Abstract Number: 925 • 2018 ACR/ARHP Annual Meeting
Abortive Viral Infection Becomes Macrophage Activation Syndrome in Mice with Chronically Elevated Interleukin-18: Evidence for Synergy with Cytotoxic Impairment
Background/Purpose: Macrophage Activation Syndrome (MAS) and Hemophagocytic lymphohistiocytosis (HLH) are clinically similar life-threatening hyperinflammatory syndromes, often triggered by viral infection. HLH is associated with cytotoxic…Abstract Number: 926 • 2018 ACR/ARHP Annual Meeting
Truncating Mutations in SAMD9L Cause an Early-Onset Immune-Dysregulatory Syndrome of Neutrophilic Panniculitis, Interstitial Lung Disease and Cytopenias
Background/Purpose: The Sterile Alpha Motif Domain Containing 9 Like protein that is encoded by SAMD9L plays a role in endosome fusion, and deletions (haploinsufficiency) of…Abstract Number: 927 • 2018 ACR/ARHP Annual Meeting
The Reprogramming of Regulatory T Cells to a Th17 Phenotype in Systemic Juvenile Idiopathic Arthritis
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is characterized by fever and rash at disease onset, which are mediated in part by IL-1β and IL-6. In…Abstract Number: 928 • 2018 ACR/ARHP Annual Meeting
Single Cell RNA-Sequencing of Rheumatoid Synovial Fibroblasts Reveals a Disease-Associated Spatial Gradient Modulated By Inductive Notch Signaling
Background/Purpose: In rheumatoid arthritis (RA), tissue resident fibroblasts orchestrate chronic inflammation and regulate pathologic bone and cartilage remodeling that causes irreversible joint damage. Recently, we…Abstract Number: 929 • 2018 ACR/ARHP Annual Meeting
Transcriptional Profiling of the Subcutaneous Rheumatoid Nodule: An Insight into Pathogenic Mechanisms and Cellular Content
Background/Purpose: Rheumatoid nodules are the most common cutaneous manifestation in patients with RA, often associated with longstanding and a more severe disease course. Paradoxically, therapy…Abstract Number: 930 • 2018 ACR/ARHP Annual Meeting
Joint Location-Specific IL6 and JAK-STAT Signaling in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS)
Background/Purpose: Recent studies suggest that epigenetic marks distinguish FLS isolated from different joints in RA. Hip and knee joint-derived FLS, in particular, have distinctive DNA…Abstract Number: 931 • 2018 ACR/ARHP Annual Meeting
Patients with Seropositive Rheumatoid Arthritis Who Do Not Mount a CRP Response When They Have Synovitis Are Immunologically Distinct and Are Poorly Served By Current Management Strategies
Background/Purpose: An atypical subgroup of patients with seropositive rheumatoid arthritis (RA) has been identified with confirmed synovitis but normal levels of the acute phase protein…Abstract Number: 932 • 2018 ACR/ARHP Annual Meeting
Fibroblasts Senescence Is Observed in Rheumatoid and Osteoarthritic Synovial Tissues and Triggers a Pro-Inflammatory Program Ex Vivo
Background/Purpose: Inflammation is an important component of most age-related disorders. Cellular changes associated to aging are tightly connected with pro-inflammatory mechanisms. The purpose of this…Abstract Number: 933 • 2018 ACR/ARHP Annual Meeting
Inflammation in the Hippocampus Affects Insulin-like Growth Factor-1 Receptor Signaling and Contributes to Neurological Sequelae in Rheumatoid Arthritis
Background/Purpose: The central nervous system is not the primary target in rheumatoid arthritis (RA). However, neuropsychiatric symptoms including pain, depression and anxiety are common and…Abstract Number: 934 • 2018 ACR/ARHP Annual Meeting
HIV Protease Inhibitors Cure Lupus-Prone Mice and Prevent T Helper 17 Cell-Driven Inflammation By Inhibiting CD95-Non-Apoptotic Signaling Pathway
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by loss of tolerance to nuclear components; this results in production of autoantibodies, immune…Abstract Number: 935 • 2018 ACR/ARHP Annual Meeting
Neuropsychiatric Systemic Lupus Erythematosus Is Dependent on Lipocalin-2
Background/Purpose: Although the pathogenesis of neuropsychiatric lupus (NPSLE) is not fully understood, neuroinflammation plays a major role in disease. Lipocalin-2, an acute phase reactant protein…Abstract Number: 936 • 2018 ACR/ARHP Annual Meeting
Selective Deficiency of Serine Arginine-Rich Splicing Factor 1 (SRSF1) in T Lymphocytes Leads to mTORC1 Activation, Treg Dysfunction and Systemic Autoimmune Disease
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) exhibit defects in signaling and cytokine production, and aberrant numbers and/or function of regulatory T…Abstract Number: 937 • 2018 ACR/ARHP Annual Meeting
Evidence of a Common Microglial Signature in Models of ‘Neuropsychiatric Symptoms of Systemic Lupus Erythematosus’
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune syndrome affecting multiple organs, including the brain. More than 60% of patients experience neuropsychiatric symptoms of…Abstract Number: 938 • 2018 ACR/ARHP Annual Meeting
Dermal Lymphatic Dysfunction and Photosensitivity in the MRL/Lpr Lupus Model
Background/Purpose: Proper function of lymphatic vessels is needed to limit the magnitude and duration of tissue inflammation. Chronic inflammatory states such as obesity and psoriasis…Abstract Number: 939 • 2018 ACR/ARHP Annual Meeting
Rab4A Protects from Lupus Nephritis By Limiting Germinal Center Formation and Pro-Inflammatory Expression of GLUT1 and Integrin By Renal Epithelial Cells
Background/Purpose: Lupus nephritis is most common cause of mortality and morbidity in systemic lupus erythematosus (SLE) patients and 60% of SLE patients develops lupus nephritis.…
ACR Meeting Abstracts