Abstracts Archive - Page 1246 of 2607 - ACR Meeting Abstracts

Abstract Number: 895 • 2018 ACR/ARHP Annual Meeting
Associations of Statin Usage with Disease Activity in Ankylosing Spondylitis
Jonathan Dau¹, Lianne S. Gensler², MinJae Lee³, Michael Ward⁴, Matthew Brown⁵, Laura A. Diekman⁶, Mohammad H. Rahbar⁷, Mariko Ishimori⁸, Michael Weisman⁹ and John D. Reveille¹⁰, ¹McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, ²University of California San Francisco, San Francisco, CA, ³Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, ⁴National Institutes of Health, Bethesda, MD, USA, Bethesda, MD, ⁵Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ⁶Rheumatology, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, ⁷Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, ⁸Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁹Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹⁰McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: Recent studies have shown possible anti-inflammatory effects and a survival benefit with statin usage in ankylosing spondylitis (AS). The purpose of this study was…
Abstract Number: 896 • 2018 ACR/ARHP Annual Meeting
Pharmacogenomics Study of Predicting Response of TNF Blocker and Medical Image Progression in Chinese Han Ankylosing Spondylitis Population
Jing Liu¹, Weilin Pu¹, Qi Zhu², He Fan¹, Wei Wan³, Hejian Zou⁴, Xiaodong Zhou⁵, John D. Reveille⁶, Dongyi He² and Jiucun Wang¹, ¹State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China, ²Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Guanghua Integrative Medicine Hospital, Shanghai, China, ³Division of Rheumatology, Changhai Hospital, Shanghai, China, ⁴Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China, ⁵Internal Medicine-Rheumatology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, ⁶McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: TNF blockers, have been widely used in immune-mediated diseases and many genetic variations predicting treatment response have been described. We applied previously published genetic…
Abstract Number: 897 • 2018 ACR/ARHP Annual Meeting
Prevalence of Inflammatory and Chronic Changes Suggestive of Axial Spondyloarthritis in Magnetic Resonance Images of the Axial Skeleton in Individuals < 45 Years in the General Populationas Part of a Large Community Study (SHIP)
Xenofon Baraliakos¹, Daniel Feldmann², Anne Ott², Carsten Oliver Schmidt³, Martin Albers³, Adrian Richter³ and Jürgen Braun¹, ¹Ruhr-University Bochum, Herne, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
Background/Purpose: Magnetic resonance imaging (MRI) is crucial for classification and diagnosis of axial spondyloarthritis (axSpA). Characteristic MRI lesions of axSpA are bone marrow edema (BME)…
Abstract Number: 898 • 2018 ACR/ARHP Annual Meeting
Efficacy and Safety of Tocilizumab for the Treatment of Systemic Sclerosis: Results from a Phase 3 Randomized Controlled Trial
Dinesh Khanna¹, Celia J. F. Lin², Masataka Kuwana³, Yannick Allanore⁴, Anastas Batalov⁵, Irena Butrimiene⁶, Patricia Carreira⁷, Marco Matucci Cerinic⁸, Oliver Distler⁹, Dusanka Martinović Kaliterna¹⁰, Carina Mihai¹¹, Mette Mogensen¹², Marzena Olesinska¹³, Janet E. Pope¹⁴, Gabriela Riemekasten¹⁵, Tatiana S. Rodriguez-Reyna¹⁶, Maria José Santos¹⁷, Jacob van Laar¹⁸, Helen Spotswood¹⁹, Jeffrey Siegel², Angelika Jahreis², Daniel E. Furst²⁰ and Christopher P. Denton²¹, ¹University of Michigan, Ann Arbor, MI, ²Genentech, Inc., South San Francisco, CA, ³Nippon Medical School, Tokyo, Japan, ⁴Cochin Hospital, Paris Descartes University, Paris, France, Paris, France, ⁵Medical University of Plovdiv, Plovdiv, Bulgaria, ⁶Rheumatology Clinic, Medical Faculty, Vilnius University, Vilnius, Lithuania, ⁷Servicio de Reumatología, Hospital Universitario, Madrid, Spain, ⁸University of Florence, Florence, Italy, ⁹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ¹⁰University of Split, Split, Croatia, ¹¹Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, ¹²Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, ¹³National Institute of Geriatrics, Rheumatology and Rehabilitation,, Warsaw, Poland, ¹⁴Department of Medicine, University of Western Ontario, London, ON, Canada, ¹⁵Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany, ¹⁶Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ¹⁷Serviço de Reumatologia do Hospital Garcia de Orta, Almada, Portugal, Almada, Portugal, ¹⁸University Medical Center Utrecht, Utrecht, Netherlands, ¹⁹Roche Products Ltd., Welwyn Garden City, United Kingdom, ²⁰University of California Los Angeles, Los Angeles, CA, ²¹University College London, London, United Kingdom
Background/Purpose: The anti–interleukin-6 (IL-6) receptor-alpha antibody tocilizumab (TCZ) demonstrated numeric improvement in skin thickening (modified Rodnan skin score [mRSS]) and clinically meaningful lung function preservation…
Abstract Number: 899 • 2018 ACR/ARHP Annual Meeting
Changes in the Systemic Sclerosis Molecular Signatures after Myeloablation Followed By Autologous Hematopoietic Stem Cell Transplantation and Their Clinical Correlates
Shervin Assassi¹, Xuan Wang², Jun Ying³, Lynette Keyes-Elstein⁴, Ellen Goldmuntz⁵, Jacob Turner⁶, Wenjin Zheng⁷, Guocai Chen⁷, Maria Virginia Pascual⁸, John Varga⁹, Monique Hinchcliff¹⁰, Chiara Bellocchi¹¹, Peter McSweeney¹², Daniel E. Furst¹³, Richard Nash¹², Leslie Crofford¹⁴, Beverly Welch¹⁵, Ashley Pinckney¹⁶, Maureen D. Mayes¹ and Keith Sullivan¹⁷, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Baylor Scott & White Health, Dallas, TX, ³Department of Internal Medicine - Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁴Rho, Inc, Chapel Hill, NC, ⁵NIAID, National Institutes of Health, Bethesda, MD, ⁶Stephen F Austin University, Nacogdoches, TX, ⁷University of Texas Health Science Center at Houston, Houston, TX, ⁸Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, ⁹Northwestern University, Chicago, IL, ¹⁰Rheumatology, Northwestern University, Chicago, IL, ¹¹Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ¹²Colorado Blood Cancer Institute, Denver, CO, ¹³University of California Los Angeles, Los Angeles, CA, ¹⁴Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, ¹⁵National Institutes of Health, Bethesda, MD, ¹⁶Rho Federal Systems, Inc., Chapel Hill, NC, ¹⁷Duke University Medical Center, Durham, NC
Background/Purpose: Myeloablation followed by autologous hematopoietic stem cell transplantation (HSCT) led to improved clinical outcomes compared to 12 monthly infusions of cyclophosphamide (CYC) in patients…
Abstract Number: 900 • 2018 ACR/ARHP Annual Meeting
Abatacept Vs. Placebo in Early Diffuse Cutaneous Systemic Sclerosis— Results of a Phase 2 Investigator Initiated, Double-Blind, Placebo-Controlled, Multicenter, Randomized Controlled Trial Study
Dinesh Khanna¹, Cathie Spino², Erica Bush³, Sindhu Johnson⁴, Lorinda Chung⁵, Jerry Molitor⁶, Virginia D. Steen⁷, Robert Lafyatis⁸, Robert W. Simms⁹, Christopher P. Denton¹⁰, Suzanne Kafaja¹¹, Tracy M. Frech¹², Vivien Hsu¹³, Robyn T. Domsic¹⁴, Janet E. Pope¹⁵, Jessica K. Gordon¹⁶, Maureen D. Mayes¹⁷, Elena Schiopu³, Amber Young¹, Nora Sandorfi¹⁸, Jane Park¹⁹, Faye N. Hant²⁰, Elana J. Bernstein²¹, Soumya Chatterjee²², Flavia V. Castelino²³, Ali Ajam²⁴, Yannick Allanore²⁵, Marco Matucci-Cerinic²⁶, Oliver Distler²⁷, Ora Singer²⁸, Haoyan Zhong², David Fox²⁹ and Daniel E. Furst³⁰, ¹Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, ²Biostatistics, University of Michigan, Ann Arbor, MI, ³University of Michigan, Ann Arbor, MI, ⁴Rheumatology, Mount Sinai Hospital and University Health Network, Toronto, ON, Canada, ⁵Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ⁶Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN, ⁷Rheumatology, MedStar Georgetown University Hospital, Washington, DC, ⁸Medicine/Division of Rheumatology, Pittsburgh University Medical Center, Pittsburgh, PA, ⁹Rheumatology, Boston University School of Medicine, Boston, MA, ¹⁰UCL Division of Medicine, Royal Free Campus, London, United Kingdom, ¹¹Department of Internal Medicine, University of California Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ¹²Division of Rheumatology, University of Utah, Salt Lake City, UT, ¹³Rheumatology, Robert Wood Johnson University Scleroderma Program, New Brunswick, NJ, ¹⁴Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ¹⁵Department of Medicine, University of Western Ontario, London, ON, Canada, ¹⁶Rheumatology, Hospital for Special Surgery, New York, NY, ¹⁷Rheumatology, University of Texas McGovern Medical School, Houston, TX, ¹⁸Perelman School of Medicine, University of Pennsylvania, Pittsburgh, PA, ¹⁹Seattle Rheumatology Associates, Seattle, WA, ²⁰Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ²¹Rheumatology, Columbia University, New York, NY, ²²Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ²³Rheumatology, Harvard Medical School, Boston, MA, ²⁴Division of Rheumatology-Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ²⁵Service de Rhumatologie A, Hôpital Cochin, Paris, France, ²⁶Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, ²⁷Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²⁸Medicine, University of Michigan, Ann Arbor, MI, ²⁹Internal Medicine, University of Michigan, Ann Arbor, MI, ³⁰UCLA, Los Angeles, CA
Background/Purpose: Abatacept (ABA) is a recombinant fusion protein including extracellular domain of human CTLA4 and hinge‑ CH2‑CH3 of the Fc domain of human IgG. This…
Abstract Number: 901 • 2018 ACR/ARHP Annual Meeting
Changes in Quantitative Scleroderma Lung CT Measures in Patients Treated with Cyclophosphamide or Transplantation
Jonathan Goldin¹, Lynette Keyes-Elstein², Leslie Crofford³, Daniel E. Furst⁴, Ellen Goldmuntz⁵, Maureen D. Mayes⁶, Peter McSweeney⁷, Richard Nash⁷, Hyun J. Grace Kim⁸, Mathew Brown⁹ and Keith Sullivan¹⁰, ¹Department of Radiological Sciences at UCLA, University of California, Los Angeles, David Geffen School of Medicine, Santa Monica, CA, ²Rho, Inc, Chapel Hill, NC, ³Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, ⁴University of Washington, Seattle, WA, ⁵NIAID, NIH, Bethesda, MD, ⁶Rheumatology, University of Texas McGovern Medical School, Houston, TX, ⁷Colorado Blood Cancer Institute, Denver, CO, ⁸Radiology, UCLA, LA, CA, ⁹Radiology, UCLA, Los Angeles, CA, ¹⁰Duke University Medical Center, Durham, NC
Background/Purpose: Scleroderma related interstitial lung disease (SLD) is a major cause of morbidity and mortality in severe systemic sclerosis (SSc). The Scleroderma: Cyclophosphamide or Transplantation…
Abstract Number: 902 • 2018 ACR/ARHP Annual Meeting
Longitudinal Trends in Clinical Disease Features after Myeloablative Autologous Stem-Cell Transplantation or Cyclophosphamide in Severe Scleroderma
Lynette Keyes-Elstein¹, Ellen Goldmuntz², Ashley Pinckney³, Leslie Crofford⁴, Daniel E. Furst⁵, Maureen D. Mayes⁶, Peter McSweeney⁷, Richard Nash⁷, Beverly Welch⁸ and Keith Sullivan⁹, ¹Biostatistics, Rho Federal Systems, Inc, Chapel Hill, NC, ²NIAID, NIH, Bethesda, MD, ³Rho Federal Systems, Inc., Chapel Hill, NC, ⁴Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, ⁵UCLA, Los Angeles, CA, ⁶Rheumatology, University of Texas McGovern Medical School, Houston, TX, ⁷Colorado Blood Cancer Institute, Denver, CO, ⁸6610 Rockledge Dr., NIAID/NIH, Bethesda, MD, ⁹Duke University Medical Center, Durham, NC
Background/Purpose: The Scleroderma: Cyclophosphamide or Transplantation (SCOT) study established the long-term superiority of hematopoietic stem cell transplant (HSCT) over cyclophosphamide (CYC) [Sullivan KM, et al.…
Abstract Number: 903 • 2018 ACR/ARHP Annual Meeting
Riociguat in Patients with Early Diffuse Cutaneous Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Phase IIb Study (RISE-SSc)
Oliver Distler¹, Yannick Allanore², Christopher P. Denton³, Masataka Kuwana⁴, Marco Matucci-Cerinic⁵, Janet E. Pope⁶, Janethe Pena⁷, Kaisa Laapas⁸, Zhen Yao⁹ and Dinesh Khanna¹⁰, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Rheumatology A Department, Cochin Hospital, Paris Descartes University, Sorbonne Paris Cité, Paris, France, ³UCL Division of Medicine, Royal Free Campus, London, United Kingdom, ⁴Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ⁵Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, ⁶Department of Medicine, University of Western Ontario, London, ON, Canada, ⁷Clinical Development, Bayer US LLC, Whippany, NJ, ⁸StatFinn Oy, Espoo, Finland, ⁹Bayer Healthcare Co. Ltd.,, Beijing, China, ¹⁰Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI
Background/Purpose: There are few disease-modifying therapies for the treatment of systemic sclerosis (SSc), particularly the more severe diffuse cutaneous form (dcSSc). The soluble guanylate cyclase…
Abstract Number: 904 • 2018 ACR/ARHP Annual Meeting
Long-Term Safety of Rituximab in Granulomatosis with Polyangiitis or Microscopic Polyangiitis: Results of the Four-Year Study of Rituximab in ANCA-Associated Vasculitis Registry
John L. Niles¹, Peter A. Merkel², Lester Mertz³, Patricia B. Lehane⁴, Pooneh Pordeli⁵ and Félix Erblang⁶, ¹Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, MA, ²Division of Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Roche Products Ltd., Welwyn Garden City, United Kingdom, ⁵Hoffmann-La Roche Ltd., Mississauga, ON, Canada, ⁶Hoffmann-La Roche Ltd., Basel, Switzerland
Background/Purpose: Potential therapy-related toxicities are important causes of morbidity in patients with the ANCA-associated vasculitides granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA). Long-term safety…
Abstract Number: 905 • 2018 ACR/ARHP Annual Meeting
Serum Interleukin-6 Levels in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Alvise Berti¹, Roscoe Warner², Kent Johnson³, Divi Cornec⁴, Darrell Schroeder⁵, Brian Kabat⁵, Carol Langford⁶, Gary S. Hoffman⁷, Cees G.M. Kallenberg⁸, Philip Seo⁹, Robert F. Spiera¹⁰, Eugene William St. Clair¹¹, Fernando Fervenza¹², John H. Stone¹³, Paul A. Monach¹⁴, Ulrich Specks¹⁵ and Peter A. Merkel¹⁶, ¹Pulmonary and Critical Care, Mayo Clinic College of Medicine, Rochester, MN, ²University of Michigan Medical School, Ann Arbor,, MI, ³University of Michigan Medical School, Ann Arbor, MI, ⁴Rheumatology and UMR1227, Lymphocytes B et Autoimmunité, CHU Brest, Brest, France, ⁵Mayo Clinic, Rochester, MN, ⁶Rheumatic and Immunologic Diseases, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ⁷Rheumatology, Cleveland Clinic, Cleveland, OH, ⁸Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁹Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ¹⁰Hospital for Special Surgery, New York, NY, ¹¹Medicine, Duke University Medical Center, Durham, NC, ¹²Nephrology, Mayo Clinic, Rochester, MN, ¹³Rheumatology (Medicine), Massachusetts General Hospital, Harvard Medical School, Boston, MA, ¹⁴Section of Rheumatology, Boston University School of Medicine, Boston, MA, ¹⁵Mayo Clinic College of Medicine, Rochester, MN, ¹⁶Division of Rheumatology and the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA
Background/Purpose: The deregulated overproduction of interleukin (IL)-6 has been implicated in several inflammatory and antibody-mediated autoimmune diseases. We aimed to investigate serum IL-6 levels (sIL-6)…
Abstract Number: 906 • 2018 ACR/ARHP Annual Meeting
Defining the Gut Microbiome in Patients with ANCA-Associated Vasculitis
Catherine E. Najem¹, Jung-Jin Lee², Ceylan Tanes², Antoine G. Sreih¹, Rennie L. Rhee¹, Abdallah Geara³, Hongzhe Li⁴, Kyle Bittinger², James D. Lewis⁵ and Peter A. Merkel^4,6, ¹Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, ³Division of Nephrology and Hypertension, University of Pennsylvania, Philadelphia, PA, ⁴Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, ⁵Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, ⁶Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose:Although a link between gut microbiome and autoimmune diseases has been suggested, there is a gap in the understanding of the gut microbiome in ANCA-associated…
Abstract Number: 907 • 2018 ACR/ARHP Annual Meeting
Characterization of Preferential Recognition of a Chimeric Recombinant Proteinase 3 Variant By Anti-Neutrophil Cytoplasmic Antibodies
Gwen Thompson¹, Marta Casal Moura², Darlene Nelson¹, Amber Hummel¹, Dieter E. Jenne³, Fernando Fervenza⁴, Gary S. Hoffman⁵, Cees G.M. Kallenberg⁶, Carol Langford⁷, Joseph W. McCune⁸, Peter A. Merkel⁹, Paul A. Monach¹⁰, Philip Seo¹¹, Robert F. Spiera¹², Eugene William St. Clair¹³, Steven R. Ytterberg¹⁴, John H. Stone¹⁵, William H. Robinson¹⁶, Yuan-Ping Pang¹ and Ulrich Specks¹⁷, ¹Mayo Clinic, Rochester, MN, ²Pulmonary and Critical Care, Thoracic Disease Research Unit, Mayo Clinic College of Medicine, Rochester, MN, ³Helmholtz Zentrum München, Munich, Germany, ⁴Nephrology, Mayo Clinic, Rochester, MN, ⁵Rheumatology, Cleveland Clinic, Cleveland, OH, ⁶University of Gronigen, Groningen, Netherlands, ⁷Rheumatic and Immunologic Diseases, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ⁸University of Michigan, Ann Arbor, MI, ⁹University of Pennsylvania, Philadelphia, PA, ¹⁰Section of Rheumatology, Boston University School of Medicine, Boston, MA, ¹¹Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ¹²Hospital for Special Surgery, New York, NY, ¹³Medicine, Duke University Medical Center, Durham, NC, ¹⁴Rheumatology, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN, ¹⁵Rheumatology (Medicine), Massachusetts General Hospital, Harvard Medical School, Boston, MA, ¹⁶Stanford, Stanford, CA, ¹⁷Mayo Clinic College of Medicine, Rochester, MN
Background/Purpose: Human-murine chimeric variants have been used to study specific epitope recognition by anti-neutrophil cytoplasmic antibodies (ANCAs) targeting proteinase 3 (PR3) in patients with ANCA-associated…
Abstract Number: 908 • 2018 ACR/ARHP Annual Meeting
Early Prediction of Long-Term Evolutionary Profiles of Eosinophilic Granulomatosis with Polyangiitis (Churg–Strauss) Based on Baseline and Follow-up Characteristics
Matthias Papo¹, Giacomo Emmi², Franco Schiavon³, Matthieu Groh⁴, Maria-Letizia Urban², Chiara Marvisi⁵, Jean-Emmanuel Kahn⁴, Alberto Sinico⁶, Maxime Samson⁷, Pascal Cohen¹, Xavier Puéchal¹, Luc Mouthon¹, Loïc Guillevin¹, Augusto Vaglio⁵ and Benjamin Terrier⁸, ¹Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, ²Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, ³Operative Unit of Rheumatology, Department of Medicine DIMED, University of Padova, Padova, Italy, ⁴Service de Médecine Interne, Centre de Référence des Syndromes Hyperéosinophiliques-CEREO, Hôpital Foch, Université Versailles–Saint-Quentin-en-Yvelines, Suresnes, France, ⁵Nephrology Unit, Parma University Hospital, Parma, Italy, ⁶UOS di Immunologia Clinica e UOC di Nefrologia, Azienda Ospedaliera San Carlo Borromeo, Milan, Italy, ⁷Department of Internal Medicine and Clinical Immunology, François-Mitterrand Teaching Hospital, University of Bourgogne-Franche-Comté, Dijon, France, ⁸Department of Internal Medicine, Centre de Référence pour les Maladies Auto-immunes Rares, Paris, France, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) (Churg–Strauss) is a small-vessel necrotizing vasculitis characterized by blood and tissue eosinophilia and asthma. Glucocorticoids (GCs) effectively control the…
Abstract Number: 909 • 2018 ACR/ARHP Annual Meeting
Temporal Trends of ANCA-Associated Vasculitis Comorbidities: Results from a National, Longitudinal, Matched-Cohort Study
Shifa Sarica¹, Neeraj Dhaun², Jan Sznajd³, John Harvie³, Nicola Joss³, John McLaren⁴, Lucy McGeoch⁵, Nicole Amft⁶, Vinod Kumar⁷, Angharad Marks¹, Corri Black¹ and Neil Basu¹, ¹Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom, ²University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom, ³Department of Rheumatology, Raigmore Hospital, Inverness, United Kingdom, ⁴Fife Rheumatic Diseases Unit, Whyteman's Brae Hospital, Kirkcaldy, United Kingdom, ⁵Center for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, United Kingdom, ⁶Department of Rheumatology, Western General Hospital, Edinburgh, United Kingdom, ⁷Rheumatology Department, Ninewells Hospital, Dundee, United Kingdom
Background/Purpose: Comorbidity is common in patients with ANCA-associated vasculitis (AAV). However, this comorbidity and its burden over time remains unexplored. In this large multicenter study,…

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