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  • Abstract Number: 805 • 2018 ACR/ARHP Annual Meeting

    Diastolic Dysfunction in Scleroderma: An Investigation into Associated Risk Factors and Impact on Survival

    Alicia M. Hinze1,2, Laura K. Hummers1, Fredrick M. Wigley1, Monica Mukherjee3 and Ami A. Shah1, 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Division of Rheumatology, Mayo Clinic, Rochester, MN, 3Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Scleroderma heart disease often goes unrecognized until severe clinical manifestations are present. Diastolic dysfunction (DD) may identify patients at risk for cardiac complications by…
  • Abstract Number: 806 • 2018 ACR/ARHP Annual Meeting

    Estradiol Levels Are Elevated in Older Men with Diffuse Cutaneous SSc and Are Associated with Decreased Survival

    DeAnna Baker Frost1, Bethany J Wolf2, Christine Peoples3, Katherine Silver4, Maureen Laffoon5, Thomas A. Medsger Jr.3,6 and Carol A. Feghali-Bostwick4, 1Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 2Public Health Sciences, Medical University of South Carolina, Charleston, SC, 3Department of Medicine, University of Pittsburgh, Division of Rheumatology and Clinical Immunology, Pittsburgh, PA, 4Department of Medicine, Medical University of South Carolina, Division of Rheumatology and Immunology, Charleston, SC, 5Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, 6Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by excessive extracellular matrix deposition (ECM), leading to dermal and internal organ fibrosis. As in other…
  • Abstract Number: 807 • 2018 ACR/ARHP Annual Meeting

    The Effects of DNA Methylation on Differential Expression in Dermal Fibroblasts from African-American Patients with Systemic Sclerosis

    DeAnna Baker Frost1, Willian da Silveira2, Ilia Atanelishvili3, Robert C. Wilson4, E. Starr Hazard2, Jim C. Oates5, Galina S. Bogatkevich3, Carol A. Feghali-Bostwick6, Gary Hardiman7 and Paula S. Ramos8, 1Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 2Center for Genomic Medicine, Medical University of South Carolina, Charleston, SC, 3Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 4Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, 5Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 6Department of Medicine, Medical University of South Carolina, Division of Rheumatology and Immunology, Charleston, SC, 7Department of Medicine, Medical University of South Carolina, Charleston, SC, 8Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC

    Background/Purpose: The etiology and reasons underlying the ethnic disparities in systemic sclerosis (SSc) remain unknown. African-Americans (AA) are disproportionally affected by SSc, yet dramatically underrepresented…
  • Abstract Number: 808 • 2018 ACR/ARHP Annual Meeting

    Mean Number of Nailfold Capillaries Is Associated with Disease Activity at 6 Months Follow-up in Systemic Sclerosis Patients

    Ana Maria Gheorghiu1, Raida Oneata2, Alexandra Radu1, Anca Briceag1, Cristiana Draganescu1, Cristina Vrancianu1, Stefania Magda3, Tudor Constantinescu4, Alina Soare5, Rucsandra Dobrota6, Ioan Ancuta7, Claudia Ciofu7, Liviu Macovei7, Mihaela Milicescu7, Mariana Sasu7, Alexandra Enuica8, Octavian Linte8, Gheorghe Stan8, Brindus Comanescu8, Teodor Necsoiu8, Mihai Bojinca1, Victor Stoica7 and Carina Mihai7,9, 1Internal Medicine and Rheumatology, Carol Davila University of Medicine and Pharmacy, Cantacuzino Hospital, Bucharest, Romania, 2Internal Medicine and Rheumatology Department, Carol Davila University of Medicine and Pharmacy, Cantacuzino Hospital, Bucharest, Romania, 3Cardiology Department, University Emergency Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, 4Marius Nasta National Pneumology Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, 5Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 6Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, 7Carol Davila University of Medicine and Pharmacy, Cantacuzino Hospital, Bucharest, Romania, 8Optoelectronica, Bucharest, Romania, 9Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Nailfold capillaroscopy (NFC) is essential in the evaluation and classification of systemic sclerosis (SSc). The mean number of capillaries is considered a promising tool…
  • Abstract Number: 809 • 2018 ACR/ARHP Annual Meeting

    The Lymphangiogenetic Factors VEGF-C, CCL21 and Ang-2 Are Associated with Pulmonary Arterial Hypertension in Systemic Sclerosis

    Henriette Didriksen1, Håvard Fretheim1, Vyacheslav Palchevskiy2, Arne K Andreassen1, Torhild Garen1, Oyvind Midtvedt1, Einar Gude1, John A Belperio3, Øyvind Molberg1 and Anna-Maria Hoffmann-Vold1, 1Oslo University Hospital, Oslo, Norway, 2University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 3University of California, Los Angeles, Los Angeles, CA

    Background/Purpose: Systemic sclerosis (SSc) is characterized by abnormalities in vascular pathways and lymphatic vessels with pulmonary hypertension as a major complication. Vascular endothelial growth factor…
  • Abstract Number: 810 • 2018 ACR/ARHP Annual Meeting

    Sexual Dysfunction in Women with Systemic Sclerosis

    Marina Soledad Dalpiaz1, Juan Argüello2, Maria Florencia Rodriguez3, Marta Mamani4, Anastasia Secco5, Natalia Tamborenea2, Eduardo Kerzberg6, Sandra Fabiana Montoya6, Carolina Aimo6, Fernando Manuel Villalobos6, Eliana Rebeca Serrano7, Maria Elena Crespo Espindola8 and Ana Lía Gervilla Galan9, 1Hospital Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Argentina, 2Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 3Reumatologia, Hospital Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Argentina, 4Rheumatology Department, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 5Rheumatology Section, Hospital Bernardino Rivadavia, CABA, Argentina, 6Hospital General de Agudos José María Ramos Mejía, BUENOS AIRES, Argentina, 7Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, 8Reumatologia, Hospital Señor del Milagro, Salta, Argentina, 9Hospital San Roque, San Salvador de Jujuy, Argentina

    Background/Purpose: Impaired sexual function is common among women with chronic illnesses, including Systemic Sclerosis (SSc). Studies of sexual functioning among women with SSc have concluded…
  • Abstract Number: 811 • 2018 ACR/ARHP Annual Meeting

    Identification of Risk Factors for Gastric Antral Vascular Ectasia (GAVE) Among Systemic Sclerosis Patients

    Naomi Serling-Boyd1, Shufeng Li2, David Fiorentino2, Laren Becker3, Nielsen Fernandez-Becker3, John Clarke4 and Lorinda Chung5,6, 1Medicine, Stanford University School of Medicine, Stanford, CA, 2Dermatology, Stanford University School of Medicine, Stanford, CA, 3Gastroenterology, Stanford University School of Medicine, Palo Alto, CA, 4Gastroenterology, Stanford University School of Medicine, Stanford, CA, 5VA Palo Alto Health Care System, Palo Alto, CA, 6Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA

    Background/Purpose: Gastric Antral Vascular Ectasia (GAVE) is a vascular manifestation of systemic sclerosis (SSc) characterized by erythematous streaks and longitudinal rugal folds in the stomach…
  • Abstract Number: 812 • 2018 ACR/ARHP Annual Meeting

    Inflammatory Stays Inflammatory: A Subgroup of Systemic Sclerosis Characterized By High Morbidity and Inflammatory Resistance to Cyclophosphamide

    Aleksey Mitev1, Daria Feldmann1, Moritz Binder2, Kim Möller3, Anna-Maria Kanne1, Thomas Hügle4, Peter M. Villiger5, Reinhard Voll6, Stephanie Finzel1 and Florian Kollert7, 1Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 2Department of Internal Medicine, Mayo Clinic, Rochester, MN, 3Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 4Rheumatology, University Hospital Lausanne (CHUV), Lausanne, Switzerland, 5Rheumatology and Clin Immunol, Bern, Switzerland, 6Clinic for Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 7Department of Rheumatology, Immunology, and Allergology, Inselspital, University Hospital Bern, Bern, Switzerland

    Background/Purpose: Elevated levels of C-reactive protein (CRP) in systemic sclerosis (SSc) have been linked to early inflammatory stages of the disease. This study has been…
  • Abstract Number: 813 • 2018 ACR/ARHP Annual Meeting

    Prevalence of Gastroesophageal Disease in Systemic Sclerosis and Its Impact on Lung Disease: Fact or Fiction

    Tasneam Shagroni1, David Lin2, Jeremy Wang2, Isela Valera3, Aly M Aly4, Philip J. Clements2, Daniel E. Furst2, Rajan Saggar5, Jeffrey Conklin6 and Suzanne Kafaja2, 1Rheumatology, University of California Los Angeles, Los Angeles, CA, 2University of California Los Angeles, Los Angeles, CA, 3Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, UCLA, Los Angeles, CA, 4Alexandria University Faculty of Medicine, Alexandria, Egypt, 5UCLA, Los Angeles, CA, 6Medicine, University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Systemic sclerosis (SSc) patients frequently have upper gastrointestinal (GI) symptoms, with GI involvement being the leading cause of morbidity. Meanwhile, interstitial lung disease (ILD)…
  • Abstract Number: 814 • 2018 ACR/ARHP Annual Meeting

    NON Diffuse SSc, Peripheral Neuropathy, Concomitant Sjogren Syndrome and ANTI-RNA Polymerase III Represent Risk Factors for the Higher Frequency of Cancer in a Large Single Cohort of Patients with Systemic Sclerosis

    Ana Paula Luppino-Assad1, Adriana Bortoluzzo2, Henrique Carriço da Silva3, Danieli Andrade4 and Percival Sampaio-Barros4, 1Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., sao paulo, Brazil, 2c Instituto Insper de Educação e Pesquisa, São Paulo, SP, Brasil, sao paulo, Brazil, 3Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., SAO PAULO, Brazil, 4Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., São Paulo, Brazil

    Background/Purpose: A higher prevalence of cancer has been described in patients with systemic sclerosis (SSc), but the magnitude of this risk and the type of…
  • Abstract Number: 815 • 2018 ACR/ARHP Annual Meeting

    Classic and Atypical Polymyalgia Rheumatica, Are Different Syndromes? Study of 93 Patients with PET/CT from a Single Center

    Diana Prieto Peña1, Monica Calderón Goercke1, Javier Loricera2, Isabel Martínez-Rodríguez3, Ignacio Banzo3, Belén Atienza-Mateo4, José Luis Martín-Varillas4, Vanesa Calvo-Río1, Carmen Gonzalez Vela5, Miguel Angel González-Gay2, José Luis Hernández2 and Ricardo Blanco4, 1Rheumatology, Rheumatology. Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 2Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 3Nuclear Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 4Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 5Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain

    Background/Purpose: Polymyalgia rheumatica (PMR) is a common inflammatory rheumatic disease of the elderly whose diagnosis is usually based on clinical, analytical and ultrasound findings. However,…
  • Abstract Number: 816 • 2018 ACR/ARHP Annual Meeting

    Development of Thoracic Aortic Aneurysms in Patients with Polymyalgia Rheumatica: Underdiagnosed Giant Cell Arteritis?

    Nicolas Martin Marin Zucaro1, Marina Scolnik2, Florencia Beatriz Mollerach3, Valeria Scaglioni2, Luciano Fernando Lo Giudice1, Jose Maximiliano Martinez P4, John Fredy Jaramillo Gallego1 and Enrique R Soriano5, 1Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Capital Federal, Argentina, 2Rheumatology Unit, Internal Medicine Service. Hospital Italiano Buenos Aires. Argentina, Buenos Aires, Argentina, 3Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 4Rheumatology, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 5Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, CABA, Argentina

    Background/Purpose: Polymyalgia Rheumatica (PMR) and Giant Cell Arteritis (GCA) are close-related entities. Imaging studies have suggested that subclinical inflammation of the large arteries is frequent…
  • Abstract Number: 817 • 2018 ACR/ARHP Annual Meeting

    Current Diagnostic Delays in Vasculitis and Factors Associated with Time to Diagnosis

    Antoine G. Sreih1, Dianne Shaw2, Kalen Young3, Cristina Burroughs4, Joyce Kullman5, Kirthi Machireddy6, Carol A. McAlear1, George Casey3 and Peter A. Merkel7, 1Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, 2University of North Carolina, Chapel Hill, NC, 3Vasculitis Foundation, Kansas city, MO, 4University of South Florida, Tampa, FL, 5Vasculitis, Vasculitis Foundation, Kansas City, MO, 6University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, 7Division of Rheumatology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA

       Background/Purpose: Despite recent advancements in the evaluation and management of vasculitis, patients with vasculitis continue to encounter diagnostic delays. These delays are often associated…
  • Abstract Number: 818 • 2018 ACR/ARHP Annual Meeting

    Visual Involvement in Giant Cell Arteritis: A Prospective Multi Center Study

    Faidra Laskou1, Tin Aung2, Dawn Gayford3, Siwalik Banerjee2, Cynthia S. Crowson4, Eric L. Matteson5 and Bhaskar Dasgupta6, 1Rheumatology, Southend University Hospital NHS Foundation Trust, Southend, UK, Southend-On-Sea, United Kingdom, 2Rheumatology, Southend University Hospital NHS Foundation Trust, Southend, UK, Southend-on-Sea, United Kingdom, 3Rheumatology, Southend University Hospital NHS Foundation Trust, Southend, UK, westcliff-on-Sea, United Kingdom, 4Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, 5Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, 6Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea, United Kingdom

    Background/Purpose: Under reporting of visual impairment attributable to GCA is likely; certificates of visual impairment do not include GCA as a category. Delayed presentation, recognition…
  • Abstract Number: 819 • 2018 ACR/ARHP Annual Meeting

    Use of Takayasu Arteritis Damage Score (TADS) to Measure Damage in Takayasu Arteritis

    Sivakumar Mambakkam Rajappa1 and Krishnamurthy Venkataraman2, 1Rheumatology and Immunology, GLB Hospitals, Chennai, India, 2Rheumatology, Apollo Speciality Hospitals, Chennai, India

    Background/Purpose: Takayasu Arteritis (TA) in India frequently present with complications, indicating the need for a specific damage index to capture the accumulation of disease-related scars…
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