Abstract Number: 682 • 2017 ACR/ARHP Annual Meeting
Complement Activation in Peripheral Blood in Relation to Lupus, Antiphospholipid and Rheumatoid Arthritis Autoantibodies: Insights from Clinical Laboratory Evaluations
Background/Purpose: Abnormal activation of the complement system is emerging as a useful biomarker in the evaluation of patients presenting symptoms of autoimmune rheumatic diseases. We…Abstract Number: 683 • 2017 ACR/ARHP Annual Meeting
The Presence of Anti-Ro and Anti-La Antibodies Is Associated with Tubulointerstitial Damage in Lupus Nephritis
Background/Purpose: Moderate-to-severe tubulointerstitial damage (TID) is associated with poor renal outcomes in lupus-related kidney disease, independent of glomerular pathology1. Unlike glomerular damage, TID is not…Abstract Number: 684 • 2017 ACR/ARHP Annual Meeting
ANTI-RO52 KDa and ANTI-RO60 KDa Analysis in Systemic LUPUS Erythematous Patients to Detect ANTI-RO False-Negatives
Background/Purpose: Systemic lupus erythematous (SLE) is an autoimmune disease characterized by immune system disruption with autoantibodies production. One of the upregulated autoantibodies is the specific…Abstract Number: 685 • 2017 ACR/ARHP Annual Meeting
Anti-C1q Antibodies and Disease Activity in a Multi-Ethnic Lupus Cohort
Background/Purpose: Anti-C1q antibodies (C1Q Ab) are observed in 30-60% of patients with Systemic Lupus Erythematosus (SLE). A number of studies have shown that the presence…Abstract Number: 686 • 2017 ACR/ARHP Annual Meeting
Endothelial Dysfunction in Systemic Lupus Erythematosus Patients without Cardiovascular events and Risk Factors: Correlation with Microvascular Alterations and angiogenic t Cells
Background/Purpose: early identification of subclinical cardiovascular disease (CVD) in systemic lupus erythematosus (SLE) patients is mandatory to reduce morbidity and mortality. Endothelial dysfunction (ED) is…Abstract Number: 687 • 2017 ACR/ARHP Annual Meeting
Homocysteine Levels Are Independently Associated with Damage Accrual in Systemic Lupus Erythematosus Patients (SLE)
Background/Purpose: Homocysteine level is a predictor of the occurrence of cardiovascular diseases, however, its role as a predictor of damage in SLE has not been…Abstract Number: 688 • 2017 ACR/ARHP Annual Meeting
Associations between Standard Serological Markers and Different Clinical Phenotypes in Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus (SLE) affects various body organs making its clinical presentation highly variable. While previous studies have demonstrated associations between lab abnormalities and…Abstract Number: 689 • 2017 ACR/ARHP Annual Meeting
Apolipoprotein L1 Risk Variants Associate with Hypertension and Nephritis Progression Despite Lower dsDNA Titers in Ghanaian Systemic Lupus Erythematous Patients
Background/Purpose: Two Apolipoprotein L1 (APOL1) risk variants (RV), G1 and G2 are enriched in African populations due to a conferred resistance to Trypanosoma brucei. This…Abstract Number: 690 • 2017 ACR/ARHP Annual Meeting
SSA Antibodies Are Associated with Valvular Abnormalities in SLE Patients without Clinical Cardiovascular Disease
Background/Purpose: Cardiovascular involvement including pericardium, conduction system, coronary arteries and valvular abnormalities are frequent manifestations of SLE. It is estimated to occur in more than…Abstract Number: 691 • 2017 ACR/ARHP Annual Meeting
Serum Anti-NR2 Has a Better Specificity Than Sensitivity in Diagnosing Neuropsychiatric Systemic Lupus Erythematosus (NPSLE)
Background/Purpose: Anti-NR2, a subclass of anti-NMDA receptor antibodies, is reportedly associated with NPSLE syndromes. However, its diagnostic accuracy is inconsistent across prior studies. Hence, we…Abstract Number: 692 • 2017 ACR/ARHP Annual Meeting
High Plasma Factor XIII Transglutaminase Activity Inversely Correlates with SLE Disease Activity Yet Associates with Higher Carotid Artery IMT and Low CD14+CD16+ Monocyte Levels
Background/Purpose: The transglutaminase Factor XIII (FXIII) stabilizes blood clots through crosslinking fibrin lysine and glutamine residues at the end of the complement cascade. Enzymatic activity…Abstract Number: 693 • 2017 ACR/ARHP Annual Meeting
The Utility of a Rise in Anti – Double Stranded DNA Antibodies for Predicting Disease Flares in Systemic Lupus Erythematosus. a Meta-Analysis
Background/Purpose: The ability of predicting disease flares in systemic lupus erythematosus (SLE) by serial measurements of antibodies to double stranded DNA (anti-dsDNA) remains uncertain. Previous…Abstract Number: 694 • 2017 ACR/ARHP Annual Meeting
Serum Wisteria Floribunda Agglutinin-Positive Mac-2-Binding Protein Can Reflect Systemic Lupus Erythematosus Activity
Abstract Background/Purpose : Serum Mac-2-binding protein (M2BP) is elevated in various chronic inflammatory diseases. Recently, the Wisteria floribunda agglutinin positive-M2BP (WFA+-M2BP) immunoassay has shown promise…Abstract Number: 695 • 2017 ACR/ARHP Annual Meeting
Development of a Multimarker Model for the Detection of Systemic Lupus Erythematosus Based on New and Traditional Autoantibodies
Background/Purpose: Given the heterogeneity of clinical presentations, the diagnosis of Systemic Lupus Erythematosus (SLE) can be challenging, in particular in those patients presenting with early…Abstract Number: 696 • 2017 ACR/ARHP Annual Meeting
An ANA Screening Assay Containing Multiple Antigens Increases the Sensitivity and Specificity of ANA Testing By Indirect Immunofluorescence
Background/Purpose: Indirect immunofluorescence (IIF) on Hep-2 cells is still considered the gold standard for screening of antinuclear antibodies (ANA), the serological hallmark of connective tissue…
ACR Meeting Abstracts