Abstracts Archive - Page 1239 of 2607 - ACR Meeting Abstracts

Abstract Number: 790 • 2018 ACR/ARHP Annual Meeting
Gastrointestinal Symptom Burden and Quality of Life in Systemic Sclerosis: Understanding the Role of Diet
Kelly Jensen¹, Linda Wang², Rosemary Kovacic², Veronika K. Jaeger³, Monika Lammi⁴ and Lesley Ann Saketkoo⁵, ¹Tulane University School of Medicine, New Orleans, LA, ²Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, ³Department of Rheumatology, University Hospital Basel, Basel, Switzerland, ⁴GI Motility Program at Ochsner Medical Center, New Orleans, LA, ⁵Tulane, New Orleans, LA
Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune disease affecting multiple organ systems including vascular, musculoskeletal, cardiac, renal, pulmonary, and gastrointestinal (GI). 90% of SSc…
Abstract Number: 791 • 2018 ACR/ARHP Annual Meeting
Safety and Suitability of a Direct Thrombin Inhibitor, Dabigatran Etexilate, in Scleroderma-Associated Interstitial Lung Disease (SSc-ILD) Patients
Rick Silver¹, Ilia Atanelishvili², Tanjina Akter², Kelley Kajdasz³, Dulaney Wilson⁴, Paul J. Nietert⁵, J. Terrill Huggins⁶, Kristin B. Highland⁷ and Galina S. Bogatkevich², ¹Rheumatology, Medical University of SC, Charleston, SC, ²Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ³Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁴Public Health Sciences, Medical University of South Carolina, Charleston, SC, ⁵Public Health Science, Medical University of South Carolina, Charleston, SC, ⁶Pulmonology, Medical University of South Carolina, Charleston, SC, ⁷Rheumatology.org, Cleveland Clinic, Cleveland, OH
Background/Purpose: Studies from our laboratory and others have shown thrombin to be a fibrogenic mediator implicated in the pathogenesis of ILD, including scleroderma-associated ILD (SSc-ILD).…
Abstract Number: 792 • 2018 ACR/ARHP Annual Meeting
Evaluation of Esophageal Dysmotility in Systemic Sclerosis: Clinical VALUE of Computed Tomography
Cristina Sobrino¹, Cristina Pijoan-Moratalla¹, Nicolás Almeida-Arostegui², Luis Gorospe-Sarasúa² and Carlos de la Puente-Bujidos¹, ¹Rheumatology Unit. Ramón y Cajal University Hospital, Madrid, Spain, ²Radiology Unit. Ramón y Cajal University Hospital, Madrid, Spain
Background/Purpose: Esophageal dysmotility is common in Systemic Sclerosis (SSc), affecting 50-80% of patients, usually associated with poor prognosis. SSc leads to atrophy and fibrosis of…
Abstract Number: 793 • 2018 ACR/ARHP Annual Meeting
Clinical Associations of Anti-U11/U12 (RNPC-3) Autoantibodies in Patients with Systemic Sclerosis
Lorenzo Beretta¹, Michael Mahler², Chelsea Bentow², Andrea Seaman², Fabrece Roup², Michelle Amio², Karl Norvell², Jay Milo², Susan Encabo², Janire Perurena³, Maite Sanz³, Alfredo Guillen⁴, Ana Marín³, Vicent Fonollosa³, Eduardo Callejas³ and Carmen Pilar Simeón⁴, ¹Scleroderma Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy, ²Research and Development, Inova Diagnostics, San Diego, CA, ³Scleroderma Unit, Internal Medicine Department, Vall d’Hebron Hospital, Barcelona, Spain, ⁴Scleroderma Unit, Internal Medicine Department, Vall d’Hebron Hospital, Barcelona, Spain
Background/Purpose: Anti-nuclear antibodies (ANA) are present in approximately 90% of sera from systemic sclerosis (SSc) patients and play an important role in the diagnosis and…
Abstract Number: 794 • 2018 ACR/ARHP Annual Meeting
Identification of an Immunodominant Epitope on Rnpc-3 As a Target of Autoantibodies in Patients with Systemic Sclerosis
Michael Mahler¹, Chelsea Bentow¹, Jay Milo¹, Marie Hudson^2,3, Murray Baron³, May Choi⁴ and Marvin J. Fritzler⁴, ¹Research and Development, Inova Diagnostics, San Diego, CA, ²Division of Rheumatology, Jewish General Hospital, Lady Davis Institute for Medical Research, Montreal, QC, Canada, ³Department of Medicine, McGill University, Montreal, QC, Canada, ⁴Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Background/Purpose: Anti-nuclear antibodies (ANA) are present in approximately 90% of sera from systemic sclerosis (SSc) patients and play an important role in the diagnosis and…
Abstract Number: 795 • 2018 ACR/ARHP Annual Meeting
Frequency and Clinical Associations of Rare Antibodies in a Large Connective Tissue Disease Cohort
Kristina E.N. Clark¹, Corrado Campochiaro², Lauren V. Host³, Alper Sari⁴, Svetlana I. Nihtyanova⁵, Carmen Fonseca⁶, Christopher P. Denton⁷ and Voon H. Ong⁸, ¹Centre of Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, London, United Kingdom, ³Department of Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁴Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁵Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ⁶UCL Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, ⁷University College London, London, United Kingdom, ⁸Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Connective tissue diseases (CTDs) are characterised by specific autoantibodies which are useful for diagnosis. Rare antibodies have been described in CTDs in several case…
Abstract Number: 796 • 2018 ACR/ARHP Annual Meeting
Demographic and Clinical Features of Systemic Sclerosis Patients with Anti-U1RNP Antibodies: A European Scleroderma Trials and Research (EUSTAR) Analysis
Wanlong Wu^1,2, Petra Hoederath¹, Eric Hachulla³, Paolo Airò⁴, Gabriele Valentini⁵, Marco Matucci Cerinic⁶, Franco Cozzi⁷, Gabriela Riemekasten⁸, Yannick Allanore⁹, Patricia Carreira¹⁰, Suzana Jordan¹¹ and Oliver Distler¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ³Department of Internal Medicine and Clinical Immunology, Hôpital Claude Huriez, University of Lille, Lille, France, ⁴Rheumatology and Clinical immunology Unit, Spedali Civili of Brescia, Brescia, Italy, ⁵Department of Clinical and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ⁶Division of Rheumatology, Division of Rheumatology, University of Florence, Florence, Italy, ⁷Division of Rheumatology, Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ⁸Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany, ⁹Cochin Hospital, Paris Descartes University, Paris, France, Paris, France, ¹⁰Servicio de Reumatologia, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹¹Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Anti-U1RNP antibodies can be detected in patients with systemic sclerosis (SSc). However, their prevalence and clinical correlation with organ-specific complications have not been well…
Abstract Number: 797 • 2018 ACR/ARHP Annual Meeting
Absolute Reduction of Peripheral CD4+ Regulatory T Cells in Patients with Systemic Sclerosis and Its Restoration By Short-Term and Low Dose IL-2 Treatment
Lili Shang¹, Jing Luo², Chong Gao³, Jingman Yuan¹, Qian Li¹, Xiaoli Liu¹, Huiying Gao¹ and Xiao-Feng Li⁴, ¹Department of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, China, ²the Second Hospital of Shanxi Medical University, Taiyuan, China, ³Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA, ⁴Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China
Background/Purpose: The aim of the present study was to investigate whether the imbalance of CD4+ T subsets can be corrected by supplementing low dose interleukin -2 (IL-2).Methods:…
Abstract Number: 798 • 2018 ACR/ARHP Annual Meeting
Predominant Fasciitis and Mild Intramuscular Edema on Muscle Magnetic Resonance Imaging in Scleroderma-Associated Myopathy
Julie J. Paik¹, Shivani Ahlawat², Filippo DelGrande³, Laura K. Hummers⁴, Fredrick M. Wigley⁴, Ami A. Shah⁴, Andrew Mammen⁵ and Laura Fayad⁶, ¹Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Johns Hopkins University, Baltimore, MD, ⁴Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁶Radiology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Skeletal myopathy in systemic sclerosis is poorly defined. The spectrum of muscle histopathology in systemic sclerosis has been previously studied and shown to be…
Abstract Number: 799 • 2018 ACR/ARHP Annual Meeting
Progressive Lung Fibrosis in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease in the Eustar Database
Anna-Maria Hoffmann-Vold¹, Yannick Allanore², Margarida Alves³, Nicole Graf⁴, Paolo Airò⁵, Lidia Ananyeva⁶, László Czirják⁷, Serena Guiducci⁸, Eric Hachulla⁹, Mengtao Li¹⁰, Carina Mihai¹¹, Petros Sfikakis¹², Gabriele Valentini¹³, Otylia Kowal-Bielecka¹⁴ and Oliver Distler¹¹, ¹Oslo University Hospital, Oslo, Norway, ²Service de Rhumatologie A, Hôpital Cochin, Paris, France, ³Boehringer Ingelheim International GmbH, Ingelheim, Germany, ⁴Graf Biostatistics, Winterthur, Switzerland, ⁵UO Reumatologia e Immunologia Clinica, Spedali Civili di Brescia, Brescia, Italy, ⁶VA Nasonova Institute of Rheumatology, Moscow, Russian Federation, ⁷Department of Rheumatology and Immunology, University of Pécs, Pécs, Hungary, ⁸Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Firenze, Italy, ⁹Department of Internal Medicine and Clinical Immunology, Hôpital Claude Huriez, University of Lille, Lille, France, ¹⁰Department of Rheumatology, Peking Union Medical College Hospital (West Campus), Beijing, China, ¹¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ¹²Joint Rheumatology Programme, National & Kapodistrian University of Athens Medical School, Athens, Greece, ¹³Dipartimento di Medicina di Precisione, II Policlinico U.O. Reumatologia, Napoli, Italy, ¹⁴Department of Rheumatology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: Systemic sclerosis (SSc) carries a high risk for interstitial lung disease (ILD). Patients with SSc-ILD are prone to develop progressive lung fibrosis, but there…
Abstract Number: 800 • 2018 ACR/ARHP Annual Meeting
Assessment of Recent Evidence to Support Treatment Recommendations in Patients with SSc-ILD
Anna-Maria Hoffmann-Vold¹, Toby Maher², Edward Philpot³, Ali Ashrafzadeh⁴, Diwakar Jha⁵, Margarida Alves⁶ and Oliver Distler⁷, ¹Oslo University Hospital, Oslo, Norway, ²Royal Brompton Hospital, London, United Kingdom, ³IQVIA, Durham, NC, ⁴IQVIA, Los Angeles, CA, ⁵IQVIA, Gurugram, India, ⁶Boehringer Ingelheim International GmbH, Ingelheim, Germany, ⁷Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Systemic Sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis of skin and internal organs with an estimated worldwide prevalence of 110-430 cases/million.…
Abstract Number: 801 • 2018 ACR/ARHP Annual Meeting
Cardiac Autonomic Modulation at Rest and during Orthostatic Stress in Systemic Sclerosis Patients
Adriana Severino¹, Gabriel Dias Rodrigues², Chiara Bellocchi¹, Eleonora Tobaldini^3,4, Nicola Montano^3,4 and Lorenzo Beretta¹, ¹Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ²Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University, Niterói, Brazil, ³Department of Internal Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ⁴Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Background/Purpose: Autonomic dysfunction is a marker of myocardial involvement in systemic sclerosis (SSc) and heart rate variability (HRV) is impaired in SSc patients (1). The…
Abstract Number: 802 • 2018 ACR/ARHP Annual Meeting
Prognostic Significance of Bicaudal D2 Antibodies in Sistemic Sclerosis (SSc) Patients
Giulia Segatto¹, Chiara Bellocchi², Gaia Montanelli¹, Silvia Casas³, Karl Norvell⁴, Michelle Amino³, Fabrece Roup⁴, Michael Mahler⁴ and Lorenzo Beretta², ¹Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy, ²Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ³Inova Diagnostics, San Diego, CA, ⁴Research and Development, Inova Diagnostics, San Diego, CA
Background/Purpose: Antibodies (Ab) toward Bicaudal D homolog 2 (BlCD2) can be found in 25% of Systemic Sclerosis (SSc) sera, mostly in association with anti-centromere (ACA)…
Abstract Number: 803 • 2018 ACR/ARHP Annual Meeting
Treating Interstitial Lung Disease and Skin Involvement in Systemic Sclerosis with Oral Versus Intravenous Cyclophosphamide: Preliminary Efficacy and Safety Data from 2 Randomized Clinical Trials and 1 Registry
Cosimo Bruni¹, Donald P. Tashkin², Virginia D. Steen³, Yannick Allanore⁴, Oliver Distler⁵, Jonathan Grotts⁶, Marco Matucci-Cerinic⁷ and Daniel E. Furst⁸, ¹Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Firenze, Italy, ²University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ³Rheumatology, MedStar Georgetown University Hospital, Washington, DC, ⁴Cochin Hospital, Paris Descartes University, Paris, France, Paris, France, ⁵Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁶Biostatistics, University of California Los Angeles, Los Angeles, CA, ⁷Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, ⁸University of California Los Angeles, Los Angeles, CA
Background/Purpose: Two randomized controlled trials showed modest but significant effects for oral (po) CYC ( superior to placebo and equal to mycophenolate mofetil). A number…
Abstract Number: 804 • 2018 ACR/ARHP Annual Meeting
Prevalence of Echocardiographic Abnormalities in Patients with Systemic Sclerosis
Judit Lluch¹, Francisco Javier Narváez², Pablo Juárez¹ and Joan Miquel Nolla¹, ¹Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ²Rheumatology Department, Hospital Universitario de Bellvitge, Idibell, Barcelona, Spain
Background/Purpose: To determine the prevalence of echocardiographic abnormalities and to identify associated clinical and laboratory features in a large systemic sclerosis (SSc) cohort. Methods: The…

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