Abstracts Archive - Page 1244 of 2425 - ACR Meeting Abstracts

Abstract Number: 577 • 2017 ACR/ARHP Annual Meeting
The Value of C-Reactive Protein As a Predictor of Radiographic Spinal Progression Is Strongly Dependent on β-Fibrinogen and Factor XIII a-Subunit Genotypes in Patients with Axial Spondyloarthritis
Denis Poddubnyy^1,2, Christian Schwedler², Hildrun Haibel², Martin Rudwaleit^2,3, Joachim Sieper² and Berthold Hoppe⁴, ¹German Rheumatism Research Centre, Berlin, Germany, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany, ⁴Unfallkrankenhaus Berlin, Berlin, Germany
Background/Purpose: It has been shown in the past that inflammatory activity (i.e., elevated C-reactive protein) predicts radiographic spinal progression in patients with axial spondyloarthritis (axSpA).…
Abstract Number: 578 • 2017 ACR/ARHP Annual Meeting
Added Value of Biomarkers Compared to Routine Clinical Parameters for the Prediction of Radiographic Spinal Progression in Axial Spondyloarthritis
Lorraine Tietz¹, Lien Le², Agnes Hartl¹, Martin Rudwaleit^1,3, Joachim Sieper¹, Ulrich Mansmann² and Denis Poddubnyy^1,4, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Ludwig-Maximilian University, Munich, Germany, ³Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany, ⁴German Rheumatism Research Centre, Berlin, Germany
Background/Purpose: Structural damage in the spine is an important determinant of the functional status and spinal mobility in axial spondyloarthritis (axSpA). Already present syndesmophytes, elevated…
Abstract Number: 579 • 2017 ACR/ARHP Annual Meeting
Circulating MiR-145 As a Marker of Therapeutic Response to Anti-TNF Therapy in Patients with Ankylosing Spondylitis
Klára Prajzlerová¹, Veronika Hruskova¹, Martin Komarc², Šárka Forejtová¹, Karel Pavelka³, Jiri Vencovsky³, Ladislav Senolt³ and Maria Filkova¹, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ²Department of Anthropometrics and Methodology, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic, ³Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: The altered expression of miRNAs contributes to the pathophysiology of inflammatory conditions. In addition, circulating miRNAs may serve as promising therapeutic and prognostic biomarkers.…
Abstract Number: 580 • 2017 ACR/ARHP Annual Meeting
Tenascin-C, a TLR 4 Endogenous Ligand Levels Are Increased in Ankylosing Spondylitis
Latika Gupta, Shruti Bhattacharya and Amita Aggarwal, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Monocytes of patients with Ankylosing Spondylitis (AS) over-express Toll-like receptor (TLR) 4 on their monocytes. Tenascin-C (TNC) is an extracellular-matrix-glycoprotein and acts as an…
Abstract Number: 581 • 2017 ACR/ARHP Annual Meeting
Diagnostic Value of Anti-CD74 Antibodies in Early Axial Spondyloarthritis: Data from the Spondyloarthritis Caught Early (SPACE) Cohort
Janneke de Winter¹, Marleen van de Sande¹, Niklas Thomas Baerlecken², Inger Berg³, Roberta Ramonda⁴, Désirée van der Heijde⁵, Floris van Gaalen⁶, Torsten Witte⁷ and Dominique Baeten^1,8, ¹Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Rheumatology, Private Practice, Cologne, Germany, ³Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padova, Italy, ⁵Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Leiden University Medical Center, Leiden, Netherlands, ⁷Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, ⁸UCB Pharma, Slough, United Kingdom
Background/Purpose: Anti-CD74 IgG antibodies are reported to be elevated in serum of patients with axial spondyloarthritis (axSpA). This study aimed to assess the diagnostic value…
Abstract Number: 582 • 2017 ACR/ARHP Annual Meeting
Low Dose Computed Tomography Detects More Progression of Bone Formation in Comparison to Conventional Radiography in Patients with Ankylosing Spondylitis
Anoek de Koning¹, Freek de Bruin², Rosaline van den Berg³, Sofia Ramiro⁴, Xenofon Baraliakos⁵, Jürgen Braun⁵, Floris van Gaalen³, M. Reijnierse⁶ and Désirée van der Heijde⁷, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²LUMC, Leiden, Netherlands, ³Rheumatology, LUMC, Leiden, Netherlands, ⁴Rheumatology, Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands, ⁵Rheumazentrum Ruhrgebiet, Herne, Germany, ⁶Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁷Leiden University Medical Center, Leiden, Netherlands
Background/Purpose : A newly developed scoring method for low dose CT (ldCT) of the whole spine, CT Syndesmophyte Score (CTSS), has shown good inter-reader reliability…
Abstract Number: 583 • 2017 ACR/ARHP Annual Meeting
Associations of Changes of Radiographic Disease and Spinal Mobility Measures in Ankylosing Spondylitis
Mark Hwang^1,2,3, Michael Weisman⁴, MinJae Lee⁵, Lianne S. Gensler⁶, Matt Brown⁷, Amirali Tahanan⁵, Laura A. Diekman⁸, Thomas Learch⁹, Seth Eisen¹⁰, Mohammad H. Rahbar⁵, Michael Ward¹¹ and John D. Reveille¹², ¹Medicine, University of Texas-McGovern Medical School, Houston, TX, ²Internal Medicine-Rheumatology, University of Texas-McGovern Medical School, Saint Louis, MO, ³Washington University at Saint Louis School of Medicine, Saint Louis, MO, ⁴Cedars-Sinai Medical Center Division of Rheumatology, Los Angeles, CA, ⁵Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, ⁶Medicine/Rheumatology, UCSF, San Francisco, CA, ⁷Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ⁸Rheumatology, University of Texas-McGovern Medical School, Houston, TX, ⁹Radiology, Cedars Sinai Medical Center, Los Angeles, CA, ¹⁰Division of Rheumatology, Washington University at Saint Louis School of Medicine, St Louis, MO, ¹¹NIH/NIAMS, Bethesda, MD, ¹²University of Texas McGovern Medical School, Houston, TX
Background/Purpose: Metrology indices aimed as assessing spinal mobility in ankylosing spondylitis (AS) patients are used in clinical trials and clinical practice to assess disease severity…
Abstract Number: 584 • 2017 ACR/ARHP Annual Meeting
Factors Associated with the “Bamboo Spine” Phenotype – Data from the Comospa Study
Koei Oh¹, Anna Molto², Corinne Miceli-Richard³, Soksay Singvongsa⁴, Adrien Etcheto⁴ and Maxime Dougados⁴, ¹Departmen of Rheumatology, Paris Descartes University, Hôpital Cochin, Paris, France, ²Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ³Department of Rheumatolgy, Paris Descartes University, Hôpital Cochin, Paris, France, ⁴Department of Rheumatology, Paris Descartes University, Hôpital Cochin, Paris, France
Background/Purpose: The factors associated with “Bamboo spine” occurrence, i.e. the most severe axial phenotype of SpA patients, have been poorly assessed to date. The aim…
Abstract Number: 585 • 2017 ACR/ARHP Annual Meeting
Frequencies of Ligament Ossification in Patients with Ankylosing Spondylitis According to Several Ligaments Around Spine By Whole Spine CT Scan
Ran Song¹, Ji-Young Choi², Yeon-Ah Lee², Seung-Jae Hong², Hyung-In Yang³ and Sang-Hoon Lee¹, ¹Rheumatology, Kyung Hee University Hospital at Gang dong, Seoul, Korea, Republic of (South), ²Rheumatology, Kyung Hee University Hospital, Seoul, Korea, Republic of (South), ³Kyung Hee University Hospital at Gang dong, Seoul, Korea, Republic of (South)
Background/Purpose: Ankylosing spondylitis is chronic inflammatory arthritis with ligament ossification in spine such as ant. longitudinal ligaments, post. longitudinal ligaments, or other several ligaments around…
Abstract Number: 586 • 2017 ACR/ARHP Annual Meeting
Validation of Online Calibration Modules for the Spondyloarthritis Research Consortium of Canada MRI Scores Based on Real-Time Experiential Learning
Matthew Maksymowych¹, Hanne Boutrup², Jonathan Cheah³, Riccardo Guglielmi⁴, Eric Heffernan⁵, Jacob Jaremko¹, Mats-Peter Johansson⁶, Simon Krabbe⁷, Georg Kroeber⁸, Fardina Malik⁹, Susanne Juhl Pedersen⁷, Sander Shafer⁶, Ulrich Weber¹⁰, Pam Weiss¹¹, Brian Trinh¹², Joel Paschke¹³ and Robert G. Lambert¹⁴, ¹Radiology, University of Alberta, Edmonton, AB, Canada, ²University of Copenhagen, Copenhagen, Denmark, ³Medicine, Hospital for Special Surgery, New York, NY, ⁴Radiology, Ente Ospedaliero Cantonale, Lugano, Switzerland, ⁵Radiology, St. Vincent's University Hospital, Dublin, Ireland, ⁶Rheumatology, Gentofte Hospital, Copenhagen, Denmark, ⁷Center for Rheumatology and Spine Diseases, Copenhagen Center for Arthritis Research, Rigshospitalet, Copenhagen, Denmark, ⁸University of Southern Denmark, Odense, Denmark, ⁹Medicine- Rheumatology, Weill Cornell Medical College, New York, NY, ¹⁰Department of Research, King Christian 10th Hospital for Rheumatic Diseases, Graasten, Denmark, ¹¹Pediatrics, Children's Hospital Philadelphia, Philadelphia, PA, ¹²CARE Arthritis, EDMONTON, AB, Canada, ¹³CARE Arthritis, Edmonton, AB, Canada, ¹⁴University of Alberta, Edmonton, AB, Canada
Background/Purpose: The appropriate use of imaging-based scoring instruments is usually an ad hoc process based on passive learning from published manuscripts. Moreover, most instruments lack…
Abstract Number: 587 • 2017 ACR/ARHP Annual Meeting
Detection of Structural Lesions on T1 Weighted MRI Versus Radiography of the Sacroiliac Joints in Early Axial Spa: 2-Year Data
Walter P. Maksymowych¹, Pascal Claudepierre², Manouk de Hooge³, Robert G. Lambert⁴, Robert B.M. Landewé⁵, Anna Molto⁶, Désirée van der Heijde³, Jack F Bukowski⁷, Heather Jones⁸, Isabelle Logeart⁹, Lisa Marshall⁸, Ronald Pedersen¹⁰, Annette Szumski¹¹, Bonnie Vlahos¹² and Maxime Dougados¹³, ¹Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, ²Universite Paris Est Creteil, Paris, France, ³Leiden University Medical Center, Leiden, Netherlands, ⁴University of Alberta, Edmonton, AB, Canada, ⁵Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands, ⁶Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ⁷Clinical Affairs, Pfizer, Collegeville, PA, ⁸Inflammation & Immunology Global Medical Affairs, Pfizer, Collegeville, PA, ⁹Medical Affairs, Pfizer, France, Paris, France, ¹⁰Department of Biostatistics, Pfizer, Collegeville, PA, ¹¹inVentiv Health, Princeton, NJ, ¹²Clinical Sciences, Pfizer, Collegeville, PA, ¹³Hopital Cochin, Paris Descartes University, Paris, France
Background/Purpose: At the SI joint (SIJ) level, several methods exist for evaluating structural damage, e.g., MRI, CT scan, radiographs. In EMBARK (NCT01258738) and DESIR (NCT01648907),…
Abstract Number: 588 • 2017 ACR/ARHP Annual Meeting
Inflammatory Lesions of the Sacroiliac Joints, but Not of the Spine, Are of High Utility for Recent Onset Axial Spondyloarthritis Recognition
Anna Molto¹, Laure Gossec², Violaine Foltz², Romain Beaufort³, Jean Denis Laredo⁴, Pascal Richette⁵, Philippe Dieude⁶, Philippe Goupille⁷, Antoine Feydy⁸ and Maxime Dougados⁹, ¹Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ²UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France, ³Private Practice,, Paris, France, ⁴Radiology Department, Lariboisière Hospital, Paris, France, ⁵Rheumatology Department, Université Paris Diderot, Paris, France, ⁶Université Paris-Diderot, Paris, France, ⁷Université François-Rabelais, Tours, France, ⁸Univ. Paris Descartes, PRES Sorbonne Paris Cité, Service de radiologie B, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, Paris, France, ⁹Department of Rheumatology, Paris Descartes University, Hôpital Cochin, Paris, France
Background/Purpose: only scarce data are available regarding the prevalence of MRI inflammatory lesions of the sacroiliac joints (SIJ) or the spine suggestive of axial Spondyloarthritis…
Abstract Number: 589 • 2017 ACR/ARHP Annual Meeting
Erosions at the Sacroiliac Joints and Fatty Lesions at the Spine Are the Most Discriminant Lesions for Recent Onset Axial Spondyloarthritis Recognition
Anna Molto¹, Laure Gossec², Violaine Foltz², Romain Beaufort³, Jean Denis Laredo⁴, Pascal Richette⁵, Philippe Dieude⁶, Philippe Goupille⁷, Antoine Feydy⁸ and Maxime Dougados⁹, ¹Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ²UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France, ³Private Practice,, Paris, France, ⁴Radiology Department, Lariboisière Hospital, Paris, France, ⁵Rheumatology Department, Université Paris Diderot, Paris, France, ⁶Université Paris-Diderot, Paris, France, ⁷Department of Rheumatology, CHRU de Tours; and Université François-Rabelais de Tours, Tours, France, ⁸Univ. Paris Descartes, PRES Sorbonne Paris Cité, Service de radiologie B, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, Paris, France, ⁹Paris, Paris, France
Background/Purpose: only scarce data are available regarding the prevalence of MRI structural lesions of the sacroiliac joints (SIJ) or the spine suggestive of axial Spondyloarthritis…
Abstract Number: 590 • 2017 ACR/ARHP Annual Meeting
X-Ray Spine Lesions Are Rare and Not Discriminant for Axial Spondyloarthritis Recognition in Patients with Recent Onset Chronic Back Pain
Anna Molto¹, Laure Gossec², Violaine Foltz², Romain Beaufort³, Jean Denis Laredo⁴, Pascal Richette⁵, Philippe Dieude⁶, Philippe Goupille⁷, Antoine Feydy⁸ and Maxime Dougados⁹, ¹Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ²UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France, ³Private Practice,, Paris, France, ⁴Radiology Department, Lariboisière Hospital, Paris, France, ⁵Rheumatology Department, Université Paris Diderot, Paris, France, ⁶Université Paris-Diderot, Paris, France, ⁷Université François-Rabelais, Tours, France, ⁸Univ. Paris Descartes, PRES Sorbonne Paris Cité, Service de radiologie B, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, Paris, France, ⁹Department of Rheumatology, Paris Descartes University, Hôpital Cochin, Paris, France
Background/Purpose: only very scarce data is available regarding the prevalence of spine Xrays abnormalities suggestive of axial Spondyloarthritis (axSpA) in patients with recent onset mechanical…
Abstract Number: 591 • 2017 ACR/ARHP Annual Meeting
Inflammation on MRI of Spine and Sacroiliac Joints Is Highly Predictive of Structural Damage in Axial Spondyloarthritis: The 5 Years Data of the DESIR Cohort
Alexandre Sepriano¹, Sofia Ramiro², Robert B.M. Landewé³, Maxime Dougados⁴ and Désirée van der Heijde¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands, ³University of Amsterdam and Atrium Medical Center, Amsterdam, Netherlands, ⁴Paris-Descartes University,, Paris, France
Background/Purpose: The effect of local inflammation on structural damage in patients (pts) with axial spondyloarthritis is not well known. We aimed to test the possible…

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