Abstract Number: 1075 • 2018 ACR/ARHP Annual Meeting
Automated Multiparameter Microscopy and Image Analysis: Next Generation Synovial Tissue Histology
Background/Purpose: Currently, histological assessment of synovial tissue (ST) in Rheumatoid Arthritis (RA) is hampered by 3 main factors: 1) tissue is a finite resource, 2)…Abstract Number: 1076 • 2018 ACR/ARHP Annual Meeting
Phospholipase C-eta2, As a C2 Domain-Containing Protein, Regulate Aggressiveness of Fibroblast‐like Synoviocytes and Ameliorate Arthritis in Experimental Animal Models of Rheumatoid Arthritis
Background/Purpose: The C2 domain is a Ca2+-dependent membrane-targeting motif found in many cellular proteins involved in signal transduction or inflammatory pathway. However, the effects of…Abstract Number: 1077 • 2018 ACR/ARHP Annual Meeting
Identification of Biomarkers Involved in the Resolution Phase of Inflammation: Specialized Pro-Resolving Mediator Receptors Expression in Rheumatoid Arthritis
Background/Purpose: Inflammation is part of the complex biological response of body tissues to harmful stimuli, involving immune cells, blood vessels, and molecular mediators. At the…Abstract Number: 1078 • 2018 ACR/ARHP Annual Meeting
Standardization of Synovial Biopsies Procedures across Centers: A Consensus Initiative Using a Delphi Survey
Background/Purpose: Synovial biopsies are increasingly performed in both clinical setting and translational research. Synovial tissue analysis role in prediction of response to treatment is to…Abstract Number: 1079 • 2018 ACR/ARHP Annual Meeting
Plasma Metabolomic Analysis Combined with Transcriptome Data Has Revealed the Importance of Amino Acids Homeostasis in SLE Pathogenesis
Background/Purpose: Recently, many reports on immune metabolism have been accumulated and metabolic changes are now considered to be a key factor for controlling immune cell…Abstract Number: 1080 • 2018 ACR/ARHP Annual Meeting
Hypomethylation of STAT1 and HLA-DRB1 in CD8+ T Cells Is Associated with Type-I Interferon-Dependent HLA-DRB1 Overexpression and Activation of Autologous CD4+ T Cells in Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus is a chronic autoimmune disease characterized by epigenetic dysregulation, and increased autoantibody and type-I interferon (IFN) production. The goal of this…Abstract Number: 1081 • 2018 ACR/ARHP Annual Meeting
Associations between Daily Alcohol Intake and SLE-Related Cytokines and Chemokines U.S. Female Nurses without SLE
Background/Purpose: Low or no alcohol intake (0-5 gm/day or <0.5 drinks/day) has been associated with increased SLE risk among women. Several cytokines and chemokines are…Abstract Number: 1082 • 2018 ACR/ARHP Annual Meeting
Peripheral Blood CD11c+ CD21- Age-Associated B Cells (ABCs) in Human Systemic Lupus Erythematosus Are Associated with Innate Type III Interferon and Disease Activity
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by an interferon-stimulated gene (ISG) signature typically attributed to interferon (IFN)-α. However, ISGs can be induced by other…Abstract Number: 1083 • 2018 ACR/ARHP Annual Meeting
Changes of Innate Lymphoid Cells in Peripheral Blood of Patients with Systemic Lupus Erythematosus and Its Correlations with Clinical Markers
Background/Purpose: Innate Lymphoid Cells (ILCs) are a novel group of innate immune cells, according to the cytokine profile, they were divided into three major subsets:…Abstract Number: 1084 • 2018 ACR/ARHP Annual Meeting
Dysfunction of the DNASE1L3 Pathway and Antigen Accumulation in Lupus Nephritis
Background/Purpose: DNASE1L3 is a unique secreted DNase that is capable of degrading DNA complexed with proteins and/or encapsulated in membranes, such as chromatin within microparticles…Abstract Number: 1085 • 2018 ACR/ARHP Annual Meeting
Natural Gingerols Inhibit Neutrophil Extracellular Trap Release Elicited By Lupus Autoantibodies
Background/Purpose: Recent studies have revealed a role for neutrophils in the pathogenesis of lupus and antiphospholipid syndrome (APS). Indeed, neutrophils are activated by various disease-relevant…Abstract Number: 1086 • 2018 ACR/ARHP Annual Meeting
Low-Dose IL-2 Combined with Rapamycin Efficiently Promotes Remission of Refractory Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease. Regulatory T (Treg) cells and T helper type 17 (Th17) cells play opposite roles…Abstract Number: 1087 • 2018 ACR/ARHP Annual Meeting
Association between Cigarette Smoking and Systemic Lupus Erythematosus – a Bayesian Multivariate Meta-Analysis of Case-Control and Cohort Studies
Background/Purpose: The association between cigarette smoking and the occurrence of SLE has been studied over the past two decades but results are conflicting. The global…Abstract Number: 1088 • 2018 ACR/ARHP Annual Meeting
Pro-Inflammatory and Regulatory Soluble Mediator Pathways Vary between African American and European American SLE Patients
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease that primarily affects women, and is associated with periods of elevated and suppressed clinical symptoms. SLE…Abstract Number: 1089 • 2018 ACR/ARHP Annual Meeting
Commensal Gut Bacteria of Anti-Ro Positive Mothers of Children with Neonatal Lupus in Aggregate Resemble Healthy Subjects without Overt Dysbiosis of Abundance of Microorganisms
Background/Purpose: Anti-Ro60 autoantibodies are present in asymptomatic individuals years before onset of disease. We hypothesize that differences in autoreactivity-inducing commensal abundances may drive progression to…
ACR Meeting Abstracts