elashoff⁶ and Keith Sullivan⁷, ¹University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²University of Michigan, Ann Arbor, MI, ³Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁴Rho Federal Systems, Inc., Chapel Hill, NC, ⁵NIAID, NIH, Bethesda, MD, ⁶University of California, Los Angeles, Los Angeles, CA, ⁷Duke University, Durham, NC
Background/Purpose: While prior observational studies have identified predictors of mortality in systemic sclerosis-interstitial lung disease (SSc-ILD), no studies have evaluated predictors of long-term mortality in…
Abstract Number: 944 • 2017 ACR/ARHP Annual Meeting
Long-Term Survival and Follow-up of Anti-Th/to Antibody Positive Systemic Sclerosis Patients
Devon Charlton¹, Maureen Laffoon², Thomas A. Medsger Jr.³ and Robyn T. Domsic⁴, ¹Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, ³Department of Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Anti-Th/To antibody is an autoantibody associated with systemic sclerosis (SSc), occurring in 5-10% of patients. To date, only relatively small case series have described…
Abstract Number: 945 • 2017 ACR/ARHP Annual Meeting
Autoantibodies to the hPOP1 and Rpp25/38 Components of the Th/to Complex Identify a Subgroup of Systemic Sclerosis (SSc) Associated Interstitial Lung Disease (ILD) and Antibodies to hPOP1 Are Associated with Reduced Survival
Jennifer G Walker¹, Mandana Nikpour², Molla Huq³, Karen Patterson¹, Peter Roberts-Thomson⁴, Susanna Proudman⁵, Wendy Stevens⁶, Susan Lester⁷, Maureen Rischmueller⁸, Jane Zochling⁹, Joanne Sahhar¹⁰, Peter Nash¹¹, Janet Roddy¹², Catherine Hill¹³, Marie Hudson¹⁴, Murray Baron¹⁵, Janet E. Pope¹⁶, Maureen D. Mayes¹⁷, Shervin Assassi¹⁸, Michael Mahler¹⁹ and Marvin J. Fritzler²⁰, ¹Flinders University of South Australia, Adelaide, Australia, ²Melbourne University, Melbourne, Australia, ³Department of Medicine (Rheumatology), Melbourne University, Melbourne, Australia, ⁴Immunology, Flinders University of South Australia, Adelaide, Australia, ⁵University of Adelaide, Adelaide, Australia, ⁶Rheumatology, St. Vincent’s Hospital, Melbourne, Australia, ⁷Queen Elizabeth Hospital, Adelaide, Australia, ⁸Medicine, University of Adelaide, Adelaide, Australia, ⁹Menzies Institute for Medical Research, Tasmania, Hobart, Australia, ¹⁰Department of Rheumatology, Monash Medical Centre, Melbourne, Australia, ¹¹University of Queensland, Brisbane, Australia, ¹²Royal Perth Hospital, Perth, Australia, ¹³Medicine, The University of Adelaide, Adelaide, Australia, ¹⁴Division of Rheumatology, Jewish General Hospital, Lady David Institute for Medical Research, Montreal, QC, Canada, ¹⁵Medicine, McGill University, Quebec, Montreal, QC, Canada, ¹⁶Department of Medicine, Division of Rheumatology, University of Western Ontario, St Joseph's Health Care, London, ON, Canada, ¹⁷Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ¹⁸University of Texas McGovern Medical School, Houston, TX, ¹⁹Research and Development, Inova Diagnostics, San Diego, CA, ²⁰Medicine, University of Calgary, Calgary, AB, Canada
Background/Purpose: The clinical associations of anti-Th/To antibodies (Abs) are not fully established, and until recently immunoprecipitation (IP) was the only reliable assay. Using IP, anti-Th/To…
Abstract Number: 946 • 2017 ACR/ARHP Annual Meeting
Clinical and Serological Features of Systemic Sclerosis in a Multicenter African American Cohort: Analysis of the Genome Research in African American Scleroderma Patients Clinical Database
Nadia D. Morgan¹, Ami A. Shah¹, Maureen D. Mayes², Robyn T. Domsic³, Thomas A. Medsger Jr.⁴, Virginia D. Steen⁵, John Varga⁶, Mary A. Carns⁷, Paula S. Ramos⁸, Richard M. Silver⁹, Elena Schiopu¹⁰, Dinesh Khanna¹⁰, Vivien Hsu¹¹, Jessica K. Gordon¹², Heather Gladue¹³, Lesley A. Saketkoo¹⁴, Lindsey A. Criswell¹⁵, Chris T. Derk¹⁶, Marcin A. Trojanowski¹⁷, Victoria K. Shanmugam¹⁸, Lorinda Chung¹⁹, Antonia Valenzuela²⁰, Reem Jan²¹, Avram Goldberg²², Elaine F. Remmers²³, Daniel L. Kastner²³, Fredrick M. Wigley²⁴, Pravitt Gourh²⁵ and Francesco Boin²⁶, ¹Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ³Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁵Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, ⁶Rheumatology and Dermatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁷Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁸Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ⁹Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ¹⁰University of Michigan, Ann Arbor, MI, ¹¹Rheumatology, Robert Wood Johnson University Scleroderma Program, New Brunswick, NJ, ¹²Rheumatology, Hospital for Special Surgery, New York, NY, ¹³Rheumatology, Arthritis and Osteoporosis Consultants of the Carolinas, Charlotte, NC, ¹⁴Rheumatology, Tulane University School of Medicine, New Orleans, LA, ¹⁵Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ¹⁶Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁷Boston University School of Medicine, Boston, MA, ¹⁸Rheumatology, The George Washington University, Washington, DC, ¹⁹Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²⁰Stanford University School of Medicine, Stanford, CA, ²¹Medicine, Rheumatology, University of Chicago, Chicago, IL, ²²NYU Langone Medical Center, New York, NY, ²³National Institutes of Health (NIH), National Human Genome Research Institute, Bethesda, MD, ²⁴Rheum Div/Mason F Lord, Johns Hopkins University, Baltimore, MD, ²⁵NIAMS-Rheumatology, National Institutes of Health (NIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, ²⁶Rheumatology, University of California, San Francisco, San Francisco, CA
Background/Purpose: Racial differences exist in the severity of systemic sclerosis (SSc). To enhance our knowledge about SSc in African Americans, we established a comprehensive clinical…
Abstract Number: 947 • 2017 ACR/ARHP Annual Meeting
Norway As a National Reference Population for Systemic Sclerosis; Preliminary Results from a Complete, Nationwide Cohort
Anna-Maria Hoffmann-Vold¹, Håvard Fretheim¹, Anne Kristine Halse², Marit Seip³, Marianne Wallenius⁴, Helle Bitter⁵, Torhild Garen¹, Oyvind Midtvedt¹ and Øyvind Molberg¹, ¹Oslo University Hospital, Oslo, Norway, ²Haukeland University Hospital, Bergen, Norway, ³University Hospital of North Norway, Tromso, Norway, ⁴St. Olav's University Hospital, Trondheim, Norway, ⁵Hospital of Southern Norway, Kristiansand, Norway
Background/Purpose: To fully understand the impact of Systemic sclerosis (SSc) there is a need to complement existing multi-center registry data with novel, unbiased, high resolution…
Abstract Number: 948 • 2017 ACR/ARHP Annual Meeting
Application of a Diagnostic Algorithm to Identify Inflammatory Myopathy in Systemic Sclerosis
Vandana Bhushan^1,2, Adam Maundrell¹, Charlotte Proudman^1,2, Leah McWilliams¹, Llew Spargo¹, Robert Metcalf¹, Jennifer Walker³, Mandana Nikpour^4,5, Wendy Stevens⁴, Vidya Limaye^1,2 and Susanna Proudman^1,2, ¹Rheumatology Unit, Royal Adelaide Hospital, South Australia, Adelaide, Australia, ²Discipline of Medicine, University of Adelaide, South Australia, Adelaide, Australia, ³Flinders University of South Australia, Adelaide, Australia, ⁴St Vincent's Hospital, Melbourne, Victoria, Melbourne, Australia, ⁵Department of Medicine, University of Melbourne, Victoria, Melbourne, Australia
Background/Purpose: Muscle involvement in systemic sclerosis (SSc) is under-recognised and poorly understood. Reported prevalence varies up to 15%, reflecting lack of consistent definition, the heterogeneous…
Abstract Number: 949 • 2017 ACR/ARHP Annual Meeting
Sequence Homology and Immune Reactivity between T Cell Epitopes of Related Gut Microbes and Two Novel Autoantigens Provide a Link between Microbial and Host Immunity in Patients with Rheumatoid Arthritis
Annalisa Pianta¹, Sheila Arvikar², Klemen Strle³, Elise E. Drouin¹, Qi Wang⁴, Catherine E. Costello⁴ and Allen C. Steere⁵, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ³Department of Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ⁴Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA, ⁵Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: It has been proposed that immunological triggers at mucosal sites, such as the gut microbiota, may promote autoimmunity affecting joints in patients with rheumatoid…
Abstract Number: 950 • 2017 ACR/ARHP Annual Meeting
Identification of Naturally Processed Immunodominant Topoisomerase I Epitopes in Patients with Systemic Sclerosis
Eleni Tiniakou¹, Andrea Fava², Tara Guhr³, Francesco Boin⁴ and Erika Darrah⁵, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins University, Baltimore, MD, ³University of North Carolina, Chapel Hill, NC, ⁴Rheumatology, University California, San Francisco, San Francisco, CA, ⁵Department of Medicine/Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Identification of immunodominant T cell epitopes of autoantigens is crucial to understanding the pathogenesis of autoimmune diseases and developing disease-specific diagnostic and therapeutic tools.…
Abstract Number: 951 • 2017 ACR/ARHP Annual Meeting
Cross Sectional Analysis of Citrullinated-Synovial Antigen-Specific CD4+ T Cells in an RA Cohort Demonstrates Antigen Based Differences in T Cell Frequency, Phenotype and the Influence of Immunotherapy
Cliff Rims¹, Sylvia Posso¹, Bernard Ng², Jeffrey Carlin³, Eddie James⁴ and Jane H. Buckner⁴, ¹Translational Research, Benaroya Research Institute at Virginia Mason, Seattle, WA, ²Rheumatology, VA Puget Sound Healthcare System, Seattle, WA, ³Rheumatology, Virginia Mason Medical Center, Seattle, WA, ⁴Benaroya Research Institute at Virginia Mason, Seattle, WA
Background/Purpose: The presence of ACPA in RA indicates that an immune response directed toward citrullinated synovial antigens participates in disease development or persistence. Research from…

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