Abstracts Archive - Page 1254 of 2425 - ACR Meeting Abstracts

Abstract Number: 727 • 2017 ACR/ARHP Annual Meeting
Survival and Clinical-Capillaroscopic Characteristics of French Canadian Systemic Sclerosis Patients: Analysis Based on Systemic Sclerosis Autoantibodies and the Novel Anti-BICD2 Autoantibody
Boyang Zheng¹, Michael Mahler², Jean-Luc Senécal³, France Joyal⁴ and Martial Koenig⁵, ¹Division of Internal Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada, ²Research and Development, Inova Diagnostics, San Diego, CA, ³Rheumatology, Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada, ⁴Internal Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada, ⁵Internal Medicine, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada
Background/Purpose: Systemic sclerosis (SSc) autoantibodies (aAbs) are invaluable for SSc diagnosis and prognosis. Anti-centromere (ACA), anti-topoisomerase I (ATA) and anti-RNA polymerase III (RNAP) have been…
Abstract Number: 728 • 2017 ACR/ARHP Annual Meeting
Symptoms of Autonomic Dysfunction in Systemic Sclerosis Assessed By the Compass-31 Questionnaire
Brittany Adler¹, James Russell², Laura K. Hummers³ and Zsuzsanna McMahan⁴, ¹Rheumatology, Johns Hopkins University, Baltimore, MD, ²Neurology, Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, ³Medical and Rheumatology, Johns Hopkins University, Baltimore, MD, ⁴Department of Internal Medicine, Johns Hopkins University, Baltimore, MD
Background/Purpose: Autonomic dysfunction is a known complication of systemic sclerosis (SSc) and can affect vascular tone, gastrointestinal (GI) motility, and heart rate and blood pressure…
Abstract Number: 729 • 2017 ACR/ARHP Annual Meeting
Clinically Relevant Serum Proteins in Patients with Early Diffuse Cutaneous Systemic Sclerosis
Guoshuai Cai¹, Kelsey S. Flood², Shervin Assassi³, Elana J. Bernstein⁴, Robyn T. Domsic⁵, Jessica K. Gordon⁶, Faye Hant⁷, Elena Schiopu⁸, Virginia D. Steen⁹, Tracy M. Frech¹⁰, Dinesh Khanna¹¹, Ami A. Shah¹², Victoria K. Shanmugam¹³, Flavia V. Castelino¹⁴ and Monique Hinchcliff¹⁵, ¹Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Internal Medicine, Northwestern Medicine, Chicago, IL, ³University of Texas McGovern Medical School, Houston, TX, ⁴Rheumatology, Columbia University, New York, NY, ⁵Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁶Rheumatology, Hospital for Special Surgery, New York, NY, ⁷Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁸Internal Medicine, University of Michigan Medical System, Ann Arbor, MI, ⁹Rheumatology, MedStar Georgetown University Hospital, Washington, DC, ¹⁰Division of Rheumatology, University of Utah, Salt Lake City, UT, ¹¹Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ¹²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ¹³Rheumatology, The George Washington University, Washington, DC, ¹⁴Rheumatology, Harvard Medical School, Boston, MA, ¹⁵Rheumatology, Northwestern Medicine, Chicago, IL
Background/Purpose: The Prospective Registry of Early Systemic Sclerosis (PRESS), an 11 center US cohort study of early diffuse cutaneous systemic sclerosis (dcSSc) patients, was designed…
Abstract Number: 730 • 2017 ACR/ARHP Annual Meeting
The Association of Pulmonary Hypertension with Isolated Nucleolar Serum Autoantibodies in Systemic Sclerosis
Kathleen Aren¹, Mary A. Carns¹, Michael Cuttica², Julia (Jungwha) Lee³, Virginia D. Steen⁴ and Monique Hinchcliff⁵, ¹Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ²Northwestern University, Feinberg School of Medicine, Division of Pulmonary and Critical Care, Chicago, IL, ³Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, ⁵Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Serum antibodies are used to identify SSc patients who may be at higher risk for SSc-PH. The Pulmonary Hypertension Assessment and Recognition of Outcomes…
Abstract Number: 731 • 2017 ACR/ARHP Annual Meeting
Prediction of Progression of Interstitial Lung Disease in Patients with Systemic Sclerosis
Wanlong Wu¹, Suzana Jordan², Mike Oliver Becker³, Rucsandra Dobrota³, Shuang Ye⁴, Britta Maurer⁵ and Oliver Distler², ¹Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich; Department of Rheumatology, Renji Hospital South Campus, Shanghai Jiao Tong University School of Medicine, Zurich, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ⁵Department of Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: No data are available to distinguish between progressive and stable patients when mild lung fibrosis is diagnosed in systemic sclerosis (SSc) patients. This study…
Abstract Number: 732 • 2017 ACR/ARHP Annual Meeting
Progression of Skin Fibrosis Is Associated with Decline in Lung Function in Patients with Diffuse Cutaneous Systemic Sclerosis: A European Scleroderma Trials and Research (EUSTAR) Analysis
Wanlong Wu¹, Suzana Jordan², Nicole Graf³, Janethe Pena⁴, John Curram⁵, Yannick Allanore⁶, Marco Matucci-Cerinic⁷, Janet E. Pope⁸, Christopher Denton⁹, Dinesh Khanna¹⁰ and Oliver Distler¹, ¹Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Graf Biostatistics, Winterthur, Switzerland, ⁴Bayer HealthCare Pharmaceuticals Inc, Whippany, NJ, ⁵Bayer Plc, Newbury, United Kingdom, ⁶Department of Rheumatology, Cochin Hospital, Paris Descartes University, Paris, France, ⁷Dept of Medicine/Div of Rheum, University of Florence, Florence, Italy, ⁸Department of Medicine, Division of Rheumatology, University of Western Ontario, St Joseph's Health Care, London, ON, Canada, ⁹Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom, ¹⁰Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, University of Michigan, Ann Arbor, MI
Background/Purpose: Previously, we have identified short disease duration (≤15 months) and low baseline modified Rodnan skin score (mRSS) (≤22/51) as independent predictors of progressive skin…
Abstract Number: 733 • 2017 ACR/ARHP Annual Meeting
Ethnic Variation in Systemic Sclerosis Morbidity and Mortality
Sindhu Johnson¹, Zareen Ahmad² and Haifa Al Sheikh³, ¹Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, ²Toronto Scleroderma Program, Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Systemic sclerosis (SSc) is an uncommon connective tissue disease characterized by pathological skin thickening and can involve multiple internal organs. Ethnic variations in SSc…
Abstract Number: 734 • 2017 ACR/ARHP Annual Meeting
Correlation of the American College of Rheumatology Provisional Composite Response Index in Systemic Sclerosis with Serum Biomarkers of Fibrogenesis in an Observational Cohort
Giuseppina Abignano¹, Sookhoe Eng², Maya H. Buch³, Paul Emery⁴, Dinesh Khanna⁵ and Francesco Del Galdo², ¹Rheumatology Department of Lucania,, Rheumatology Institute of Lucania (IReL), San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera,, Potenza, Italy, ²Leeds Musculoskeletal Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ⁴NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁵University of Michigan, Ann Arbor, MI
Background/Purpose: The CRISS is a composite index of response in diffuse cutaneous systemic sclerosis (dcSSC). It is a 2-step process for the probability of improvement…
Abstract Number: 735 • 2017 ACR/ARHP Annual Meeting
Cardiopulmonary Exercise Testing to “Detect” Pulmonary Arterial Hypertension in Systemic Sclerosis
Rosa Casella¹, Alessandro Santaniello^2,3, Marco Vicenzi¹ and Lorenzo Beretta², ¹Cardiovascular Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy, ²Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ³VIA FRANCESCO SFORZA 28, OSPEDALE MAGGIORE POLICLINICO, MILANO, Italy
Background/Purpose: Pulmonary arterial hypertension (PAH) is one of the leading death causes in SSc patients. To gain a better prognosis, screening methods are needed to…
Abstract Number: 736 • 2017 ACR/ARHP Annual Meeting
N-Terminal Pro-Brain Natriuretic Peptide Is Disproportionately Elevated in Scleroderma Associated Pulmonary Arterial Hypertension Compared to Idiopathic Pulmonary Arterial Hypertension
Alexander Hannan¹, Raed Dweik², Kristin B. Highland³, Gustavo Heresi⁴, Adriano Tonelli⁵, William Messner⁶ and Soumya Chatterjee^1,7, ¹Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ²Respiratory Institute, Cleveland Clinic, Cleveland, OH, ³Rheumatology.org, Cleveland Clinic, Cleveland, OH, ⁴Respiratory Institute - Pulmonary Medicine, Cleveland Clinic, Cleveland, OH, ⁵Pulmonary Medicine - Respiratory Institute, Cleveland Clinic, Cleveland, OH, ⁶Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ⁷Rheumatic and Immunologic Ds, Cleveland Clinic, Cleveland, OH
Background/Purpose: N-Terminal pro-brain natriuretic peptide (NT-proBNP) level tends to correlate with myocardial wall stress and/or myocardial damage (fibrosis). Hence, it has been promoted as a…
Abstract Number: 737 • 2017 ACR/ARHP Annual Meeting
Dynamic Prediction of Pulmonary Hypertension Development in Systemic Sclerosis Patients Using Landmark Analysis – Comparison of Two Models
Svetlana I. Nihtyanova¹, Voon H. Ong², Emma C. Derrett-Smith³, Benjamin Schreiber⁴, J. Gerry Coghlan⁴, Bianca DeStavola⁵ and Christopher Denton⁶, ¹Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ²Rheumatology, UCL Division of Medicine, London, United Kingdom, ³Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, London, United Kingdom, ⁴National Pulmonary Hypertension Service, Royal Free Hospital, London, United Kingdom, ⁵Faculty of Population Health Sciences, UCL Institute of Child Health, London, United Kingdom, ⁶Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom
Background/Purpose: Pulmonary hypertension (PH) contributes substantially to systemic sclerosis (SSc)-related morbidity and mortality. It tends to develop later in the disease, creating an opportunity for…
Abstract Number: 738 • 2017 ACR/ARHP Annual Meeting
Prospective Validation of the Systemic Sclerosis Skin Symptoms Patient-Reported Outcome (SSPRO) in a Phase 2 Trial of Anabasum (JBT-101) in Diffuse Cutaneous Systemic Sclerosis (dcSSc)
Ada Man¹, Nancy Dgetluck² and Barbara White³, ¹Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ²Biostatistics, Corbus Pharmaceuticals, Norwood, MA, ³Corbus Pharmaceuticals, Inc., Norwood, MA
Background/Purpose: Skin thickening is the defining manifestation of dcSSc. A dcSSc patient’s assessment of their skin involvement can provide information about how that patient feels…
Abstract Number: 739 • 2017 ACR/ARHP Annual Meeting
How Effective Is the Home Exercise Program for Hands in Patients with Systemic Sclerosis: Preliminary Results from a Randomized Controlled, Single-Blind, Clinical Trial
Neslihan Gokcen¹, Suade Ozlem Badak², Tunay Sarpel³, Yasar Sertdemir⁴ and Eren Erken², ¹Physical Medicine and Rehabilitation, Division of Rheumatology, Cukurova University School of Medicine, Adana, Turkey, ²Internal Medicine, Division of Rheumatology, Cukurova University School of Medicine, Adana, Turkey, ³Physical Medicine and Rehabilitation, Cukurova University School of Medicine, Adana, Turkey, ⁴Department of Biostatistics and Medical Informatics, Cukurova University School of Medicine, Adana, Turkey
Background/Purpose: Systemic sclerosis (SSc) represents a heterogeneous autoimmune disease characterized by fibrosis of skin and internal organs. In particular, thickening of the skin, puffy hands,…
Abstract Number: 740 • 2017 ACR/ARHP Annual Meeting
Prediction of Fibrosis Progression in Systemic Sclerosis By Collagen Biomarkers
Rucsandra Dobrota¹, Suzana Jordan², Pernille Juhl³, Britta Maurer⁴, Lukas Wildi⁴, Anne-C. Bay-Jensen⁵, Morten Karsdal⁶, Anne Sofie Siebuhr⁷ and Oliver Distler², ¹Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Nordic Bioscience, Herlev, Denmark, ⁴Department of Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark, ⁶Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, ⁷Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, Herlev, Denmark
Background/Purpose: Altered extracellular matrix (ECM) remodeling leading to fibrosis is a key pathogenic process in systemic sclerosis (SSc). We previously showed that collagen formation and…
Abstract Number: 741 • 2017 ACR/ARHP Annual Meeting
Cardiac MRI in Systemic Sclerosis As Prognostic Tool of Cardiac Mortality in Symptomatic Patients
Silvia Bosello¹, Giovanni Canestrari¹, Enrico De Lorenzis¹, Gerlando Natalello², Federico Parisi¹, Agostino Meduri³, Riccardo Marano³, Gianfranco Ferraccioli⁴ and Elisa Gremese⁵, ¹Division of Rheumatology, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy, ²Division of Rhematology, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy, ³Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy, ⁴Institute of Rheumatology, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy, ⁵Division of Rheumatology - Institute of Rheumatology and Affine Sciences, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy
Background/Purpose: Cardiac involvement is a relevant prognostic determinant of outcome in Systemic Sclerosis (SSc). Since the role of cardiac MRI (CMR) is still uncertain, we…

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